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Optimizing γ-Aminobutyric Acid (GABA) Production via Fermentation of Morinda citrifolia L.

Taiwanese Journal of Agricultural Chemistry and Food Science 2024年第2期62卷 83-90页

作者： Wu, Po-Hua Guo, Huei-Rong Liao, Mei-Qi Lin, Chia-Yu Wu, Chien-Hui Hsieh, Chang-Wei Best News Biomedical Co. Ltd. Department of Food Science and Biotechnology National Chung Hsing University Ph.D. Program of Aquatic Science and Technology National Kaohsiung University of Science and Technology Department of Seafood Science National Kaohsiung University of Science and Technology

Noni fruit (Morinda citrifolia L.) is a tropical and subtropical plant grown on Pacific islands traditionally used as folk medicine to treat a wide range of bioactive compounds, including fatty acids, anthraquinones, flavonoids, polysaccharides, carotenoids and sterols. Noni juice can enhance immune-nerve interaction, while inhibiting age-related diseases. γ-Aminobutyric acid (GABA), can be produced in large quantities by lactic acid bacteria, is an inhibitory nerve conductive substances. It can help relieve depression, insomnia, metabolic syndrome and other problems. In this study, lactic acid bacteria strains with the ability to produce GABA were screened from noni fruit. The lactic acid bacteria screened were used to ferment to improve the GABA functional components. Improve the efficacy of fermentation broth. And establish optimal fermentation parameters. Fermentation parameters have a great influence on the fermentation process and the amount of product produced. It is extremely important to understand the optimal culture conditions for the selected lactic acid bacteria. The optimal fermentation temperature (25,30,35 and 40oQ, the number of inoculated bacteria (6,7 and 8 Log CFUI mL), fermentation time (0 to 96 hours) and the amount of added Monosodium glutamate (MSG) (400, 500, 600 and 700 Mm), screen out the conditions that can produce high amounts of GABA. To establish optimal fermentation parameters, lactic acid bacteria and GABA help maintain human gastrointestinal function, resist free radicals, relieve sleep, relieve emotions and regulate blood sugar, in order to develop noni functional supplements. © 2024 Chinese Agricultural Chemical Society. All rights reserved.

关键词： Fermentation conditions Lactic acid bacteria Monosodium glutamate (MSG) Morinda citrifolia L γ-Aminobutyric acid (GABA)

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Reusable Hydrogen Storage Tank with Flange design 10

Reusable Hydrogen Storage Tank with Flange Design

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10th International Conference on Applied System Innovation, ICASI 2024

作者： Li, Yun-Qi Chen, Hsuan-Jung Yang, Hsi-Wen Chen, Chih-Yuan Chang, Shao-Fu Chen, Ssu-Ying Chen, Chien-Chon College of Engineering and Science Ph.D. Program in Materials and Chemical Engineering National United University Miaoli Taiwan Michigan State University Department of Chemistry MI48824 United States National United University Department of Materials Engineering Miaoli Taiwan Graduate Institute of Intellectual Property National Taipei University of Technology Taiwan National United University Department of Energy Engineering Miaoli Taiwan

ISBN: (纸本)9798350394924

For how to store and transport hydrogen, the first thought is to store hydrogen directly in the cylinder. However, this method is not desirable, because generally at least 700 atm high pressure, the hydrogen contained in the cylinder to be useful. Therefore it is very unsafe at such high pressures. In This paper, we design and production of a new generation of solid-state hydrogen storage and discharge container. The goal of 'development of solid-state hydrogen storage technology' is to break through the bottlenecks of hydrogen storage technology safety, hydrogen storage density, high-efficiency hydrogen absorption and release, transportation safety, and engineering practice. © 2024 IEEE.

关键词： Aluminum

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Metacognitive-Based Collaborative programming: A Novel Approach to Enhance Learning Performance in programming Courses 6th

Metacognitive-Based Collaborative Programming: A Novel Appro...

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Proceedings of the 6th International Conference on Innovative Technologies and Learning, ICITL 2023

作者： Li, Wei Tseng, Judy C. R. Cheng, Li-Chen STEM Education Research Center Wenzhou University Zhejiang Province Wenzhou China Ph.D. Program in Engineering Science Chung Hua University Hsinchu Taiwan Department of Computer Science and Information Engineering Chung Hua University Hsinchu Taiwan Department of Information and Finance Management National Taipei University of Technology Taipei City Taiwan

ISBN: (纸本)9783031401121

Students’ computational thinking and programming skills may grow due to collaborative programming. But as the researchers have noted, students frequently do not use metacognition to manage their cognitive activities while collaborating, which negatively affects learning. This study created a metacognition-based collaborative programming (MCP) system to improve students’ performance in collaborative programming. A seven-week study examined how the approach affected students’ performance in programming courses. The 88 middle school students were split into two groups: the experimental group received the metacognition-based collaborative programming approach, and the control group received the conventional computer-supported collaborative programming approach. The results indicated that the metacognitive-based collaborative programming approach enhanced students’ academic scores in programming courses and their computational thinking tendencies. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Learning systems

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A Review on digital Simulation Strategies and Its Applications for Advanced Compression Garments 16

A Review on Digital Simulation Strategies and Its Applicatio...

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16th Textile Bioengineering and Informatics Symposium, TBIS 2023

作者： Youn, Seonyoung darden, Ryan Mathur, Kavita Fiber and Polymer Science Ph.D. Program North Carolina State University RaleighNC27606 United States Department of Textile Engineering Chemistry and Sciences M.S. Textile Engineering Program North Carolina State University RaleighNC27606 United States Department of Textile and Apparel Technology and Management North Carolina State University RaleighNC27606 United States

ISBN: (纸本)9781713879473

This paper presents a comprehensive review on the current state of digital simulation technology and its strategic application usages with a key focus on advanced compression garments. Although three-dimensional (3d) digital garment simulators have significantly impacted the apparel and textile industry, their use has been limited to visual prototyping, quality checking, or marketing. The physical properties of garment simulators have been overlooked in advanced functional manufacturing. This literature review investigates the possibility of strategically utilizing virtual physical properties to enhance garment functions, specifically in wearables and medical-grade compression fields. The first phase of this paper gives an overview of the current state of 3d garment simulation tools and their measurement features. This is followed by a gap analysis between simulated and physical property evaluations, focusing on minimizing the gaps. The literature is thoroughly examined to identify appropriate studies that uses digital tools for compressional garments and add value to wearables and healthcare applications. This paper provides valuable insights for apparel and textile engineers, enabling them to better understand the limitations and capabilities of garment simulators in improving advanced features for specific end users. © TBIS 2023. All rights reserved.

关键词： physical properties

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A dual-channel Converter with a Positive Output and a Negative Voltage Output

A Dual-channel Converter with a Positive Output and a Negati...

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International Symposium on Computer, Consumer and Control (IS3C)

作者： Yau Yeu-Torng Luu Thanh-phu Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung Taiwan Department of Electrical Engineering National Chin-Yi University of Technology Taichung Taiwan

In this paper, a dual-channel converter with a positive output and negative voltage output is proposed. It integrates a positive voltage output converter and a negative voltage output converter, and shares the same switches. The number of active components can be reduced. In addition, the circuit can achieve dual output voltage control with a single controller and PWM drive signal by appropriately designing the ratio of the number of windings of the coupling inductor. A regulated positive voltage output and negative voltage output can be achieved.

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Characterization of Bacterial Strains Isolated from Wastewater Polluted Soil for Synthetic dye decolorization Attributes

Characterization of Bacterial Strains Isolated from Wastewat...

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2021 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2021

作者： Ahsan, Wazir Aitizaz Lin, Chitsan National Kaohsiung University of Science and Technology Ph.D. Program In College of Hydrosphere Kaohsiung Taiwan National Kaohsiung University of Science and Technology Department of Marine Environmental Engineering Kaohsiung Taiwan

ISBN: (纸本)9781665419512

Soil is a renewable and valuable medium for variety of life. In Pakistan, factory effluents and domestic wastewater is generally not recycled and it contaminates the agricultural soils adjacent to nearby drains. Five screened isolates were subjected to azo dye decolorization (Reactive Black, Red Reactive, Blue direct, Congo Red direct) in the presence of NaCl, at variable ph levels and at different carbon sources. Isolate Sr-7, Ss-2-1 showed best decolorization ability in terms of all the azo dyes studied. Similarly, isolates Sr-2-1/1 and Mr-1/1 exhibited maximum phosphate solubilization and IAA production potential. The screened isolates can be used as inoculants to increase crop productivity in problem soils and can also be applied in wastewater treatments processes. © 2021 IEEE.

关键词： Azo dyes

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PEARL: projection-estimation accelerated Richardson-Lucy deconvolution for rapid volumetric imaging

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Optics Express 2025年第11期33卷 22685-22698页

作者： Shunan Wu Wenhao Liu Xuanwen Hua Jiajia Luo Xunbin Wei Shu Jia Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta Georgia 30332 USA Department of Biomedical Engineering College of Future Technology Peking University Beijing 100871 China PKU-GT-Emory Joint Ph.D. Program China xwei@*** shu.jia@gatech.edu

Three-dimensional imaging of biological specimens requires high spatiotemporal resolution, but the intensive computational demands of processing continuously recorded images hinder the real-time reconstruction of millisecond cellular events. Here, we introduce projection-estimation accelerated Richardson-Lucy (PEARL) deconvolution, an accelerated 3d reconstruction technique that significantly reduces iteration requirements for image reconstruction based on Richardson-Lucy deconvolution. We validate PEARL's capabilities by imaging immuno-stained mitochondria, GFP-labeled peroxisomes, and human pluripotent stem cell-derived organoids, demonstrating enhanced reconstruction speed and accuracy across diverse biological applications.

关键词： Biomedical imaging Image reconstruction Machine learning phase retrieval Three dimensional imaging Three dimensional reconstruction

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Acoustic Scene Classification Using Perceptually Weighted Log Mel Spectrogram and Buttom-up Broadcast Neural Network

Acoustic Scene Classification Using Perceptually Weighted Lo...

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IEEE International Conference on Consumer Electronics-Taiwan (ICCE-TW)

作者： Riyad Ali Ahmad Abuirbaiha Chang-Hsing Lee Cheng Chang Lien Ph.D. Program in Engineering Science Chung Hua University Hsinchu Taiwan Bachelor Program in Industrial Artificial Intelligence Ming Chi University of Technology New Taipei City Taiwan Department of Computer Science and Information Engineering Chung Hua University Hsinchu Taiwan

ISBN: (数字)9798350386844

ISBN: (纸本)9798350386851

The study explores various 2d feature representations including spectrogram, MFCC spectrogram, log Mel-spectrogram, and the perceptual weighted log Mel-spectrogram (PW-LMSP) for acoustic scene classification (ASC). These 2d feature representations were classified using a bottom-up broadcast neural network (BBNN). The experimental results have shown that PW-LMSP outperforms other 2d representations. Further, the proposed method (PW-LMSP with BBNN) achieves accuracies of 91.2% and 91.6% respectively on the dCASE2018 and dCASE2019 development datasets, outperforming all the submissions in dCASE2018 and dCASE2019, as well as state-of-the-art approaches.

关键词： Scene classification Accuracy Neural networks LoRa Feature extraction Acoustics Mel frequency cepstral coefficient

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photothermal Temperature-Modulated Cancer Metastasis Harnessed Using Proteinase-Triggered Assembly of Near-Infrared II photoacoustic/photothermal Nanotheranostics

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ACS Applied Materials and Interfaces 2024年第31期16卷 40611-40627页

作者： Chuang, Yao-Chen Hsia, Yu Chu, Chia-Hui Maharajan, Sivasubramanian Hsu, Fang-Chi Lee, Hsin-Lun Chiou, Jeng Fong Ch’ang, Hui-Ju Liao, Lun-de Lo, Leu-Wei Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli Zhunan35053 Taiwan Department of Radiation Oncology Taipei Medical University Hospital Taipei110301 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu30013 Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei110301 Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei110301 Taiwan National Institute of Cancer Research National Health Research Institutes Miaoli Zhunan35053 Taiwan

Here we demonstrate that cancer metastasis could be modulated by the judicious tuning of physical parameters such as photothermal temperature in nanoparticle-mediated photothermal therapy (PTT). This is supported by theranostic nanosystem design and characterization, in vitro and in vivo analyses, and transcriptome-based gene profiling. In this work, the highly efficient near-infrared II (NIR-II) photoacoustic image (PA)-guided PTT are selectively activated using our developed matrix metalloproteinase (MMP)-triggered in situ assembly of gold nanodandelions (GNds@gelatin). Unlike other "always-on" NIR PTT agents lacking specific bioactivation and suffering from the intrinsic nonspecific pseudosignals and treatment-related side effects such as metastasis, our GNds@gelatin possesses important advantages while deployed in cancer PTT that include the following: (1) The theranostic effects could be "turned on" only after specific MMP-2/-9 activity and with acidity in the tumor microenvironment. (2) The quantitative PA diagnosis allows for precise PTT planning for better cancer treatment. (3) GNds@gelatin could noninvasively quantify MMP activity and efficiently harness NIR-I (808 nm) and NIR-II (1064 nm) energies for tumor ablation. (4) The multibranched nanostructures reabsorb scattered laser photons, thus enhancing the surface plasmons for the pronounced photothermal conversion of aggregated GNds@gelatin in situ. (5) It is noteworthy that in situ tumor eradication at higher PTT temperature (>55 °C) mediated by GNds@gelatin could induce subsequent metastasis, which could be otherwise abolished at lower PTT temperatures (50 °C > T > 43 °C). (6) Furthermore, the gene profiling using transcriptome-based microarray including GO and KEGG analyses revealed that 315 differentially expressed genes were identified in higher PTT temperature treated tumors compared with lower PTT temperature ones. These were enriched into some well-known cancer-related pathways, such as cell migrat

关键词： Plasmonics

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Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer

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Cell and Bioscience 2023年第1期13卷 1页

作者： Fan, Yu-Ching Fong, Yu-Cin Kuo, Chun-Tse Li, Chia-Wei Chen, Wei-Yu Lin, Jian-da Bürtin, Florian Linnebacher, Michael Bui, Quoc Thang Lee, Kuan-der Tsai, Yuan-Chin Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Department of Pathology Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Biochemical Science and Technology College of Life Science National Taiwan University Taipei City 10617 Taiwan Center for Computational and Systems Biology National Taiwan University Taipei City 10617 Taiwan Clinic of General Surgery University Medical Center Rostock Schillingallee 35 Rostock 18057 Germany Clinic of General Surgery Molecular Oncology and Immunotherapy University Medical Center Rostock Schillingallee 69 Rostock 18057 Germany International Ph.D. Program for Cell Therapy and Regeneration Medicine (IPCTRM) School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine Natioanl Chung Hsing University Taichung Taiwan Cell Therapy and Regenerative Medicine Center and Comprehensive Cancer Center Taichung Veterans General Hospital Taichung Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Background: Pancreatic ductal adenocarcinoma (PdA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a natural anti-inflammatory cytokine;however, its contribution to cancer pathogenesis and immunosuppression remains elusive. In this research, we investigated the role and mechanism of IL-1Ra in malignant progression of PdA. Results: Through analyzing clinical dataset and examining the pathological tumor tissues and serum samples, we have demonstrated that IL-1Ra expression is elevated in human PdA and positively associated with malignant progression of PdA. To study the biological function of IL-1Ra in tumors, we generated a set of mouse pancreatic cancer cell lines with a knockout (KO) of the Il1rn gene, encoding IL-1Ra, and compared the tumor growth rates in immune-competent and immune-deficient mice. We found that the Il1rn KO cells exhibited greater tumor inhibition in immune-competent mice, highlighting the crucial role of a functional immune system in Il1rn KO-mediated anti-tumor response. Consistently, we found an increase in Cd8⁺ T cells and a decrease in Cd11b⁺Ly6G⁻ immunosuppressive mononuclear population in the tumor microenvironment of Il1rn KO-derived tumors. To monitor the inhibitory effects of IL-1Ra on immune cells, we utilized a luciferase-based reporter Cd4⁺ T cell line and splenocytes, which were derived from transgenic mice expressing ovalbumin-specific T cell receptors in Cd8⁺ T cells, and mice immunized with ovalbumin. We showed that IL-1Ra suppressed T cell receptor signaling and inhibited antigen-specific interferon-γ (IFN-γ) secretion and cytolytic activity in splenocytes. Conclusions: Our findings illustrate the immunosuppressive properties of the natural anti-inflammatory cytokine IL-1Ra, and provide a rationale for considering IL-1Ra-targeted therapies in the treatment of

关键词： IFN-γ Immunosuppression interleukin-1 receptor antagonist Pancreatic adenocarcinoma Patient-derived xenograft Tumor microenvironment

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