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Using an online community of practice to explore the informal use of mobile phones by health workers

Oxford open digital health 2023年第1期1卷 oqac003页

作者： Claire Glenton Josephine Nabukenya Smisha Agarwal Michele Meltzer Elisabeth Mukendi Immaculate Nakityo Lwanga Josephine Namitala Sunanda Reddy Geoff Royston Tigest Tamrat Neil Pakenham-Walsh Department of Health and Functioning Western Norway University of Applied Sciences 5020 Bergen Norway. Department of Information Systems School of Computing & Informatics Technology Makerere University 7062 Kampala Uganda. Department of International Health Johns Hopkins University Bloomberg School of Public Health Baltimore MD 20205 USA. Department of Medicine Thomas Jefferson University Philadelphia PA 19107 USA. Department of Health Senghor University Alexandria Governorate 5361022 Egypt. School of Public Health Makerere University 7062 Kampala Uganda. Department of Adult and Community Education Makerere University 7062 Kampala Uganda. Centre for Applied Research and Education on Neurodevelopmental Impairments and Disability-related Health Initiatives New Delhi 110075 India. Healthcare Information for All Global Healthcare Information Network Oxfordshire UK. UNDP/UNFPA/UNICEF/World Bank Special Program of Research Development and Research Training in Human Reproduction (HRP) Department of Sexual and Reproductive Health and Research World Health Organization Geneva 1211 Switzerland.

Health workers are increasingly harnessing mobile phones to develop their own solutions to work challenges. The mHEALTH-INNOVATE project aims to explore this topic further. In 2022, Healthcare Information for All organized an online discussion among health workers and other stakeholders to inform the project. Twenty-five people joined the discussion. Contributors' descriptions of the varieties of mobile phone use tallied with previous research, including for communication with patients and colleagues. In addition, they described increased mobile phone use in response to the COVID-19 pandemic and the increased need for communication, monitoring and reporting, including during lockdowns. Some solutions were health worker-initiated, including the establishment of WhatsApp groups. The discussion has helped develop a definition of informal mobile phone use.

关键词： digital health digital innovation health workforce informal mhealth mobile device mobile health

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AIRR community curation and standardised representation for immunoglobulin and T cell receptor germline sets

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Immunoinformatics (Amsterdam, Netherlands) 2023年 10卷 100025页

作者： William D Lees Scott Christley Ayelet Peres Justin T Kos Brian Corrie Duncan Ralph Felix Breden Lindsay G Cowell Gur Yaari Martin Corcoran Gunilla B Karlsson Hedestam Mats Ohlin Andrew M Collins Corey T Watson Christian E Busse Institute of Structural and Molecular Biology Birkbeck College London England. Human-Centered Computing and Information Science Institute for Systems and Computer Engineering Technology and Science Porto Portugal. Peter O'Donnell Jr. School of Public Health UT Southwestern Medical Center Dallas TX USA. Bioengineering Program Faculty of Engineering Bar-Ilan University Ramat Gan Israel. Department of Biochemistry and Molecular Genetics School of Medicine University of Louisville KY USA. Department of Biological Sciences Simon Fraser University Burnaby BC Canada. Fred Hutchinson Cancer Research Center Seattle WA USA. Peter O'Donnell Jr. School of Public Health Department of Immunology School of Biomedical Sciences UT Southwestern Medical Center Dallas TX USA. Department of Microbiology Tumor and Cell Biology Karolinska Institutet Stockholm Swede. Department of Immunotechnology and SciLifeLab Lund University Lund Sweden. School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney NSW Australia. Division of B Cell Immunology German Cancer Research Center Heidelberg Germany.

Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends upon accurate and relatively complete germline sets, but current sets are known to be incomplete. Established processes for the review and systematic naming of receptor germline genes and alleles require specific evidence and data types, but the discovery landscape is rapidly changing. To exploit the potential of emerging data, and to provide the field with improved state-of-the-art germline sets, an intermediate approach is needed that will allow the rapid publication of consolidated sets derived from these emerging sources. These sets must use a consistent naming scheme and allow refinement and consolidation into genes as new information emerges. Name changes should be minimised, but, where changes occur, the naming history of a sequence must be traceable. Here we outline the current issues and opportunities for the curation of germline IG/TR genes and present a forward-looking data model for building out more robust germline sets that can dovetail with current established processes. We describe interoperability standards for germline sets, and an approach to transparency based on principles of findability, accessibility, interoperability, and reusability.

关键词： AIRR-seq Immune receptor Immune receptor germline Immune receptor repertoire Rep-seq

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Scientific discovery in the age of artificial intelligence

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NATURE 2023年第7978期621卷 E33-E33页

作者： Wang, Hanchen Fu, Tianfan Du, Yuanqi Gao, Wenhao Huang, Kexin Liu, Ziming Chandak, Payal Liu, Shengchao Van Katwyk, Peter Deac, Andreea Anandkumar, Anima Bergen, Karianne Gomes, Carla P. Ho, Shirley Kohli, Pushmeet Lasenby, Joan Leskovec, Jure Liu, Tie-Yan Manrai, Arjun Marks, Debora Ramsundar, Bharath Song, Le Sun, Jimeng Tang, Jian Velickovic, Petar Welling, Max Zhang, Linfeng Coley, Connor W. Bengio, Yoshua Zitnik, Marinka Department of Engineering University of Cambridge Cambridge UK Department of Computing and Mathematical Sciences California Institute of Technology Pasadena CA USA NVIDIA Santa Clara CA USA Department of Computational Science and Engineering Georgia Institute of Technology Atlanta GA USA Department of Computer Science Cornell University Ithaca NY USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA Department of Computer Science Stanford University Stanford CA USA Department of Physics Massachusetts Institute of Technology Cambridge MA USA Harvard-MIT Program in Health Sciences and Technology Cambridge MA USA Mila – Quebec AI Institute Montreal Quebec Canada Université de Montréal Montreal Quebec Canada HEC Montréal Montreal Quebec Canada CIFAR AI Chair Toronto Ontario Canada Department of Earth Environmental and Planetary Sciences Brown University Providence RI USA Data Science Institute Brown University Providence RI USA Center for Computational Astrophysics Flatiron Institute New York NY USA Department of Astrophysical Sciences Princeton University Princeton NJ USA Department of Physics Carnegie Mellon University Pittsburgh PA USA Department of Physics and Center for Data Science New York University New York NY USA Google DeepMind London UK Department of Computer Science and Technology University of Cambridge Cambridge UK Microsoft Research Beijing China Department of Biomedical Informatics Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Harvard Data Science Initiative Cambridge MA USA Kempner Institute for the Study of Natural and Artificial Intelligence Harvard University Cambridge MA USA Department of Systems Biology Harvard Medical School Boston MA USA Deep Forest Sciences Palo Alto CA USA BioMap Beijing China Mo

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The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels (vol 400, pg 1619, 2022)

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LANCET 2022年第10365期400卷 1766-1766页

作者： Romanello, M. Di Napoli, C. Drummond, P. Institute for Global Health University College London London UK School of Agriculture Policy and Development University of Reading Reading UK Institute for Sustainable Resources University College London London UK Department of Global Health Centre for Health and the Global Environment University of Washington Seattle WA USA UCL Energy Institute University College London London UK Department of Health Sciences University of York York UK Department of Meteorology University of Reading Reading UK Institute for Risk and Disaster Reduction University College London London UK School of Earth and Environment University of Leeds Leeds UK Centre on Climate Change and Planetary Health London School of Hygiene & Tropical Medicine London UK School of Population Health University of Melbourne Melbourne VIC Australia Department of Earth System Science Tsinghua University Beijing China Mercator Research Institute on Global Commons and Climate Change Berlin Germany Department of Environment Climate Change and Health World Health Organization Geneva Switzerland Institute of Environmental Sciences University of Geneva Geneva Switzerland Cardiovascular Epidemiology Unit Department of Public Health & Primary Care University of Cambridge Cambridge UK School of Government University of Birmingham Birmingham UK Economic Analysis of Climate Impacts and Policy Division Centro Euro-Mediterraneo sui Cambiamenti Climatici Venice Italy Institute for Environmental Design and Engineering University College London London UK Natural Resources Institute University of Greenwich London UK Department of Environmental Health Sciences and Yale Center on Climate Change and Health Yale University New Haven CT USA Department of Civil and Environmental Engineering Northeastern University Boston MA USA Department of Fish and Wildlife Conservation Virginia Polytechnic Institute and State University Blacksburg VA USA Department of Geography University College London London UK NU

With advancements in the science of detection and attribution studies, the influence of climate change over many events has now been quantified. Because of the rapidly increasing temperatures, vulnerable populations (adults older than 65 years, and children younger than one year of age) were exposed to 3·7 billion more heatwave days in 2021 than annually in 1986–2005 (indicator 1.1.2), and heat-related deaths increased by 68% between 2000–04 and 2017–21 (indicator 1.1.5), a death toll that was significantly exacerbated by the confluence of the COVID-19 pandemic. Despite the local cooling and overall health benefits of urban greenspaces, only 277 (27%) of 1038 global urban centres were at least moderately green in 2021 (indicator 2.2.3), and the number of households with air conditioning increased by 66% from 2000 to 2020, a maladaptive response that worsens the energy crisis and further increases urban heat, air pollution, and greenhouse gas emissions. [...]millions of people do not have access to the energy needed to keep their homes at healthy temperatures, preserve food and medication, and meet the seventh Sustainable Development Goal (to ensure access to affordable, reliable, sustainable, and modern energy for all). Aggravating this situation even further, governments continue to incentivise fossil fuel production and consumption: 69 (80%) of 86 countries reviewed had net-negative carbon prices (ie, provided a net subsidy to fossil fuels) for a net total of US$400 billion

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CEMCO: A Novel Competitive Evolutionary Multi-Colony Optimization Algorithm for Constrained Problems

CEMCO: A Novel Competitive Evolutionary Multi-Colony Optimiz...

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International Conference on Fuzzy systems and Knowledge Discovery (FSKD)

作者： Mário Tasso Ribeiro Serra Neto Marco Antônio Florenzano Mollinetti Demison Rolins de Souza Alves Rodrigo Lisbôa Pereira Otávio Noura Teixeira University Centre of the State of Pará (CESUPA) Computational Intelligence Laboratory (LINCOMP) Belém Pará Brazil Systems Optimization Laboratory Tsukuba University Tsukuba Ibaraki Japan Federal Rural University of Amazon (UFRA) Electrical Engineering Post Graduation Program of the Federal University of Par (UFPA) Paragominas Pará Brazil Applied Computing Post Graduation Program (PPCA) Federal University of Pará Tucuruí (UFPA-TUC) Tucuruí Pará Brazil

ISBN: (纸本)9781538680988;9781538680971

The following paper presents a hybrid Swarm Intelligence algorithm, named Competitive Evolutionary Multi-Colony Optimization (CEMCO). CEMCO is based on the well-known bee inspired algorithm Artificial Bee Colony (ABC), introducing Evolutionary Strategies (ES)under a parallel master-slave architecture utilizing the General Purpose computing on Graphics Processing Units (GPGPU)paradigm. The goal of this approach is to enhance the overall performance of the master algorithm, producing high quality solutions, and significant solutions under a reduced processing time. Performance evaluation of CEMCO is performed by two large scale constrained optimization problems: Design of Pressure Vessel (DPV)and Welded Beam Design (WBD). Results obtained are compared against prominent techniques found in the literature.

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The association for the advancement of artificial intelligence 2020 workshop program

The association for the advancement of artificial intelligen...

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作者： Bang, Grace Barash, Guy Bea, Ryan Cali, Jacques Castillo-Effen, Mauricio Chen, Xin Cynthia Chhaya, Niyati Dhoopar, Rohan Dumancic, Sebastijan Espinoza, Huáscar Farchi, Eitan Fioretto, Ferdinando Fuentetaja, Raquel Galley, Michel Geib, Christopher Hernández-Orallo, José Huang, Xiaowei Keren, Sarah Kim, Seokhwan Jaidka, Kokil Liu, Xiaomo Lu, Tyler Ma, Zhiqiang Mallah, Richard McDermid, John Michalowski, Martin Mirsky, Reuth Héigeartaigh, Seán Ó. Ramachandran, Deepak Segovia-Aguas, Javier Shaban-Nejad, Arash Shehory, Onn Shwartz, Vered Srivastava, Siddharth Talamadupula, Kartik Tang, Jian Zhang, Dell Zhang, Jian S&P Global. Western Digital University of Southampton United Kingdom Blue Prism Group PLC Lockheed Martin's Advanced Technology Laboratories ArlingtonVA United States University of Hong Kong Hong Kong Adobe Research Google Research Katholieke Universiteit Leuven Belgium Commissariat à ĺÉnergie Atomique France IBM Research Department of Electrical Engineering and Computer Science Syracuse University United States Universidad Carlos III de Madrid Spain Microsoft Research AI SIFT LLC Universitat Politècnica de València Spain Leverhulme Centre for the Future of Intelligence United Kingdom Department of Computer Science University of Liverpool United Kingdom National University of Singapore Singapore Harvard School of Engineering and Applied Sciences in the of Fields of Multiagent Environment Design and Goal Recognition Design Amazon Alexa AI Future of Life Institute United States University of York Assuring Autonomy International Program United Kingdom University of Minnesota School of Nursing MinneapolisMN United States University of Texas at Austin AustinTX United States Institut de Robòtica i Informàtica Industrial Spanish Council for Scientific Research Technical University of Catalonia Spain Oak Ridge National Laboratory Center for Biomedical Informatics Department of Pediatrics University of Tennessee Health Science Center United States Bar Ilan University Israel University of Washington SeattleWA United States Autonomous Agents and Intelligent Robots lab of the School of Computing Informatics Decision Systems Arizona State University United States DiDi AI Labs School of Industrial and System Engineering Georgia Institute of Technology United States University of London United Kingdom Microsoft Azure

The Association for the Advancement of Artificial Intelligence 2020 Workshop program included twenty-three workshops covering a wide range of topics in artificial intelligence. This report contains the required reports, which were submitted by most, but not all, of the workshop chairs. Copyright © 2020, Association for the Advancement of Artificial Intelligence. All rights reserved.

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Change in Terrestrial Human Footprint Drives Continued Loss of Intact Ecosystems

SSRN

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SSRN 2020年

作者： Williams, Brooke A. Venter, Oscar Allan, James R. Atkinson, Scott C. Rehbein, Jose A. Ward, Michelle S. Marco, Moreno Di Grantham, Hedley S. Ervin, Jamison Goetz, Scott Hansen, Andrew J. Jantz, Patrick Pillay, Rajeev Rodríguez-Buriticá, Susana Supples, Christina Virnig, Anne L.S. Watson, James E.M. School of Earth and Environmental Sciences University of Queensland St LuciaQLD Australia Centre for Biodiversity and Conservation Science School of Biological Sciences University of Queensland St LuciaQLD4072 Australia University of Northern British Columbia Prince GeorgeBritish Colombia Canada University of Amsterdam P.O. Box 94240 Amsterdam1090 GE Netherlands 304 East 45 Street Floor 15 New YorkNY10017 United States World Bank WashingtonDC20433 United States Dept. of Biology and Biotechnology Sapienza University of Rome viale dell’Università 32 Rome00185 Italy Wildlife Conservation Society Global Conservation Program New York United States Northern Arizona University Flagstaff AZ86011-5693 United States Ecology Department Montana State University BozemanMT59717 United States School of Informatics Computing and Cyber Systems Northern Arizona University Natural Resources and Environmental Studies Institute University of Northern British Columbia Prince GeorgeBCV2N 4Z9 Canada

Our ability to map humanity’s influence across Earth has evolved, thanks to powerful computing, a network of earth observing satellites, and new bottom-up census and crowd-sourced data. Here, we provide the latest temporally inter-comparable maps of the terrestrial Human Footprint, and assessment of change in human pressure at global, biome, and ecoregional scales. In 2013, 42% of terrestrial Earth could be considered relatively free of anthropogenic disturbance, and 25% could be classed as ‘wilderness’ (the least degraded end of the human footprint spectrum). Between 2000 and 2013, 1.9 million km 2 - an area the size of Mexico - of land relatively free of human disturbance became highly modified. The majority of this occurred within tropical and subtropical grasslands, savannah, and shrubland ecosystems, but the rainforests of Southeast Asia also underwent rapid modification . Our results show that humanity’s footprint is eroding Earth’s last intact ecosystems, and greater efforts are urgently needed to retain them. © 2020, The Authors. All rights reserved.

关键词： Biodiversity

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BioBankWarden: A web-based system to support translational cancer research by managing clinical and biomaterial data

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COMPUTERS IN BIOLOGY AND MEDICINE 2017年 84卷 254-261页

作者： Ferretti, Yuri Brandao Miyoshi, Newton Shydeo Silva, Wilson Araujo, Jr. Felipe, Joaquim Cezar [a] Inter-institutional Post-graduation Program on Bioinformatics University of São Paulo Brazil[b] Department of Computing and Mathematics Faculty of Philosophy Sciences and Languages of Ribeirão Preto University of São Paulo Brazil[c] Center for Integrative Systems Biology - CISBi NAP/USP University of São Paulo Brazil[d] Department of Genetics School of Medicine of Ribeirão Preto University of São Paulo Brazil

Background: Researchers of translational medicine face numerous challenges in attempting to bring research results to the bedside. This field of research covers a wide range of resources, including blood and tissue samples, which are processed for isolation of RNA and DNA to study cancer omics data (genomics, proteomics and metabolomics). Clinical information about patients' habits, family history, physical examinations, remissions, etc., is also important to underpin studies aimed at identifying patterns that lead to the development of cancer and to its successful treatment. Purpose: Development of a web-based computer system-BioBankWarden-to manage, consolidate and integrate these diversified data, enabling cancer research groups to retrieve and analyze clinical and biomolecular data within an integrative environment. The system has a three-tier architecture comprising database, logic and user-interface layers. Results: The system's integrated database and user-friendly interface allow for the control of patient records, biomaterial storage, research groups, research projects, users and biomaterial exchange. Conclusions: BioBankWarden can be used to store and retrieve specific information from different clinical fields linked to biomaterials collected from patients, providing the functionalities required to support translational research in the field of cancer. (C) 2015 Elsevier Ltd. All rights reserved.

关键词： Translational medicine Biological databases Oncogenomics Biomaterial management Clinical data management

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BioWorkbench: A high-performance framework for managing and analyzing bioinformatics experiments

arXiv

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arXiv 2018年

作者： Mondelli, Maria Luiza Magalhães, Thiago Loss, Guilherme Wilde, Michael Foster, Ian Mattoso, Marta Katz, Daniel S. Barbosa, Helio J.C. Vasconcelos, Ana Tereza R. Ocaña, Kary Gadelha, Luiz M.R. National Laboratory for Scientific Computing Petrópolis Brazil Computation Institute Argonne National Laboratory University of Chicago Chicago United States Computer and Systems Engineering Program Federal University of Rio de Janeiro Brazil National Center for Supercomputing Applications University of Illinois Urbana United States Federal University of Juiz de Fora Minas Gerais Brazil

Advances in sequencing techniques have led to exponential growth in biological data, demanding the development of large-scale bioinformatics experiments. Because these experiments are computation- and data-intensive, they require high-performance computing (HPC) techniques and can benefit from specialized technologies such as Scientific Workflow Management systems (SWfMS) and databases. In this work, we present BioWorkbench, a framework for managing and analyzing bioinformatics experiments. This framework automatically collects provenance data, including both performance data from workflow execution and data from the scientific domain of the workflow application. Provenance data can be analyzed through a web application that abstracts a set of queries to the provenance database, simplifying access to provenance information. We evaluate BioWorkbench using three case studies: SwiftPhylo, a phylogenetic tree assembly workflow;SwiftGECKO, a comparative genomics workflow;and RASflow, a RASopathy analysis workflow. We analyze each workflow from both computational and scientific domain perspectives, by using queries to a provenance and annotation database. Some of these queries are available as a pre-built feature of the BioWorkbench web application. Through the provenance data, we show that the framework is scalable and achieves high-performance, reducing up to 98% of the case studies execution time. We also show how the application of machine learning techniques can enrich the analysis process. Copyright © 2018, The Authors. All rights reserved.

关键词： Bioinformatics

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Author Correction: Greengenes2 unifies microbial data in a single reference tree

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Nature biotechnology 2024年第5期42卷 813页

作者： Daniel McDonald Yueyu Jiang Metin Balaban Kalen Cantrell Qiyun Zhu Antonio Gonzalez James T Morton Giorgia Nicolaou Donovan H Parks Søren M Karst Mads Albertsen Philip Hugenholtz Todd DeSantis Se Jin Song Andrew Bartko Aki S Havulinna Pekka Jousilahti Susan Cheng Michael Inouye Teemu Niiranen Mohit Jain Veikko Salomaa Leo Lahti Siavash Mirarab Rob Knight Department of Pediatrics University of California San Diego School of Medicine La Jolla CA USA. Department of Electrical and Computer Engineering University of California San Diego La Jolla CA USA. Bioinformatics and Systems Biology Program University of California San Diego La Jolla CA USA. Department of Computer Science and Engineering University of California San Diego La Jolla CA USA. School of Life Sciences Arizona State University Tempe AZ USA. Biodesign Center for Fundamental and Applied Microbiomics Arizona State University Tempe AZ USA. Biostatistics & Bioinformatics Branch Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA. Halicioglu Data Science Institute University of California San Diego La Jolla CA USA. Australian Centre for Ecogenomics School of Chemistry and Molecular Biosciences The University of Queensland St Lucia Queensland Australia. Department of Obstetrics and Gynecology Columbia University New York NY USA. Department of Chemistry and Bioscience Aalborg University Aalborg Denmark. Department of Informatics Second Genome Brisbane CA USA. Center for Microbiome Innovation Jacobs School of Engineering University of California San Diego La Jolla CA USA. Finnish Institute for Health and Welfare Helsinki Finland. Institute for Molecular Medicine Finland FIMM-HiLIFE Helsinki Finland. Division of Cardiology Brigham and Women's Hospital Boston MA USA. Cedars-Sinai Medical Center Los Angeles CA USA. Cambridge Baker Systems Genomics Initiative Baker Heart and Diabetes Institute Melbourne Victoria Australia. Cambridge Baker Systems Genomics Initiative Department of Public Health and Primary Care University of Cambridge Cambridge UK. Division of Medicine Turku University Hospital and University of Turku Turku Finland. Sapient Bioanalytics LLC San Diego CA USA. Department of Computing University of Turku Turku Finland. Department of Pediatrics Uni

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