检索结果-内蒙古大学图书馆

Harnessing the bishomolithocholic acid scaffold for selective sialyltransferase inhibition: A targeted approach to suppress breast cancer metastasis

引用

European Journal of Medicinal Chemistry 2025年 292卷 117674页

作者： Perez, Ser John Lynon P. Hsu, Zih-Fan Chang, Tzu-Ting Chen, Chia-Ling Li, Wen-Shan Institute of Chemistry Academia Sinica Taipei 115 Taiwan Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Sustainable Chemical Science and Technology Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan Biomedical Translation Research Center Academia Sinica Taipei 115 Taiwan Department of Chemistry National Taiwan Normal University Taipei 116 Taiwan Department of Medicinal and Applied Chemistry College of Life Science Kaohsiung Medical University Kaohsiung 807 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei 110 Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University Kaohsiung 804 Taiwan

ST6GAL1 plays a crucial role in the progression of triple-negative breast cancer (TNBC), highlighting its potential as a therapeutic target for this aggressive cancer subtype. due to the high metastatic potential of TNBC and the limitations of current therapies, selective and potent ST6GAL1 inhibitors are urgently needed. In this study, a scaffold-hopping approach from lithocholic acid to bishomolithocholic acid successfully led to the discovery of novel ST6GAL1 inhibitors, SPP-037 and HZF01, with enhanced biological activity and selectivity. Both compounds significantly inhibited MdA-MB-231 cell migration, HUVEC tube formation, tumor growth, and metastasis in vitro and in vivo. Molecular docking studies revealed key interactions between the ST inhibitors and ST6GAL1, supporting their enhanced selectivity and binding affinity. Additionally, SPP-037 and HZF01 were found to block integrin α2,6-sialylation, disrupting integrin activation and downstream signaling pathways involving the phosphorylation of focal adhesion kinase (FAK) and paxillin, which are critical for cell migration. These results underscore the potential of targeting ST6GAL1 to suppress tumor progression and metastasis, offering a promising avenue for treating aggressive breast cancer. © 2025 Elsevier Masson SAS

关键词： Bishomolithocholic acid Breast cancer metastasis Integrin-FAK-Paxillin axis N-glycan sialylation Sialyltransferase inhibitor ST6GAL1

来源：评论

学校读者我要写书评

暂无评论

Enhanced deep Learning Model Performance in 3d Multimodal Brain Tumor Segmentation with Gabor Filter 10

Enhanced Deep Learning Model Performance in 3D Multimodal Br...

引用

10th International Conference on Applied System Innovation, ICASI 2024

作者： Ahmad, Nisar Chen, Yao-Tien International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan

ISBN: (纸本)9798350394924

Medical image segmentation plays a crucial role in identifying and analyzing anatomical structures in medical images. This requires an accurate medical segmentation tool to delineate and quantitatively analyze the target regions, diagnose any abnormality, and assist in treatment planning. deep learning approaches have emerged as a promising solution for automating medical segmentation. However, challenges arise when dealing with the complex shapes and spatial variations of some target regions, especially in 3d MRI scans. To deal with such transformations, specific techniques are required to properly analyze and preprocess the dataset and perform image filtering to provide better features for improved prediction performance of deep learning architectures. This study focuses on improving brain tumor segmentation in multimodal 3d MRI images. We observed significant improvements in multimodal brain tumor segmentation results (accuracy, IoU, and mIoU) using an optimized 3d Gabor filter, which helps extract meaningful features. Multichannel input images were preprocessed to remove noise and select an appropriate resolution to reduce computational complexity. An improvement in mean Intersection over Union (mIoU) from 0.714 to 0.804 and accuracy from 0.982 to 0.991 were achieved, which shows a major improvement. This work contributes to the field of medical image segmentation by offering an improved and efficient approach for brain tumor analysis in 3d MRI scans, potentially aiding in diagnosis and treatment planning. © 2024 IEEE.

关键词： Magnetic resonance imaging

来源：评论

学校读者我要写书评

暂无评论

Integration of the PEMFC with a hydrogen production device adopting sodium borohydride and metal cobalt catalyst

引用

International Journal of Hydrogen Energy 2024年第PartB期52卷 905-916页

作者： Chang, Pai-Chun Lai, Jyun-Lin Huang, Ching-His Kuan, Yean-der Department of Refrigeration and Air Conditioning and Energy Engineering National Chin-Yi University of Technology 411 Taichung Taiwan Ph.D. Program Intelligent Machinery and Smart Manufacturing National Chin-Yi University of Technology 411 Taichung Taiwan

Hydrolysis technology that releases hydrogen from chemical hydrogen storage materials is a method to produce hydrogen. Hydrogen storage has excellent development potential and is also one of the sources of large amounts of hydrogen. A sodium borohydride hydrogen production experiment was carried out based on steam hydrolysis technology. The system reaction tank is divided into a water-carrying bed and a catalyst bed. A mixed aqueous solution with a concentration of 1 wt% sodium hydroxide (NaOH) + 10 wt% sodium borohydride (NaBH4) was used for the hydrogen production reaction test. These experiments determined the appropriate aqueous solution and water vapor combination, and optimal parameters for hydrogen production. The hydrogen production catalyst powder, blend ratio, different steel ball ratios, and ball milling time at the steam hydrogen production end will all affect the powder's fineness and hydrogen production stability. Under catalyst temperature control, the by-products solidify at a specific temperature, which affects the gas passage and causes blockage. Increasing the hydrogen production in an aqueous solution requires a Co2+/Al2O3 catalyst, or a temperature control method to catalyze hydrogen production to obtain stable hydrogen production suitable for emergencies without hydrogen storage containers. This experiment built a hydrogen production system combined with a fuel cell for power generation testing. The test process and results indicate whether the aqueous solution and steam technology can be an effective solution when the hydrolysis hydrogen production technology is matched. © 2023 Hydrogen Energy Publications LLC

关键词： Hydrogen production

来源：评论

学校读者我要写书评

暂无评论

Boost dC-dC Converter with Non-dissipative Snubber

引用

IEEJ Transactions on Electrical and Electronic Engineering 2024年第11期19卷 1858-1878页

作者： Yau, Yeu-Torng Department of Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung No.57 Sec. 2 Zhongshan Rd. Taiping Dist Taichung41170 Taiwan

To provide a hold-up time function in dC-dC supplies for cell site stations or data centers, using a boost converter with a bulk output capacitor as a front-end converter stage is a simple and highly cost-effective solution. However, conventional boost converters with a hard-switching operation result in low conversion efficiency and increased electromagnetic interference emissions. In this paper, a boost converter with a new non-dissipative snubber is proposed that only requires two additional diodes, an inductor, and a multilayer ceramic capacitor. The main feature of the proposed snubber is that the components are not located on the main power processing path. This means they only require low ratings, improving cost-effectiveness. A prototype converter is analyzed, realized, and applied to a 300 W redundant dC-dC power supply module for a 5G cell base station. © 2024 The Author(s). IEEJ Transactions on Electrical and Electronic Engineering published by Institute of Electrical Engineers of Japan and Wiley Periodicals LLC. © 2024 The Author(s). IEEJ Transactions on Electrical and Electronic Engineering published by Institute of Electrical Engineers of Japan and Wiley Periodicals LLC.

关键词： Boost converter

来源：评论

学校读者我要写书评

暂无评论

design and fabrication of composite current collector used in 2-cell stacks for portable power generator

引用

International Journal of Hydrogen Energy 2024年 54卷 294-304页

作者： Wang, Chong-Kai Kuan, Yean-der Ph.D. Program Intelligent Machinery and Smart Manufacturing National Chin-Yi University of Technology Taichung411 Taiwan Department of Refrigeration and Air Conditioning and Energy Engineering National Chin-Yi University of Technology Taichung411 Taiwan

This study designed a planar carbon fiber composite collector plate with excellent conductivity and mechanical strength for use in the proton exchange membrane fuel cell (PEMFC). The collector plate is made of phenolic resin mixed with conductive particles such as graphite powder, and coated onto carbon fiber cloth. After the solvent is allowed to evaporate, the prepreg is cut and stacked layer by layer into a mold for the heat pressing process at 150 °C. The resin in the carbon fiber prepreg cloth is cured into a carbon fiber composite board. A computer numerical control (CNC) engraving machine was used to engrave the carbon fiber composite board into the current collector shape. The carbon fiber composite current collectors were placed into a high temperature furnace for the carbonization process. The resin between the carbon fibers is removed by the high temperature to increase conductivity. The carbon fiber composite collectors were assessed for conductivity, mechanical strength, and performance. Afterwards, a planar two cell fuel cell stack was assembled for testing performance and stability. A printed circuit board (PCB) was used to design the circuit and the planar two cell fuel cell module made using the heat pressing process. The planar two cell module was combined with a small hydrogen storage tank to form a portable power generation device. © 2023 Hydrogen Energy Publications LLC

关键词： Carbon fibers

来源：评论

学校读者我要写书评

暂无评论

dextran-integrated polypyrrole-Cu2O composite for improved electrochemical quantification of melatonin in biological samples

引用

International Journal of Biological Macromolecules 2025年第Pt 2期310卷 143247页

作者： Aiswarya, B. Gopika, M.G. Saraswathyamma, Beena Kuo, Chih-Yu Jeridi, Mouna Alshahrani, Thamraa Govindasamy, Mani International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Polymer Science Central Institute of Petrochemical Engineering and Technology Kochi Eloor Udyogamandal P O Kochi683501 India Department of Chemistry Amrita Vishwa Vidyapeetham Amritapuri campus Clappana P O Kerala Kollam690525 India Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan High-Value Biomaterials Research and Commercialization Center National Taipei University of Technology Taipei106 Taiwan Biology Department College of Science King Khalid University Abha61413 Saudi Arabia Department of Physics College of Science Princess Nourah bint Abdulrahman University P. O. Box 84428 Riyadh11671 Saudi Arabia Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai602105 India

Monitoring the level of melatonin (MEL), a neurohormone that plays a vital role in governing the body's circadian rhythms and sleep cycles, is critical due to its physiological importance and potential adverse side effects during overexposure. This research deals with the design and development of a novel electrochemical sensor by modifying a glassy carbon electrode (GCE) with a composite of poly(vinyl alcohol) (PVA), dextran (dex), polypyrrole (PPy) and copper oxide particles (Cu2O) forming the PdPC composite. The synthesized composite was analyzed using both structural and morphological characterization methods. Additionally, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were conducted to examine electrochemical behaviour of the composite. Significantly, the dextran inclusion, which is a biocompatible polysaccharide, makes the composite more hydrophilic, film forming, and stable enhancing sensor properties, more importantly, electrochemically. The sensor showed high electrocatalytic activity towards MEL oxidation as studied using CV and dPV. For MEL oxidation, the oxidation peak was found at +0.6 V in phosphate buffer (ph 7.0) with an increase in current with respect to melatonin concentration. The sensor has a detection limit of 5.2 nM with a linear range of 10.0 nM to 850.0 μM, found to be better than most reported sensors. Analysis of real samples, such as human serum and urine, demonstrated the ability to selectively, stably, and reproducibly detect MEL. These data confirm the potential possibilities of using the sensor for clinical and point-of-care testing showing a significant development in polysaccharide-based electrochemical sensors. © 2025 Elsevier B.V.

关键词： dextran-based composite Electrochemical sensor Melatonin

来源：评论

学校读者我要写书评

暂无评论

CompressedMediQ: Hybrid Quantum Machine Learning Pipeline for High-dimensional Neuroimaging data

CompressedMediQ: Hybrid Quantum Machine Learning Pipeline fo...

引用

Acoustics, Speech, and Signal Processing Workshops (ICASSPW), IEEE International Conference on

作者： Kuan-Cheng Chen Yi-Tien Li Tai-Yu Li Chen-Yu Liu Po-Heng Henry Lee Cheng-Yu Chen Department of Electrical and Electronic Engineering Imperial College London London UK Centre for Quantum Engineering Science and Technology (QuEST) Imperial College London London UK Translational Imaging Research Center Taipei Medical University Hospital Taipei Taiwan Research Center for Neuroscience Taipei Medical University Taipei Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan National Center for High-Performance Computing NARlabs Hsinchu Taiwan Graduate Institute of Applied Physics National Taiwan University Taipei Taiwan Department of Medical Imaging Taipei Medical University Hospital Taipei Taiwan Department of Radiology National Defense Medical Center Taipei Taiwan Department of Radiology School of Medicine College of Medicine Taipei Taiwan

ISBN: (数字)9798331519315

ISBN: (纸本)9798331519322

This paper introduces CompressedMediQ, a novel hybrid quantum-classical machine learning pipeline specifically developed to address the computational challenges associated with high-dimensional multi-class neuroimaging data analysis. Standard neuroimaging datasets, such as large-scale MRI data from the Alzheimer’s disease Neuroimaging Initiative and Neuroimaging in Frontotemporal dementia, present significant hurdles due to their vast size and complexity. CompressedMediQ integrates classical HPC nodes for advanced MRI pre-processing and Convolutional Neural Network (CNN)-PCA-based feature extraction and reduction, addressing the limited-qubit availability for quantum data encoding in the NISQ era. This is followed by Quantum Support Vector Machine (QSVM) classification. By utilizing quantum kernel methods, the pipeline optimizes feature mapping and classification, enhancing data separability and outperforming traditional neuroimaging analysis techniques. Experimental results highlight the pipeline’s superior accuracy in dementia staging, validating the practical use of quantum machine learning in clinical diagnostics. despite the limitations of NISQ devices, this proof-of-concept demonstrates the transformative potential of quantum-enhanced learning, paving the way for scalable and precise diagnostic tools in healthcare and signal processing.

关键词： Neuroimaging Support vector machines Quantum computing Accuracy Magnetic resonance imaging Pipelines Machine learning Medical services Signal processing Standards

来源：评论

学校读者我要写书评

暂无评论

Preclinical Assessment of Enhanced Chemodynamic Therapy by an FeMnOx-Based Nanocarrier: Tumor-Microenvironment-Mediated Fenton Reaction and ROS-Induced Chemotherapeutic for Boosted Antitumor Activity

引用

ACS Applied Materials and Interfaces 2023年第48期15卷 55258-55275页

作者： dirersa, Worku Batu Kan, Tzu-Chun Getachew, Girum Wibrianto, Aswandi Ochirbat, Sonjid Rasal, Akash Chang, Jungshan Chang, Jia-Yaw Department of Chemical Engineering National Taiwan University of Science and Technology Taiwan Taipei106335 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan

In recent studies, iron-containing Fenton nanocatalysts have demonstrated significant promise for clinical use due to their effective antitumor activity and low cytotoxicity. A new approach was reported in this work utilizing cation exchange synthesis to fabricate FeMnOx nanoparticles (NPs) that boost Fenton reactions and responses to the tumor microenvironment (TME) for chemodynamic therapy (CdT) and chemotherapy (CT). Within the TME, the redox metal pair of Fe2+/Mn2+ helps break down endogenous hydrogen peroxide (H2O2) into very harmful hydroxyl radicals (•OH) while simultaneously deactivating glutathione (GSH) to boost CdT performance. To further enhance the therapeutic potential, FeMnOx NPs were encapsulated with thioketal-linked camptothecin (CPT-TK-COOH), a reactive oxygen species (ROS)-responsive prodrug, achieving a high CPT-loading capacity of up to 51.1%. Upon ROS generation through the Fenton reaction, the prodrug TK linkage was disrupted, releasing 80% of the CPT payload within 48 h. Notably, FeMnOx@CPT exhibited excellent dual-modal imaging capabilities, enabling magnetic resonance and fluorescence imaging for image-guided therapy. In vitro studies showed the cytocompatibility of FeMnOx NPs using MdA-Mb-231 and 4T1 cells, but in the presence of H2O2, they induced significant cytotoxicity, resulting in 80% cell death through CdT and CT effects. Upon intravenous administration, FeMnOx@CPT displayed remarkable tumor accumulation, which enhanced tumor suppression in xenografts through improved CdT and CT effects. Moreover, no significant adverse effects were observed in the FeMnOx NP-treated animals. In the current study, the FeMnOx@CPT anticancer platform, with its boosted •OH-producing capability and ROS-cleavable drug release, has been validated utilizing in vitro and animal studies, suggesting its capacity as a viable strategy for clinical trials. © 2023 American Chemical Society.

关键词： Chemotherapy

来源：评论

学校读者我要写书评

暂无评论

designing together while apart: The role of computer-mediated communication and collaborative virtual environments on design collaboration

Designing together while apart: The role of computer-mediate...

引用

2009 IEEE International Conference on Systems, Man and Cybernetics, SMC 2009

作者： Lee, Seunghyun Ezer, Neta Sanford, Jon do, Ellen Yi-Luem College of Architecture Georgia Institute of Technology Ph.D. Program and Industrial Design Program Atlanta GA United States College of Architecture Georgia Institute of Technology Industrial Design Program Atlanta GA United States College of Architecture Georgia Institute of Technology Center for Assistive Technology and Environmental Access Atlanta GA United States Ph.D. Program School of Interactive Computing College of Computing Atlanta GA United States

ISBN: (纸本)9781424427949

This paper presents an empirical study of two student pairs collaborating on two small products design session in both face-to-face and distributed settings while using Computer-Mediated Communication (CMC) technologies and a Collaborative Virtual Environment (CVE). To gain insight about the way designers communicate and collaborate, the observation focused on how much time the students worked together and individually in the design process. The study shows that teams worked together more in the distributed setting than in the face-to-face setting. In the post-test questionnaires, participants reported that they found the distributed setting a more engaging environment to work with teammates. Findings of the study suggest plausible design criteria for a communication system for distributed collaboration that supports interaction and sharing design information. ©2009 IEEE.

关键词： Product design

来源：评论

学校读者我要写书评

暂无评论

A High-step-down Converter with Negative Output Voltage 11

A High-step-down Converter with Negative Output Voltage

引用

11th International Conference on Power Electronics - ECCE Asia, ICPE 2023-ECCE Asia

作者： Yau, Yeu-Torng Luu, Thanh-phu. National Chin-Yi University of Technology Ph.D. Program Ptoeecs Taichung Taiwan National Chin-Yuuuuuuui University of Technology Department of Electrical Engineering Taichung Taiwan

ISBN: (纸本)9788957083505

This paper proposes a new high step-down converter with negative voltage output, which has the following advantages: (1) Compared to conventional buck-boost or SEPIC converters, the proposed converter operates with zero voltage turn-on function. (2) The voltage gain of this circuit does not contain non-linear components, and the control is simple and can be driven by existing buck control ICs. (3) due to the dC blocking capacitor between the output and input terminals, the high voltage at the input will not pass through to the output when the converter fails to be controlled. The load is protected. Finally, a prototype is completed and the proposed method is verified to be feasible. © 2023 The Korean Institute of Power Electronics.

关键词： Buck-Boost converter

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：