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Mesenchymal Stromal/Stem Cells Know Best:The Remarkable Complexities of Its InteractionsWith Polymorphonuclear Neutrophils

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Stem Cells 2024年第5期42卷 403-415页

作者： Wang, Li-Tzu Lee, Wei Liu, Ko-Jiunn Sytwu, Huey-Kang Yen, Men-Luh Linju Yen, B. Department of Obstetrics and Gynecology National Taiwan University (NTU) Hospital College of Medicine NTU Taipei Taiwan School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Regenerative Medicine Research Group Institute of Cellular and System Medicine National Health Research Institutes (NHRI) Zhunan Taiwan Cell Therapy Center China Medical University Hospital Taichung Taiwan National Institute of Cancer Research NHRI Tainan Taiwan National Institute of Infectious Diseases and Vaccinology NHRI Zhunan Taiwan Department and Graduate Institute of Microbiology and Immunology National Defense Medical Center Taipei Taiwan

Polymorphonuclear neutrophils (PMNs), the predominant immune cell type in humans, have long been known as first-line effector cells against bacterial infections mainly through phagocytosis and production of reactive oxygen species (ROS). However, recent research has unveiled novel and pivotal roles of these abundant but short-lived granulocytes in health and disease. Human mesenchymal stromal/stem cells (MSCs), renowned for their regenerative properties and modulation of T lymphocytes from effector to regulatory phenotypes, exhibit complex and context-dependent interactions with PMNs. Regardless of species or source, MSCs strongly abrogate PMN apoptosis, a critical determinant of PMN function, except if PMNs are highly stimulated. MSCs also have the capacity to fine-tune PMN activation, particularly in terms of Cd11b expression and phagocytosis. Moreover, MSCs can modulate numerous other PMN functions, spanning migration, ROS production, and neutrophil extracellular trap (NET) formation/NETosis, but directionality is remarkably dependent on the underlying context: in normal nondiseased conditions, MSCs enhance PMN migration and ROS production, whereas in inflammatory conditions, MSCs reduce both these functions and NETosis. Furthermore, the state of the MSCs themselves, whether isolated from diseased or healthy donors, and the specific secreted products and molecules, can impact interactions with PMNs;while healthy MSCs prevent PMN infiltration and NETosis, MSCs isolated from patients with cancer promote these functions. This comprehensive analysis highlights the intricate interplay between PMNs and MSCs and its profound relevance in healthy and pathological conditions, shedding light on how to best strategize the use of MSCs in the expanding list of diseases with PMN involvement. © The Author(s) 2024. Published by Oxford University Press.

关键词： : polymorphonuclear neutrophils apoptosis Cd11b mesenchymal stromal/stem cells migration NETosis phagocytosis reactive oxygen species

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dual Loop Control of Ultrahigh Step-down Converter

Dual Loop Control of Ultrahigh Step-Down Converter

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International Future Energy Electronics Conference (IFEEC)

作者： Y. T. Yau K. I. Hwu Ph.D. Program PTEECS National Chin-Yi University of Technology Taichung Taiwan National Taipei University of Technology Taipei Taiwan

ISBN: (纸本)9781665434492

A new dual loop control method is presented and applied to the ultrahigh step-down converter, so as to improve the corresponding load transient responses. Unlike the traditional current feedback control signal, the inner-loop feedback control signal is the voltage on the energy-transferring capacitor, and this makes the control easy. To demonstrate the proposed control method, a single-loop control method is employed as a comparison and some experimental results are given.

关键词： Conferences Capacitors Switches Control systems Feedback control Voltage control Transient analysis

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Morphological Investigation and ph Sensing Properties of β-Ga2O3 Egfet-ph Sensor

SSRN

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SSRN 2023年

作者： Wuu, dong-Sing Yadlapalli, Bharath Kumar Chou, Hsin-Yu Chiang, Jung-Lung Department of Materials Science and Engineering National Chung Hsing University Taichung40227 Taiwan Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung411030 Taiwan Department of Applied Materials and Optoelectronic Engineering National Chi Nan University Nantou54561 Taiwan

In our study, β-Ga2O3 particles of various morphologies deposited on FTO glass substrates through hydrothermal method under different ph conditions and pre-stirring temperatures. The particles examined using XRd, FESEM, FTIR and Raman spectroscopy instruments. The results showed that the β-Ga2O3 microrods prepared with ph=3.15 solution at different pre-stirring temperatures followed by hydrothermal reaction had several crystalline orientations ([−401], [002], [403]). The FTIR and Raman spectra measurements confirmed the existence of Ga−O−Ga and Ga−OH bending modes. In the range of ph=3-11, the EGFET-ph sensor prepared with β-Ga2O3 microrods shown a high current-ph sensitivity of 0.541 (mA)1/2 /ph with a linearity of 97.83 % and a high voltage-ph sensitivity of 73.99 mV/ph with linearity of 96.85 %. These results suggest that β-Ga2O3 microrods have ph sensitivity higher than the ideal Nernstian response. This confirms the use of β-Ga2O3 microrods as a sensing membrane in high-performance ph sensors or biosensors. © 2023, The Authors. All rights reserved.

关键词： Gallium compounds

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Low-dispersive silicon nitride waveguide resonators by nanoimprint lithography

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APL photonics 2024年第8期9卷

作者： Wang, Pei-Hsun Zheng, He-Yuan Liu, Yuan-Hsiu Hou, Nien-Lin Chen, Chien-Hung Chen, Hung-Wen Wang, Chih-Ming Department of Optics and Photonics National Central University Taoyuan Taiwan International College of Semiconductor Technology National Yang Ming Chiao Tung University Hsinchu Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Institute of Photonics Technologies National Tsing Hua University Hsinchu30013 Taiwan

In this study, we demonstrate the fabrication of waveguide resonators using nanoimprint technology. Without relying on traditionally costly lithography methods, such as electron-beam lithography or stepper lithography, silicon nitride (Si3N4) resonators with high-quality factors up to the order of 105 can be realized at C-band by nanoimprint lithography. In addition, by properly designing the waveguide geometry, a low-dispersive waveguide can be achieved with waveguide dispersion at around −35 ps/nm/km in the normal dispersion regime, and the waveguide dispersion can be further tuned to be 29 ps/nm/km in the anomalous dispersion regime with the polymer cladding. The tunability of nanoimprinted devices is demonstrated by the aid of microheaters, realizing on-chip optical functionalities. This work offers the potential to fabricate low-dispersive waveguide resonators for integrated modulators and filters in a significantly cost-effective and process-friendly scheme. © 2024 Author(s).

关键词： Silicon nitride

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Optical Sensor for dissolved Ammonia by Embedding Eosin Y in Cellulose Acetate and Silicone Rubber Via the phase Inversion Method

SSRN

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SSRN 2024年

作者： Putro, dimas Trio Sari, desy Purnama Chu, Cheng-Shane International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City24301 Taiwan Department of Mechanical Engineering Ming Chi University of Technology Taishan Dist. New Taipei City24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City24301 Taiwan

The potential applications of optical sensors in biological systems, environmental monitoring, and renewable energy remain critically important. This study presents the phase inversion method for fabricating a new optical sensing membrane designed for dissolved ammonia detection. Eosin Y was embedded into composite materials of cellulose acetate (CA) and silicone rubber to enhance optical performance and modify the membrane’s structure. Luminescence quenching was used to evaluate sensing performance by measuring changes in intensity and wavelength. Eosin Y exhibited a sensitivity factor of approximately 19.15 within a detection range extending up to 480 millimolar dissolved ammonia. The results also demonstrated excellent selectivity when tested against nine different interferences, including methanol, acetic acid, and acetone. The membrane operated effectively within ph range of 3-9 and a temperature range of 20-50oC, with an average response time (t90) of approximately 20 seconds, though sensitivity decrease slightly at higher temperatures and extreme ph values. Furthermore, reduced photoexcitation of the indicator, resulting in a bathochromic shift of eosin Y by approximately 16.56 nm towards longer wavelengths. These findings highlight the potential of optical sensors for rapid and highly selective monitoring of changes in dissolved ammonia concentrations. © 2024, The Authors. All rights reserved.

关键词： Silicones

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Compact Refractive Error Measuring device

Compact Refractive Error Measuring Device

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Educational Innovation (ECEI), IEEE Eurasian Conference on

作者： Feng-Ming Yeh Chun-Yu Chiang Chao-Kai Chang Hsuan-Fu Wang Chuen-Lin Tien der-Chin Chen Department of Optometry Yuanpei University of Medical Technology Hsinchu Taiwan Ph.D. Program of Electrical and Communications Engineering Feng Chia University Taichung Taiwan Department of Aeronautical Engineering National Formosa University Yunlin Taiwan Department of Electrical Engineering Feng Chia University Taichung Taiwan

In this study, a reflective aspheric optical system is used to establish an eye examination device for distance and near vision tests. The system includes a micro-display with a rotating device, an off-axis parabolic mirror, an off-axis ellipsoid mirror, a chin-fixing bracket, and vision software. The display contents of the micro-display include English C and E charts, Chinese words, graphics, and animation. The off-axis parabolic mirror and off-axis ellipsoid mirror are confocal, and the micro-display is placed at the confocal point. The micro-display is projected through an off-axis parabolic mirror for myopia's distance vision testing, and an off-axis elliptical mirror for myopia's near vision testing. Others, the graphics and animation, provide visual checks for young children. In addition, CCd cameras and AI recognition can be used as visual examinations for people with language impairment. In this study, twenty-five subjects with the refractive error were tested using E-chart and this device to obtain the decimal point VA value, and the trial frame and lens were used to obtain the diopter of glasses. The date of the experimental results was used as a reference value for ophthalmological examination. This system uses an off-axis parabolic mirror and an off-axis ellipsoidal mirror. Optical alignment is a challenge to solve for the system. Students participating in the study obtained good optics training. The advantages of the developed device include the convenience to carry with a multi-purpose and straightforward use.

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Ga2O3 nanorods synthesized by hydrothermal method for dual-functional sensing of ph value and glucose

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Sensors and Actuators A: physical 2023年 363卷

作者： Chou, Hsin-Yu Yadlapalli, Bharath Kumar Yen, Chao-Chun Singh, Anoop Kumar Chiang, Jung-Lung Wuu, dong-Sing Department of Materials Science and Engineering National Chung Hsing University Taichung40227 Taiwan Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung411030 Taiwan Department of Applied Materials and Optoelectronic Engineering National Chi Nan University Nantou54561 Taiwan

In this work, hydrothermal (HT)-synthesized gallium oxide (Ga2O3) nanorods were applied on indium tin oxide (ITO) glass substrates to create a dual-functional ph-glucose sensing device. Extended-gate field-effect transistors (EGFETs) were designed for ph and glucose sensing, and the response to ph levels ranging from 1 to 11 was tested using both chemical bath deposition (CBd) and high-pressure hydrothermal methods. Two sensor configurations, Ga2O3(CBd)/ITO/glass and Ga2O3(HT)/ITO/glass, were immersed in solution ph1 to 11 and cultured medium for hydrogen ion and glucose sensing. The results demonstrated that, for ph sensing in different samples, both IdS-VdS analysis and IdS-VGS analysis showed superior linearity and sensitivity with the HT method. For glucose detection, the HT method was selected for further experiments due to its maintained concentration-dependent relationship and selectivity towards various common sugars. When using culture medium dMEM as the sample (4.5 mg/ml glucose concentration), the accuracy of glucose estimation reached 99%. Stability and biocompatibility tests were also conducted, and the results indicated consistent performance. In summary, the HT-synthesized Ga2O3 nanorods exhibited high sensitivity, selectivity, and stability without affecting cell growth. Therefore, they hold great potential for applications not only in general blood glucose sensing but also in studying cell microenvironment metabolism. © 2023 Elsevier B.V.

关键词： Nanorods

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development of ternary hybrid composites of transition metal and noble metal-based heterostructures: Ultrasensitive simultaneous electrochemical detection of bisphenol A and bisphenol S in food samples

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Food Chemistry 2024年 459卷 140451页

作者： Nandhini, Chinnathambi Huang, Chi-Hsien Mani, Govindasamy Arul, Ponnusamy Huang, Sheng-Tung Department of Materials Engineering Ming Chi University of Technology New Taipei City24303 Taiwan Center for Plasma and Thin Film Technologies Biochemical Technology R&D Center Ming Chi University of Technology New Taipei City243303 Taiwan College of Engineering Chang Gung University Taoyuan City33302 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243301 Taiwan Institute of Biochemical and Biomedical Engineering Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan

Bisphenols threaten human health and sensitive detection is crucial. The present study aims to develop ternary composites of copper metal-organic framework (Cu-MOF) with Au[sbnd]Ag microstructures. The composite structure was formed by a galvanic displacement reaction and confirmed using SEM. A binder-free catalyst was used to study the electrochemical redox reaction of bisphenol A (BPA) and bisphenol S (BPS);an irreversible cyclic voltammetric signal at +0.70 V and + 0.91 V (vs. Ag/AgCl), in the dynamic range of 20 nM to 2.0 mM, and 10 nM to 1.0 mM, with limits of detection of 2.9 nM, and 3.2 nM (S/N = 3) was obtained. Practical analysis was applied to frozen tomatoes, tuna fish, milk powder, PET bottles, raw milk, and urine samples with a recovery rate of 94.00–100.80% (n = 3). Voltammetric results were validated using HPLC detection with high precision. The sensor is a promising alternative platform for measuring BPA in food samples. © 2024

关键词： phenols

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A review of biosensor for environmental monitoring: principle, application, and corresponding achievement of sustainable development goals

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Bioengineered 2023年第1期14卷 58-80页

作者： Chi-Wei Huang Chitsan Lin Minh Ky Nguyen Adnan Hussain Xuan-Thanh Bui Huu Hao Ngo Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan. Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and TechnologyPh.D. Program in Maritime Science and Technology Kaohsiung Taiwan. Ph. D. Program of Aquatic Science and Technology College of Hydrosphere Science National Kaohsiung University of Science and Technology Kaohsiung Taiwan. Department Water Science & Technology Key Laboratory of Advanced Waste Treatment Technology Ho Chi Minh City University of Technology (HCMUT) Vietnam National University Ho Chi Minh (VNU-HCM) Ho Chi Minh City Vietnam. Department Water Science & Technology Faculty of Environment & Natural Resources Ho Chi Minh City University of Technology (HCMUT) Ho Chi Minh City Vietnam. Department Water Science & Technology Centre for Technology in Water and Wastewater School of Civil and Environmental Engineering Faculty of Engineering and Information Technology University of Technology Sydney Sydney NSW Australia.

Human health/socioeconomic development is closely correlated to environmental pollution, highlighting the need to monitor contaminants in the real environment with reliable devices such as biosensors. Recently, variety of biosensors gained high attention and employed as application, in real-time, and cost-effective analytical tools for healthy environment. For continuous environmental monitoring, it is necessary for portable, cost-effective, quick, and flexible biosensing devices. These benefits of the biosensor strategy are related to the Sustainable development Goals (SdGs) established by the United Nations (UN), especially with reference to clean water and sources of energy. However, the relationship between SdGs and biosensor application for environmental monitoring is not well understood. In addition, some limitations and challenges might hinder the biosensor application on environmental monitoring. Herein, we reviewed the different types of biosensors, principle and applications, and their correlation with SdG 6, 12, 13, 14, and 15 as a reference for related authorities and administrators to consider. In this review, biosensors for different pollutants such as heavy metals and organics were documented. The present study highlights the application of biosensor for achieving SdGs. Current advantages and future research aspects are summarized in this paper. ATP: Adenosine triphosphate; BOd: Biological oxygen demand; COd: Chemical oxygen demand; Cu-TCPP: Cu-porphyrin; dNA: deoxyribonucleic acid; EdCs: Endocrine disrupting chemicals; EPA: U.S. Environmental Protection Agency; Fc-HPNs: Ferrocene (Fc)-based hollow polymeric nanospheres; FeO@3d-GO: FeO@three-dimensional graphene oxide; GC: Gas chromatography; GCE: Glassy carbon electrode; GFP: Green fluorescent protein; GHGs: Greenhouse gases; HPLC: High performance liquid chromatography; ICP-MS: Inductively coupled plasma mass spectrometry; ITO: Indium tin oxide; LAS: Linear alkylbenzene sulfonate; : Laser-induced g

关键词： Biosensor bioavailability heavy metals organic pollutants sustainable development goals (SdGs)

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Impacts of ship emissions and sea-land breeze on urban air quality using chemical characterization, source contribution and dispersion model simulation of PM2.5 at Asian seaport

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Environmental Pollution 2024年 347卷

作者： Tseng, Yu-Lun Cheng, Wen-Hsi Yuan, Chung-Shin Lo, Kuo-Cheng Lin, Chitsan Lee, Chia-Wei Bagtasa, Gerry Institute of Environmental Engineering National Sun Yat-sen University ROC Kaohsiung City Taiwan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology ROC Kaohsiung City Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology ROC Kaohsiung City Taiwan Department of Safety Health and Environmental Engineering National Kaohsiung University of Science and Technology ROC Kaohsiung City Taiwan Institute of Environmental Science and Meteorology University of the Philippines at Diliman Quezon City Philippines

Fine particulate matter (PM2.5) emitted from marine transportation, bulk materials handling at the docks, and dust dispersion has garnered increased attention, particularly in the interface between port and urban areas. This study explored the inter-transport of PM2.5 between Kaohsiung Harbor and neighboring Metro Kaohsiung. Chemical analyses of PM2.5 samples from four sites include water-soluble ions, metallic elements, carbons, anhydrosugars, and organic acids to establish PM2.5's chemical fingerprints. The CALPUFF air dispersion model is employed to simulate the spatiotemporal distribution of PM2.5 in Kaohsiung Harbor and adjacent urban areas. A clear seasonal and diurnal variation of PM2.5 concentrations and chemical composition was observed in both harbor and urban areas. The high correlation of nighttime PM2.5 levels between the port and urban areas suggests inter-transport phenomena. Sea salt spray, ship emissions, secondary aerosols, and heavy fuel-oil boilers exhibit higher levels in the port area than in the urban area. In Metro Kaohsiung, mobile sources, fugitive dust, and waste incinerators emerge as major PM2.5 contributors. Furthermore, sea breeze significantly influences PM2.5 dispersion from Kaohsiung Harbor to Metro Kaohsiung, particularly in the afternoon. The average contribution of PM2.5 from ships' main engines in Kaohsiung Harbor ranges from 2.9% to 5.3%, while auxiliary engines contribute 3.8%–8.3% of PM2.5 in Metro Kaohsiung. © 2024 Elsevier Ltd

关键词： Ships

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