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β-1，3-glucans-rich Euglena gracilis supplementation alleviates high-fat-high-fructose diet-induced cognitive impairment in middle-aged mice via the gut-brain axis

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Food science and Human Wellness 2024年

作者： Haoxie Xu Yachao Wang Xiangzhu Li Xuli Wu Louise Weiwei Lu Jiayi He Mingfu Wang Bin Liu Hui Xu Jiehua Chen Kawing Cheng Shenzhen Key Laboratory of Marine Microbiome Engineering， Institute for Advanced Study， Shenzhen University Department of Food Science and Engineering， College of Chemistry and Environmental Engineering， Shenzhen University Institute for Innovative Development of Food Industry， Shenzhen University Department of Neurosurgery， The Institute Translational Medicine， The First Affiliated Hospital of Shenzhen University， Shenzhen Second People's Hospital Shenzhen Traditional Chinese Medicine Hospital School of Public Health， Shenzhen University School of Biological Sciences， Faculty of Science， the University of Auckland

The growing aging population along with the shifting dietary paradigm to Western-type diet worldwide has been implicated in the increasing prevalence of cognitive impairment. Emerging evidence suggests that a high-fiber diet may help improve cognitive function through the gut-brain axis. Euglena gracilis， a unicellular microalga rich in β-1，3-glucans， has gained attention due to its modulatory effect on gut dysbiosis and inflammatory response. This study aimed to explore the efficacy and mechanism of β-1，3-glucans-rich Euglena gracilis powder (EG) against high-fat-high-fructose (HFHF) diet-induced cognitive disorders in mice. A middle-aged (52-week-old C57BL/6J) mouse model with the following groups was adopted: HFHF， HFHF+EG， and control. At the end of the dietary intervention (8 weeks)， cognitive behaviors， metabolic parameters， endotoxin levels， gut microbiota composition， and colon and brain pathology were examined. The results showed that EG supplementation attenuated HFHF-induced cognitive impairment， promoted synaptogenesis in the hippocampus， and improved synaptic ultrastructure. These beneficial effects were partly mediated through the upregulation of PTP1B-IRS-pAKT-pGSK3β-pTau signaling. Furthermore， it prevented gut dysbiosis as evidenced by an increase in β-diversity and enrichment of Akkermansia relative to control. EG supplementation was also able to partly reverse the HFHF-induced disruption of intestinal barrier， which was accompanied by reduced systemic and neuronal inflammation， normalized short-chain fatty acid production， and decreased serum lipopolysaccharide concentration. The findings from the present study support that β-1，3-glucans-rich EG is a promising natural agent for the prevention of HFHF diet-induced deterioration in cognitive function that merits further investigation.

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Origin of Interstitial Doping Induced Coercive Field Reduction in Ferroelectric Hafnia

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Physical Review Letters 2025年第5期134卷 056802-056802页

作者： Tianyuan Zhu Liyang Ma Xu Duan Shiqing Deng Shi Liu Department of Physics School of Science Westlake University Hangzhou Zhejiang 310030 China Institute of Natural Sciences Westlake Institute for Advanced Study Hangzhou Zhejiang 310024 China School of Science Zhejiang University of Science and Technology Hangzhou Zhejiang 310023 China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Beijing 100083 China

Hafnia-based ferroelectrics hold promise for nonvolatile ferroelectric memory devices. However, the high coercive field required for polarization switching remains a prime obstacle to their practical applications. A notable reduction in coercive field has been achieved in ferroelectric Hf(Zr)1+xO2 films with interstitial Hf(Zr) dopants [science 381, 558 (2023)], suggesting a less-explored strategy for coercive field optimization. Supported by density functional theory calculations, we demonstrate the Pca21 phase, with a moderate concentration of interstitial Hf dopants, serves as a minimal model to explain the experimental observations, rather than the originally assumed rhombohedral phase. Large-scale deep potential molecular dynamics simulations suggest that interstitial defects promote the polarization reversal by facilitating Pbcn-like mobile 180° domain walls. A simple prepoling treatment could reduce the switching field to less than 1 MV/cm and enable switching on a subnanosecond timescale. High-throughput calculations reveal a negative correlation between the switching barrier and dopant size and identify a few promising interstitial dopants for coercive field reduction.

关键词： Polarization

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Ordered mesoporous materials for water pollution treatment:Adsorption and catalysis

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Green Energy & Environment 2024年第8期9卷 1239-1256页

作者： Peng Zhang Mingming He Wei Teng Fukuan Li Xinyuan Qiu Kexun Li Hao Wang College of Environmental Science and Engineering MOE Key Laboratory of Pollution Processes and Environmental CriteriaTianjin Key Laboratory of Environmental Remediation and Pollution TreatmentTianjin Key Laboratory of Environmental Technology for Complex Trans-Media PollutionNankai UniversityTianjin300350China Department of Chemistry and State Key Laboratory Marine Pollution Hong Kong Institute for Advanced Study City University of Hong KongHong Kong999077China State Key Laboratory for Pollution Treatment College of Environmental Science and EngineeringShanghai Institute of Pollution Treatment and Ecological SecurityTongji UniversityShanghai200092China State Key Laboratory of Simulation and Regulation of Water Cycles in River Basins China Institute of Water Resources and Hydropower ResearchBeijing100038China

To meet the growing emission of water contaminants,the development of new materials that enhance the efficiency of the water treatment system is *** mesoporous materials provide opportunities in environmental processing applications due to their exceptionally high surface areas,large pore sizes,and enough pore *** properties might enhance the performance of materials concerning adsorption/catalysis capability,durability,and *** this review,we enumerate the ordered mesoporous materials as adsorbents/catalysts and their modifications in water pollution treatment from the past decade,including heavy metals(Hg^(2+),Pb^(2+),Cd^(2+),Cr^(6+),etc.),toxic anions(nitrate,phosphate,fluoride,etc.),and organic contaminants(organic dyes,antibiotics,etc.).These contributions demonstrate a deep understanding of the synergistic effect between the incorporated framework and homogeneous active ***,the challenges and perspectives of the future developments of ordered mesoporous materials in wastewater treatment are *** work provides a theoretical basis and complete summary for the application of ordered mesoporous materials in the removal of contaminants from aqueous solutions.

关键词： Water pollution treatment Ordered mesoporous materials Toxic contaminants Adsorption Catalysis

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Quantum Criticality with Emergent Symmetry in the Extended Shastry-Sutherland Model

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Physical Review Letters 2024年第2期133卷 026502-026502页

作者： Wen-Yuan Liu Xiao-Tian Zhang Zhe Wang Shou-Shu Gong Wei-Qiang Chen Zheng-Cheng Gu Division of Chemistry and Chemical Engineering School of Physics Department of Physics School of Physical Sciences Great Bay University Dongguan 523000 China and Great Bay Institute for Advanced Study Dongguan 523000 China Institute for Quantum Science and Engineering and Department of Physics Shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices

Motivated by the novel phenomena observed in the layered material SrCu2(BO3)2, the Shastry-Sutherland model (SSM) has been extensively studied as the minimal model for SrCu2(BO3)2. However, the nature of its quantum phase transition from the plaquette valence-bond solid to antiferromagnetic phase is under fierce debate, posing a challenge to understand the underlying quantum criticality. Via the state-of-the-art tensor network simulations, we study the ground state of the SSM on large-scale size up to 20×20 sites. We identify the continuous transition nature accompanied by an emergent O(4) symmetry between the plaquette valence-bond solid and antiferromagnetic phase, which strongly suggests a deconfined quantum critical point (DQCP). Furthermore, we map out the phase diagram of an extended SSM that can be continuously tuned to the SSM, which demonstrates the same DQCP phenomena along a whole critical line. Our results indicate a compelling scenario for understanding the origin of the proposed proximate DQCP in recent experiments of SrCu2(BO3)2.

关键词： Frustrated magnetism Quantum criticality Strongly correlated systems Tensor network methods

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Smart tailoring of molecular catalysts:Mounting approach to oxygen reduction reaction

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Journal of Materials science & Technology 2024年第1期168卷 169-184页

作者： Anuj Kumar Mohd Ubaidullah Guoxin Zhang Jasvinder Kaur Saira Ajmal Mudassir Hasan Krishna Kumar Yadav Hafiz M.Adeel Sharif Ram K.Gupta Ghulam Yasin Nano-Technology Research Laboratory Department of ChemistryGLA UniversityMathuraUttar Pradesh 281406India Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdaoShandong 266590China Institute for Advanced Study Shenzhen UniversityShenzhenGuangdong 518060China Department of Chemistry Kansas Polymer Research CenterPittsburg State UniversityPittsburgKS 66762United States Faculty of Science and Technology Madhyanchal Professional UniversityRatibadBhopal 462044India Environmental and Atmospheric Sciences Research Group Scientific Research CenterAl-Ayen UniversityThi-QarNasiriyah 64001Iraq Department of Chemical Engineering King Khalid University Saudi Arabia Department of Chemistry School of SciencesIFTM UniversityMoradabadUttar Pradesh 244102India Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan 523808China School of Environment and Civil Engineering Dongguan University of TechnologyDongguanGuangdong 523808China

Efficient electrocatalytic rupture of energy-rich molecules(H_(2)and O_(2))is a green approach for gener-ating clean energy for modern *** this context,porphyry-type molecular electrocatalysts act intelligently toward oxygen reduction reaction(ORR),a fundamental process in fuel cells,due to their redox-rich chemistry,which involves core metal ions and macrocyclic *** concerned scientific community has tried many times to correlate the ORR intermediates with their formation kinetics and simplify the associated multi H+/e-stages during the ORR process,constructing several volcano plots be-tween catalytic Tafel data,turnover frequencies,and overpotentials for many *** the fact that many review articles on molecular electrocatalysts for ORR have been published,understanding the strategic implications and molecular catalyst intelligence towards homogenous ORR has been poorly *** review examined the relationships between volcano plots of current *** parameters and the Sabatier principle in order to explain the intelligence of molecular electrocatalysts and approaches for their creation,as well as the difficulties and potential prospects of molecular *** facts distinguish this review from previously published articles and will pique the scien-tific community’s interest in avoiding trial-and-error procedures for catalyst creation while also allowing for more exact evaluations of the molecular catalyst’s performance.

关键词： Electrocatalysis Molecular catalysts Oxygen reduction reaction Sabatier principle

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Oral Cancer Classification Using a Hybrid Attention-Aided Deep Learning Model 5th

Oral Cancer Classification Using a Hybrid Attention-Aided D...

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5th International Conference on Medical Imaging and Computer Aided Diagnosis, MICAD 2024

作者： Dutta, Srinjan Roy, Jibesh Mandal, Diptarka Kaplun, Dmitrii Shpakovskaya, Irina Sarkar, Ram Department of Computer Science and Engineering Jalpaiguri Government Engineering College Jalpaiguri India School of Computer Engineering and Mathematical Sciences Defence Institute of Advanced Technology Pune India Artificial Intelligence Research Institute China University of Mining and Technology Xuzhou China Department of Automation and Control Process Saint Petersburg Electrotechnical University "LETI" Saint Petersburg Russia Department of Computer Science and Engineering Jadavpur University West Bengal Kolkata India I.P. Pavlov Saint Petersburg First State Medical University St. Petersburg Russia

ISBN: (纸本)9789819638628

Oral cancer remains a critical global health challenge, characterized by high morbidity and mortality due to late-stage diagnosis. This paper addresses the need for improved diagnostic accuracy by introducing a novel hybrid-attention aided deep learning model for oral cancer classification. Our approach integrates the EfficientNetB0 model for feature extraction with a customized hybrid attention module, combining self, spatial, and soft attention mechanisms to emphasize crucial features. The model has been trained and evaluated on both microscopic and macroscopic oral cancer datasets, demonstrating its generalizability. Our proposed model achieves an accuracy of 96.97% on a macroscopic dataset and 92% on a microscopic dataset, with respective F1-scores of 0.97 and 0.89, outperforming baseline models. This hybrid attention-aided deep learning model shows significant potential in improving early detection and treatment planning of oral cancer. Source code and additional results of this work can be found at the GitHub repository. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Contrastive Learning

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Numerical Simulation of Flow Field around NACA 0012 Airfoil at Low Reynold’s Number Assuming Mars Environment using OpenFoam

Numerical Simulation of Flow Field around NACA 0012 Airfoil ...

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AIAA science and Technology Forum and Exposition, AIAA SciTech Forum 2025

作者： Okamoto, Atsushi Yamada, Takafumi Advanced Mechanical and Control System Engineering Course National Institute of Technology Tsuyama College 624-1 Okayama Numa Tsuyama708-8509 Japan Associate Professor Department of Integrated Science and Technology National Institute of Technology Tsuyama College 624-1 Okayama Numa Tsuyama708-8509 Japan

ISBN: (数字)9781624107238

ISBN: (纸本)9781624107238

In this study, incompressible flow fields around a NACA0012 airfoil were numerically simulated at low Reynolds number for a Mars environment. For mesh generation, the standard Open FOAM utilities block Mesh and snappy HexMesh were used. Using those meshes and pisoFoam, which is PISO method-based analysis solver, NASA wind tunnel test conditions were numerically simulated in the Earth environment and obtained a similar lift gradient as in the experiment up to the stall. Then, the flow field of 12,000 Reynolds number, which simulates the Martian environment, was calculated. The variation of lift coefficient with increasing angle of attack was almost consistent with the experimental value in the Earth environment, and the stall angle was 16°. From the results of pressure distribution on the wing surface, it is suggested that compared to the Earth environment, the separation point movesfrom the leading edge to aft of the wing upper surface in the Martian environment. The flow field at the stall angle was similar to that of the Earth environment, and vortices were formed, however, their velocity vectors were very small, and dead water regions were observed near the trailing edge of the wing upper surface. More detailed aerodynamic characteristics should be clarified by evaluating the results using drag and moment coefficients until the SciTech Forum 2025. © 2025, American institute of Aeronautics and Astronautics Inc, AIAA. All rights reserved.

关键词： NASA

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Utilization of Energy Storage and Hydrogen in Power and Energy Systems:Viewpoints from Five Aspects

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CSEE Journal of Power and Energy Systems 2023年第1期9卷 1-7页

作者： Yonghua Song Mohammad Shahidehpour Saifur Rahman Nigel Brandon Kai Strunz Jin Lin Yuxuan Zhao State Key Laboratory of Internet of Things for Smart City University of MacaoTaipaMacao 999078China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China Galvin Center for Electricity Innovation Illinois Institute of TechnologyChicagoIL 60616USA Department of Advanced Research Institute Virginia Polytechnic Institute and State UniversityArlingtonVA 22203USA Department of Earth Science and Engineering Imperial College LondonLondon SW72AZU.K Department of Sustainable Electric Networks and Sources of Energy Technische Universitt Berlin10587 BerlinGermany State Key Laboratory of Control and Simulation of Power Systems and Generation Equipment Department of Electrical EngineeringTsinghua UniversityBeijing 100084China

Decarbonizing power systems is crucial to mitigating climate change impacts and achieving carbon *** renewable energy supply can reduce greenhouse gas emissions and accelerate the decarbonization ***,renewable energy sources(RESs)such as wind and solar power are characterized by intermittency and often non-dispatchability,significantly challenging their high-level integration into power *** storage is acknowledged as a vital indispensable solution for mitigating the intermittency of renewables such as wind and solar power and boosting the penetrations of *** the CSEE JPES Forum,five well-known experts were invited to give keynote speeches,and the participating experts and scholars had comprehensive exchanges and discussions on energy storage ***,the views on the design,control,performance,and applications of new energy storage technologies,such as the fuel cell vehicle,water electrolysis,and flow battery,in the coordination and operation of power and energy systems were *** experts also provided experience that could be used to develop energy storage for constructing and decarbonizing new power systems.

关键词： Electrolysis electric vehicle energy storage flow battery fuel cell electric vehicle hydrogen energy

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Ammonium Sensing Patch with Ultrawide Linear Range and Eliminated Interference for Universal Body Fluids Analysis

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Nano-Micro Letters 2025年第4期17卷 332-346页

作者： Mingli Huang Xiaohao Ma Zongze Wu Jirong Li Yuqing Shi Teng Yang Jiarun Xu Shuhan Wang Kongpeng Lv Yuanjing Lin School of Microelectronics Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Interventional Radiology Shenzhen People’s HospitalShenzhen 518020People’s Republic of China College of Mechanical and Energy Engineering Shaoyang UniversityShaoyang 422000HunanPeople’s Republic of China Shenzhen Hainwise Medical Technology Co. LTDShenzhen 518118People’s Republic of China Shenzhen Institute for Drug Control(Shenzhen Testing Center of Medical Devices) Shenzhen 518000People’s Republic of China Institute of Innovative Materials Guangming Advanced Research InstituteSouthern University of Science and TechnologyShenzhen 518055People’s Republic of China

Ammonium level in body fluids serves as one of the critical biomarkers for healthcare,especially those relative to liver *** continuous and real-time monitoring in both invasive and noninvasive manners is highly desired,while the ammonium concentrations vary largely in different body ***,the sensing reliability based on ion-selective biosensors can be significantly interfered by potassium *** tackle these challenges,a flexible and biocompatible sensing patch for wireless ammonium level sensing was reported with an ultrawide linear range for universal body fluids including blood,tears,saliva,sweat and *** as-prepared biocompatible sensors deliver a reliable sensitivity of 58.7 mV decade-1 in the range of 1-100 mM and a desirable selectivity coefficient of 0.11 in the interference of potassium ions,attributed to the cross-calibration within the sensors *** sensor’s biocompatibility was validated by the cell growth on the sensor surface(>80%),hemolysis rates(<5%),negligible cellular inflammatory responses and weight changes of the mice with implanted *** biocompatible sensors with ultrawide linear range and desirable selectivity open up new possibility of highly compatible biomarker analysis via different body fluids in versatile approaches.

关键词： Biocompatible sensors Implantable bioelectronics Ammonium sensing Cross-calibration Ultrawide linear range

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A pseudovirus-based method to dynamically mimic SARS-CoV-2-associated cell-to-cell fusion and transmission

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生物化学与生物物理学报（英文版） 2023年第11期55卷 1840-1843页

作者： Xiangpeng Sheng Yi Yang Fang Zhu Fan Yang Honghua Wang Ronggui Hu Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Animal Disease Control Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China Department of Thoracic Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China School of Medicine Guizhou UniversityGuiyang 550025China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),responsible for the COVID-19 pandemic,has caused tremendous global loss and continues to evolve to generate *** of SARS-CoV-2 into target host cells is primarily mediated by spike(S),which binds to the host receptor hACE2 and initiates virus-cell membrane fusion[1].

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