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Amplifying concerns: An exploration of community noise levels in rural communities impacted by wood pellet production

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Environmental Challenges 2024年 17卷

作者： Walker, E.D. Lee, N. Franzen Nica, C. Barnes, A. Graham, B. Martin, K. Community Noise Lab Department of Epidemiology Brown University School of Public Health Providence RI United States Environmental Science PhD Program College of Science Engineering and Technology Jackson State University Jackson MS United States Greater Greener Gloster Project Gloster MS United States

Wood pellets are increasingly promoted as a renewable and sustainable energy source, driving the global wood pellet market to a projected value of $16 billion by 2026. However, the rapid expansion of this industry disproportionately affects predominantly Black and low-income communities in the rural South, where approximately 100 pellet manufacturing plants are currently located in the United States. From August 2023 to March 2024, we conducted a noise exposure assessment in Gloster, Mississippi, a community affected by pellet production, and compared it to Mendenhall, a nearby community without industrial activity. In collaboration with a local organization, we measured noise metrics and found significantly higher A-weighted, C-weighted, and Z-weighted sound levels in Gloster, along with elevated decibels at multiple center frequencies. These findings suggest that wood pellet manufacturing can severely alter the soundscape of rural communities, raising environmental justice concerns. Our findings underscore the importance of investigating the cumulative health impacts of noise and other environmental burdens on these vulnerable communities to better inform policy. © 2024

关键词： Community noise Environmental justice Low-frequency noise Mississippi Rural Wood biomass Wood pellet production

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Perspectives of Indonesian Muslim patients with advanced lung cancer on good death: A qualitative study

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European Journal of Oncology Nursing 2023年 62卷 102251-102251页

作者： Pribadi, Dimas Ria Angga Shih, Whei-Mei Wu, Guey-Hau Lin, Hung-Ru PhD Program School of Nursing National Taipei University of Nursing and Health Sciences Taipei Taiwan Department of Nursing Muhammadiyah University of Surakarta Jawa Tengah Indonesia Department of Gerontology and Health Care Management Chang Gung University of Science and Technology Taoyuan Taiwan School of Nursing National Taipei University of Nursing and Health Sciences Taipei Taiwan

Purpose: Lung cancer is the leading cause of cancer-related death. Patients with advanced lung cancer may experience burdensome distress at the end of life. The concept of good death has been shown to be complex, and continues to be expanded by gaining a better understanding of the cultural views of different populations. This study aimed to explore the perspective of Indonesian Muslims patients with advanced cancer on the concept of good death. Method: A qualitative design comprising in-depth interviews was employed. Seven male and 3 female Muslim patients between ages 36 and 68 and diagnosed with advanced lung cancer were recruited from a teaching hospital in Central Java, Indonesia. Results: Content analysis of the interviews revealed five themes: dying without physical discomfort, dying in religious ways and in a desirable place, dying without emotional discomfort, receiving help and support, and having a good relationship with medical staff. Conclusions: Indonesian Muslim patient with advanced lung cancer have unique perspectives on good death, especially based on the themes of religious ways of dying and support from family. health care providers should be aware that good death is not an individual concern and should thus adopt highly sensitive observation skills to assess the physical and emotional state of patients. These providers must also understand their patients’ preferences and respect their needs, regardless of their own beliefs. © 2022 Elsevier Ltd

关键词： Advanced lung cancer Content analysis Good death Indonesian Muslim patients Interview Qualitative

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Chlorine-containing polyacetoxybriarane diterpenoids from the octocoral Junceella fragilis

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RSC Advances 2024年第24期14卷 17195-17201页

作者： Do, Hai Nhat Chen, Yu-Ta Chien, Su-Ying Chen, You-Ying Zhang, Mingzi M. Tsou, Lun Kelvin Chen, Jih-Jung Wen, Zhi-Hong Lo, Yi-Hao Zheng, Li-Guo Sung, Ping-Jyun Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung804201 Taiwan National Museum of Marine Biology & Aquarium Pingtung944401 Taiwan Department of Family Medicine Zuoying Armed Forces General Hospital Kaohsiung813204 Taiwan Instrumentation Center National Taiwan University Taipei106319 Taiwan Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli350401 Taiwan Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Miaoli350401 Taiwan Department of Pharmacy School of Pharmaceutical Sciences National Yang Ming Chia Tung University Taipei112304 Taiwan Shu-Zen Junior College of Medicine and Management Kaohsiung821004 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung804201 Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-sen University Kaohsiung804201 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung807378 Taiwan PhD Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City242062 Taiwan

The chemical screening of an octocoral identifed as Junceella fragilis has led to the isolation of five chlorinated briarane-type diterpenoids, including three known metabolites, gemmacolide X (1), frajunolide I (2), and fragilide F (3), along with two new analogs, 12α-acetoxyfragilide F (4) and 12α-acetoxyjunceellin (5). Single-crystal X-ray diffraction analysis was carried out to determine the absolute configurations of 1 and 2, while the structures of new compounds 4 and 5 were ascertained with 2D NMR experiments. Briaranes 1 and 3-5 were active in enhancing alkaline phosphatase (ALP) activity. © 2024 The Royal Society of Chemistry.

关键词： Metabolites

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RISEUP Project: An Innovative Application of Microsecond Electric Pulses for Spinal Cord Injury Regeneration

RISEUP Project: An Innovative Application of Microsecond Ele...

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IEEE MTT-S International Microwave Bio Conference ((IMBIOC)

作者： Giorgia Innamorati Giulia Bergafora Camilla Codazzi Francesca Camera Caterina Merla Noemi Dolciotti Micol Colella Laura Caramazza Sara Fontana Maria Pedraza Marina Sanchez Petidier Paolo Marracino Claudia Consales Department of Biology PhD Program in Cellular and Molecular Biology University “Tor Vergata” Health Division ENEA Rome Italy Health Division ENEA Rome Italy DIET Sapienza University Rome Italy Neuronal and Tissue Regeneration Laboratory Centro de Investigación Príncipe Felipe Valencia Spain Université Paris-Saclay Institut Gustave Roussy Villejiuf France RISE TECHNOLOGY SRL Ostia (RM) Italy

Spinal cord injury (SCI) is a disabling, devasting and irreversible condition that strongly impacts on patients' life and their families. Every year among 250.000 and 500.000 new SCI cases are diagnosed. Most of them are traumatic and the average of age at diagnosis is 20–29 years for males, while females are most at risk in adolescence (15–19), which means a tremendous socioeconomic impact on affected individuals and the health care system. Recent advances in medical management of SCI have significantly improved diagnosis, stabilization, survival rate and well-being of SCI patients. However, there has been small progress on treatment options for improving the neurological outcomes of SCI patients. This is principally due to the high complexity of spinal cord tissue and to all events that occur after its lesion. RISEUP is a H2020 FET-Open project (nr. 964562) aimed at introducing stem cells microsecond (µs) electric pulses stimulation as a strategy for guiding their differentiation towards a neuronal phenotype for SCI regeneration. Here the Authors report the first results on molecular response induced by µs pulses on mesenchymal stem cells (MSCs) and induced neuronal stem cells (iNSCs).

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Improving the lifestyle behavior of type 2 diabetes mellitus patients using a mobile application

Improving the lifestyle behavior of type 2 diabetes mellitus...

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IEEE Symposium on Computers and Communications (ISCC)

作者： Andreia Pinto João Viana Diogo Martinho Vítor Crista José Miguel Diniz Joana Reis João Matos David Greer Goreti Marreiros Alberto Freitas Department of Community Medicine Information and Health Decision Sciences (MEDCIDS) Faculty of Medicine Center for Health Technology and Services Research (CINTESIS) University of Porto Porto Portugal Research Group on Intelligent Engineering and Computing for Advanced Innovation and Development (GECAD) Institute of Engineering Polytechnic of Porto Porto Portugal Health Data Science PhD Program Faculty of Medicine Center for Health Technology and Services Research (CINTESIS) University of Porto Lisboa Portugal CLOO - Behavioral Insights Unit Faculty of Psychology CICPSI - Research Center for Psychological Science University of Lisbon Lisboa Portugal Behavioral Insights Unit CLOO Porto Portugal Behavioral Insights Unit CLOO Lisboa Portugal

ISBN: (数字)9781665497923

ISBN: (纸本)9781665497930

Type 2 diabetes is an increasingly prevalent disease and patients do not always manage the disease properly. Therefore, creating tools that help diabetics self-manage their condition over time is of the utmost importance. Technological tools that include features meeting this population's needs, with an integrated personalized feedback system, in an environment of gamified incentives, may be the way for developing a sustained app's usage. This work aims to present a still in development, novel approach to managing diabetes type 2 with a focus on data analysis from user-inputs, gamification, and personalized coaching, with an accessible user interface. Thus, we will present some functionalities, in particular the theoretical and practical concept that is behind this development, namely the Transtheoretical model of behavior change to create different profiles, to provide customized feedback according to the user's behavioral stage, and also to ascertain if it induces any improvement at the behavioral level.

关键词： Computers Data analysis Computational modeling User interfaces Diabetes Behavioral sciences Mobile applications

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Enhanced IGF-IIRα Expression Exacerbates Lipopolysaccharide-Induced Cardiac Inflammation, Hypertrophy, and Apoptosis Through Calcineurin Activation

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Environmental Toxicology 2024年第11期39卷 5173-5186页

作者： Boonha, Khwanchit Kuo, Wei-Wen Tsai, Bruce Chi-Kang Hsieh, Dennis Jine-Yuan Lin, Kuan-Ho Lu, Shang-Yeh Kuo, Chia-Hua Yang, Liang-Yo Huang, Chih-Yang Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Faculty of Tropical Medicine Mahidol University Bangkok Thailand Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan PhD Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan Department of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan Department of Emergency Medicine China Medical University Hospital Taichung Taiwan College of Medicine China Medical University Taichung Taiwan Division of Cardiovascular Medicine Department of Internal Medicine China Medical University Hospital Taichung Taiwan Laboratory of Exercise Biochemistry University of Taipei Taipei Taiwan Institute of Sports Sciences University of Taipei Taipei Taiwan Department of Kinesiology and Health Science College of William and Mary WilliamsburgVA United States School of Physical Education and Sports Science Soochow University Suzhou China Department of Physiology School of Medicine College of Medicine China Medical University Taichung Taiwan Laboratory for Neural Repair China Medical University Hospital Taichung Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan

Cardiovascular disease is one of the leading causes of death worldwide and has a high prevalence. Insulin-like growth factor-II receptor α (IGF-IIRα) acts as a stress-inducible negative regulator. This study focused on the substantial impact of heightened expression of IGF-IIRα in cardiac myoblasts and its association with the exacerbation of cardiac dysfunction. Using lipopolysaccharide (LPS)-induced H9c2 cardiac myoblasts as a model for sepsis, we aimed to elucidate the molecular interactions between IGF-IIRα and LPS in exacerbating cardiac injury. Our findings demonstrated a synergistic induction of cardiac inflammation and hypertrophy by LPS stimulation and IGF-IIRα overexpression, leading to decreased cell survival. Excessive calcineurin activity, triggered by this combined condition, was identified as a key factor exacerbating the negative effects on cell survival. Cellular changes such as cell enlargement, disrupted actin filaments, and upregulation of hypertrophy-related and inflammation-related proteins contributed to the overall hypertrophic and inflammatory responses. Overexpression of IGF-IIRα also exacerbated apoptosis induced by LPS in H9c2 cardiac myoblasts. Inhibiting calcineurin in LPS-treated H9c2 cardiac myoblasts with IGF-IIRα overexpression effectively reversed the detrimental effects, reducing cell damage and mitigating apoptosis-related cardiac mechanisms. Our study suggests that under sepsis-like conditions in the heart with IGF-IIRα overexpression, hyperactivation of calcineurin worsens cardiac damage. Suppressing IGF-IIRα and calcineurin expression could be a potential intervention to alleviate the impact of the illness and improve cardiac function. © 2024 Wiley Periodicals LLC.

关键词： Heart

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Personal health records - Potential one-stop approach in polypharmacy

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Computer Methods and programs in Biomedicine Update 2022年 2卷

作者： Chen, Ya-Lin Satria, Fauzi Budi Jamshed, Shazia Babar, Zaheer-Ud-Din Mukherjee, Nilesh Yang, Hsuan-Chia Li, Yu-Chuan Iqbal, Usman Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan PhD Program in Global Health & Health Security College of Public Health Taipei Medical University Taipei Taiwan Department of Pharmacy Practice Faculty of Pharmacy UniSZA Kuala Terengganu Malaysia Qualitative Research-Methodological Application in Health Sciences Research Group Kulliyyah of Pharmacy International Islamic University Malaysia Kuantan Malaysia Centre for Pharmaceutical Policy and Practice Research Department of Pharmacy University of Huddersfield Huddersfield United Kingdom Master of Science in Systems Biology Manipal School of Life Sciences Manipal Academy of Higher Education Manipal India International Center for Health Information Technology (ICHIT) Taipei Medical University Taipei Taiwan

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Overexpression of tyrosine phosphorylated proteins in reproductive tissues of polycystic ovary syndrome rats induced by letrozole

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Asian pacific Journal of Reproduction 2020年第6期9卷 275-282页

作者： Sudtida Bunsueb Supatcharee Arun Arada Chaiyamoon Alexander Tsang-Hsien Wu Sitthichai Iamsaard Department of Anatomy Faculty of MedicineKhon Kaen UniversityKhon Kaen40002Thailand Research Institute for Human High Performance and Health Promotion Khon Kaen University40002Khon KaenThailand The PhD Program for Translational Medicine College of Medical Science and TechnologyTaipei Medical University and Academia SinicaTaipei Graduate Institute of Medical Sciences National Defense Medical CenterTaipei

Objective:To identify the alteration of tyrosine phosphorylated protein expression in rats with polycystic ovary syndrome(PCOS).Methods:Sixteen female Sprague-Dawley rats were divided into the control and letrozole-induced PCOS *** oestrus cycle of rats was performed by vaginal *** hormones and morphology of the ovary,oviduct,and uterus were *** and intensity of androgen receptor and tyrosine phosphorylated proteins of reproductive organs were investigated by Western ***:Various polycysts and increased androgen receptor expression were present in the ovary of the PCOS *** levels of follicle-stimulating hormone and testosteone were significantly higher in the PCOS group while progesterone and estradiol levels were significantly decreased as compared with the control group(P<0.05).Only the size of uterus in the PCOS group was significantly smaller than the control ***,the density of collagen fibers observed in PCOS uterus was greater than the control ***,tyrosine phosphorylated proteins were significantly overexpressed in ovary(52,42,and 28 kDa),oviduct(72,56,42,and 28 kDa),and uterus(53 and 42 kDa)of the PCOS group compared to the control ***:Presence of tyrosine phosphorylated proteins in the ovary,oviduct and uterus suggests that overexpression of tyrosine phosphorylated proteins may be involved in potential mechanism of female infertility especially in PCOS.

关键词： Polycystic ovary syndrome Overexpression Tyrosine phosphorylated proteins Ovary Oviduct Uterus

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Microsecond electric pulses effects in spinal cord injuries: results from RISEUP project

Microsecond electric pulses effects in spinal cord injuries:...

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International Conference on Electromagnetics in Advanced Applications (ICEAA)

作者： Giorgia Innamorati Camilla Codazzi Giulia Bergafora Paola Giardullo Caterina Merla Francesca Camera Marina Sanchez Petidier Leslie Vallet Micol Colella Laura Caramazza Noemi Dolciotti Sara Fontana Maria Pedraza Paolo Marracino Claudia Consales Department of Biology PhD Program in Cellular and Molecular Biology University of Rome “Tor Vergata” Rome Italy Division of Health Protection Technologies ENEA-Italian National Agency for New Technologies Energy and Sustainable Economic Development Rome Italy Institut Gustave Roussy CNRS Metabolic and Systemic aspects of the oncogenesis (METSY) Université Paris-Saclay Villejuif France Department of Information Engineering Electronics and Telecommunications Sapienza BioEMLab Group DIET University of Rome Italy Neuronal and Tissue Regeneration Laboratory Centro de Investigación Príncipe Felipe Valencia Spain RISE TECHNOLOGY SRL Ostia (RM) Italy

Spinal Cord Injury (SCI), a major cause of paralysis, currently has no effective therapies. Every year almost 500.000 people are diagnosed with SCI worldwide. he difficulty on the neuronal restoration after SCI is based on the complex cascade of events that inexorably cause a degenerative chronic stage mainly favored by the non-permissive environment and limited capacity for axonal regrowth. RISEUP, an Europen project, proposes to attain neuronal functional regeneration after SCI by an unprecedented and unique bio-hybrid-compatible electro-activated and wireless rechargeable implantable technology. RISEUP introduces high voltage microsecond electric pulses stimulations and low amplitude direct currents on a combination of stem cells, induced neural stem cells (iNSCs) and multipotent stromal cells (MSCs), whose transplantation is facilitated by an innovative scaffold biomaterial (Fig.1).

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Authors’ Response to Peer Reviews of “The Role of Animal-Assisted Therapy in Enhancing Patients’ Well-Being: Systematic Study of the Qualitative and Quantitative Evidence”

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JMIRx Med 2024年 5卷

作者： Ramendra Pati Pandey Himanshu Gunjan Riya Mukherjee Chung-Ming Chang School of Health Sciences & Technology University of Petroleum and Energy Studies Dehradun Uttarakhand India Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Taiwan Master & PhD Program in Biotechnology Industry Chang Gung University Taoyuan Taiwan Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan Taiwan

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