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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker

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BIOLOGICAL PSYCHIATRY 2021年第8期90卷 529-539页

作者： Qi, Shile Schumann, Gunter Bustillo, Juan Turner, Jessica A. Jiang, Rongtao Zhi, Dongmei Fu, Zening Mayer, Andrew R. Vergara, Victor M. Silva, Rogers F. Iraji, Armin Chen, Jiayu Damaraju, Eswar Ma, Xiaohong Yang, Xiao Stevens, Michael Mathalon, Daniel H. Ford, Judith M. Voyvodic, James Mueller, Bryon A. Belger, Aysenil Potkin, Steven G. Preda, Adrian Zhuo, Chuanjun Xu, Yong Chu, Congying Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Quinlan, Erin Burke Desrivieres, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny Heinz, Andreas Martinot, Jean-Luc Martinot, Marie-Laure Paillere Artiges, Eric Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomas Poustka, Luise Hohmann, Sarah Frohner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Calhoun, Vince D. Sui, Jing [a]Tri-institutional Center for Translational Research in Neuroimaging and Data Science Georgia State University Georgia Institute Technology and Emory University Atlanta Georgia [b]Department of Psychiatry University of New Mexico Albuquerque New Mexico [c]Department of Psychology Georgia State University Atlanta Georgia [d]Olin Neuropsychiatry Research Center Hartford Connecticut [e]Department of Psychiatry University of California San Francisco San Francisco California [f]Department of Radiology Duke University Durham North Carolina [g]Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill North Carolina [h]Department of Psychiatry University of Minnesota Minneapolis Minnesota [i]Department of Psychiatry University of California Irvine Irvine California [j]Departments of Psychiatry and Psychology University of Vermont Burlington Vermont [k]Centre for Population Neuroscience and Stratified Medicine Institute for Science and Technology of Brain-Inspired Intelligence Fudan University Shanghai China [l]University of Chinese Academy of Sciences Beijing China [dd]Department of Computer Science and Engineering Nanjing University of Aeronautics and Astronautics Nanjing China [m]Brainnetome Center and National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing China [ee]State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing China [n]Psychiatric Laboratory and Mental Health Center the State Key Laboratory of Biotherapy West China Hospital of Sichuan University Chengdu China [o]Department of Psychiatric-Neuroimaging-Genetics and Morbidity Laboratory Nankai University Affiliated Anding Hospital Tianjin China [p]Department of Humanities and Social Science Shanxi Medical University Taiyuan China [q]Department of Psychiatry and Psychotherapy Charité – Universitätsmedizin Berlin Campus Charité Mitte corporate member of Freie Universität Berlin Humboldt-Univers

BACKGROUND: Dysfunctional reward processing is implicated in multiple mental disorders. Novelty seeking (NS) assesses preference for seeking novel experiences, which is linked to sensitivity to reward environmental cues. METHODS: A subset of 14-year-old adolescents (IMAGEN) with the top 20% ranked high-NS scores was used to identify high-NS-associated multimodal components by supervised fusion. These features were then used to longitudinally predict five different risk scales for the same and unseen subjects (an independent dataset of subjects at 19 years of age that was not used in predictive modeling training at 14 years of age) (within IMAGEN, n z 1100) and even for the corresponding symptom scores of five types of patient cohorts (non-IMAGEN), including drinking (n = 313), smoking (n = 104), attention-deficit/hyperactivity disorder (n = 320), major depressive disorder (n = 81), and schizophrenia (n = 147), as well as to classify different patient groups with diagnostic labels. RESULTS: Multimodal biomarkers, including the prefrontal cortex, striatum, amygdala, and hippocampus, associated with high NS in 14-year-old adolescents were identified. The prediction models built on these features are able to longitudinally predict five different risk scales, including alcohol drinking, smoking, hyperactivity, depression, and psychosis for the same and unseen 19-year-old adolescents and even predict the corresponding symptom scores of five types of patient cohorts. Furthermore, the identified reward-related multimodal features can classify among attention-deficit/hyperactivity disorder, major depressive disorder, and schizophrenia with an accuracy of 87.2%. CONCLUSIONS: Adolescents with higher NS scores can be used to reveal brain alterations in the reward-related system, implicating potential higher risk for subsequent development of multiple disorders. The identified high-NS- associated multimodal reward-related signatures may serve as a transdiagnostic neuroimaging bi

关键词： ADHD Attention-deficit/hyperactivity disorder Major depressive disorders MDD Novelty seeking Reward processing Schizophrenia Substance use

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On the Problem of Flying Robots Deployment to Improve Cellular User Experience

On the Problem of Flying Robots Deployment to Improve Cellul...

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Chinese Control Conference (CCC)

作者： Hailong Huang Andrey V. Savkin Ming Ding Mohamed Ali Kaafar Chao Huang Networks Research Group Data61 CSIRO Eveleigh Sydney Australia School of Electrical Engineering and Telecommunications University of New South Wales Sydney Australia School of Electrical Computer and Telecommunications Engineering University of Wollongong Wollongong Australia

In this paper, we consider the problem of using flying robots to provide internet service to mobile users. Two important aspects are accounted in this context: the robot deployment problem and the relocation problem. Where to deploy the flying robots directly influences the user coverage and the quality of service, and the relocation problem looks for an efficient scheme to relocate the flying robots such that the total moving distance is minimized, with the aim of saving the previous energy resource preloaded on the flying robots. We formulate these two problems and show that the drone deployment problem is a NP-hard problem. Then, we propose a heuristic algorithm to address it. For the relocation problem, we formulate it as the conventional assignment problem and use a liner programming algorithm to solve it. We conduct extensive computer simulations to demonstrate the effectiveness of the proposed approaches.

关键词： Robots Drones Electronic mail Australia Quality of service Wireless communication Signal to noise ratio

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Searching for gravitational wave optical counterparts with the Zwicky Transient Facility: summary of O4a

arXiv

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arXiv 2024年

作者： Ahumada, Tomás Anand, Shreya Coughlin, Michael W. Gupta, Vaidehi Kasliwal, Mansi M. Karambelkar, Viraj R. Stein, Robert D. Waratkar, Gaurav Swain, Vishwajeet Jegou du Laz, Theophile Anumarlapudi, Akash Andreoni, Igor Bulla, Mattia Srinivasaragavan, Gokul P. Toivonen, Andrew Wold, Avery Bellm, Eric C. Cenko, S. Bradley Kaplan, David L. Sollerman, Jesper Bhalerao, Varun Perley, Daniel Salgundi, Anirudh Suresh, Aswin Hinds, K.-Ryan Reusch, Simeon Necker, Jannis Cook, David O. Pletskova, Natalya Singer, Leo P. Banerjee, Smaranika Barna, Tyler Copperwheat, Christopher M. Healy, Brian Kiendrebeogo, R. Weizmann Kumar, Harsh Kumar, Ravi Pezzella, Marianna Sagués-Carracedo, Ana Sravan, Niharika Bloom, Joshua S. Chen, Tracy X. Graham, Matthew Helou, George Laher, Russ R. Mahabal, Ashish A. Purdum, Josiah Anupama, G.C. Barway, Sudhanshu Basu, Judhajeet Raman, Dhananjay Roychowdhury, Tamojeet Division of Physics Mathematics and Astronomy California Institute of Technology PasadenaCA91125 United States School of Physics and Astronomy University of Minnesota MinneapolisMN55455 United States Department of Physics Indian Institute of Technology West Bengal Kharagpur721302 India Department of Physics Indian Institute of Technology Bombay Powai 400 076 India Department of Physics University of Wisconsin-Milwaukee P.O. Box 413 MilwaukeeWI53201 United States Joint Space-Science Institute University of Maryland College ParkMD20742 United States Department of Astronomy University of Maryland College ParkMD20742 United States Astrophysics Science Division NASA Goddard Space Flight Center MC 661 GreenbeltMD20771 United States Department of Physics and Earth Science University of Ferrara via Saragat 1 FerraraI-44122 Italy INFN Sezione di Ferrara via Saragat 1 FerraraI-44122 Italy INAF Osservatorio Astronomico d’Abruzzo via Mentore Maggini snc Teramo64100 Italy IPAC California Institute of Technology 1200 E. California Blvd PasadenaCA91125 United States DIRAC Institute Department of Astronomy University of Washington 3910 15th Avenue NE SeattleWA98195 United States The Oskar Klein Centre Department of Astronomy Albanova Stockholm University StockholmSE-106 91 Sweden Astrophysics Research Institute Liverpool John Moores University IC2 Liverpool Science Park 146 Brownlow Hill LiverpoolL3 5RF United Kingdom Deutsches Elektronen-Synchrotron DESY Platanenallee 6 Zeuthen15738 Germany Department of Physics Drexel University PhiladelphiaPA19104 United States Astrophysics Research Institute IC2 Liverpool Science Park 146 Brownlow Hill LiverpoolL3 5RF United Kingdom Laboratoire de Physique et de Chimie de l’Environnement Université Joseph KI-ZERBO Ouagadougou Burkina Faso Artemis Observatoire de la Côte d’Azur Université Côte d’Azur Boulevard de l’Observatoire NiceF-06304 France Department of Physics Indian Institute o

During the first half of the fourth observing run (O4a) of the International Gravitational Wave Network (IGWN), the Zwicky Transient Facility (ZTF) conducted a systematic search for kilonova (KN) counterparts to binary neutron star (BNS) and neutron star–black hole (NSBH) merger candidates. Here, we present a comprehensive study of the five high-significance (False Alarm Rate less than 1 per year) BNS and NSBH candidates in O4a. Our follow-up campaigns relied on both target-of-opportunity observations (ToO) and re-weighting of the nominal survey schedule to maximize coverage. We describe the toolkit we have been developing, Fritz, an instance of SkyPortal, instrumental in coordinating and managing our telescope scheduling, candidate vetting, and follow-up observations through a user-friendly interface. ZTF covered a total of 2841 deg2 within the skymaps of the high-significance GW events, reaching a median depth of g ≈ 20.2 mag. We circulated 15 candidates, but found no viable KN counterpart to any of the GW events. Based on the ZTF non-detections of the high-significance events in O4a, we used a Bayesian approach, nimbus, to quantify the posterior probability of KN model parameters that are consistent with our non-detections. Our analysis favors KNe with initial absolute magnitude fainter than -16 mag. The joint posterior probability of a GW170817-like KN associated with all our O4a follow-ups was 64%. Additionally, we use a survey simulation software, simsurvey, to determine that our combined filtered efficiency to detect a GW170817-like KN is 36%, when considering the 5 confirmed astrophysical events in O3 (1 BNS and 4 NSBH events), along with our O4a follow-ups. Following Kasliwal et al. (2020), we derived joint constraints on the underlying KN luminosity function based on our O3 and O4a follow-ups, determining that no more than 76% of KNe fading at 1 mag day-1 can peak at a magnitude brighter than -17.5 mag. Copyright © 2024, The Authors. All rights reserved.

关键词： Gravity waves

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Author Correction: Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision

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Nature methods 2025年第2期22卷 448页

作者： Marieke Vromman Jasper Anckaert Stefania Bortoluzzi Alessia Buratin Chia-Ying Chen Qinjie Chu Trees-Juen Chuang Roozbeh Dehghannasiri Christoph Dieterich Xin Dong Paul Flicek Enrico Gaffo Wanjun Gu Chunjiang He Steve Hoffmann Osagie Izuogu Michael S Jackson Tobias Jakobi Eric C Lai Justine Nuytens Julia Salzman Mauro Santibanez-Koref Peter Stadler Olivier Thas Eveline Vanden Eynde Kimberly Verniers Guoxia Wen Jakub Westholm Li Yang Chu-Yu Ye Nurten Yigit Guo-Hua Yuan Jinyang Zhang Fangqing Zhao Jo Vandesompele Pieter-Jan Volders OncoRNALab Cancer Research Institute Ghent (CRIG) Department of Biomolecular Medicine Ghent University Ghent Belgium. Department of Molecular Medicine University of Padova Padova Italy. Genomics Research Center Academia Sinica Taipei City Taiwan. Institute of Crop Science and Institute of Bioinformatics Zhejiang University Zhejiang China. Department of Biomedical Data Science and of Biochemistry Stanford University Stanford CA USA. Klaus Tschira Institute for Integrative Computational Cardiology Department of Internal Medicine III University Hospital Heidelberg German Center for Cardiovascular Research (DZHK) Heidelberg Germany. School of Basic Medical Science Department of Medical Genetics Wuhan University Wuhan China. EMBL-EBI Hinxton UK. Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine School of Artificial Intelligence and Information Technology Nanjing University of Chinese Medicine Nanjing China. Computational Biology Group Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) Jena Germany. Biosciences Institute Faculty of Medical Sciences Newcastle University Newcastle UK. Translational Cardiovascular Research Center University of Arizona - College of Medicine Phoenix Phoenix AZ USA. Sloan Kettering Institute New York NY USA. Bioinformatics Group Department of Computer Science and Interdisciplinary Center for Bioinformatics Universität Leipzig Leipzig Germany. Data Science Institute I-Biostat Hasselt University Hasselt Belgium. State Key Laboratory of Bioelectronics School of Biological Sciences and Medical Engineering Southeast University Nanjing China. Department of Biochemistry and Biophysics National Bioinformatics Infrastructure Sweden Science for Life Laboratory Stockholm University Stockholm Sweden. Center for Molecular Medicine Children's Hospital Fudan University and Shanghai Key Laboratory of Medical Epigenetics International Laboratory of Medical Epigenetics and Metab

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Beyond Low Earth Orbit: Biological research, Artificial Intelligence, and Self-Driving Labs

arXiv

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arXiv 2021年

作者： Sanders, Lauren M. Yang, Jason H. Scott, Ryan T. Qutub, Amina Ann Martin, Hector Garcia Berrios, Daniel C. Hastings, Jaden J.A. Rask, Jon Mackintosh, Graham Hoarfrost, Adrienne L. Chalk, Stuart Kalantari, John Khezeli, Kia Antonsen, Erik L. Babdor, Joel Barker, Richard Baranzini, Sergio E. Beheshti, Afshin Delgado-Aparicio, Guillermo M. Glicksberg, Benjamin S. Greene, Casey S. Haendel, Melissa Hamid, Arif A. Heller, Philip Jamieson, Daniel Jarvis, Katelyn J. Komarova, Svetlana V. Komorowski, Matthieu Kothiyal, Prachi Mahabal, Ashish Manor, Uri Mason, Christopher E. Matar, Mona Mias, George I. Miller, Jack Myers, Jerry G. Nelson, Charlotte Oribello, Jonathan Park, Seung-Min Parsons-Wingerter, Patricia Prabhu, R.K. Reynolds, Robert J. Saravia-Butler, Amanda Saria, Suchi Sawyer, Aenor Singh, Nitin Kumar Soboczenski, Frank Snyder, Michael Soman, Karthik Theriot, Corey A. van Valen, David Venkateswaran, Kasthuri Warren, Liz Worthey, Liz Zitnik, Marinka Costes, Sylvain V. Blue Marble Space Institute of Science Space Biosciences Division NASA Ames Research Center Moffett Field CA94035 United States Center for Emerging and Re-Emerging Pathogens Department of Microbiology Biochemistry and Molecular Genetics Rutgers New Jersey Medical School NewarkNJ07103 United States KBR Space Biosciences Division NASA Ames Research Center Moffett Field CA94035 United States AI MATRIX Consortium Department of Biomedical Engineering University of Texas San Antonio and UT Health Sciences San AntonioTX78249 United States Biological Systems and Engineering Division Lawrence Berkeley National Lab. BerkeleyCA94608 United States DOE Agile BioFoundry EmeryvilleCA94608 United States Joint BioEnergy Institute EmeryvilleCA94608 United States Department of Physiology and Biophysics Weill Cornell Medicine New YorkNY10065 United States Office of the Center Director NASA Ames Research Center Moffett Field CA94035 United States Bay Area Environmental Research Institute NASA Ames Research Center Moffett Field CA94035 United States Space Biosciences Division NASA Ames Research Center Moffett Field CA94035 United States Department of Chemistry University of North Florida JacksonvilleFL32224 United States Center for Individualized Medicine Department of Surgery Department of Quantitative Health Sciences Mayo Clinic RochesterMN55905 United States Department of Emergency Medicine Center for Space Medicine Baylor College of Medicine HoustonTX77030 United States Department of Microbiology and Immunology Department of Otolaryngology Head and Neck Surgery University of California San Francisco San FranciscoCA94143 United States The Gilroy AstroBiology Research Group The University of Wisconsin - Madison MadisonWI53706 United States Weill Institute for Neurosciences Department of Neurology University of California San Francisco San FranciscoCA94158 United States Data Science Analytics Georgia Institute of Technology Lima15024

Space biology research aims to understand fundamental effects of spaceflight on organisms, develop foundational knowledge to support deep space exploration, and ultimately bioengineer spacecraft and habitats to stabilize the ecosystem of plants, crops, microbes, animals, and humans for sustained multi-planetary life. To advance these aims, the field leverages experiments, platforms, data, and model organisms from both spaceborne and ground-analog studies. As research is extended beyond low Earth orbit, experiments and platforms must be maximally autonomous, light, agile, and intelligent to expedite knowledge discovery. Here we present a summary of recommendations from a workshop organized by the National Aeronautics and Space Administration on artificial intelligence, machine learning, and modeling applications which offer key solutions toward these space biology challenges. In the next decade, the synthesis of artificial intelligence into the field of space biology will deepen the biological understanding of spaceflight effects, facilitate predictive modeling and analytics, support maximally autonomous and reproducible experiments, and efficiently manage spaceborne data and metadata, all with the goal to enable life to thrive in deep space. © 2021, CC BY.

关键词： Predictive analytics

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Beyond Low Earth Orbit: Biomonitoring, Artificial Intelligence, and Precision Space Health

arXiv

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arXiv 2021年

作者： Scott, Ryan T. Antonsen, Erik L. Sanders, Lauren M. Hastings, Jaden J.A. Park, Seung-Min Mackintosh, Graham Reynolds, Robert J. Hoarfrost, Adrienne L. Sawyer, Aenor Greene, Casey S. Glicksberg, Benjamin S. Theriot, Corey A. Berrios, Daniel C. Miller, Jack Babdor, Joel Barker, Richard Baranzini, Sergio E. Beheshti, Afshin Chalk, Stuart Delgado-Aparicio, Guillermo M. Haendel, Melissa Hamid, Arif A. Heller, Philip Jamieson, Daniel Jarvis, Katelyn J. Kalantari, John Khezeli, Kia Komarova, Svetlana V. Komorowski, Matthieu Kothiyal, Prachi Mahabal, Ashish Manor, Uri Martin, Hector Garcia Mason, Christopher E. Matar, Mona Mias, George I. Myers, Jerry G. Nelson, Charlotte Oribello, Jonathan Parsons-Wingerter, Patricia Prabhu, R.K. Qutub, Amina Ann Rask, Jon Saravia-Butler, Amanda Saria, Suchi Singh, Nitin Kumar Soboczenski, Frank Snyder, Michael Soman, Karthik van Valen, David Venkateswaran, Kasthuri Warren, Liz Worthey, Liz Yang, Jason H. Zitnik, Marinka Costes, Sylvain V. KBR Space Biosciences Division NASA Ames Research Center Moffett FieldCA94035 United States Department of Emergency Medicine Center for Space Medicine Baylor College of Medicine HoustonTX77030 United States Blue Marble Space Institute of Science Space Biosciences Division NASA Ames Research Center Moffett FieldCA94035 United States Department of Physiology and Biophysics Weill Cornell Medicine New YorkNY10065 United States Department of Urology Department of Radiology Stanford University School of Medicine StanfordCA94305 United States Bay Area Environmental Research Institute NASA Ames Research Center Moffett FieldCA94035 United States Mortality Research & Consulting Inc. HoustonTX77058 United States Space Biosciences Division NASA Ames Research Center Moffett FieldCA94035 United States UC Space Health Department of Orthopaedic Surgery University of California San Francisco San FranciscoCA94143 United States Center for Health AI Department of Biochemistry and Molecular Genetics University of Colorado School of Medicine Anschutz Medical Campus AuroraCO80045 United States Hasso Plattner Institute for Digital Health at Mount Sinai Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New YorkNY10065 United States Department of Preventive Medicine and Community Health UTMB GalvestonTX77551 United States Human Health and Performance Directorate NASA Johnson Space Center HoustonTX77058 United States Department of Microbiology and Immunology Department of Otolaryngology Head and Neck Surgery University of California San Francisco San FranciscoCA94143 United States The Gilroy AstroBiology Research Group The University of Wisconsin Madison MadisonWI53706 United States Weill Institute for Neurosciences Department of Neurology University of California San Francisco San FranciscoCA94158 United States Department of Chemistry University of North Florida JacksonvilleFL32224 United States Data Scienc

Human space exploration beyond low Earth orbit will involve missions of significant distance and duration. To effectively mitigate myriad space health hazards, paradigm shifts in data and space health systems are necessary to enable Earth-independence, rather than Earth-reliance. Promising developments in the fields of artificial intelligence and machine learning for biology and health can address these needs. We propose an appropriately autonomous and intelligent Precision Space Health system that will monitor, aggregate, and assess biomedical statuses;analyze and predict personalized adverse health outcomes;adapt and respond to newly accumulated data;and provide preventive, actionable, and timely insights to individual deep space crew members and iterative decision support to their crew medical officer. Here we present a summary of recommendations from a workshop organized by the National Aeronautics and Space Administration, on future applications of artificial intelligence in space biology and health. In the next decade, biomonitoring technology, biomarker science, spacecraft hardware, intelligent software, and streamlined data management must mature and be woven together into a Precision Space Health system to enable humanity to thrive in deep space. © 2021, CC BY.

关键词： Earth (planet)

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MedShapeNet - A Large-Scale dataset of 3D Medical Shapes for computer Vision

arXiv

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arXiv 2023年

作者： Li, Jianning Zhou, Zongwei Yang, Jiancheng Pepe, Antonio Gsaxner, Christina Luijten, Gijs Qu, Chongyu Zhang, Tiezheng Chen, Xiaoxi Li, Wenxuan Wodzinski, Marek Friedrich, Paul Xie, Kangxian Jin, Yuan Ambigapathy, Narmada Nasca, Enrico Solak, Naida Melito, Gian Marco Vu, Viet Duc Memon, Afaque R. Schlachta, Christopher De Ribaupierre, Sandrine Patel, Rajnikant Eagleson, Roy Chen, Xiaojun Mächler, Heinrich Kirschke, Jan Stefan de la Rosa, Ezequiel Christ, Patrick Ferdinand Li, Hongwei Bran Ellis, David G. Aizenberg, Michele R. Gatidis, Sergios Küstner, Thomas Shusharina, Nadya Heller, Nicholas Andrearczyk, Vincent Depeursinge, Adrien Hatt, Mathieu Sekuboyina, Anjany Löffler, Maximilian Liebl, Hans Dorent, Reuben Vercauteren, Tom Shapey, Jonathan Kujawa, Aaron Cornelissen, Stefan Langenhuizen, Patrick Ben-Hamadou, Achraf Rekik, Ahmed Pujades, Sergi Boyer, Edmond Bolelli, Federico Grana, Costantino Lumetti, Luca Salehi, Hamidreza Ma, Jun Zhang, Yao Gharleghi, Ramtin Beier, Susann Sowmya, Arcot Garza-Villarreal, Eduardo A. Balducci, Thania Angeles-Valdez, Diego Souza, Roberto Rittner, Leticia Frayne, Richard Ji, Yuanfeng Ferrari, Vincenzo Chatterjee, Soumick Dubost, Florian Schreiber, Stefanie Mattern, Hendrik Speck, Oliver Haehn, Daniel John, Christoph Nürnberger, Andreas Pedrosa, João Ferreira, Carlos Aresta, Guilherme Cunha, António Campilho, Aurélio Suter, Yannick Garcia, Jose Lalande, Alain Vandenbossche, Vicky Van Oevelen, Aline Duquesne, Kate Mekhzoum, Hamza Vandemeulebroucke, Jef Audenaert, Emmanuel Krebs, Claudia van Leeuwen, Timo Vereecke, Evie Heidemeyer, Hauke Röhrig, Rainer Hölzle, Frank Badeli, Vahid Krieger, Kathrin Gunzer, Matthias Chen, Jianxu van Meegdenburg, Timo Dada, Amin Balzer, Miriam Fragemann, Jana Jonske, Frederic Rempe, Moritz Malorodov, Stanislav Bahnsen, Fin H. Seibold, Constantin Jaus, Alexander Marinov, Zdravko Jaeger, Paul F. Stiefelhagen, Rainer Santos, Ana Sofia Lindo, Mariana Ferreira, André Alves, Victor Kamp, Michael Abourayya, Amr Nensa, Felix Hörst, Fabian Brehmer, Alexander Hein Girardetstraße 2 Essen45131 Germany Graz University of Technology Inffeldgasse 16c Graz8010 Austria Graz Austria The Department of Computer Science Johns Hopkins University Malone Hall 3400 N Charles St BaltimoreMD21218 United States Rte Cantonale Lausanne1015 Switzerland The Department of Measurement and Electronics AGH University of Science and Technology Krakow Poland Sierre Switzerland Department of Biomedical Engineering University of Basel Hegenheimermattweg Allschwil167C CH-4123 Switzerland The Boston College 140 Commonwealth Ave Chestnut HillMA02467 United States University Hospital B7-200 339 Windermere Road LondonN6A 5A5 Canada The Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai200240 China The Research Center for Connected Healthcare Big Data ZhejiangLab Zhejiang Hangzhou311121 China The Faculty of Statistics Technical University Dortmund August-Schmidt-Straße 1 Dortmund44227 Germany The Institute of Mechanics Graz University of Technology Kopernikusgasse 24/IV Graz8010 Austria The Institute of Biomedical Manufacturing and Life Quality Engineering State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai200240 China The Department of Cardiac Surgery Medical University Graz Auenbruggerplatz 29 Graz8036 Austria The Department of Diagnostic and Interventional Radiology University Hospital Giessen Justus-Liebig-University Giessen Klinikstraße 33 Giessen35392 Germany The Department of Mechanical Engineering Mehran University of Engineering and Technology Jamshoro Sindh76062 Pakistan The Institute of Medical Robotics Shanghai Jiao Tong University Shanghai China The Geschäftsführender Oberarzt Abteilung für Interventionelle und Diagnostische Neuroradiologie Universitätsklinikum der Technischen Universität München Ismaningerstr. 22 München81675 Germany icometrix Kolonel Be

Prior to the deep learning era, shape was commonly used to describe the objects. Nowadays, state-of-the-art (SOTA) algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from numerous shape-related publications in premier vision conferences as well as the growing popularity of ShapeNet (about 51,300 models) and Princeton ModelNet (127,915 models). For the medical domain, we present a large collection of anatomical shapes (e.g., bones, organs, vessels) and 3D models of surgical instrument, called MedShapeNet, created to facilitate the translation of data-driven vision algorithms to medical applications and to adapt SOTA vision algorithms to medical problems. As a unique feature, we directly model the majority of shapes on the imaging data of real patients. As of today, MedShapeNet includes 23 datasets with more than 100,000 shapes that are paired with annotations (ground truth). Our data is freely accessible via a web interface and a Python application programming interface (API) and can be used for discriminative, reconstructive, and variational benchmarks as well as various applications in virtual, augmented, or mixed reality, and 3D printing. Exemplary, we present use cases in the fields of classification of brain tumors, skull reconstructions, multi-class anatomy completion, education, and 3D printing. In future, we will extend the data and improve the interfaces. The project pages are: https://***/ and https://***/Jianningli/*** Codes 68T01 © 2023, CC BY.

关键词： Large dataset

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Dual encoding for zero-example video retrieval

arXiv

引用

arXiv 2018年

作者： Dong, Jianfeng Li, Xirong Xu, Chaoxi Ji, Shouling He, Yuan Yang, Gang Wang, Xun College of Computer and Information Engineering Zhejiang Gongshang University Key Lab of Data Engineering and Knowledge Engineering Renmin University of China AI & Media Computing Lab School of Information Renmin University of China College of Computer Science Zhejiang University Alibaba-Zhejiang University Joint Research Institute of Frontier Technologies Alibaba Group

This paper attacks the challenging problem of zero-example video retrieval. In such a retrieval paradigm, an end user searches for unlabeled videos by ad-hoc queries described in natural language text with no visual example provided. Given videos as sequences of frames and queries as sequences of words, an effective sequence-to-sequence cross-modal matching is required. The majority of existing methods are concept based, extracting relevant concepts from queries and videos and accordingly establishing associations between the two modalities. In contrast, this paper takes a concept-free approach, proposing a dual deep encoding network that encodes videos and queries into powerful dense representations of their own. Dual encoding is conceptually simple, practically effective and end-to-end. As experiments on three benchmarks, i.e. MSR-VTT, TRECVID 2016 and 2017 Ad-hoc Video Search show, the proposed solution establishes a new state-of-the-art for zero-example video retrieval. Copyright © 2018, The Authors. All rights reserved.

关键词： Signal encoding

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Prediction of solar energetic events impacting space weather conditions

引用

Advances in Space research 2024年

作者： Georgoulis, Manolis K. Yardley, Stephanie L. Guerra, Jordan A. Murray, Sophie A. Ahmadzadeh, Azim Anastasiadis, Anastasios Angryk, Rafal Aydin, Berkay Banerjee, Dipankar Barnes, Graham Bemporad, Alessandro Benvenuto, Federico Bloomfield, D. Shaun Bobra, Monica Campi, Cristina Camporeale, Enrico DeForest, Craig E. Emslie, A. Gordon Falconer, David Feng, Li Gan, Weiqun Green, Lucie M. Guastavino, Sabrina Hapgood, Mike Kempton, Dustin Kitiashvili, Irina Kontogiannis, Ioannis Korsos, Marianna B. Leka, K.D. Massa, Paolo Massone, Anna Maria Nandy, Dibyendu Nindos, Alexander Papaioannou, Athanasios Park, Sung-Hong Patsourakos, Spiros Piana, Michele Rawafi, Nour E. Sadykov, Viacheslav M. Toriumi, Shin Vourlidas, Angelos Wang, Haimin L. Wang, Jason T. Whitman, Kathryn Yan, Yihua Zhukov, Andrei N. Research Center for Astronomy and Applied Mathematics of the Academy of Athens Athens11527 Greece Department of Mathematics Physics and Electrical Engineering Northumbria University Newcastle upon TyneNE1 8ST United Kingdom Department of Meteorology University of Reading ReadingRG6 6ET United Kingdom Paseo Manuel de Lardizabal 4 San Sebastián20018 Spain CIRES University of Colorado BoulderCO80309 United States NOAA Space Weather Prediction Center BoulderCO80305 United States School of Cosmic Physics Dublin Institute for Advanced Studies Dunsink Observatory DublinD15 XR2R Ireland Computer Science Department Georgia State University AtlantaGA30303 United States National Observatory of Athens Penteli15236 Greece Uttarakhand Nainital263001 India NorthWest Research Associates BoulderCO80301 United States INAF Turin Astrophysical Observatory via Osservatorio 20 10025 Pino Torinese Torino Italy MIDA Dipartimento di Matematica Università di Genova via Dodecaneso 35 16146 Genova Italy State of California Office of Data and Innovation 401 I Street Ste 200 SacramentoCA95814 United States Southwest Research Institute BoulderCO80302 United States Department of Physics & Astronomy Western Kentucky University Bowling GreenKY42101 United States Center for Space Plasma and Aeronomic Research University of Alabama in Huntsville HuntsvilleAL35899 United States NASA/Marshall Space Flight Center HuntsvilleAL35812 United States Key Laboratory of Dark Matter and Space Astronomy Purple Mountain Observatory Chinese Academy of Sciences Nanjing210023 China Mullard Space Science Laboratory University College London Holmbury St. MaryRH5 6NT United Kingdom University of Chinese Academy of Sciences Nanjing211135 China Visiting Scientist RAL Space STFC Rutherford Appleton Laboratory Oxfordshire DidcotOX11 0QX United Kingdom NASA Ames Research Center Moffett FieldCA94035 United States An der Sternwarte 16 Potsdam14482 Germany Dipartime

Aiming to assess the progress and current challenges on the formidable problem of the prediction of solar energetic events since the COSPAR/ International Living With a Star (ILWS) Roadmap paper of Schrijver et al. (2015), we attempt an overview of the current status of global research efforts. By solar energetic events we refer to flares, coronal mass ejections (CMEs), and solar energetic particle (SEP) events. The emphasis, therefore, is on the prediction methods of solar flares and eruptions, as well as their associated SEP manifestations. This work complements the COSPAR International Space Weather Action Teams (ISWAT) review paper on the understanding of solar eruptions by Linton et al. (2023) (hereafter, ISWAT review papers are conventionally referred to as ’Cluster’ papers, given the ISWAT structure). Understanding solar flares and eruptions as instabilities occurring above the nominal background of solar activity is a core solar physics problem. We show that effectively predicting them stands on two pillars: physics and statistics. With statistical methods appearing at an increasing pace over the last 40 years, the last two decades have brought the critical realization that data science needs to be involved, as well, as volumes of diverse ground- and space-based data give rise to a Big data landscape that cannot be handled, let alone processed, with conventional statistics. Dimensionality reduction in immense parameter spaces with the dual aim of both interpreting and forecasting solar energetic events has brought artificial intelligence (AI) methodologies, in variants of machine and deep learning, developed particularly for tackling Big data problems. With interdisciplinarity firmly present, we outline an envisioned framework on which statistical and AI methodologies should be verified in terms of performance and validated against each other. We emphasize that a homogenized and streamlined method validation is another open challenge. The performance of the

关键词： Solar energy

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