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Longitudinal study on Puberty Onset and Adolescent Obesity—Suzhou City,Jiangsu Province,China,2012–2022

China CDC weekly 2024年第45期6卷 1183-1187,I0001页

作者： Huiling Lyu Ziyao Ding Bowen Chen Di Han Xi Wang Xiao Jiang Jiale Hu Hui Shen Jia Hu School of Public Health Nanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of School Health Suzhou Center for Disease Prevention and ControlSuzhou CityJiangsu ProvinceChina Department of Computer and Information Science University of PennsylvaniaPhiladelphiaPAUSA Suzhou Institute of Advanced Study in Public Health Gusu SchoolNanjing Medical UniversitySuzhou CityJiangsu ProvinceChina

What is already known about this topic?The early onset of puberty increases the risk of cardiovascular *** research has focused on the association between the onset of puberty,based on sudden increases in height,and obesity in late *** is added by this report?This report assessed the age at take-off and age at peak height velocity for children and adolescents in China from 2012 to *** results indicated that age at take-off and age at peak height velocity were negatively associated with the risk of late adolescence obesity in boys,independent of childhood body mass index;however,no similar association was found in *** are the implications for public health practice?Puberty timing influences *** monitoring and management of pubertal development are necessary,and attention should be paid to sex differences.

关键词： les Pub Jiangsu

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The ubiquitin codes in cellular stress responses

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Protein & Cell 2024年第3期15卷 157-190页

作者： Xiangpeng Sheng Zhixiong Xia Hanting Yang Ronggui Hu Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China State Key Laboratory of Animal Disease Control Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China Department of Neurology State Key Laboratory of Medical NeurobiologyInstitute for Translational Brain ResearchMOE Frontiers Center for Brain ScienceZhongshan HospitalFudan UniversityShanghai 200032China

Ubiquitination/ubiquitylation,one of the most fundamental post-translational modifications,regulates almost every critical cellular process in *** evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses,from exogenous factors to cellular reactions,causing a dazzling variety of functional *** forms of ubiquitin sig-nals generated by ubiquitylation events in specific milieus,known as ubiquitin codes,constitute an intrinsic part of myriad cellular stress *** ubiquitination events,leading to proteolytic turnover of the substrates or just switch in functionality,initiate,regulate,or supervise multiple cellular stress-associated responses,supporting adaptation,homeostasis recovery,and survival of the stressed *** this review,we attempted to summarize the crucial roles of ubiquitination in response to different environmental and intracellular stresses,while discussing how stresses modulate the ubiquitin *** review also updates the most recent advances in understanding ubiquitination machinery as well as different stress responses and discusses some important questions that may warrant future investigation.

关键词： ubiquitin E3 ligase environmental stresses intercellular stresses stress response homeostasis

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Diverse Hazy Image Synthesis via Coloring Network

IEEE Transactions on Artificial Intelligence

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IEEE Transactions on Artificial Intelligence 2024年第7期5卷 3703-3713页

作者： Zhang, Shengdong Zhang, Xiaoqin Wan, Shaohua Ren, Wenqi Zhao, Liping Zhao, Li Shen, Linlin Shaoxing University Department of Computer Science and Engineering Shaoxing312000 China Shenzhen United Aircraft Technology Company Ltd. Guangdong Shenzhen518129 China Wenzhou University College of Computer and Artificial Intelligence Wenzhou325035 China University of Electronic Science and Technology of China Shenzhen Institute for Advanced Study Shenzhen518110 China Sun Yat-sen University School of Cyber Science and Technology Shenzhen518110 China Shenzhen University College of Computer Science and Software Engineering Shenzhen518060 China

Convolutional neural network (CNN)-based dehazing methods have achieved great success in single image dehazing. However, the absence of real-world haze image datasets hinders the deep development of single image dehazing. To address this issue, we propose a diverse hazy image synthesis method based on generative adversarial network (GAN) and matting. Specially, we train a GAN-based model that can transform a gray image into a hazy image. To boost the diversity of hazy images, we propose to simulate hazy images via image matting, which can fuse a real haze image with another image containing diverse objects. To evaluate the performance of dehazing methods, we propose two novel metrics: part-based peak signal-to-noise ratio (PSNR) and structure similarity index measure (SSIM). Extensive experiments are conducted to show the effectiveness of the proposed model, dataset, and criteria. © 2020 IEEE.

关键词： Three dimensional displays

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Failure evolution and instability prediction of fiber-reinforced polymer-confined cement mortar specimens under axial compression

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Environmental science and Pollution Research 2024年第20期31卷 29730-29748页

作者： Li, Jian Bai, Jinwen Han, Yanna Feng, Guorui Shi, Xudong Ma, Junbiao Cui, Boqiang Wang, Kai Mi, Jiachen College of Mining Engineering Taiyuan University of Technology Shanxi Province Taiyuan030024 China Key Laboratory of Shanxi Province for Mine Rock Strata Control and Disaster Prevention Taiyuan University of Technology Taiyuan030024 China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan030024 China Department of Mining Engineering Shanxi Institute of Energy Jinzhong030600 China College of Safety and Emergency Management Engineering Taiyuan University of Science and Technology Taiyuan030024 China

In geotechnical engineering, a large number of pillars are often left in underground space to support the overlying strata and protect the surface environment. To enhance pillar stability and prevent instability, this study proposes an innovative technology for pillar reinforcement. Specifically, local confinement of the pillar is achieved through fiber-reinforced polymer (FRP) strips, resulting in the formation of a more stable composite structure. In order to validate the effectiveness of this structural approach, acoustic emission characteristics and surface strain field characteristics were monitored during failure processes, while mathematical models were employed to predict specimen instability. The test results revealed that increasing FRP strip confinement width led to heightened activity in acoustic emission events during failure processes, accompanied by a decrease in shear cracks but an increase in tensile cracks. Moreover, ductility was improved and deformation resistance capacity was enhanced within specimens. Notably, initial crack generation occurred within unconfined regions of specimens during failures;however, both length and width as well as overall numbers of cracks significantly decreased due to implementation of FRP strips. Consequently, specimen failure speed was slowed down accordingly. Finally, the instability of the partial FRP-confined cement mortar could be more accurately predicted based on the model of FRP-confined concrete. It was verified by the test results. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Stability

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A CNN and Transformer Hybrid Network for Multi-Class Arrhythmia Detection from Photoplethysmography 46

A CNN and Transformer Hybrid Network for Multi-Class Arrhyth...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Liu, Zeng-Ding Zhou, Bin Liu, Ji-Kui Zhao, Honglei Li, Ye Miao, Fen Chinese Academy of Sciences Shenzhen Institute of Advanced Technology Shenzhen China Fuwai Hospital Chinese Academy of Medical Sciences Department of Cardiology Shenzhen China Shenzhen Polytechnic University Institute of Intelligence Science and Engineering Shenzhen China Fuwai Hospital Chinese Academy of Medical Sciences Department of Clinical Research Center Shenzhen China University of Electronic Science and Technology of China Shenzhen Institute for Advanced Study Shenzhen China

ISBN: (纸本)9798350371499

Photoplethysmography (PPG)-based arrhythmia detection methods have gained attention with wearable technology, enabling early detection of undiagnosed arrhythmias. Existing methods excel in single arrhythmia detection but struggle with multiple arrhythmias due to challenges in extracting discriminative features from PPG signals. This study introduces a hybrid convolutional neural network (CNN)-transformer network for multiple arrhythmia detection from PPG signals. The model incorporates convolutional operations and self-attention mechanisms to capture both local features and global temporal dependencies within the PPG signals. A feature fusion layer with channel attention is implemented to integrate the local and global features. Experimental results show the model achieves an average precision, recall, and F1-score of 87.0%, 87.1%, and 86.8%, respectively, in classifying sinus rhythm and five types of arrhythmias (premature ventricular contraction, premature atrial contraction, ventricular tachycardia, supraventricular tachycardia, and atrial fibrillation). These results surpass state-of-the-art methods, highlighting the model's promise for accurate multi-class arrhythmia detection from PPG signals. © 2024 IEEE.

关键词： Convolutional neural networks

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Near-Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024年第47期63卷 e202411802页

作者： Liu, Wenkai He, Shan Ma, Xue Lv, Chengyuan Gu, Hua Cao, Jianfang Du, Jianjun Sun, Wen Fan, Jiangli Peng, Xiaojun State Key Laboratory of Fine Chemicals Frontier Science Center for Smart Materials Dalian University of Technology Dalian 116024 China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study Hong Kong University of Science and Technology Hong Kong 999077 China School of Chemical Engineering Dalian University of Technology Panjin 124221 China Ningbo Institute of Dalian University of Technology Ningbo 315016 China Liaoning Binhai Laboratory Dalian 116023 China

Near-infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen ( 1 O 2 ) generation ability, indicated by low 1 O 2 quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S ( Scy7 ) and Se ( Secy7 ) atom. We observe that Secy7 exhibits a redshift in the main absorption to ~840 nm and an ultra-efficient 1 O 2 generation capacity. The emergence of a strong intramolecular charge transfer effect between the Se atom and polymethine chain considerably narrows the energy gap (0.51 eV), and the heavy atom effect of Se strengthens spin–orbit coupling (1.44 cm −1 ), both of which greatly improved the high triplet state yield (61 %), a state that determines the energy transfer to O 2 . Therefore, Secy7 demonstrated excellent 1 O 2 generation capacity, which is ~24.5-fold that of indocyanine green, ~8.2-fold that of IR780, and ~1.3-fold that of methylene blue under low-power-density 850 nm irradiation (5 mW cm −2 ). Secy7 exhibits considerable phototoxicity toward cancer cells buried under 12 mm of tissue. Nanoparticles formed by encapsulating Secy7 within amphiphilic polymers and lecithin, demonstrated promising antitumor and anti-pulmonary metastatic effects, exhibiting remarkable potential for advancing PDT in deep tissues.

关键词： Photochemistry NIR light Intramolecular charge transfer Ultra-efficient ROS generation Photodynamic therapy

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Influence of Interfacial Enantiomeric Grafting on Melt Rheology and Crystallization of Polylactide/Cellulose Nanocrystals Composites

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Chinese Journal of Polymer science 2022年第1期40卷 93-106页

作者： Hua-Gao Fang Kang-Jie Yang Qi-Zheng Xie Xu Chen Sheng-Li Wu Yun-Sheng Ding Department of Polymer Science and Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China Anhui Province Key Laboratory of Advanced Functional Materials and Devices Hefei 230009China Anhui Institute for Food and Drug Control Hefei230051China

Incorporating the surface-grafted cellulose nanocrystals(CNCs)with enantiomeric polylactide(PLLA or PDLA)is an effective and sustainable way to modify PLLA,but their difference in promoting matrix crystallization is still *** this study,the CNCs with identical content and length of PLLA and PDLA(CNC-g-L and CNC-g-D)were prepared and blended with *** rheological properties of PLLA/CNC-gD are greatly improved,indicating that the stereocomplexation can significantly improve the interfacial strength as compared with the conventional van der Waals force in PLLA/***,the matrix crystallizes at a higher rate in PLLA/CNC-g-L than PLLA/***/CNC-g-L15 reaches its half crystallinity in 8.26 min while a longer period of 13.41 min is required for PLLA/*** observation reveals that the superior crystallization behavior in PLLA/CNC-g-L is originated from its higher nucleation efficiency and faster growth *** formation of low content of sc-PLA at the interface can restrict the diffusion of PLLA but contribute less to generate crystalline nuclei,which synergistically leads to the retarded crystallization kinetics in PLLA/*** the mechanism of different interfacial enantiomeric grafting on the melt rheology and crystallization of PLLA is of great significance for the development of high-performance polylactide materials.

关键词： Cellulose nanocrystal Polylactide nanocomposite Interfacial stereocomplexation Crystallization Rheology

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Higher-order polysulfides induced thermal runaway for 1.0 Ah lithium sulfur pouch cells

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Particuology 2023年第8期79卷 10-17页

作者： Feng-Ni Jiang Shi-Jie Yang Zi-Xian Chen He Liu Hong Yuan Lei Liu Jia-Qi Huang Xin-Bing Cheng Qiang Zhang College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan030024ShanxiChina Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing100084China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing211189JiangsuChina School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjing210044JiangsuChina

Comprehensive analyses on thermal runaway mechanisms are critically vital to achieve the safe lithium-sulfur(Li-S)*** reactions between dissolved higher-order polysulfides and Li metal were found to be the origins for the thermal runaway of 1.0 Ah cycled Li-S pouch cells.16-cycle pouch cell indicates high safety,heating from 30 to 300 ℃ without thermal runaway,while 16-cycle pouch cell with additional electrolyte undergoes severe thermal runaway at 147.9 ℃,demonstrating the key roles of the electrolyte on the thermal safety of *** the contrary,thermal runaway does not occur for 45-cycle pouch cell despite the addition of the *** is found that the higher-order polysulfides(Li_(2)S_(x) ≥ 6)are discovered in 16-cycle electrolyte while the sulfur species in 45-cycle electrolyte are Li_(2)S_(x) ≤ *** addition,strong exothermic reactions are discovered between cycled Li and dissolved higher-order polysulfide(Li_(2)S_(6) and Li_(2)S_(8))at 153.0 ℃,driving the thermal runaway of cycled Li-S pouch *** work uncovers the potential safety risks of Li-S batteries and negative roles of the polysulfide shuttle for Li-S batteries from the safety view.

关键词： Lithium-sulfur batteries Thermal runaway Polysulfides Pouch cell Polysulfide shuttle

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Structural Properties of Ions and Polyelectrolytes in Aqueous Solutions under External Electric Fields:The Sign Effect

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Chinese Journal of Polymer science 2024年第9期42卷 1341-1352,I0007页

作者： Cheng-Jiang Lin Jun-Jun Wang Yuan Jiang Shu-Li Chen Hong-Fei Li Wen-Han Zhao Qing-Rong Huang Chang-Ru Rong Xiao-Zheng Duan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China National Key Laboratory of Advanced Vehicle Integration and Control China FAW Group Co.Ltd.Changchun130013China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Department of Food Science Rutgers University65 Dudley RoadNew BrunswickNew Jersey08901USA

We utilize molecular dynamics simulations to investigate the microstructures of ions and polyelectrolytes in aqueous solutions under external electric *** focusing on the multi-body interactions between ionic components and H_(2)O molecules,as well as their responses to the external electric fields,we clarify several nontrivial molecular features of the ionic and polyelectrolyte solutions,such as the solvations of cations and anions,clustering of the ions,and dispersions/aggregations of polyelectrolyte chains,as well as the corresponding responses of H_(2)O molecules in these *** simulations illustrate the variations in structures of ionic solutions caused by reversing the charge sign of the ions,and elucidate the disparity in structures between anionic and cationic polyelectrolyte solutions in the presence of the external electric *** work clarifies the mechanism for the alternations in complex multi-body interactions in aqueous solutions caused by the application electric field,which can contribute to the fundamental understanding of the physical and chemical natures of ion-containing and charged polymeric systems.

关键词： Polyelectrolyte Ions Aqueous solutions External electric fields Asymmetric dipole

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3D bioprinting of in vitro porous hepatoma models:establishment,evaluation,and anticancer drug testing

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Bio-Design and Manufacturing 2024年第2期7卷 137-152页

作者： Xiaoyuan Wang Zixian Liu Qianqian Duan Boye Zhang Yanyan Cao Zhizhong Shen Meng Li Yanfeng Xi Jianming Wang Shengbo Sang Shanxi Key Laboratory of Micro Nano Sensors and Artificial Intelligence Perception College of Electronic Information and Optical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China Shanxi Institute of 6D Artificial Intelligence Biomedical Science Taiyuan 030031China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China Department of Pathology Shanxi Provincial Cancer HospitalTaiyuan 030024China General Hospital of Taiyuan Iron and Steel Company Taiyuan 030809China

Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted *** address this,this study describes the use of threedimensional(3D)bioprinting technology to construct a 3D model with human hepatocarcinoma SMMC-7721 cells(3DP-7721)by combining gelatin methacrylate(GelMA)and poly(ethylene oxide)(PEO)as two immiscible aqueous phases to form a bioink and innovatively applying fluorescent carbon quantum dots for long-term tracking of *** GelMA(10%,mass fraction)and PEO(1.6%,mass fraction)hydrogel with 3:1 volume ratio offered distinct pore-forming characteristics,satisfactorymechanical properties,and biocompatibility for the creation of the 3DP-7721 *** analysis and quantitative real-time fluorescence polymerase chain reaction(PCR)were used to evaluate the biological properties of the *** with the two-dimensional culture cell model(2D-7721)and the 3D mixed culture cell model(3DM-7721),3DP-7721 significantly improved the proliferation of cells and expression of tumor-related proteins and ***,we evaluated the differences between the three culture models and the effectiveness of antitumor drugs in the three models and discovered that the efficacy of antitumor drugs varied because of significant differences in resistance proteins and genes between the three *** addition,the comparison of tumor formation in the three models found that the cells cultured by the 3DP-7721 model had strong tumorigenicity in nude *** evaluation of the levels of biochemical indicators related to the formation of solid tumors showed that the 3DP-7721 model group exhibited pathological characteristics of malignant tumors,the generated solid tumors were similar to actual tumors,and the deterioration was *** research therefore acts as a foundation for the application of 3DP-7721 models in drug devel

关键词： 3D bioprinting Hepatoma tumor models Drug screening Antitumor drug development

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