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GCN2 inhibition reduces mutant SOD1 clustering and toxicity and delays disease progression in an amyotrophic lateral sclerosis mouse model

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Translational Neurodegeneration 2024年第1期13卷 351-355页

作者： Didio Alberto Ortiz Nuria Peregrín Miguel Valencia Rodrigo Vinueza-Gavilanes Elisa Marín-Ordovas Roberto Ferrero María Jesús Nicolás Gloria González-Aseguinolaza Montserrat Arrasate Tomás Aragón DNA and RNA Medicine Program Center for Applied Medical Research(CIMA)University of NavarraPamplonaSpain Biomedical Engineering Program Center for Applied Medical Research(CIMA)University of NavarraPamplonaSpain Institute of Data Science and Artificial Intelligence(DATAI) University of NavarraPamplonaSpain Navarra Institute for Health Research(IdiSNA) PamplonaSpain Neuroimmunology Department Multiple Sclerosis Center of Catalonia(Cemcat)Vall d’Hebron Research Institute(VHIR)BarcelonaSpain School of Medicine University of NavarraPamplonaSpain Brain Lab Biobizkaia Health Research InstituteBarakaldoSpain Present Address:Ikerbasque Basque Foundation for ScienceBilbaoSpain

Main text The disruption of protein folding homeostasis in motoneurons(MNs)and the accumulation of protein aggregates are some of the main molecular hallmarks of amyotrophic lateral sclerosis(ALS).Evidence from sporadic and familial ALS(fALS)patients and from ALS models suggests that protein aggregation directly participates in *** turn,the loss of MN homeostasis triggers a coping mechanism,the integrated stress response(ISR)[1].The ISR is initiated by four independent stress-sensing kinases,each of them activated by distinct stresses:protein kinase R(PKR)by double-strand RNA,protein kinase RNA-like endoplasmic reticulum kinase(PERK)by protein misfolding at the endoplasmic reticulum(ER),general control nonderepressible 2(GCN2)by nutrient starvation,and heme-regulated inhibitor(HRI)by heme deprivation.

关键词： homeostasis amyotrophic sclerosis

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Correction: Learning distribution-free anchored linear structural equation models in the presence of measurement error

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Journal of the Korean Statistical Society 2025年 1-2页

作者： Chung, Junhyoung Ahn, Youngmin Shin, Donguk Park, Gunwoong Department of Statistics Seoul National University Seoul Republic of Korea Institute for Data Innovation in Science Seoul National University Donguk Shin Seoul Republic of Korea Interdisciplinary Program in Artificial Intelligence Seoul National University Seoul Republic of Korea

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Momentum-Based Distributed Economic Dispatch of Smart Grids in Time-Varying Directed Networks

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IEEE Transactions on Network science and Engineering 2025年

作者： Zhang, Keke Lu, Qingguo Zhou, Qixing Li, Huaqing Xia, Dawen Huang, Tingwen Chongqing University College of Computer Science China Southwest University College of Electronic and Information Engineering China Kaili University College of Microelectronics and Artificial Intelligence College of Big Data Engineering China Texas A&M University at Qatar Science Program Doha23874 Qatar

In this paper, we investigate the economic dispatch problem of smart grids in time-varying directed networks. The EDP essentially revolves around optimizing the distribution of generation power amongst multiple generators, with the aim of fulfilling load demands at the lowest possible total generation cost, while strictly conforming to the constraints imposed by the local generation capacity. For a faster resolution of the EDP, we propose an efficient distributed accelerated economic dispatch algorithm that incorporates a unified momentum acceleration strategy into the push-pull deviation tracking approach. The involved acceleration strategy under specific momentum parameters includes two well-known acceleration strategies, i.e., the heavy-ball and Nesterov acceleration strategies, which is more flexible and provides additional improvements in convergence. We present rigorously theoretical proof of linear convergence to the optimal dispatch with explicit bounds for step size and momentum parameters. Finally, to verify the effectiveness of our algorithm and the correctness of the theoretical analysis, we conduct simulations of diverse EDP studies in smart grids. © 2013 IEEE.

关键词： Smart power grids

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Fitness Landscape Optimization Makes Stochastic Symbolic Search By Genetic programming Easier

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IEEE Transactions on Evolutionary Computation 2024年

作者： Huang, Zhixing Mei, Yi Zhang, Fangfang Zhang, Mengjie Banzhaf, Wolfgang Victoria University of Wellington Centre for Data Science and Artificial Intelligence School of Engineering and Computer Science Wellington6140 New Zealand Michigan State University BEACON Center for the Study of Evolution in Action and Ecology Evolution and Behavior Program Department of Computer Science and Engineering East LansingMI48864 United States

Searching for symbolic models plays an important role in a wide range of domains such as neural architecture search and automatic program synthesis. Genetic programming is a promising stochastic method for searching effective symbolic models within an acceptable time. The genetic programming performance is closely related to the hardness of the fitness landscape. A better fitness landscape with less local optima normally implies that it is easier to search for better solutions. In recent years, there have been many studies enhancing genetic programming performance by forming better fitness landscapes. However, the better design of the fitness landscape highly relies on specific domain knowledge and consumes a lot of expert effort. This paper proposes a fitness landscape optimization method to automatically design better fitness landscapes for genetic programming search than the manually designed ones. We optimize the landscapes by optimizing the neighborhood structures of symbolic solutions. We verify the effectiveness of the proposed method in both supervised learning and combinatorial optimization problems. The results show that the proposed method significantly reduces the hardness of fitness landscapes. By simply searching against the automatically optimized fitness landscapes, a genetic programming method can have a very competitive performance with state-of-the-art methods. © 1997-2012 IEEE.

关键词： Genetic programming

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Rethinking RGB Color Representation for Image Restoration Models

arXiv

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arXiv 2024年

作者： Lee, Jaerin Park, JoonKyu Baik, Sungyong Lee, Kyoung Mu ASRI Department of ECE Seoul National University Seoul Korea Republic of Department of Data Science Hanyang University Seoul Korea Republic of Interdisciplinary Program in Artificial Intelligence Seoul National University Seoul Korea Republic of

Image restoration models are typically trained with a pixel-wise distance loss defined over the RGB color representation space, which is well known to be a source of blurry and unrealistic textures in the restored images. The reason, we believe, is that the three-channel RGB space is insufficient for supervising the restoration models. To this end, we augment the representation to hold structural information of local neighborhoods at each pixel while keeping the color information and pixel-grainedness unharmed. The result is a new representation space, dubbed augmented RGB (aRGB) space. Substituting the underlying representation space for the per-pixel losses facilitates the training of image restoration models, thereby improving the performance without affecting the evaluation phase. Notably, when combined with auxiliary objectives such as adversarial or perceptual losses, our aRGB space consistently improves overall metrics by reconstructing both color and local structures, overcoming the conventional perception-distortion trade-off. Copyright © 2024, The Authors. All rights reserved.

关键词： Image reconstruction

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An Object Driven Fuzzy Decision Model for Sugarcane Yield Prediction in Indonesia’s Sugar Industry

An Object Driven Fuzzy Decision Model for Sugarcane Yield Pr...

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International Seminar on Research of Information Technology and Intelligent Systems (ISRITI)

作者： Ditdit Nugeraha Utama Muhammad Asrol Suharjito Christian Harito Napthaleni Muhammad Syafrudin Computer Science Department BINUS Graduate Program Master of Computer Science Bina Nusantara University Jakarta Indonesia Industrial Engineering Department BINUS Graduate Program Master of Industrial Engineering Bina Nusantara University Jakarta Indonesia Department of Artificial Intelligence and Data Science Sejong University Seoul South Korea

ISBN: (数字)9798331519643

ISBN: (纸本)9798331519650

A sugarcane yield of one plantation area depends on several independent variables. Practically it is challenging to predict accurately by using conventional methods. This study aims to develop a decision model based on a combination of fuzzy logic and object-oriented methods to predict sugarcane yield. The research is conducted in four main stages, employing object-oriented methods for model design and fuzzy logic for model construction. Object and activity diagrams are used for the object-oriented model design. The fuzzy membership functions employed are a combination of trapezoidal and triangular shapes. The resulting decision model can simulate 2,225 data from plantation areas in Indonesia. Based on the 10 examples of plantation area data in Indonesia, plantation number one obtained the largest sugarcane yield, which was 4.79%, with a similarity value of 0.90 (when compared to manual calculations as its ground truth). This similarity value is a higher value when compared to the average similarity value, which is 0.89.

关键词： Fuzzy logic Seminars Shape Object oriented modeling Plantations Manuals Predictive models Sugar industry Intelligent systems Information technology

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EUDRL: Explainable Uncertainty-Based Deep Reinforcement Learning for Portfolio Management

EUDRL: Explainable Uncertainty-Based Deep Reinforcement Lear...

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International Conference on Computing and Networking Technology (ICCNT)

作者： Jia Lina Shahab S. Banda Hao-Ting Paib Bharat S. Rawal International Graduate School of Artificial Intelligence Douliu City Yunlin Taiwan Bachelor Program of Big Data Applications National Pingtung University Pingtung Taiwan Department of Computer Science Digital Technologies University Ggrambling La USA

ISBN: (数字)9798350370249

ISBN: (纸本)9798350370270

Supervised deep learning (SDL) has shown remarkable success in various financial applications, such as stock prediction and fraud detection. However, SDL’s reliance on class labels renders it unsuitable for portfolio management (PM) tasks, where such labels are often unavailable. To address this limitation, we propose a novel two-level architecture based on deep reinforcement learning (DRL) for PM, which does not require class labels. Our approach comprises several local agents that provide trading decisions and uncertainty assessments for individual stocks, and a global agent that makes portfolio management decisions based on the outputs of the local agents. Additionally, we incorporate the concept of explainable AI (XAI) into our framework using the SHAP (Shapley additive explanations) method, enhancing the transparency and interpretability of the global agent’s decisions. Our experimental results demonstrate that the proposed architecture consistently yields profitable outcomes in the market.

关键词： Uncertainty Correlation Additives Explainable AI Computational modeling Computer architecture Deep reinforcement learning Fraud Portfolios

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Vision-Language Models for Autonomous Driving: CLIP-Based Dynamic Scene Understanding

arXiv

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arXiv 2025年

作者： Elhenawy, Mohammed Ashqar, Huthaifa I. Rakotonirainy, Andry Alhadidi, Taqwa I. Jaber, Ahmed Tami, Mohammad Abu CARRS-Q and Centre for Data Science Queensland University of Technology Kelvin GroveQLD4059 Australia Data Science and AI Department Arab American University P.O Box 240 Jenin Palestine Artificial Intelligence Program Fu Foundation School of Engineering and Applied Science Columbia University New YorkNY10027 United States

Scene understanding is essential for enhancing driver safety, generating human-centric explanations for Automated Vehicle (AV) decisions, and leveraging artificial intelligence (AI) for retrospective driving video analysis. This study developed a dynamic scene retrieval system using Contrastive Language–Image Pretraining (CLIP) models, which can be optimized for real-time deployment on edge devices. The proposed system outperforms state-of-the-art in-context learning methods, including the zero-shot capabilities of GPT-4o, particularly in complex scenarios. By conducting frame-level analysis on the Honda Scenes dataset, which contains a collection of about 80 hours of annotated driving videos capturing diverse real-world road and weather conditions, our study highlights the robustness of CLIP models in learning visual concepts from natural language supervision. Results also showed that fine-tuning the CLIP models, such as ViT-L/14 and ViT-B/32, significantly improved scene classification, achieving a top F1-score of 91.1%. These results demonstrate the ability of the system to deliver rapid and precise scene recognition, which can be used to meet the critical requirements of Advanced Driver Assistance Systems (ADAS). This study shows the potential of CLIP models to provide scalable and efficient frameworks for dynamic scene understanding and classification. Furthermore, this work lays the groundwork for advanced autonomous vehicle technologies by fostering a deeper understanding of driver behavior, road conditions, and safety-critical scenarios, marking a significant step toward smarter, safer, and more context-aware autonomous driving systems. © 2025, CC BY.

关键词： Advanced driver assistance systems

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Additive Poisson regression via forced categorical covariates and generalized fused Lasso 27

Additive Poisson regression via forced categorical covariate...

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27th International Conference on Knowledge Based and Intelligent Information and Engineering Sytems, KES 2023

作者： Yamamura, Mariko Ohishi, Mineaki Yanagihara, Hirokazu Department of Statistics Radiation Effects Research Foundation 5-2 Hijiyama Park Minami-ku Hiroshima732-0815 Japan Center for Data-driven Science and Artificial Intelligence Tohoku University 41 Kawauchi Aoba-ku Miyagi Sendai980-8576 Japan Mathematics Program Graduate School of Advanced Science and Engineering Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima Hiroshima739-8526 Japan

In this study, we use the log-linear link function and propose a generalized fused Lasso (GFL) Poisson regression model in which the nonlinear trend is discretely represented by categorical covariates in the additive model. We use the coordinate descent algorithm for the estimation and show that the optimal solution in a coordinate axis can be found explicitly. To demonstrate the proposed approach, we analyze Japanese crime data. Simulation results showed a fitness ratio for true fusion to be more than 90% in total, demonstrating the reliability of the estimates. © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://***/licenses/by-nc-nd/4.0)

关键词： Additive Poisson regression Coordinate descent algorithm Generalized fused Lasso Spatio-temporal analysis

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Over the Quantum Rainbow: Explaining Hybrid Quantum Reinforcement Learning

Over the Quantum Rainbow: Explaining Hybrid Quantum Reinforc...

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Quantum Computing and Engineering (QCE), IEEE International Conference on

作者： Junghoon Park Jiook Cha Samuel Yen-Chi Chen Shinjae Yoo Huan-Hsin Tseng Interdisciplinary Program in Artificial Intelligence Seoul National University Department of Psychology Seoul National University Department of Brain and Cognitive Sciences Seoul National University Graduate School of Data Science Seoul National University Wells Fargo Computational Science Initiative Brookhaven National Laboratory

ISBN: (数字)9798331541378

ISBN: (纸本)9798331541385

In the realm of artificial intelligence, deep rein-forcement learning (RL) agents struggle with generalizability and require substantial computational resources, unlike humans who easily adapt and generalize across tasks. To address these challenges, we introduce Quantum Rainbow, a hybrid algorithm that leverages the neural mechanisms of human decision-making and the efficiency of quantum computing. Quantum Rainbow combines variational quantum circuits with the Rainbow Deep Q-Network (DQN) model to create a novel approach in rein-forcement learning that integrates quantum principles into deep learning paradigms. We evaluate our model using behavioral experiments through the Iowa Gambling Task and 4-Armed Bandit Task. Our investigations reveal a significant relationship between the architecture of quantum circuits and the performance of quantum RL agents. Specifically, using causal discovery methods, we demonstrate the critical role of quantum entanglement in enhancing model performance. These findings not only show promising results but also pave the way for future explorations into optimizing quantum circuit architectures for reinforcement learning applications. This study underscores the potential of quantum-enhanced algorithms to achieve “quantum advantage” by addressing fundamental limitations in conventional deep RL methods.

关键词： Analytical models Quantum computing Quantum algorithm Quantum advantage Quantum entanglement Computational modeling Reinforcement learning Quantum state Integrated circuit modeling Quantum circuit

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