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International Conference on Computation in Science and Engineering, ICCSE 2017

作者： Sundari, C.D.D. Setiadji, S. Nuryadin, B.W. Syafia, R. Huda, A.F. Ivansyah, A.L. Department of Chemistry Education UIN Sunan Gunung Djati Bandung Jl. A.H. Nasution No.105 Bandung West Java40614 Indonesia Department of Chemistry Faculty of Science and Technology UIN Sunan Gunung Djati Bandung Jl. A.H. Nasution No.105 Bandung West Java40614 Indonesia Department of Physics Faculty of Science and Technology UIN Sunan Gunung Djati Bandung Jl. A.H. Nasution No.105 Bandung West Java40614 Indonesia Department of Mathematics Faculty of Science and Technology UIN Sunan Gunung Djati Bandung Jl. A.H. Nasution No.105 Bandung West Java40614 Indonesia Master Program in Computational Science Faculty of Mathematics and Natural Science Institut Teknologi Bandung Jl. Ganesha No. 10 West-Java Bandung40132 Indonesia

Imidazole and some of its derivatives have been known as a good candidate for corrosion inhibition application. In this study, ab initio calculation was carried out for several imidazole derivatives i.e. 2-phenylimidazole[1,2-α]pyridine, 6-methyl-2-phenylimidazole[1,2-α]pyridine, 6-methyl-2-(4-metoxyplenylimidazole)[1,2-α]pyridine, and 6-methyl-2-(4-chlorophenylimidazole)[1,2α]pyridine, in order to investigate their electronic properties as well as its correlation with their corrosion inhibition properties. Calculations were performed using Firefly software package with RHF method and 6-31G(d,p) basis set. Based on calculation results and analysis, it was found that 6-methyl-2-(4-metoxyphenylimidazole) [1,2α]pyridine compound has better potential as corrosion inhibitor than the rest of the compounds due to its small HOMO-LUMO energy gap, low ionization potential, low electron affinity, low electronegativity, and low global hardness i.e. 10.184 eV, 7.199 eV, -2.985 eV, 2.107 eV and 5.092 eV respectively. This compound also has the highest global softness (0.098 eV), while the greatest value of the dipole moment was owned by 6-methyl-2-(4-chlorophenylimidazole)[1,2α]pyridine with value of 6.125 Debye due to the existence of Cl atom that has larger polarity than the other substituents. © Published under licence by IOP Publishing Ltd.

关键词： Pyridine

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Systematic study of flow vector fluctuations in sNN=5.02 TeV Pb-Pb collisions

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Physical Review C 2024年第6期109卷 065202-065202页

作者： S. Acharya D. Adamová A. Agarwal G. Aglieri Rinella L. Aglietta M. Agnello N. Agrawal Z. Ahammed S. Ahmad S. U. Ahn I. Ahuja A. Akindinov V. Akishina M. Al-Turany D. Aleksandrov B. Alessandro H. M. Alfanda R. Alfaro Molina B. Ali A. Alici N. Alizadehvandchali A. Alkin J. Alme G. Alocco T. Alt A. R. Altamura I. Altsybeev J. R. Alvarado M. N. Anaam C. Andrei N. Andreou A. Andronic E. Andronov V. Anguelov F. Antinori P. Antonioli N. Apadula L. Aphecetche H. Appelshäuser C. Arata S. Arcelli M. Aresti R. Arnaldi J. G. M. C. A. Arneiro I. C. Arsene M. Arslandok A. Augustinus R. Averbeck M. D. Azmi H. Baba A. Badalà J. Bae Y. W. Baek X. Bai R. Bailhache Y. Bailung R. Bala A. Balbino A. Baldisseri B. Balis D. Banerjee Z. Banoo V. Barbasova F. Barile L. Barioglio M. Barlou B. Barman G. G. Barnaföldi L. S. Barnby E. Barreau V. Barret L. Barreto C. Bartels K. Barth E. Bartsch N. Bastid S. Basu G. Batigne D. Battistini B. Batyunya D. Bauri J. L. Bazo Alba I. G. Bearden C. Beattie P. Becht D. Behera I. Belikov A. D. C. Bell Hechavarria F. Bellini R. Bellwied S. Belokurova L. G. E. Beltran Y. A. V. Beltran G. Bencedi A. Bensaoula S. Beole Y. Berdnikov A. Berdnikova L. Bergmann M. G. Besoiu L. Betev P. P. Bhaduri A. Bhasin M. A. Bhat B. Bhattacharjee L. Bianchi N. Bianchi J. Bielčík J. Bielčíková A. P. Bigot A. Bilandzic G. Biro S. Biswas N. Bize J. T. Blair D. Blau M. B. Blidaru N. Bluhme C. Blume G. Boca F. Bock T. Bodova J. Bok L. Boldizsár M. Bombara P. M. Bond G. Bonomi H. Borel A. Borissov A. G. Borquez Carcamo H. Bossi E. Botta Y. E. M. Bouziani L. Bratrud P. Braun-Munzinger M. Bregant M. Broz G. E. Bruno M. D. Buckland D. Budnikov H. Buesching S. Bufalino P. Buhler N. Burmasov Z. Buthelezi A. Bylinkin S. A. Bysiak J. C. Cabanillas Noris M. F. T. Cabrera M. Cai H. Caines A. Caliva E. Calvo Villar J. M. M. Camacho P. Camerini F. D. M. Canedo S. L. Cantway M. Carabas A. A. Carballo F. Carnesecchi R. Caron L. A. D. Carvalho J. Castillo Castellanos M. Castoldi F. Catalano S. Cattaruzzi C. Ceballos Sanchez R. Cerri I. Chakabe CNRS/IN2P3 LPC Clermont-Ferrand France Nuclear Physics Institute of the Czech Academy of Sciences Husinec-Řež Czech Republic Homi Bhabha National Institute Kolkata India Geneva Switzerland and Sezione INFN Turin Italy and Sezione INFN Bologna Italy Department of Physics Daejeon Republic of Korea Faculty of Science Affiliated with an institute covered by a cooperation agreement with CERN Frankfurt Institute for Advanced Studies Research Division and ExtreMe Matter Institute EMMI Turin Italy Wuhan China Instituto de Física Houston Texas USA Sungkyunkwan University Suwon City Republic of Korea Department of Physics and Technology Cagliari Italy Institut für Kernphysik Bari Italy Physik Department Technische Universität München Munich Germany High Energy Physics Group Bucharest Romania University of Derby Derby United Kingdom Institut für Kernphysik Münster Germany Physikalisches Institut Padova Italy Bologna Italy Berkeley California USA SUBATECH Université Grenoble-Alpes CNRS-IN2P3 Grenoble France and Sezione INFN Cagliari Italy São Paulo Brazil New Haven Connecticut USA Tokyo Japan Catania Italy Gangneung Republic of Korea Hefei China Indore India Physics Department Université Paris-Saclay Centre d'Etudes de Saclay (CEA) IRFU Départment de Physique Nucléaire (DPhN) Saclay France Cracow Poland Department of Physics and Centre for Astroparticle Physics and Space Science (CAPSS) Kolkata India and Sezione INFN Bari Italy School of Science Department of Physics Athens Greece Department of Physics Guwahati India Budapest Hungary Liverpool United Kingdom Department of Physics Division of Particle Physics Lund Sweden Affiliated with an international laboratory covered by a cooperation agreement with CERN Mumbai India Sección Física Departamento de Ciencias Niels Bohr Institute CNRS IPHC UMR 7178 F-67000 Strasbourg France Strasbourg France Universidad Autónoma de Sinaloa Culiacá

Measurements of the pT-dependent flow vector fluctuations in Pb–Pb collisions at sNN=5.02TeV using azimuthal correlations with the ALICE experiment at the Large Hadron Collider are presented. A four-particle correlation approach [ALICE Collaboration, Phys. Rev. C 107, L051901 (2023)] is used to quantify the effects of flow angle and magnitude fluctuations separately. This paper extends previous studies to additional centrality intervals and provides measurements of the pT-dependent flow vector fluctuations at sNN=5.02TeV with two-particle correlations. Significant pT-dependent fluctuations of the V⃗2 flow vector in Pb–Pb collisions are found across different centrality ranges, with the largest fluctuations of up to ∼15% being present in the 5% most central collisions. In parallel, no evidence of significant pT-dependent fluctuations of V⃗3 or V⃗4 is found. Additionally, evidence of flow angle and magnitude fluctuations is observed with more than 5σ significance in central collisions. These observations in Pb–Pb collisions indicate where the classical picture of hydrodynamic modeling with a common symmetry plane breaks down. This has implications for hard probes at high pT, which might be biased by pT-dependent flow angle fluctuations of at least 23% in central collisions. Given the presented results, existing theoretical models should be reexamined to improve our understanding of initial conditions, quark–gluon plasma properties, and the dynamic evolution of the created system.

关键词： Particle correlations & fluctuations Quark-gluon plasma Relativistic heavy-ion collisions

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Gauges, loops, and polynomials for partition functions of graphical models

arXiv

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arXiv 2018年

作者： Chertkov, Michael Chernyak, Vladimir Maximov, Yury Program in Applied Mathematics University of Arizona TucsonAZ United States CNLS and T-Division LANL Los AlamosNM United States Skolkovo Institute of Technology Moscow Russia Department of Chemistry Wayne State University MI United States

Graphical models (GM) represent multivariate and generally not normalized probability distributions. Computing the normalization factor, called the partition function (PF), is the main inference challenge relevant to multiple statistical and optimization applications. The problem is #P-hard that is of an exponential complexity with respect to the number of variables. In this manuscript, aimed at approximating the PF, we consider Multi-Graph Models (MGMs) where binary variables and multivariable factors are associated with edges and nodes, respectively, of an undirected multigraph. We suggest a new methodology for analysis and computations that combines the Gauge Function (GF) technique from [21, 22] with the technique developed in [34] and [5, 67] based on the recent progress in the field of real stable polynomials. We show that the GF, representing a single-out term in a finite sum expression for the PF which achieves extremum at the so-called Belief-Propagation (BP) gauge, has a natural polynomial representation in terms of gauges/variables associated with edges of the multi-graph. Moreover, GF can be used to recover the PF through a sequence of transformations allowing appealing algebraic and graphical interpretations. Algebraically, one step in the sequence consists in the application of a differential operator over gauges associated with an edge. Graphically, the sequence is interpreted as a repetitive elimination/contraction of edges resulting in MGMs on decreasing in size (number of edges) graphs with the same PF as in the original MGM. Even though the complexity of computing factors in the sequence of derived MGMs and respective GFs grow exponentially with the number of eliminated edges, polynomials associated with the new factors remain bi-stable if the original factors have this property. Moreover, we show that BP estimations in the sequence do not decrease, each low-bounding the PF. Copyright © 2018, The Authors. All rights reserved.

关键词： Graphic methods

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Relationship between high-density lipoprotein cholesterol (HDL-C) concentration and ventilator-associated pneumonia in ICU COVID-19 patients

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Anaesthesia, critical care & pain medicine 2025年第4期44卷 101535页

作者： Stefan Andrei Meilhac Olivier Christian De Tymowski Aurélie Snauwaert Jules Stern Tiphaine Robert Brice Lortat-Jacob Enora Atchade Elie Kantor Floran Begue Philippe Montravers Sébastien Tanaka Assistance Publique - Hôpitaux de Paris (AP-HP) Department of Anesthesiology and Critical Care Medicine Bichat-Claude Bernard Hospital Paris France Group of Applied Mathematics and Computational biology CNRS UMR 8542 IBENS École Normale Supérieure Paris France. Université de La Réunion INSERM UMR 1188 Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI) Saint-Pierre de La Réunion France Centre hospitalier universitaire de La Réunion Saint-Pierre France. French Institute of Health and Medical Research (INSERM) U1149 Center for Research on Inflammation Paris France. Assistance Publique - Hôpitaux de Paris (AP-HP) Department of Anesthesiology and Critical Care Medicine Bichat-Claude Bernard Hospital Paris France. Assistance Publique - Hôpitaux de Paris (AP-HP) Biochemistry Department Bichat-Claude Bernard Hospital Paris France. Université de La Réunion INSERM UMR 1188 Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI) Saint-Pierre de La Réunion France. Université Paris Cité Paris France PHERE Physiopathology and Epidemiology of Respiratory Diseases French Institute of Health and Medical Research (INSERM) U1152 Paris France. Université de La Réunion INSERM UMR 1188 Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI) Saint-Pierre de La Réunion France. Electronic address: sebastien.tanaka@aphp.fr.

BACKGROUND:Ventilator-associated pneumonia (VAP) is frequent during severe COVID-19 infection, but diagnosis remains difficult. During bacterial sepsis and COVID-19, high-density lipoprotein cholesterol (HDL-C) concentration is decreased. Furthermore, HDL particles exerting in normal conditions endothelial-protective effects are dysfunctional in bacterial sepsis. The lipidic profile in COVID-19 with associated bacterial infections is unexplored. The aim of the present study was to determine the relationship between HDL-C concentration on admission to the intensive care unit (ICU) for COVID-19 and the occurrence of VAP. METHODS:French prospective study (LIPICOR study) recording HDL-C concentration during severe COVID-19 in ICU. VAP episodes were reported prospectively. RESULTS:122 patients were consecutively included in the analysis between October 2020 and May 2021. A total of 32 patients (26%) developed at least one VAP episode during the ICU stay. The median delay of VAP occurrence was 7 [3,10] days. Upon ICU admission, the median HDL-C concentration was 0.80 [0.65, 1.03] mmol/L. HDL-C was significantly higher in patients who secondarily developed VAP (HDL-C: 0.93 mmol/L [0.79, 1.12] vs. 0.77 mmol/L [0.63, 0.99], p = 0.003). Surprisingly, multivariable analyses with VAP showed that HDL-C at admission is associated with the occurrence of VAP (HR = 3.91 (1.45-10.5), p = 0.007). VAP occurrence in patients with HDL-C levels above 0.8 mmol/L at admission was higher (log-rank test, p = 0.003). CONCLUSION:Increased HDL-C concentration on admission is strongly associated with the occurrence of VAP during severe COVID-19 infection. REGISTRATION:*** Identifier: NCT05113836.

关键词： COVID-19 High-density lipoprotein (HDL) High-density lipoprotein cholesterol (HDL-C) Outcome Sepsis Ventilator-associated pneumonia

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computational Study of Inclusion Complexes between Omeprazole Enantiomer with Hydroxypropyl-β-Cyclodextrin

Computational Study of Inclusion Complexes between Omeprazol...

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International Conference on Computation in Science and Engineering, ICCSE 2017

作者： Setiadji, S. Sundari, C.D.D. Nuryadin, B.W. Zayyinunnisya, H. Cahyandari, R. Ivansyah, A.L. Department of Chemistry Faculty of Science and Technology UIN Sunan Gunung Djati Bandung Jl. A.H. Nasution No.105 Bandung West Java40614 Indonesia Department of Chemistry Education UIN Sunan Gunung Djati Bandung Jl. A.H. Nasution No.105 Bandung West Java40614 Indonesia Department of Physics Faculty of Science and Technology UIN Sunan Gunung Djati Bandung Jl. A.H. Nasution No.105 Bandung West Java40614 Indonesia Department of Mathematics Faculty of Science and Technology UIN Sunan Gunung Djati Bandung Jl. A.H. Nasution No.105 Bandung West Java40614 Indonesia Master Program in Computational Science Faculty of Mathematics and Natural Science Institut Teknologi Bandung Jl. Ganesha No. 10 West Java Bandung40132 Indonesia

computational study of inclusion complexes between R/S-omeprazole as Proton Pump Inhibitor (PPI) compound with hydroxypropyl-β-cyclodextrin in three of its dimeric structure configurations (head to head, head to tail and tail to tail) has been carried out. All calculations were performed using PM3 quantum semiempirical method. computational results showed that total binding energy (BE) of R-omeprazole complex is more exothermic than total binding energy of S-omeprazole complex. The calculated binding energy of R-omeprazole complex was -74.65 kcal/mol, while for S-omeprazole complex was -64.09 kcal/mol. This results indicate that R-omeprazole inclusion complex has higher stability compared to S-omeprazole inclusion complex. The value of ΔH, ΔS, and ΔG for R-omeprazole inclusion complex formation were -77.02 kcal/mol, -0.24 cal/mol.K and -2.62 kcal/mol respectively, while the value of ΔH, ΔS, and ΔG for S-omeprazole inclusion complex formation were -66.47 kcal/mol, -0.29 cal/mol.K and 19.29 kcal/mol respectively. These values indicate that the formation of inclusion complexes between R/S-omeprazole with hydroxypropyl-β-cyclodextrin is enthalpy driven process. © Published under licence by IOP Publishing Ltd.

关键词： Binding energy

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Signatures of many-body localization in steady states of open quantum systems

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Physical Review B 2018年第2期98卷 020202(R)-020202(R)页

作者： I. Vakulchyk I. Yusipov M. Ivanchenko S. Flach S. Denisov Center for Theoretical Physics of Complex Systems IBS Daejeon 34051 Republic of Korea Basic Science Program Korea University of Science and Technology (UST) Daejeon 34113 Republic of Korea Department of Applied Mathematics Lobachevsky University Nizhny Novgorod 603950 Russia Institute of Physics University of Augsburg Universitätsstraße 1 86159 Augsburg Germany

Many-body localization (MBL) is a result of the balance between interference-based Anderson localization and many-body interactions in a high-dimensional Fock space. It is expected that dissipation is blurring interference and destroying that balance so that the asymptotic state of a system with an MBL Hamiltonian does not bear localization signatures. This is evidently true in the case of local dephasing which drives any system into an infinite-temperature state. We demonstrate, by using a set of dissipative operators, where each one is acting nontrivially on a pair of neighboring sites (or spins), that an MBL system can be brought into a Hamiltonian-specific steady state. The difference between ergodic and MBL Hamiltonians can be seen in statistics of imbalance, entanglement entropy, and level spacing of the steady-state density operator. By introducing pairwise dissipative operators into an MBL system already exposed to dephasing, these localization signatures can be restored.

关键词： Many-body localization Open quantum systems

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Measurements of jet quenching using semi-inclusive hadron+jet distributions in pp and central Pb-Pb collisions at sNN=5.02 TeV

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Physical Review C 2024年第1期110卷 014906-014906页

作者： S. Acharya D. Adamová G. Aglieri Rinella M. Agnello N. Agrawal Z. Ahammed S. Ahmad S. U. Ahn I. Ahuja A. Akindinov M. Al-Turany D. Aleksandrov B. Alessandro H. M. Alfanda R. Alfaro Molina B. Ali A. Alici N. Alizadehvandchali A. Alkin J. Alme G. Alocco T. Alt A. R. Altamura I. Altsybeev J. R. Alvarado M. N. Anaam C. Andrei N. Andreou A. Andronic V. Anguelov F. Antinori P. Antonioli N. Apadula L. Aphecetche H. Appelshäuser C. Arata S. Arcelli M. Aresti R. Arnaldi J. G. M. C. A. Arneiro I. C. Arsene M. Arslandok A. Augustinus R. Averbeck M. D. Azmi H. Baba A. Badalà J. Bae Y. W. Baek X. Bai R. Bailhache Y. Bailung A. Balbino A. Baldisseri B. Balis D. Banerjee Z. Banoo R. Barbera F. Barile L. Barioglio M. Barlou B. Barman G. G. Barnaföldi L. S. Barnby V. Barret L. Barreto C. Bartels K. Barth E. Bartsch N. Bastid S. Basu G. Batigne D. Battistini B. Batyunya D. Bauri J. L. Bazo Alba I. G. Bearden C. Beattie P. Becht D. Behera I. Belikov A. D. C. Bell Hechavarria F. Bellini R. Bellwied S. Belokurova Y. A. V. Beltran G. Bencedi S. Beole Y. Berdnikov A. Berdnikova L. Bergmann M. G. Besoiu L. Betev P. P. Bhaduri A. Bhasin M. A. Bhat B. Bhattacharjee L. Bianchi N. Bianchi J. Bielčík J. Bielčíková J. Biernat A. P. Bigot A. Bilandzic G. Biro S. Biswas N. Bize J. T. Blair D. Blau M. B. Blidaru N. Bluhme C. Blume G. Boca F. Bock T. Bodova A. Bogdanov S. Boi J. Bok L. Boldizsár M. Bombara P. M. Bond G. Bonomi H. Borel A. Borissov A. G. Borquez Carcamo H. Bossi E. Botta Y. E. M. Bouziani L. Bratrud P. Braun-Munzinger M. Bregant M. Broz G. E. Bruno M. D. Buckland D. Budnikov H. Buesching S. Bufalino P. Buhler N. Burmasov Z. Buthelezi A. Bylinkin S. A. Bysiak M. Cai H. Caines A. Caliva E. Calvo Villar J. M. M. Camacho P. Camerini F. D. M. Canedo S. L. Cantway M. Carabas A. A. Carballo F. Carnesecchi R. Caron L. A. D. Carvalho J. Castillo Castellanos F. Catalano C. Ceballos Sanchez I. Chakaberia P. Chakraborty S. Chandra S. Chapeland M. Chartier S. Chattopadhyay T. Cheng C. Cheshkov B. Cheynis V. Chibante Barroso D. D. Chinellato E. CNRS/IN2P3 LPC Clermont-Ferrand France Nuclear Physics Institute of the Czech Academy of Sciences Husinec-Řež Czech Republic Geneva Switzerland Turin Italy Bologna Italy Homi Bhabha National Institute Kolkata India Department of Physics Daejeon Republic of Korea Faculty of Science Affiliated with an institute covered by a cooperation agreement with CERN Research Division and ExtreMe Matter Institute EMMI Wuhan China Instituto de Física and Sezione INFN Bologna Italy Houston Texas USA Department of Physics and Technology Cagliari Italy Institut für Kernphysik Bari Italy Physik Department Technische Universität München Munich Germany High Energy Physics Group Bucharest Romania University of Derby Derby United Kingdom Institut für Kernphysik Münster Germany Physikalisches Institut Padova Italy Berkeley California USA SUBATECH IMT Atlantique Université Grenoble-Alpes CNRS-IN2P3 Grenoble France and Sezione INFN Cagliari Italy São Paulo Brazil New Haven Connecticut USA Tokyo Japan Catania Italy Sungkyunkwan University Suwon City Republic of Korea Gangneung Republic of Korea Hefei China Indore India Université Paris-Saclay Centre d'Etudes de Saclay (CEA) IRFU Départment de Physique Nucléaire (DPhN) Saclay France Cracow Poland Department of Physics and Centre for Astroparticle Physics and Space Science (CAPSS) Kolkata India Physics Department and Sezione INFN Catania Italy and Sezione INFN Bari Italy School of Science Department of Physics Athens Greece Department of Physics Guwahati India Budapest Hungary Nuclear Physics Group STFC Liverpool United Kingdom Department of Physics Division of Particle Physics Lund Sweden Affiliated with an international laboratory covered by a cooperation agreement with CERN Mumbai India Sección Física Departamento de Ciencias Niels Bohr Institute CNRS IPHC UMR 7178 F-67000 Strasbourg France Strasbourg France and Sezione INFN Turin Italy INFN

The ALICE Collaboration reports measurements of the semi-inclusive distribution of charged-particle jets recoiling from a high transverse momentum (high pT) charged hadron, in pp and central Pb-Pb collisions at center-of-mass energy per nucleon–nucleon collision sNN=5.02 TeV. The large uncorrelated background in central Pb-Pb collisions is corrected using a data-driven statistical approach which enables precise measurement of recoil jet distributions over a broad range in pT,chjet and jet resolution parameter R. Recoil jet yields are reported for R=0.2, 0.4, and 0.5 in the range 7

关键词： Jet quenching Quark & gluon jets Quark-gluon plasma Relativistic heavy-ion collisions Strong interaction

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Phase space homogenization of noisy hamil-tonian systems

arXiv

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arXiv 2017年

作者： Birrell, Jeremiah Wehr, Jan Department of Mathematics University of Arizona TucsonAZ85721 United States Department of Mathematics and Program in Applied Mathematics University of Arizona TucsonAZ85721 United States

We study the dynamics of an inertial particle coupled to forcing, dissipation, and noise in the small mass limit. We derive an expression for the limiting (homogenized) joint distribution of the position and (scaled) velocity degrees of freedom. In particular, weak convergence of the joint distributions is established, along with a bound on the convergence rate for a wide class of expected *** Codes 60H10, 82C31 Copyright © 2017, The Authors. All rights reserved.

关键词： Differential equations

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The Event Horizon Telescope Image of the Quasar NRAO 530

arXiv

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arXiv 2023年

作者： Jorstad, Svetlana Wielgus, Maciek Lico, Rocco Issaoun, Sara Broderick, Avery E. Pesce, Dominic W. Liu, Jun Zhao, Guang-Yao Krichbaum, Thomas P. Blackburn, Lindy Chan, Chi-Kwan Janssen, Michael Ramakrishnan, Venkatessh Akiyama, Kazunori Alberdi, Antxon Algaba, Juan Carlos Bouman, Katherine L. Cho, Ilje Fuentes, Antonio Gómez, José L. Gurwell, Mark Johnson, Michael D. Kim, Jae-Young Lu, Ru-Sen Martí-Vidal, Iván Moscibrodzka, Monika Pötzl, Felix M. Traianou, Efthalia van Bemmel, Ilse Alef, Walter Anantua, Richard Asada, Keiichi Azulay, Rebecca Bach, Uwe Baczko, Anne-Kathrin Ball, David Baloković, Mislav Barrett, John Bauböck, Michi Benson, Bradford A. Bintley, Dan Blundell, Raymond Bower, Geoffrey C. Boyce, Hope Bremer, Michael Brinkerink, Christiaan D. Brissenden, Roger Britzen, Silke Broguiere, Dominique Bronzwaer, Thomas Bustamante, Sandra Byun, Do-Young Carlstrom, John E. Ceccobello, Chiara Chael, Andrew Chatterjee, Koushik Chatterjee, Shami Chen, Ming-Tang Chen, Yongjun Cheng, Xiaopeng Christian, Pierre Conroy, Nicholas S. Conway, John E. Cordes, James M. Crawford, Thomas M. Crew, Geoffrey B. Cruz-Osorio, Alejandro Cui, Yuzhu Davelaar, Jordy De Laurentis, Mariafelicia Deane, Roger Dempsey, Jessica Desvignes, Gregory Dexter, Jason Dhruv, Vedant Doeleman, Sheperd S. Dougal, Sean Dzib, Sergio A. Eatough, Ralph P. Emami, Razieh Falcke, Heino Farah, Joseph Fish, Vincent L. Fomalont, Ed Ford, H. Alyson Fraga-Encinas, Raquel Freeman, William T. Friberg, Per Fromm, Christian M. Galison, Peter Gammie, Charles F. García, Roberto Gentaz, Olivier Georgiev, Boris Goddi, Ciriaco Gold, Roman Gómez-Ruiz, Arturo I. Gu, Minfeng Hada, Kazuhiro Haggard, Daryl Haworth, Kari Hecht, Michael H. Hesper, Ronald Heumann, Dirk Ho, Luis C. Ho, Paul Honma, Mareki Huang, Chih-Wei L. Huang, Lei Hughes, David H. Ikeda, Shiro Impellizzeri, C.M. Violette Inoue, Makoto James, David J. Jannuzi, Buell T. Jeter, Britton Jiang, Wu Jiménez-Rosales, Alejandra Joshi, Abhishek V. Jung, Taehyun Karami, Mansour Karuppusamy, Ramesh Kawashima, Tomohisa Keati Institute for Astrophysical Research Boston University 725 Commonwealth Ave. BostonMA02215 United States Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 BonnD-53121 Germany Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n GranadaE-18008 Spain INAF-Istituto di Radioastronomia Via P. Gobetti 101 BolognaI-40129 Italy Center for Astrophysics Harvard & Smithsonian 60 Garden Street CambridgeMA02138 United States NASA Hubble Fellowship Program Einstein Fellow United States Perimeter Institute for Theoretical Physics 31 Caroline Street North WaterlooONN2L 2Y5 Canada Department of Physics and Astronomy University of Waterloo 200 University Avenue West WaterlooONN2L 3G1 Canada Waterloo Centre for Astrophysics University of Waterloo WaterlooONN2L 3G1 Canada Black Hole Harvard University 20 Garden Street CambridgeMA02138 United States Steward Observatory Department of Astronomy University of Arizona 933 N. Cherry Ave. TucsonAZ85721 United States Data Science Institute University of Arizona 1230 N. Cherry Ave. TucsonAZ85721 United States Program in Applied Mathematics University of Arizona 617 N. Santa Rita TucsonAZ85721 United States Astronomy Department Universidad de Concepción Casilla 160-C Concepción Chile Finnish Centre for Astronomy with ESO University of Turku FI-20014 Finland Aalto University Metsähovi Radio Observatory Metsähovintie 114 KylmäläFI-02540 Finland Massachusetts Institute of Technology Haystack Observatory 99 Millstone Road WestfordMA01886 United States National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Department of Physics Faculty of Science Universiti Malaya Kuala Lumpur50603 Malaysia California Institute of Technology 1200 East California Boulevard PasadenaCA91125 United States Department of Astronomy and Atmospheric Sciences Kyungpook National University Daegu702-701 Korea Republic of Shanghai Astronomical Observatory Chinese Academy

We report on the observations of the quasar NRAO 530 with the Event Horizon Telescope (EHT) on 2017 April 5−7, when NRAO 530 was used as a calibrator for the EHT observations of Sagittarius A∗. At z = 0.902 this is the most distant object imaged by the EHT so far. We reconstruct the first images of the source at 230 GHz, at an unprecedented angular resolution of ∼ 20 µas, both in total intensity and in linear polarization. We do not detect source variability, allowing us to represent the whole data set with static images. The images reveal a bright feature located on the southern end of the jet, which we associate with the core. The feature is linearly polarized, with a fractional polarization of ∼5-8% and has a sub-structure consisting of two components. Their observed brightness temperature suggests that the energy density of the jet is dominated by the magnetic field. The jet extends over 60 µas along a position angle PA∼ −28◦. It includes two features with orthogonal directions of polarization (electric vector position angle, EVPA), parallel and perpendicular to the jet axis, consistent with a helical structure of the magnetic field in the jet. The outermost feature has a particularly high degree of linear polarization, suggestive of a nearly uniform magnetic field. Future EHT observations will probe the variability of the jet structure on µas scales, while simultaneous multi-wavelength monitoring will provide insight into the high energy emission origin. © 2023, CC BY.

关键词： Telescopes

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TFisher tests: Optimal and adaptive thresholding for combining p-values

arXiv

引用

arXiv 2018年

作者： Zhang, Hong Tong, Tiejun Landers, John Wu, Zheyang Department of Mathematical Sciences Worcester Polytechnic Institute WorcesterMA01609 United States Department of Mathematics Hong Kong Baptist University Kowloon Tong Hong Kong Department of Neurology University of Massachusetts Medical School WorcesterMA01655 United States Department of Mathematical Sciences Program of Bioinformatics and Computational Biology Program of Data Science Worcester Polytechnic Institute WorcesterMA01609 United States

For testing a group of hypotheses, tremendous p-value combination methods have been developed and widely applied since 1930's. Some methods (e.g., the minimal p-value) are optimal for sparse signals, and some others (e.g., Fisher's combination) are optimal for dense signals. To address a wide spectrum of signal patterns, this paper proposes a unifying family of statistics, called TFisher, with general p-value truncation and weighting schemes. Analytical calculations for the p-value and the statistical power of TFisher under general hypotheses are given. Optimal truncation and weighting parameters are studied based on Bahadur Efficiency (BE) and the proposed Asymptotic Power Efficiency (APE), which is superior to BE for studying the signal detection problem. A soft-thresholding scheme is shown to be optimal for signal detection in a large space of signal patterns. When prior information of signal pattern is unavailable, an omnibus test, oTFisher, can adapt to the given data. Simulations evidenced the accuracy of calculations and validated the theoretical properties. The TFisher tests were applied to analyzing a whole exome sequencing data of amyotrophic lateral sclerosis. Relevant tests and calculations have been implemented into an R package TFisher and published on the CRAN. Copyright © 2018, The Authors. All rights reserved.

关键词： Signal detection

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