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Engineering H2O2 Self-Supplying Platform for Xdynamic Therapies via Ru-Cu Peroxide Nanocarrier: Tumor Microenvironment-Mediated Synergistic Therapy

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ACS Applied Materials and Interfaces 2024年第19期16卷 24172-24190页

作者： dirersa, Worku Batu Kan, Tzu-Chun Chang, Jungshan Getachew, Girum Ochirbat, Sonjid Kizhepat, Shamsa Wibrianto, Aswandi Rasal, Akash Chen, Hung-An Ghule, Anil Vithal Chou, Tzung-Han Chang, Jia-Yaw Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106335 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Green Nanotechnology Laboratory Department of Chemistry Shivaji University Kolhapur416004 India Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin64002 Taiwan

Of the most common, hypoxia, overexpressed glutathione (GSH), and insufficient H2O2 concentration in the tumor microenvironment (TME) are the main barriers to the advancment of reactive oxygen species (ROS) mediated Xdynamic therapies (X = photo, chemodynamic, chemo). Maximizing Fenton catalytic efficiency is crucial in chemodynamic therapy (CdT), yet endogenous H2O2 levels are not sufficient to attain better anticancer efficacy. Specifically, there is a need to amplify Fenton reactivity within tumors, leveraging the unique attributes of the TME. Herein, for the first time, we design RuxCu1-xO2-Ce6/CPT (RCpCCPT) anticancer nanoagent for TME-mediated synergistic therapy based on heterogeneous Ru-Cu peroxide nanodots (RuxCu1-xO2 Nds) and chlorine e6 (Ce6), loaded with ROS-responsive thioketal (TK) linked-camptothecin (CPT). The Ru-Cu peroxide Nds (RCp Nds, x = 0.50) possess the highest oxygen vacancy (OV) density, which grants them the potential to form massive Lewis’s acid sites for peroxide adsorption, while the dispersibility and targetability of the Nds were improved via surface modification using hyaluronic acid (HA). In TME, RCpCCPT degrades, releasing H2O2, Ru2+/3+, and Cu+/2+ ions, which cooperatively facilitate hydroxyl radical (•OH) formation and deactivate antioxidant GSH enzymes through a cocatalytic loop, resulting in excellent tumor therapeutic efficacy. Furthermore, when combined with laser treatment, RCpCCPT produces singlet oxygen (1O2) for PdT, which induces cell apoptosis at tumor sites. Following ROS generation, the TK linkage is disrupted, releasing up to 92% of the CPT within 48 h. In vitro investigations showed that laser-treated RCpCCPT caused 81.5% cell death from PdT/CdT and chemotherapy (CT). RCpCCPT in cancer cells produces red-blue emission in images of cells taking them in, which allows for fluorescence image-guided Xdynamic treatment. The overall results show that RCp Nds and RCpCCPT are more biocompatible and have excellent Xdynamic the

关键词： Oxidation

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Visual Field Examination technology Based on Semi-transparent Elliptical Mirror 6

Visual Field Examination Technology Based on Semi-transparen...

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6th IEEE Eurasian Conference on Educational Innovation, ECEI 2023

作者： Chang, Chao-Kai Chiang, Chun-Yu Yeh, Feng-Ming Lee, Chi-Hung Tien, Chuen-Lin Chen, der-Chin Department of Optometry Yuanpei University of Medical Technology Hsinchu Taiwan Ph.D. Program of Electrical and Communications Engineering Feng Chia University Taichung Taiwan Department of Electrical Engineering Feng Chia University Taichung Taiwan

ISBN: (纸本)9798350334289

In this study, the human visual field test technology is established by using an optoelectrical system consisting of a translucent ellipsoid, an area light source, and a landscape scene with an indicator. during the test, the subjects stared at the indicator directly in front of them with one eye and kept their eyeballs still, scanning the light strip with peripheral vision and using the mouse button plus the playback program to record the start and end positions of the scanning light strip in the landscape scene. This method is tested subjectively, and the subject needs to respond during the test. Therefore, before the test, the subject needs to understand the test process and be trained in advance to improve the exam accuracy. In the experiment, fifteen subjects with normal vision and no eye disease were selected. Their visual fields were confirmed normal after a preliminary assessment. The test results showed that the subjects' eyes were within the normal visual field, indicating that this method was feasible. In this research, a digital optical platform for the near visual field is proposed to establish an optoelectric visual field measurement technology. The proposed method is characterized by small size, rapid operation, and easy portability. With the digital LCd and visual imaging technology, both dynamic and static visual fields can be tested. The test data on the eyes' upper, lower, nasal, and temporal sides were consistent with the normal visual field. This shows that this method is feasible and worthy of promotion in the optometry industry. © 2023 IEEE.

关键词： Light sources

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Rising threat of metallo-β-lactamase-producing Klebsiella oxytoca complex in Taiwan, 2013–2022

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International Journal of Antimicrobial Agents 2025年第2期66卷 107515-107515页

作者： Huang, Yu-Tsung Bregente, Carl Jay Ballena Hsu, Wei-Yu Liao, Chun-Hsing Kuo, Yao-Wen Lee, Jia-Arng Lee, Tai-fen Kao, Cheng-Yen Hsueh, Po-Ren Department of Laboratory Medicine National Taiwan University Hospital National Taiwan University College of Medicine Taipei Taiwan College of Medical Technology Southwestern University PHINMA Cebu Philippines Institute of Microbiology and Immunology College of Life Sciences National Yang Ming Chiao Tung University Taipei Taiwan Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan Department of Internal Medicine National Taiwan University Hospital National Taiwan University College of Medicine Taipei Taiwan Microbiota Research Center National Yang Ming Chiao Tung University Taipei Taiwan Departments of Laboratory Medicine and Internal Medicine China Medical University Hospital China Medical University Taichung Taiwan Ph.D. Program for Aging College of Medicine China Medical University Taichung Taiwan

Objectives: The emergence of metallo-beta-lactamases (MBLs) within the Klebsiella oxytoca complex (CRKO) poses a significant challenge in Taiwan, with so far incomplete characterization of species distribution and carbapenemase variants. This study aimed to elucidate the diversity, variants, and clinical presentations of CRKO isolates collected from 2013 to 2022. Methods: We analyzed production of carbapenemases by the modified carbapenem inhibitory method (mCIM) and the NG test^TM CARBA-5. Confirmation of five common carbapenemases and multilocus sequence typing were determined by polymerase chain reaction and sequencing. Nanopore whole-genome sequencing was used for the species differentiation and plasmids analysis. We also evaluated the clinical characteristics of the CRKO-infected patients. Results: Three species were identified: K. michiganensis (n = 102), K. pasteurii (n = 13), and K. oxytoca (n = 3). A majority of isolates (91.5%, n = 108) harbored at least one MBL gene, including bla_VIM-1 (n = 56), bla_IMP-8 (n = 26), and bla_NdM-1 (n = 19), with six isolates carrying dual carbapenemase genes. The bla_NdM-1 and bla_IMP-8 genes were located on IncFII(Yp) and IncA/C2 plasmids, respectively. Notably, 34.7% of isolates carried kleboxymycin gene clusters (KGC). Using CLSI and EUCAST criteria, 92.4% and 82.4% of isolates, respectively, were susceptible to cefiderocol. Among 92 infected patients, the 30-day mortality rate was 21.7%, associated with female gender, higher Charlson Comorbidity Index, higher Pitt bacteremia scores, presence of bacteremia, and inversely associated with KGC. Conclusion: The high prevalence of CRKO carrying MBLs and the recent surge of the ST27-bla_NdM-1 genotype, poses significant treatment challenges and underscores the urgent need for enhanced surveillance in Taiwan. © 2025 Elsevier Ltd and International Society of Antimicrobial Chemotherapy

关键词： Carbapenem-resistant Cefiderocol Klebsiella oxytoca complex Metallo-β-lactamase

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Analysis on Predictive Water Temperature with PId Controller and SCAdA System

Analysis on Predictive Water Temperature with PID Controller...

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2021 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2021

作者： Tu, Wen-Fu Wang, Yi-Shun Chen, Tu-Sheng National Kaohsiung University of Science and Technology Marit Mechatronics Engineering Lab Department of Marine Engineering Kaohsiung Taiwan National Kaohsiung University of Science and Technology Ph.D. Program In Maritime Science and Technology College of Maritime Kaohsiung Taiwan

ISBN: (纸本)9781665419512

Marine diesel engine start-up goes through the following speed stages: dead slow, slow, half, and full. The jacket water should be heated initially to prevent the cylinder from cracking due to excessive temperature difference. In this paper, PId temperature controller and SCAdA system are used to heat the jacket water. Experimental tests have been evaluated to improve closed loop response with PId temperature controller and SCAdA system. The heating mode calls the appropriate PId controller according to the design temperature to compare the actual temperature at different stages. The experimental results show that the PId controller converges the temperature well between 35and 80, the optimal PId parameter are P=3, I=198, d=495 with the auto tune function and the max. power supply current I=8.8A, voltage V=110V. © 2021 IEEE.

关键词： Three term control systems

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deep Learning-Based Positioning Error Fault diagnosis of Wire Bonding Equipment and an Empirical Study for IC Packaging

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IEEE Transactions on Semiconductor Manufacturing 2023年第4期36卷 619-628页

作者： Kao, Sheng-Xiang Chien, Chen-Fu International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Intelligent Manufacturing and Circular Economy Research Center National Tsing Hua University Artificial Intelligence for Intelligent Manufacturing Systems Research Center National Science and Technology Council Department of Industrial Engineering and Engineering Management Hsinchu300044 Taiwan

Little research has been done for artificial intelligence applications of semiconductor backend. This study aims to develop a deep learning based fault diagnosis framework as prognostics and health management (phM) solutions with a comprehensive analytics process. A linear encoder sensor is employed to measure position, while data preparation is conducted to convert position information into a signal. Then, signal processing is used to extract the features, in which high pass filter is applied to normalize the signal and emphasize the features. High-dimensional features including time domain statistical features, time-frequency domain features obtained by continuous wavelet transform (CWT), and frequency domain features converted by fast Fourier transform (FFT) are extracted to prepare the dataset. An ensemble neural network model that integrates deep neural network (dNN) and convolutional neural network (CNN) is employed to recognize the pattern and diagnose the positioning errors. The accuracy and false alarm rate are considered to support maintenance decisions. An empirical study was conducted in a world leading IC assembly and testing company for validation. The results have shown that the proposed approach can effectively detect inappropriate installation of the bond head in wire bonding equipment for predictive maintenance and cost reduction. © 1988-2012 IEEE.

关键词： Failure analysis

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Overcoming the Blood-Brain Tumor Barrier with docetaxel-Loaded Mesoporous Silica Nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma

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ACS Applied Materials and Interfaces 2024年第17期16卷 21722-21735页

作者： Hsu, Tsung-I Chen, Yi-Ping Zhang, Rong-Lin Chen, Zih-An Wu, Cheng-Hsun Chang, Wen-Chang Mou, Chung-Yuan Chan, Hardy Wai-Hong Wu, Si-Han Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei110 Taiwan International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Nano Targeting & Therapy Biopharma Inc. Taipei110 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei110 Taiwan Department of Chemistry National Taiwan University Taipei106 Taiwan

While temozolomide (TMZ) has been a cornerstone in the treatment of newly diagnosed glioblastoma (GBM), a significant challenge has been the emergence of resistance to TMZ, which compromises its clinical benefits. Additionally, the nonspecificity of TMZ can lead to detrimental side effects. Although TMZ is capable of penetrating the blood-brain barrier (BBB), our research addresses the need for targeted therapy to circumvent resistance mechanisms and reduce off-target effects. This study introduces the use of PEGylated mesoporous silica nanoparticles (MSN) with octyl group modifications (C8-MSN) as a nanocarrier system for the delivery of docetaxel (dTX), providing a novel approach for treating TMZ-resistant GBM. Our findings reveal that C8-MSN is biocompatible in vitro, and dTX@C8-MSN shows no hemolytic activity at therapeutic concentrations, maintaining efficacy against GBM cells. Crucially, in vivo imaging demonstrates preferential accumulation of C8-MSN within the tumor region, suggesting enhanced permeability across the blood-brain tumor barrier (BBTB). When administered to orthotopic glioma mouse models, dTX@C8-MSN notably prolongs survival by over 50%, significantly reduces tumor volume, and decreases side effects compared to free dTX, indicating a targeted and effective approach to treatment. The apoptotic pathways activated by dTX@C8-MSN, evidenced by the increased levels of cleaved caspase-3 and PARP, point to a potent therapeutic mechanism. Collectively, the results advocate dTX@C8-MSN as a promising candidate for targeted therapy in TMZ-resistant GBM, optimizing drug delivery and bioavailability to overcome current therapeutic limitations. © 2024 The Authors. Published by American Chemical Society.

关键词： Tumors

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Properties of the mixing layer height retrieved from ceilometer measurements in Slovakia and its relationship to the air pollutant concentrations

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Environmental Science and Pollution Research 2023年第54期30卷 115666-115682页

作者： Nguyen, duy-Hieu Štefánik, dušan Šedivá, Tereza Lin, Chitsan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung811213 Taiwan Slovak Hydrometeorological Institute Jeséniova 17 Bratislava833 15 Slovakia Faculty of Mathematics Physics and Informatics Comenius University in Bratislava Mlynská Dolina F1 Bratislava842 48 Slovakia Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung811213 Taiwan

Mixing layer height (MLH) is an important meteorological parameter for air quality since it significantly affects ground-level pollution in the atmosphere. This study examined the properties of the MLH on diurnal and seasonal timescales over a 3-year period (2020–2022) using high temporal resolution measurements from eight Vaisala CL31 ceilometers situated around Slovakia. Hourly averaged MLH data was retrieved from the BL-View software using merged method. The highest daily maxima for the MLH occurred mostly in summer and spring, while the lowest values occurred predominantly during winter and autumn. The average MLH daily maximum in summer was 2229 m, and just 859 m in winter. during summer, the spatial distribution of the MLH daily maxima was more uniform compared to winter, when the air masses within the individual valleys did not mix well. Correlations between ground-level pollutant concentrations and hourly mean/daily mean MLH were analyzed. The highest correlation, R≈0.6, was found for O3. For PM10, PM2.5, and NOx, the anticorrelations with MLH were found with maximum in winter (R ≈ − 0.3 for hourly data and R ≈ − 0.5 for daily mean data) but no relation in summer. Lastly, the ceilometer MLH was compared to the radiosonde retrieved MLH for various cloud covers. Our analysis is based on an extensive set of empirical data, which can improve the accuracy and effectiveness of meteorological and atmospheric chemistry models. The findings can support air pollution forecasting and warning systems, providing valuable insights for policymakers and researchers. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Air quality

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Constructing a Smart Home Control System with the Internet of Things 7

Constructing a Smart Home Control System with the Internet o...

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7th IEEE Asia-Pacific Conference on Antennas and Propagation, APCAP 2018

作者： Hsu, Huan-Po Yu, Kun-Ming Ouyang, Wen Cheng Jie, X. Ph.D. Program in Engineering Science Chung Hua University Hsinchu Taiwan Dept. of Computer Science Information Engineering Chung-Hua University Hsinchu Taiwan Faculty of Computer and Software Engineering Huaiyin Institute of Technology Jiangsu China

ISBN: (纸本)9781538656488

The development of Internet of Things (IoT) makes the application of smart homes grow rapidly. It is very popular to install smart appliances in the house. However, building a smart control system at home not only costs a lot but also has many limitations. For this reason, this study proposes a smart homes control system to easily integrate IoT, WSN, smart robot and single-board computer to implement smart home applications. We use wireless technology and automatic equipment to avoid excessive communication cable and to make the house more intelligent to keep in-house movement unimpeded and indoor space tidy and to let appliance adjust appropriate environment settings automatically. This system brings intelligence and convenience to home, making living environment more comfortable. © 2018 IEEE.

关键词： Wireless sensor networks

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Spatiotemporal variation and clustered routes of atmospheric speciated mercury transported from the East and West Channels of Taiwan Island to South China Sea

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Atmospheric Research 2025年 325卷

作者： Mei-Yun Xiao Wen-Hsi Cheng Yu-Lun Tseng Po-Hsuan Yen Chung-Shin Yuan Jia-Yi Zhao Ming-Shiou Jeng Institute of Environmental Engineering National Sun Yat-sen University Taiwan ROC Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung City Taiwan ROC Net Zero Emissions and Resource Recycling Technology Research Center National Sun Yat-Sen University Kaohsiung Taiwan ROC Biodiversity Research Center Academia Sinica Nangang Taipei City Taiwan ROC Green Island Marine Research Station Biodiversity Research Center Academia Sinica Green Island Taitung County Taiwan ROC

This study investigated the spatiotemporal variation and long-range transport characteristics of atmospheric speciated mercury (ASM) along the West and East Channels surrounding Taiwan Island toward the South China Sea (SCS) in East Asia. Field sampling was conducted at three remote island sites, and potential sources of ASM were examined using backward trajectory clustering and regional fire maps. Seasonally, ASM concentrations followed the order: spring > winter > fall > summer, with higher ASM levels observed in the western waters of Taiwan Island than those in the eastern waters. Among the mercury species, gaseous elemental mercury (GEM) was predominant, and followed by particulate-bound mercury (PBM) and gaseous oxidized mercury (GOM), with total gaseous mercury (TGM = GEM+GOM) accounting for 92.1–98.4 % of ASM. Clustered trajectory analysis indicated that Asian Northeastern Monsoons (ANMs) may transport ASMs originating from continental sources in North and East Asia to the island sites via long-range transport. Slash-and-burn activities in the Indochina Peninsula and mainland China during spring and winter contributed to elevated ASM levels. The West Channel exhibited a pronounced “channel effect,” amplifying industrial emissions across the Taiwan Strait and resulting in higher ASM levels at the Penghu Islands. Conversely, the East Channel received diluted air masses through long-range transport from the Korean Peninsula and North China via Green Island and the Bashi Channel, leading to relatively lower ASM levels at the dongsha Island. Overall, this study highlights the importance of seasonal circulation patterns and regional combustion sources in shaping mercury distribution in the marine boundary layer of East Asia.

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Mitochondrial activation via calcium peroxide/carrageenan/soybean lecithin-derived polypyrrole phototherapeutic microparticles

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Colloids and Surfaces B: Biointerfaces 2025年 254卷 114787页

作者： Chuang, Sih-Chi Yu, Shih-An Hung, Pei-Chia Chuang, Andrew E.-Y. Liang, Jia-Wei Sun, Chia-Lu Rethi, Lekshmi Fang, Hsu-Wei Nguyen, Hieu Trung Tsai, Yao-Tung Weng, Pei-Wei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Doctoral Program of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei10608 Taiwan Taipei Medical University Derived Company-Hsuan Chen Technology CO. LTD. New Taipei City22055 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan WELLCARE Health Care Supply Co. Ltd. Taipei Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh city Ho Chi Minh City700000 Viet Nam Department of Orthopaedic Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist. Taipei City11490 Taiwan Division of Traumatology Department of Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist. Taipei City11490 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan

Mitochondria, often referred to as the "powerhouses" of eukaryotic cells, play a critical role in maintaining cellular homeostasis and supporting essential life functions, particularly in cell survival and apoptosis. This study introduces a composite formulation—combining carrageenan (Car), calcium peroxide (CaO2), and microparticles, derived from soybean oil lecithin, enhanced with photothermally active polypyrrole (PPy)—to create Car-Lec-PPy MP, aimed at promoting mitochondrial activation in cells. The investigation focuses on intercellular mitochondrial transfer and activation as a therapeutic strategy. The formulation seeks to stimulate mitochondrial biogenesis and enhance cellular resilience through targeted mitochondrial activation, leveraging the synergistic effects of near-infrared (NIR) therapy. In the in vivo experiment, phototherapeutic Car-Lec-PPy MP was administered to rodent muscle tissue. The results showed increased expression of heat-shock proteins and reduced oxidative stress in the treated muscle. Preliminary findings suggest that this approach not only boosts mitochondrial activity but also improves cell proliferation and survival, presenting significant potential for applications in regenerative medicine and cellular therapy. © 2025 Elsevier B.V.

关键词： Mitochondria

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