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doping ratio between ZnO/MgO tunes antimicrobial, osteogenic, and anti-osteoclast activity of CaO-MgO-ZnO-SiO2 bioactive glass-ceramics

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Ceramics International 2025年

作者： Hung, Guan-Yi Xia, Yun-Ze Chen, Pin-Yi Lai, Po-Liang Feng, Kuei-Chih Tu, Chi-Shun Cheng, I.-C. Wang, Chi-Yun International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Department of Mechanical Engineering Ming-Chi University of Technology New Taipei City24301 Taiwan Bone and Joint Research Center Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan City33305 Taiwan College of Medicine Chang Gung University Taoyuan City33305 Taiwan Department of Mechanical Engineering Chang Gung University Taoyuan City33305 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Limitations such as donor site morbidity hamper autologous bone grafts. On the other hand, allogeneic grafts, sourced from cadavers, pose risks of viral transmission and rejection. While hydroxyapatite is a prevalent synthetic graft material, antibiotic-laden fillers addressing infection face challenges with antibiotic-resistant pathogens, driving the emergence of nonantibiotic materials to combat persistent bone infections. Bioactive glass is a potential bone void filler superior to hydroxyapatite. Thus, to improve the antibacterial efficacy and bioactivity, we adjusted the doping ratio of the novel CaO-(1-x) MgO-(x) ZnO-SiO2 glass-ceramics (x = 0, 0.25, 0.50, 0.75, 1). Using XRd, we found a typical amorphous structure alongside polycrystalline diopside (CaMgSi2O6), hardystonite (Ca2ZnSi2O7), and petedunnite (CaZnSi2O6) formations. Raman spectroscopy revealed the silicate-glass matrix structure in all the Zn(100x) glass-ceramics and confirmed that the Zn ions replaced the Mg ions. Zn-doped glass-ceramics promoted apatite layer formation and had greater antibacterial efficacy against E. coli and S. aureus. Zn25 glass-ceramic were biocompatible with L929 and MC3T3-E1 cells. Furthermore, Zn25 glass-ceramic promoted bone cell mineralization and reduced osteoclast formation without affecting ALP activity. In vivo, the Zn25 glass-ceramic exhibited greater osteointegration ability than the HAP and Zn0 glass-ceramic. Taken together, the present study demonstrated that bioactive glass-ceramics with a doping ratio between ZnO and MgO (25:75) can enhance antibacterial and osteogenic activity while impeding osteoclastogenic activity. © 2025

关键词： Escherichia coli

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A Survey on the Risk Perception of Slips, Trips, and Falls of Coal Mine Workers in China 2021

A Survey on the Risk Perception of Slips, Trips, and Falls o...

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3rd International Conference on Management Science and Industrial Engineering, MSIE 2021

作者： Khaday, Samsiya Li, Kai Way Li, Nailiang Chen, Yunxiu Ph.D. Program of Technology Management Chung Hua University Hsin-Chu Taiwan

ISBN: (纸本)9781450388887

Coal mine industry has been one of the most risky industries in terms of occupational safety and health in China. Slip, trip, and fall (STF) has been one of the most common occupational accidents globally which can lead to fatal and non-fatal accidents. This study investigated coal mine worker risk perception of occupational STF hazard. A survey was administered on 300 coal mine workers. The results showed that the age group has significant effect. The perceived risk of STF on the ramp and on the track were high. Rail track lanes on the roadway had the highest risk ratings. Moreover, underground crossing tracks and ramps were locations with frequent accidents. Workers' perception of the risky locations underground provides targets for safety promotions for coal mine authorities. © 2021 ACM.

关键词： Coal mines

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Advanced ZnFe₂O₄@f-CNF electrode: A robust electrochemical sensor for Tert-butyl hydroquinone detection in food and edible oil

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Food Chemistry 2025年 486卷 144648页

作者： Yemmi, Rajeshwari Swamy, B.E. Kumara Manjunath, Kumbar Mudakappa Yusuf, Kareem Aljuwayid, Ahmed M. Govindasamy, Mani 577451 India Division of Plant Breeding and Genetics Central Coffee Research Institute Karnataka Chikkamagaluru577117 India Department of Chemistry College of Science King Saud University Riyadh11451 Saudi Arabia International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Chemistry Korea University Seoul Seongbuk-gu Korea Republic of

Fabrication of a binary electrocatalyst is expounded in this study, which is based on a biocompatible ZnFe2O4 nanoparticles that is adorned onto the functionalized carbon nanofiber (f-CNF) through a straightforward ultrasonication technique. This electrocatalyst is applied for the reliable quantification of the food additive Tert-Butyl Hydroquinone (TBHQ) from various food samples and products. The electrochemical performance of the ZnFe2O4@f-CNF composite is investigated using cyclic voltammetry and electrochemical impedance spectroscopy analysis. The structural features of the composite, characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy which reveals its crystalline and porous attributes. Then electrochemical characteristics of the ZnFe2O4@f-CNF composite for TBHQ detection is evaluated employing cyclic voltammetry and differential pulse voltammetry methodologies. Notably, this composite demonstrates a remarkable low detection limit (LOd) of 0.026 μM with a good linear detection range, accompanied by a favorable sensitivity towards TBHQ. Lastly, the developed sensor system manifests a substantial recovery range for real sample analysis, suggesting its potential as a viable alternative to existing diagnostic tools for TBHQ detection. © 2025 Elsevier Ltd

关键词： Cyclic voltammetry

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Investigation of Short-Circuit Current density in Non-Fullerene-Based Ternary Organic Solar Cells by Incorporating Machine Learning Algorithms with Effective descriptors

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Solar RRL 2025年第10期9卷

作者： Lee, Min-Hsuan Chen, Ying-Chun Chang, Yi-Ming Hou, Bo Ph.D. Program in Biomedical Artificial Intelligence National Tsing Hua University Hsinchu Taiwan Institute of Environmental and Occupational Health Sciences School of Medicine National Yang-Ming Chiao Tung University Taipei Taiwan Institute of Environmental Engineering National Yang-Ming Chiao Tung University Hsinchu Taiwan Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei Taiwan Raynergy Tek Incorporation Hsinchu Taiwan School of Physics and Astronomy Cardiff University Cardiff United Kingdom

Non-fullerene acceptor (NFA)-based ternary organic solar cells (OSCs) are emerging as promising devices for converting sunlight into electricity, contributing to environmental solutions. However, selecting the third component remains a significant challenge, as it plays a critical role in achieving high short-circuit current density (Jsc) in NFA-based ternary OSCs (comprising donors, acceptors, and the third component). Traditional trial-and-error experimental methods face substantial limitations, including high energy consumption, cost, and time demands, which may not be sufficient for investigating the quantitative relationships between material properties and Jsc in ternary OSCs. In this study, we examine the effects of the highest occupied molecular orbital–lowest unoccupied molecular orbital (HOMO–LUMO) energy gap (ΔHOMO and ΔLUMO) between different organic materials, considering these as effective molecular descriptors, on the primary photovoltaic parameter (Jsc) in NFA-based ternary OSCs. The eXtreme Gradient Boosting (XGBoost) algorithm yields reasonable predictions, with an R2 value of 0.76. Additionally, three NFA-based ternary OSCs are fabricated and characterized experimentally to validate the predictions made by the proposed model. Using three different NFA-based ternary OSCs as inputs, the model demonstrates good predictive accuracy for Jsc values. The proposed interpretable model and effective molecular descriptors offer a practical machine-learning approach for accelerating the development of NFA-based ternary OSCs with targeted Jsc values and can also be extended to other organic electronic applications. © 2025 Wiley-VCH GmbH.

关键词： Learning algorithms

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The Bacterial Outer Membrane Vesicle-Cloaked Immunostimulatory Nanoplatform Reinvigorates T Cell Function and Reprograms Tumor Immunity

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ACS Nano 2025年 2025 May 20页

作者： Lin, Yu-Han Chen, Chia-Wei Chen, Mei-Yi Xu, Li Tian, Xuejiao Cheung, Siu-Hung Wu, Yen-Ling Siriwon, Natnaree Wu, Si-Han Mou, Kurt Yun Taiwan International Graduate Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei 11529 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei 11031 Taiwan Institute of Biomedical Sciences Academia Sinica Taipei 11529 Taiwan Research Center for Applied Sciences Academia Sinica Taipei 11529 Taiwan Chakri Naruebodindra Medical Institute Faculty of Medicine Ramathibodi Hospital Mahidol University Samutprakarn 10540 Thailand International Ph.D. Program in Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 11529 Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu 30013 Taiwan

Bacterial outer membrane vesicles (OMVs) represent powerful immunoadjuvant nanocarriers with the capacity to reprogram the tumor microenvironment (TME) and activate immune responses. Here, we investigate a nanotherapeutic platform integrating immunostimulatory cytosine-phosphate-guanine oligodeoxynucleotides (CpG-OdNs, hereafter termed CpG) into mesoporous silica nanoparticles cloaked with OMVs (CpG@MSN-PEG/PEI@OMVs) for cancer immunotherapy. Systemic administration of these nanohybrids facilitates precise tumor targeting, induces antitumor cytokines such as IFNγ, and suppresses immunosuppressive cytokine TGF-β, reshaping the TME. Additionally, CpG@MSN-PEG/PEI@OMVs promote M1 macrophage polarization, dendritic cell maturation, and the generation of durable tumor-specific immune memory, resulting in pronounced tumor regression with minimal systemic toxicity. The platform demonstrates efficacy against metastatic and solid tumor models including 4T1 breast and MC38 colorectal cancers. Transcriptomic analyses reveal that CpG@MSN-PEG/PEI@OMVs enhance mitochondrial oxidative phosphorylation in T cells within tumor-draining lymph nodes, mitigating T cell exhaustion and restoring metabolic fitness. These results support the potential of CpG@MSN-PEG/PEI@OMVs as a modular nanoplatform to modulate innate and adaptive immunity in cancer immunotherapy. © 2025 The Authors. Published by American Chemical Society.

关键词： bacterial outer membrane vesicles mesoporous silica nanoparticles mitochondrial activity T cell exhaustion phenotypes tumor microenvironment

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Boost dC-dC converter with regenerative snubber

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Energy Reports 2024年 12卷 798-819页

作者： Yau, Yeu-Torng Department of Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung Taiwan Department of Electrical Engineering National Chin-Yi University of Technology Taichung Taiwan

To accommodate the wide range of input voltages supplied by redundant batteries and ensure an adequate hold-up time for communication systems during utility power failures, power supplies used in 5 G base stations typically include a front-end boost converter as the first stage and a second-stage isolated converter. In this paper, a new topology for a regenerative snubber in boost converters is proposed. Compared to traditional active or passive snubber topologies, the proposed snubber offers the advantages of having fewer components and occupying less space. Moreover, it does not require additional active devices and can be driven by widely-used commercial PWM control integrated circuits, achieving a higher level of cost-effectiveness and offering increased industrial applications. The final prototype of a power supply for a networking switch hub (as used in 5 G base stations) is fabricated to demonstrate the feasibility of the proposed method. © 2024 The Authors

关键词： Topology

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Advanced highly precise simultaneous electrochemical detection of toxic azo dyes with Nanoengineered yttrium Iron oxide decorated functionalized carbon nanofibers

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Food Chemistry 2025年 486卷 144607页

作者： Senthilkumar, dhayanithi Kuo, Chih-Yu Aldossari, Samar A. Govindasamy, Mani National Taipei University of Technology Taipei City10608 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Taipei10608 Taiwan Department of Chemistry P. O. Box 2455 College of Science King Saud University Riyadh11451 Saudi Arabia International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Tamil Nadu Chennai602105 India Department of Chemistry Korea University Seoul Seongbuk-gu Korea Republic of

It is essential to monitor the concentration of synthetic coloring agents in food and beverages due to their potential severe side effects on human health. In this study, yttrium iron oxide (YFO) nanoparticles were synthesized via a hydrothermal method, followed by modification with functionalized carbon nanofibers (f-CNF) through a simple sono-chemical process. The synthesized YFO/f-CNF was thoroughly characterized using various analytical techniques. Concurrent electrochemical detection of sunset yellow (SSY) and tartrazine (TRT) was achieved using a glassy carbon electrode modified with the YFO/f-CNF nanocomposite, enabling highly effective detection of SSY and TRT in food samples. Under optimized conditions, the modified electrode demonstrates a wide linear range (0.05 μM – 466.15 μM) and very low limits of detection (LOd) for SSY (1.5 nM) and TRT (3.2 nM). Additionally, the modified electrode exhibits significantly higher sensitivity (7.23 μAμM1cm−2) for SSY and (3.01 μAμM−1cm−2) for TRT compared to other reported values. This work showcases excellent sensitivity and selectivity, capable of identifying trace amounts of azo dyes in complex food matrices such as fruit juices, soft drinks, and packaged foods. The sensor's performance in real food samples, including both beverages and solid food products, was comparable to traditional high-performance liquid chromatography (HPLC), with a strong correlation in detection limits and accuracy (95.7–99.1 %). Furthermore, the sensor demonstrated exceptional stability and reproducibility in food matrix analysis, providing a reliable and efficient tool for routine monitoring of azo dye contamination in food and beverage industries. © 2025

关键词： Fruit juices

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dual functional antibacterial nanofiber membranes: Polyhexamethylene biguanide-integrated alginate-chitosan-dye modified polyamide 56 for single-use biomedical applications

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International Journal of Biological Macromolecules 2025年 310卷 143331页

作者： Liao, Ting-Cjia Le, Quang-Vinh Hanh, Nguyen The duc Liu, Bing-Lan Srinophakun, Penjit Prapainainar, Paweena Chiu, Chen-Yaw Wang, Chi-Yun Ng, I-Son Chen, Kuei-Hsiang Chang, Yu-Kaung of Biochemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Center for Environmental Sustainability and Human Health Ming Chi University of Technology Taishan New Taipei City243303 Taiwan Department of Applied Chemistry Chaoyang University of Technology Taichung413310 Taiwan National Center of Excellence for Petroleum Petrochemicals and Advance Material Department of Chemical Engineering Faculty of Engineering Kasetsart University Chatuchak Bangkok10900 Thailand Center for Advanced Studies in Nanotechnology for Chemical Food and Agricultural Industries Kasetsart University Chatuchak Bangkok10900 Thailand Department of Chemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Departmental of Chemical Engineering National Cheng Kung University Tainan70101 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Zhongli Dist. Taoyuan City320315 Taiwan

Polyamide 56 (PA56) nanofiber membranes were functionalized with alginate (AG), chitosan (CS), reactive dyes (RG19, RR141), and poly(hexamethylene biguanide) (phMB) to develop multifunctional antimicrobial membranes for single-use applications. The resulting membranes, PA56-AG-CS-RG19-phMB and PA56-AG-CS-RR141-phMB, achieved high antibacterial efficiencies of 97.12 % and 90.65 %, respectively, against Escherichia coli, demonstrating potent bacterial inhibition. The antimicrobial performance results from a synergistic dual mechanism. Chitosan disrupts bacterial adhesion and biofilm formation through electrostatic interactions, while phMB compromises membrane integrity and interferes with intracellular processes. This combined action enhances bactericidal efficacy. The functionalization strategy also maintained excellent biocompatibility, with minimal cytotoxicity observed in L929 fibroblasts. Optimized concentrations of AG and CS were systematically evaluated to ensure balanced antibacterial performance and mechanical stability. These membranes, designed for single-use, exhibited significantly reduced antibacterial activity upon reuse, supporting their intended application. Overall, the integration of chemical and physical antimicrobial strategies within a nanofiber matrix presents a novel and effective approach. This strategy enables the development of next-generation materials suitable for real-world single-use biomedical applications, including wound dressings, food packaging, and protective textiles. © 2025 Elsevier B.V.

关键词： Escherichia coli

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What attracts young talent from Taiwan to start businesses in mainland China? A fuzzy analytic hierarchy process study

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technology Analysis and Strategic Management 2023年第4期35卷 394-408页

作者： Chang, Yao-Wen Lai, Yi-Hsuan Ph.D. Program of Technology Management Chung Hua University Hsinchu Taiwan Department of Industrial Management Chung Hua University Hsinchu Taiwan

Innovation and entrepreneurship drive technological evolution, social progress, and economic development. With technological competition and a stagnant economy, innovation and entrepreneurship appear to be promising approaches to growing a country’s economy. Accordingly, in this study, we identified factors influencing the entrepreneurial process by systematically integrating the opinions of 43 experts into 5 aspects and 21 key indicators by using the fuzzy analytic hierarchy process. We focused on young Taiwanese entrepreneurs starting their businesses in China. The results revealed that marketing and business development, venture fund support, investment financing, interpersonal resources and convenience administrative service were exerted the greatest influence on the entrepreneurs’ decision-making process. The findings can serve as a reference for fostering a more entrepreneur-friendly environment, especially in China, whose government has actively encouraged innovation and entrepreneurship by, in part, attracting young talents from Taiwan. These results can also provide a reference for scholars interested in the field of youth entrepreneurship research. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

关键词： cross-strait youth entrepreneurship base Entrepreneurial ecosystem fuzzy analytic hierarchy process mainland China

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PVA-based bioinks for 3d bioprinting: A comprehensive review of their applications in tissue engineering

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Bioprinting 2025年 49卷

作者： Narges Johari Zary Adabavazeh Francesco Baino Materials Engineering Group Golpayegan College of Engineering Isfahan University of Technology Golpayegan Iran Ph.D. Program Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung Taiwan ROC Institute of Materials Physics and Engineering Department of Applied Science and Technology Politecnico di Torino Torino Italy

3d bioprinting is an innovative approach that overcomes the limitations of traditional methods for creating cell-laden biomaterials and constructs. It allows for the fabrication of complex and biologically active tissue structures. This review aims to provide a comprehensive evaluation of polyvinyl alcohol (PVA)-based bioinks within a 3d bioprinting framework. PVA-based bioinks exhibit remarkable properties, such as biocompatibility, biodegradability, and the ability to enhance cell growth and differentiation. These properties make them appropriate for many tissue engineering applications. The study evaluates the physicochemical and biological properties of PVA bioinks, including how they combine with other materials such as gelatin, chitin, chitosan, alginate, agarose, cellulose, κ-carrageenan, methacrylate, nanoparticles, mineral additives, carbon nanotubes, graphene oxide, and extracellular matrix components. Furthermore, this review evaluates the benefits of market availability and enhanced printing resolution, in addition to the challenges posed by complexity, dependency on support baths, and the risk of contamination. The objective of this review is to draw attention to the capabilities of PVA-based bioinks and provide guidelines for future research to improve the effectiveness of these materials in tissue engineering and regenerative medicine.

关键词： Bioprinting Bioink Polyvinyl alcohol PVA-based bioinks

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