Cloud computing offers solutions for various scientific and business applications. Large-scale scientific applications, which are organized as scientific workflows, are carried out using cloud computing. However, the ...
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In Japan, population decline and the depopulation of local regions have become social issues. Various municipalities are working to discover and promote the unique attractions of their regions. Identifying the local r...
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Dysregulation of hepatic metabolism is a crucial factor in the development of fatty liver disease and significantly increases the risk of hepatocellular carcinoma (HCC). This study aims to identify the genes implicate...
Dysregulation of hepatic metabolism is a crucial factor in the development of fatty liver disease and significantly increases the risk of hepatocellular carcinoma (HCC). This study aims to identify the genes implicated in the prognosis of HCC among individuals suffering from metabolic fatty liver disease. We analysed protein–protein interaction (PPI) networks and constructed a weighted gene co-expression network analysis (WGCNA) using high-throughput gene expression profiling datasets. Our meta-analysis uncovered 442 differentially expressed genes (DEGs), comprising 30 upregulated and 412 downregulated genes. We constructed a PPI network from the DEGs and identified significant hub genes based on their degree centrality scores. Additionally, WGCNA highlighted impactful genes and tightly correlated modules, leading to the creation of a gene interaction network specific to metabolism-associated fatty liver disease (MAFLD). Pathway analysis revealed the candidate regulatory gene interleukin-7 receptor (IL7R), which is involved in cytokine-mediated signalling across both interaction networks. Pro-inflammatory cytokines interact with IL7R, activating the JAK/STAT pathway that influences gene expression throughout progression to HCC. IL7R activates STAT3, affecting the behaviour of activated hepatic stellate cells following initial liver damage. Furthermore, the expression of the IL7R gene was validated as a predictor of HCC malignancy through a logistic regression model, resulting in an accuracy of 92%. Findings suggest that IL7R could be the target gene associated with metabolism-linked HCC. It could significantly impact the management of metabolic-associated fatty liver disease (MAFLD) and may help enhance HCC diagnostics to improve patient outcomes.
We study a novel charged hadronic string model within the least action principle and the vacuum field theory approach based on the classical R.P. Feynman’s proper time paradigm. It is stated that the hadronic string ...
The kidney is a crucial organ in the human body, co-operating billions of pipelines to cleanse the body's water. Kidney failure, renal tumor happens when cells divide uncontrollably and form an aberrant collection...
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Hepatocellular carcinoma (HCC) represents the most prevalent form of primary liver cancer, accounting for 75 % of all cases. Individuals with metabolic dysfunctions are at risk of developing significant symptoms, incl...
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Multimodal learning analytics have become increasingly important in enabling a deeper understanding of teaching and learning in educational research. However, in comparison to other multimodal learning data, there is ...
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In Japan, population decline and the depopulation of local regions have become social issues. Various municipalities are working to discover and promote the unique attractions of their regions. Identifying the local r...
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ISBN:
(数字)9798331507817
ISBN:
(纸本)9798331507824
In Japan, population decline and the depopulation of local regions have become social issues. Various municipalities are working to discover and promote the unique attractions of their regions. Identifying the local resources can help foster attachment to the region, potentially reducing population outflow and increasing the number of new residents. In this paper, we propose a location-based system to discover local resources and their associated stories to foster attachment to the local community. To evaluate whether this system effectively identifies local attractions and cultivates attachment to the community, we organized a town walking event in collaboration with local municipalities and members of local community groups in the event area.
1 Introduction Traditional covert communication[1]usually relies on centralized channels,which are efficient in transmission but susceptible to eavesdropping and attacks,leading to information ***,distributed methods ...
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1 Introduction Traditional covert communication[1]usually relies on centralized channels,which are efficient in transmission but susceptible to eavesdropping and attacks,leading to information ***,distributed methods also exist,such as peer-to-peer networks and distributed hash *** technology,which is decentralized,anonymous,non-tamperable and anti-attack,can be applied to covert communication to solve the problems of traditional methods and improve the quality of communication.
Although precedences are often used to resolve ambiguities in programming language descriptions, there has been no parser-independent definition of languages which are generated by grammars with precedence rules. This...
Although precedences are often used to resolve ambiguities in programming language descriptions, there has been no parser-independent definition of languages which are generated by grammars with precedence rules. This paper gives such a definition for a subclass of context-free grammars. The definition is shown to be equivalent to the implicit definition an operator precedence parser gives. A problem with a language containing infix, prefix and postfix operators of different precedences is that the well-known algorithm, which transforms a grammar with infix operator precedences to an ordinary unambiguous context-free grammar, does not work. This paper gives an algorithm that works also for prefix and postfix operators, and the correctness of it is proved. An application of the algorithm is also presented.
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