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2022 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2022

作者： Yeh, Feng-Ming Huang, Liang-Ying Chiang, Chun-Yu Chang, Rong-Seng Tien, Chuen-Lin Hsieh, Ya-Hui Chen, der-Chin Yuanpei University of Medical Technology Department of Optometry Hsinchu Taiwan National Central University Department of Optics and Photonics Taoyuan Taiwan Feng Chia University Ph.D. Program of Electrical and Communications Engineering Taichung Taiwan Feng Chia University Department of Electrical Engineering Taichung Taiwan Ming Chuan University Department of Healthcare Information and Management Taoyuan Taiwan

ISBN: (纸本)9798350332421

In this study, a micro-led display, an eye chart player software, and image capture and processing module were used to construct a color refractive error exam for subject with speech disorder. This method can be used to test subjects with refractive errors, eye's color vision and other pathological problems. The micro-led display uses an eye chart player program to display the capital letters E and the other fonts, and the gaps of the E letters can be tumbled in any direction. When subjects with speech disorder were examined for vision, the E chart was displayed sequentially from big letters to small letters, and the image capture and processing module was synchronized with the eye chart player program. The subjects only need to point out the direction of the gap with gestures, and the image capture and processing module can simultaneously capture the gestures of the subjects to judge visual test status. In this study, twenty subjects were tested and all obtained the correct VA value and wore excellent eye glasses. The characteristic of this innovative method is that the subjects with a speech disorder can use simple hand gestures to complete the visual exam through the image capture and processing module during the inspection. © 2022 IEEE.

关键词： Color

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NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, photothermal, and Chemodynamic Therapy

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ACS Applied Materials and Interfaces 2024年第20期16卷 25622-25636页

作者： Thirumurugan, Senthilkumar Muthiah, Kayalvizhi Samuvel Lin, Yu-Chien dhawan, Udesh Liu, Wai-Ching Wang, An-Ni Liu, Xinke Hsiao, Michael Tseng, Ching-Li Chung, Ren-Jei No. 1 Section 3 Zhongxiao East Road Taipei10608 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Faculty of Science and Technology Technological and Higher Education Institute of Hong Kong Hong Kong New Territories999077 Hong Kong Scrona AG Grubenstrasse 9 Zürich8045 Switzerland College of Materials Science and Engineering Chinese Engineering and Research Institute of Microelectronics Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore Genomics Research Center Academia Sinica Taipei115 Taiwan Department and Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei10608 Taiwan

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to develop novel therapies to effectively treat this disease. In this study, iron selenide nanorods (FeSe2 NRs) were designed for use in magnetic hyperthermic, photothermal, and chemodynamic therapy (MHT/PTT/CdT) for breast cancer. To illustrate their efficacy, FeSe2 NRs were modified with the chemotherapeutic agent methotrexate (MTX). MTX-modified FeSe2 (FeSe2-MTX) exhibited excellent controlled drug release properties. Fe2+ released from FeSe2 NRs induced the release of •OH from H2O2 via a Fenton/Fenton-like reaction, enhancing the efficacy of CdT. Under alternating magnetic field (AMF) stimulation and 808 nm laser irradiation, FeSe2-MTX exerted potent hyperthermic and photothermal effects by suppressing tumor growth in a breast cancer nude mouse model. In addition, FeSe2 NRs can be used for magnetic resonance imaging in vivo by incorporating their superparamagnetic characteristics into a single nanomaterial. Overall, we presented a novel technique for the precise delivery of functional nanosystems to tumors that can enhance the efficacy of breast cancer treatment. © 2024 The Authors. Published by American Chemical Society

关键词： Magnetic resonance imaging

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deep Unsupervised Learning for Biomedical Image Translation from Harmonic Generation Microscopy Image to H&E-stained Image

Deep Unsupervised Learning for Biomedical Image Translation ...

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Chen, Wei-Ju Liao, En-Yu Tai, Tsung-Ming Liao, Yi-Hua Sun, Chi-Kuang Lee, Cheng-Kuang See, Simon Chen, Hung-Wen International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering Graduate Institute of Photonics and Optoelectronics National Taiwan University Taipei Taiwan NVIDIA AI Technology Center NVIDIA Taipei Taiwan Department of Dermatology National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan Institute of Photonics Technologies National Tsing Hua University Hsinchu Taiwan

This work proposes an unsupervised deep learning-based image translation from Harmonic generation microscopy (HGM) to widely used H&E-stained images. The proposed methodology is promising and hopefully will facili... 详细信息

ISBN: (纸本)9781957171258

关键词： deep learning

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Vitisin B, a resveratrol tetramer from Vitis thunbergii var. taiwaniana, ameliorates impaired glucose regulations in nicotinamide/streptozotocin-induced type 2 diabetic mice

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Journal of Traditional and Complementary Medicine 2023年第5期13卷 479-488页

作者： Liu, Yuh-Hwa Lin, Yin-Shiou Sie, Yi-Yan Wang, Ching-Chiung Chang, Chi-I Hou, Wen-Chi Department of General Medicine School of Medicine College of Medicine Taipei Medical University Taipei 110 Taiwan Division of Gastroenterology Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan Graduate Institute of Pharmacognosy Taipei Medical University Taipei 110 Taiwan Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei Taiwan School of Pharmacy College of Pharmacy Taipei Medical University Taipei 110 Taiwan Department of Biological Science and Technology National Pingtung University of Science and Technology Pingtung 912 Taiwan

Background and aim: In Taiwan, Vitis thunbergii var. taiwaniana (VTT) is used in traditional medicine and as a local tea. VTT rich in resveratrol and resveratrol oligomers have been reported to exhibit anti-obesity and anti-hypertensive activities in animal models;however, no studies have investigated type 2 diabetes mellitus (T2dM) treatments. This study aimed to investigate the anti-T2dM effects of resveratrol tetramers isolated from the VTT in nicotinamide/streptozotocin (STZ)-induced Institute of Cancer Research (ICR) mice. Experimental procedure: The oral glucose tolerance test (OGTT) was used to imitate postprandial blood glucose (BG) regulations in mice by pre-treatment with VTT extracts, resveratrol tetramers of vitisin A, vitisin B, and hopeaphenol 30 min before glucose loads. Vitisin B (50 mg/kg) was administered to treat T2dM-ICR mice once daily for 28 days to investigate its hypoglycemic activity. Results and conclusion: Mice pre-treated with VTT-S-95EE, or vitisin B (100 mg/kg) 30-min before glucose loading showed significant reductions (P < 0.001) in the area under the curve at 120-min (BG-AUC_0-120) than those without pre-treatment with VTT-S-95 E E or vitisin B. Vitisin B-treated T2dM mice showed hypoglycemic activities via a reduction in plasma dipeptidyl peptidase (dPP)-IV activities to maintain insulin actions and differed significantly than those of untreated T2dM mice (P < 0.05), and also reduced BG-AUC_0-120 and insulin-AUC_0-120 in the OGTT. These in vivo results showed that VTT containing vitisin B would be beneficial for developing nutraceuticals and/or functional foods for glycemic control in patients with T2dM, which should be investigated further. © 2023 Center for Food and Biomolecules, National Taiwan University

关键词： and hopeaphenol Nutraceuticals Resveratrol tetramers of vitisin a Type 2 diabetes mellitus (T2dM) Vitis thunbergii var. taiwaniana (VTT) Vitisin B

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ROBUST PARAMETER ESTIMATION FOR RATIONAL ORdINARY dIFFERENTIAL EQUATIONS

arXiv

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arXiv 2023年

作者： Bassik, Oren Berman, Yosef Go, Soo Hong, Hoon Ilmer, Ilia Ovchinnikov, Alexey Rackauckas, Chris Soto, Pedro Yap, Chee Ph.D. Program in Mathematics CUNY Graduate Center New YorkNY United States Ph.D. Program in Computer Science CUNY Graduate Center New YorkNY United States Department of Mathematics North Carolina State University RaleighNC United States Department of Mathematics CUNY Queens College United States Ph.D. Programs in Mathematics and Computer Science CUNY Graduate Center New YorkNY United States Department of Mathematics Massachusetts Institute of Technology CambridgeMA United States Mathematical Institute University of Oxford Oxford United Kingdom Department of Computer Science Courant Institute of Mathematical Science New York University New YorkNY United States

We present a new approach for estimating parameters in rational OdE models from given (measured) time series data. In typical existing approaches, an initial guess for the parameter values is made from a given search interval. Then, in a loop, the corresponding outputs are computed by solving the OdE numerically, followed by computing the error from the given time series data. If the error is small, the loop terminates and the parameter values are returned. Otherwise, heuristics/theories are used to possibly improve the guess and continue the loop. These approaches tend to be non-robust in the sense that their accuracy depend on the search interval and the true parameter values;furthermore, they cannot handle the case where the parameters are locally identifiable. In this paper, we propose a new approach, which does not suffer from the above non-robustness. In particular, it does not require making good initial guesses for the parameter values or specifying search intervals. Instead, it uses differential algebra, interpolation of the data using rational functions, and multivariate polynomial system solving. We also compare the performance of the resulting software with several other estimation software packages. © 2023, CC BY-NC-SA.

关键词： Parameter estimation

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Too hot to handle? Governance, markets, and the slow burn of geothermal energy in Taiwan

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Energy Research and Social Science 2025年 125卷

作者： Hsieh, Chun-Po Liu, Yuwen International Intercollegiate Ph.D. Program National Tsing Hua University 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan Institute of Technology Management National Tsing Hua University 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan

despite significant resource potential and ambitious targets, geothermal energy development in Taiwan remains limited. This study applies the Technological Innovation System (TIS) framework to examine why diffusion has stalled, using process analysis and stakeholder interviews. Findings reveal that weak market incentives, high costs, regulatory barriers, and social resistance, especially in Indigenous areas, have created a proto-virtuous cycle where progress is sustained but insufficient for large-scale adoption. The study introduces this concept to explain incomplete innovation dynamics and proposes policy reforms, including risk sharing, streamlined governance, and inclusive stakeholder engagement. These insights highlight the need to align policy, market, and social factors to advance geothermal energy in Taiwan and inform similar energy transitions elsewhere. © 2025 Elsevier Ltd

关键词： Energy policy Geothermal energy Renewable energy Taiwan Technological innovation system

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New ent-kaurene and germacrene derivatives from Mesona procumbens Hemseley and their biological activity

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Natural Product Research 2023年第13期37卷 2172-2180页

作者： Ganzon, Jerome G. Liaw, Chia-Ching Lin, Yu-Chi Lin, Zhi-Hu Wang, Chang-Hung Chen, Che-Yi Chuang, Kuo-Hsiang Kuo, Yao-Haur Division of Chinese Materia Medica Development National Research Institute of Chinese Medicine Taipei Taiwan Department of Biochemical Science and Technology National Chiayi University Chiayi Taiwan Ph.D. Program in Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei Taiwan Graduate Institute of Integrated Medicine College of Chinese Medicine China Medical University Taichung Taiwan Department of Research and Development Starsci Biotech Co. Ltd Taoyuan Taiwan

Mesona procumbens Hemseley is a well-known traditional herbal medicine used for heat-related ailments. In Taiwan, boiled extracts of M. procumbens are also used as desserts called grass jelly. In this study, the hexane extract from 75% EtOH of M. procumbens showed potent activities on inhibition of E. coli β-glucuronidase (eβG) and NO production and cytotoxicity against MCF-7 and HepG2 cancer cell lines. Furthermore, using various flash columns and HPLC chromatography on the bioactive layer led to the isolation of twelve compounds (1–12), including a new ent-kaurene, mesokaurol A (1), and a new germacrene derivative, mesogermapene A (2). Their structures were elucidated by extensive spectroscopic analyses, especially 2 d NMR and mass data. Biological assays showed that compound 9 (linolenic acid) had specific activity on inhibition of eβG (68.27%) at 100 µg/mL but was non-inhibitory to human β-glucuronidase. Compound 1 possessed significant cytotoxicity against MCF-7 (EC₅₀ = 9.76 µM) and HepG2 (EC₅₀ = 8.64 µM) cancer cell lines. © 2022 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Anti-β-glucuronidase cytotoxicity germacrene Kaurane-type diterpene Mesona procumbens Hemseley

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Modified Turnstile Antenna design for Multi-Band and Broadband Applications

Modified Turnstile Antenna Design for Multi-Band and Broadba...

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USNC-URSI Radio Science Meeting (Joint with AP-S Symposium)

作者： I-Fong Chen Chia-Mei Fei-Lung Wu Jian-An Xie Dept. of Computer and Communication School of Electronics and Electrical Engineering Dongguan Polytechnic Jinwen University of Science and Technology New Taipei City Taiwan Department of Communications Engineering Feng Chia University Taichung City Taiwan Ph.D. Program of Electrical and Communications Engineering Feng Chia University Taichung City Taiwan

ISBN: (数字)9789463968119

ISBN: (纸本)9798350359497

The proposed antenna with a size of 90 mm x 90 mm, and the ground portion is 64 mm x 64 mm, which material is FR4 glass epoxy substrate with the thickness of 1.6 mm, relative permittivity of 4.3 and loss tangent of 0.023, consists of four modified dipole elements and four power dividers, as shown in Figure. 1. For the multi-band and broadband operation, three dipole antennas were shunted to be a dipole element. The electrical-length of the dipole element can be determined from the one quarter-wave length at the 2.45 GHz, 5.5 GHz and 6.525 GHz, for covering 2400 MHz-2500 MHz, 5150 MHz-5850 MHz and 5925 MHz-7125 MHz. In order to operates in various modes such as normal mode and axial mode, the modified four port triple-band microstrip series power divider was designed. In normal mode, it radiates horizontally polarized waves where as in axial mode, it radiates circularly polarized waves. The radiated patterns of the proposed antenna as shown in Figure. 2. The features of the proposed antenna are shown in the Table I. Impressive radiated gains and efficiencies are obtained.

关键词： Power dividers dipole antennas Conferences Glass Broadband communication Broadband antennas Microstrip

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Synthesis of g-C3N4by doping Bi2S3for the photocatalytic degradation of NOxunder solar light

Synthesis of g-C3N4by doping Bi2S3for the photocatalytic deg...

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2021 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2021

作者： Hussain, Adnan Lin, Chitsan Cheng, Chih-Yu National Kaohsiung University of Science and Technology Ph.D. Program In College of Hydrosphere Kaohsiung Taiwan National Kaohsiung University of Science and Technology Department of Marine Environmental Engineering Kaohsiung Taiwan National Kaohsiung University of Science and Technology Department of Marine Biotechnology Kaohsiung Taiwan

ISBN: (纸本)9781665419512

NOx is a universal term for nitrogen oxide relevant to air pollution namely nitric oxide (NO) and nitrogen dioxide (N2). Mostly NOx is generated from the anthropogenic activities. Currently photo-catalysis is an emerging tool used for the reduction of air pollutants which helps to improve the air quality. In this experimental work Bi2S3 doped into g-C3N4 used as catalyst and the resulting products were characterized such as XRd, FTIR, EdS. Bi2S3@g-C3N4 can harvest the solar light due to narrow band gap which improve electron hole pair and generated hydroxyl and superoxide radicals. Furthermore, Bi2S3@g-C3N4 increased the photo-oxidation efficiency of the transformation from NOx to NO3. In short, this study provides accomplished and effective approach to prepare Bi2S3@g-C3N4 photocatalysts for NOx degradation under solar light. © 2021 IEEE.

关键词： Air quality

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Chrysanthemum Flower-Like Nio-Coo Hybrid as Anode for High-Performance Lithium/Sodium-Ion Batteries: Understanding Capacitive and diffusive Li+/Na+ Charge Storage Kinetics

SSRN

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SSRN 2024年

作者： Kannadasan, Kalidoss Govindasamy, Mani Kuo, Chih-Yu Elumalai, Perumal Electrochemical Energy Storage Lab Department of Green Energy Technology Madanjeet School of Green Energy Technologies Pondicherry University Puducherry605014 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei24301 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan King Saud University Saudi Arabia

In this study, chrysanthemum flower-like nickel oxide – cobalt oxide (NiO-CoO) nano hybrid was generated hydrothermally and explored as an anode in lithium/sodium-ion batteries. Various characterization techniques were employed to analyze the crystal structure, chemical composition and morphology of the synthesized NiO-CoO nano hybrid. Electrochemical studies including cyclic voltammetry (CV), galvanostatic charge-discharge (GCd) and electrochemical impedance spectroscopy (EIS) were conducted to evaluate the lithium-ion and sodium-ion storage performances of the NiO-CoO nano hybrid electrode. It turned out that the lithium-ion battery half-cell constructed in the form of CR-2032 coin cell containing the NiO-CoO hybrid anode achieved a high specific capacity of 739 mA h g-1 at 0.1C-rate showed consistent 100% Coulombic efficiency over 100 charge-discharge cycles. Additionally, the sodium-ion battery performance was also investigated, delivering a specific capacity of 340 mA h g-1 at 0.1C-rate with stable cycle life over 100 cycles. Interestingly, a full-cell lithium-ion battery (NiO-CoO|1M LiPF6|LiCoO2) was assembled for the first time employing the NiO-CoO nano hybrid as anode. The fabricated CR-2032 coin-type LIB full-cell exhibited a specific capacity of 112 mA h g-1 at 0.1C-rate. Further the full cell LIB was demonstrated for practical applications such as powering commercial LEd bulbs and a temperature sensor. The fabricated full-cell sustained illumination of a green LEd bulb for over 5 hours on a single charge. The fascinating flower-like morphology of the NiO-CoO hybrid led to better interaction with the electrolyte and offered short diffusion path as well as efficient conversion/re-conversion reactions which in turn led to high charge storage. © 2024, The Authors. All rights reserved.

关键词： Anodes

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