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12th European Conference on Radiation and Its Effects on Component and Systems, RADECS 2011

作者： Bhandaru, Shweta Zhang, En Xia Fleetwood, Daniel M. Reed, Robert A. Weller, Robert A. Weiss, Sharon M. Interdisciplinary Graduate Program in Material Science Vanderbilt University Nashville TN 37235 United States Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN 37235 United States

Enhanced rates of oxide growth have been observed on silicon when exposed to high-energy x-ray irradiation. This observed effect could potentially be utilized for remote total ionizing dose-sensing applications. ©... 详细信息

ISBN: (纸本)9781457705878

关键词： Silicon

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On-chip western blotting: In-situ renaturation of SDS-protein complexes unifies sodium dodecyl sulfate (SDS) sizing & blotting in one microdevice

On-chip western blotting: In-situ renaturation of SDS-protei...

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15th international Conference on Miniaturized Systems for Chemistry and Life sciences 2011, MicroTAS 2011

作者： Hou, Chenlu Herr, Amy E. University of California Electrical Engineering and Computer Science Berkeley United States University of California Bioengineering Berkeley United States University of California UCSF Graduate Program in Bioengineering Berkeley United States

ISBN: (纸本)9781618395955

Western blotting readily identifies specific proteins amidst complex biological backgrounds [1, 2]. Nevertheless, immunob-lotting suffers from tremendous labor-intensive and time-intensive requirements [3]. The slab-gel assays require 1-2 days for completion with multiple hands-on "blotting" steps and yield semi-quantitative information. Recently, our group has introduced new approaches for completing Western blotting. The microfluidic integration strategies introduced and used allow rapid results reporting, full assay automation, and limited sample consumption (1-10 uL). Our integration strategies use spatial, temporal, and spatiotemporal modulation of separation mechanisms in fully electrophoretic systems. The present study reports on recapitulation of immunoaffinity in previously sized proteins, using novel in-transit electrophoretic removal of SDS from SDS-protein complexes. Early results show both the length- and timescales for protein 'renaturation' are compatible with on-chip operation. Further, substantial binding affinity is recapitulated using this streamlined and promising approach.

关键词： Sodium dodecyl sulfate

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Design Management Review 2014年第3期25卷

作者： John Maeda Steven Heller Tim Hoover Has been a design partner at Kleiner Perkins Caufield & Byers since January 2014 helping entrepreneurs and portfolio companies to build design into their company cultures. He served as the president of Rhode Island School of Design for six years through 2013 and also served as an associate director of research at the MIT Media Lab. Maeda has been a practicing designer since 1990 and his work is in the permanent collections of the Museum of Modern Art San Francisco Museum of Modern Art and the Cartier Foundation. He serves on the boards of several corporations including Sonos and Wieden + Kennedy and is chair of eBay's Design Advisory Board. His four published books include The Laws of Simplicity and Redesigning Leadership. Maeda is the recipient of a variety of international awards for his creative work including induction into the Art Director's Club Hall of Fame. In 2001 he received the White House National Design Award in 2002 he received the Mainichi Design Prize in Japan and in 2005 he was awarded the Raymond Loewy Foundation Prize in Germany. Maeda earned a BS and an MS from MIT in computer science and electrical engineering. He received a PhD in design science from the University of Tsukuba Institute of Art and Design in Japan as well as an MBA from Arizona State University. Co‐chair and co‐founder of the MFA Designer as Author and Entrepreneur program at the School of Visual Arts in New York. He was the art director of The New York Times Book Review and now writes the VISUALS column for the NYTBR. He also writes “The Daily Heller” at *** a weekly online design column for Atlantic magazine. He is author co‐author and editor of more than 165 books on the history and practice of graphic design illustration and satiric art. His forthcoming books include 100 Classic Graphic Design Magazines (Laurence King Publishers) and Raw Data: The Process Behind Information Graphics (Thames + Hudson). Heller was the 2011 recipient of the Smithsonian National Design Award for Design Mind. He has also writ

John Maeda is a past president of Rhode Island School of Design and an internationally known designer. He's now involved in helping entrepreneurs build design into their company cultures. Writer and educator Steven Heller pairs up with Tim Hoover, head of product and design at Canary, to talk about designer CEOs, start‐ups, and cutting out the middleman.

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Modularity detection in protein-protein interaction networks

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BMC Research Notes 2011年第1期4卷 1-6页

作者： Narayanan, Tejaswini Gersten, Merril Subramaniam, Shankar Grama, Ananth Department of Electrical and Computer Engineering University of California San Diego United States Graduate Program in Bioinformatics and Systems Biology University of California San Diego United States Department of Bioengineering University of California San Diego United States Department of Computer Science Purdue University West Lafayette IN United States

Background: Many recent studies have investigated modularity in biological networks, and its role in functional and structural characterization of constituent biomolecules. A technique that has shown considerable promise in the domain of modularity detection is the Newman and Girvan (NG) algorithm, which relies on the number of shortest-paths across pairs of vertices in the network traversing a given edge, referred to as the betweenness of that edge. The edge with the highest betweenness is iteratively eliminated from the network, with the betweenness of the remaining edges recalculated in every iteration. This generates a complete dendrogram, from which modules are extracted by applying a quality metric called modularity denoted by Q. This exhaustive computation can be prohibitively expensive for large networks such as Protein-Protein Interaction Networks. In this paper, we present a novel optimization to the modularity detection algorithm, in terms of an efficient termination criterion based on a target edge betweenness value, using which the process of iterative edge removal may be terminated. Results: We validate the robustness of our approach by applying our algorithm on real-world protein-protein interaction networks of Yeast, *** and Drosophila, and demonstrate that our algorithm consistently has significant computational gains in terms of reduced runtime, when compared to the NG algorithm. Furthermore, our algorithm produces modules comparable to those from the NG algorithm, qualitatively and quantitatively. We illustrate this using comparison metrics such as module distribution, module membership cardinality, modularity Q, and Jaccard Similarity Coefficient. Conclusions: We have presented an optimized approach for efficient modularity detection in networks. The intuition driving our approach is the extraction of holistic measures of centrality from graphs, which are representative of inherent modular structure of the underlying network, and the applic

关键词： Biological Network Jaccard Index Input Network High Betweenness Jaccard Similarity Coefficient

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Fiber Bragg grating sensing applications in temperature monitoring of three-phase induction motors

Fiber Bragg grating sensing applications in temperature moni...

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SBMO/IEEE MTT-S international Conference on Microwave and Optoelectronics (IMOC)

作者： Kleiton de Morais Sousa Angelo Alfredo Hafner Marcos Crespim Jonas Somenzi Valmir de Oliveira Hypolito José Kalinowski Jean Carlos Cardozo da Silva Electrical Engineering Graduate Program (PPGEE) Federal University of Technology of Paraná (UTFPR) Brazil Graduate Program on Electrical Engineering and Applied Computer Science (CPGEI) Federal University of Technology of Paraná (UTFPR) Brazil

This paper presents an analysis of simultaneous temperature and electrical parameters measurements in a three phase induction motor (TIM). The electrical parameters, namely voltage and current in the motor windings, were measured with Hall effect sensors and the temperature in the stator slots were monitored using fiber Bragg grating sensors (FBG). In the performed temperature analysis, two sets of sensors were used, containing four FBG in each fiber. Eight FBG sensors were uniformly distributed in the TIM stator. A special encapsulation of the sensor was elaborated to minimize mechanical disturbances in the fiber due to motor operation. Tests were performed with motor running at no load and with intentional voltage disturbances in the windings produced at every 15 minutes periods. It was observed that the temperature distribution is not uniform in the TIM stator either with or without a balanced voltage in the windings. A mean level increase of 0.5°C in temperature was registered in all of the sensors when there is a lack of balance in the voltage windings.

关键词： Temperature sensors Induction motors Optical sensors Temperature measurement Stators Bragg gratings

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electrical characteristics of biomodified electrodes using nonfaradaic electrochemical impedance spectroscopy

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World Academy of science, engineering and Technology 2011年 73卷 295-299页

作者： Yusof, Yusmeeraz Yanagimoto, Yoshiyuki Uno, Shigeyasu Nakazato, Kazuo Department of Electrical Engineering and Computer Science Graduate School of Engineering Nagoya University Japan Agilent Technologies International Japan Ltd Kobe 651-2241 Japan

We demonstrate a nonfaradaic electrochemical impedance spectroscopy measurement of biochemically modified gold plated electrodes using a two-electrode system. The absence of any redox indicator in the impedance measurements provide more precise and accurate characterization of the measured bioanalyte at molecular resolution. An equivalent electrical circuit of the electrodeelectrolyte interface was deduced from the observed impedance data of saline solution at low and high concentrations. The detection of biomolecular interactions was fundamentally correlated to electrical double-layer variation at modified interface. The investigations were done using 20mer deoxyribonucleic acid (DNA) strands without any label. Surface modification was performed by creating mixed monolayer of the thiol-modified single-stranded DNA and a spacer thiol (mercaptohexanol) by a two-step self-assembly method. The results clearly distinguish between the noncomplementary and complementary hybridization of DNA, at low frequency region below several hundreds Hertz.

关键词： DNA

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An Extension to the Contract-Net Protocol Applied to the Transport Planning Problem of Oil Products

An Extension to the Contract-Net Protocol Applied to the Tra...

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Workshop and School of Agent Systems, their Environment and Applications (WESAAC)

作者： Roni F. Banaszewski Kelvin E. Nogueira Jean M. Simão Lucia V. Arruda Cesar A. Tacla Graduate Program in Electrical Engineering and Industrial Computer Science (CPGEI) Federal University of Technology of Paraná (UTFPR) Curitiba Brazil

In supply chains of petroleum industry, maintaining a proper inventory level for multiple petroleum products is a crucial issue. Basically, this chain has several elements like producer bases, consumer bases and terminals that are linked by means of a multi-modal transport network. These elements must cooperate to achieve the global goal of the system with a minimized cost. To achieve this goal, this paper presents a multiagent protocol for simultaneous negotiations based on the Contract-Net and the application of this in the chain aforementioned. As a result, this protocol proved to be very efficient to return a feasible solution in a low processing time.

关键词： Computational modeling Waste materials Protocols Educational institutions Planning Proposals Conferences

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Stabilization of hydroxyl-terminated silanes in porous silicon for in-situ DNA synthesis

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Physica Status Solidi (C) Current Topics in Solid State Physics 2011年第6期8卷 1851-1855页

作者： Lawrie, Jenifer L. Weiss, Sharon M. Interdisciplinary Graduate Program in Materials Science Vanderbilt University Nashville TN United States Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN United States

Passivation of porous silicon sensors is a critical issue for achieving high sensitivity and selectivity toward biomolecule targets that may be detected in complex physiologic solution. Without appropriate passivation, degradation of the porous silicon matrix inhibits the repeatability of optical measurements and limits applications in complex media. In this work, we present a method for stabilizing TEOS-HBA monolayers in porous silicon. Annealing of the silane at 200°C for 16 hours, followed by a deionized water wash for a minimum of one hour, results in a porous silicon surface that is highly stable in a number of solvents. Annealing improves cross-linking of surface-attached silane molecules for added stability, and hydrolyzing facilitates removal of weakly bound multilayers. This surface treatment procedure is of considerable interest in applications such as DNA synthesis where hydroxyl functionality is critical and a thick silane surface coating is not desired. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

关键词： Passivation

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Erratum to: Search for supersymmetry in events containing a same-flavour opposite-sign dilepton pair, jets, and large missing transverse momentum in ... TeV pp collisions with the ATLAS detector

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The European Physical Journal. C, Particles and Fields. 2015年第10期75卷 1页

作者： Aad, G Abbott, B Abdallah, J Abdinov, O Aben, R Abolins, M Abouzeid, O S Abramowicz, H Abreu, H Abreu, R Abulaiti, Y Acharya, B S Adamczyk, L Adams, D L Adelman, J Adomeit, S Adye, T Affolder, A A Agatonovic-jovin, T Aguilar-saavedra, J A Agustoni, M Ahlen, S P Ahmadov, F Aielli, G Akerstedt, H Åkesson, T P A Akimoto, G Akimov, A V Alberghi, G L Albert, J Albrand, S Alconada Verzini, M J Aleksa, M Aleksandrov, I N Alexa, C Alexander, G Alexopoulos, T Alhroob, M Alimonti, G Alio, L Alison, J Alkire, S P Allbrooke, B M M Allport, P P Aloisio, A Alonso, A Alonso, F Alpigiani, C Altheimer, A Alvarez Gonzalez, B Piqueras, D Álvarez Alviggi, M G Amako, K Amaral Coutinho, Y Amelung, C Amidei, D Amor Dos Santos, S P Amorim, A Amoroso, S Amram, N Amundsen, G Anastopoulos, C Ancu, L S Andari, N Andeen, T Anders, C F Anders, G Anderson, K J Andreazza, A Andrei, V Angelidakis, S Angelozzi, I Anger, P Angerami, A Anghinolfi, F Anisenkov, A V Anjos, N Annovi, A Antonelli, M Antonov, A Antos, J Anulli, F Aoki, M Aperio Bella, L Arabidze, G Arai, Y Araque, J P Arce, A T H Arduh, F A Arguin, J-f Argyropoulos, S Arik, M Armbruster, A J Arnaez, O Arnal, V Arnold, H Arratia, M Arslan, O Artamonov, A Artoni, G Asai, S Asbah, N Ashkenazi, A Åsman, B Asquith, L Assamagan, K Astalos, R Atkinson, M Atlay, N B Auerbach, B Augsten, K Aurousseau, M Avolio, G Axen, B Ayoub, M K Azuelos, G Baak, M A Baas, A E Bacci, C Bachacou, H Bachas, K Backes, M Backhaus, M Badescu, E Bagiacchi, P Bagnaia, P Bai, Y Bain, T Baines, J T Baker, O K Balek, P Balestri, T Balli, F Banas, E Banerjee, Sw Bannoura, A A E Bansil, H S Barak, L Baranov, S P Barberio, E L Barberis, D Barbero, M Barillari, T Barisonzi, M Barklow, T Barlow, N Barnes, S L Barnett, B M Barnett, R M Barnovska, Z Baroncelli, A Barone, G Barr, A J Barreiro, F Barreiro Guimarães Da Costa, J Bartoldus, R Barton, A E Bartos, P Bassalat, A Basye, A Bates, R L Batista, S J Batley, J R Battaglia, M Bauce, M Bauer, F Bawa, H S Beacham, J B Beattie, M D Beau, T Beauchemin, P H Beccherle, R Bechtle, 85.CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France 113.Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman OK USA 152.Institute of Physics Academia Sinica Taipei Taiwan 11.Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan 107.Nikhef National Institute for Subatomic Physics and University of Amsterdam Amsterdam The Netherlands 90.Department of Physics and Astronomy Michigan State University East Lansing MI USA 159.Department of Physics University of Toronto Toronto ON Canada 154.Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel 153.Department of Physics Technion: Israel Institute of Technology Haifa Israel 30.CERN Geneva Switzerland 147.Department of Physics Stockholm University Stockholm Sweden 227.The Oskar Klein Centre Stockholm Sweden 165.INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy 229.ICTP Trieste Italy 38.Faculty of Physics and Applied Computer Science AGH University of Science and Technology Kraków Poland 25.Physics Department Brookhaven National Laboratory Upton NY USA 108.Department of Physics Northern Illinois University De Kalb IL USA 100.Fakult?t für Physik Ludwig-Maximilians-Universit?t München Munich Germany 131.Particle Physics Department Rutherford Appleton Laboratory Didcot UK 74.Oliver Lodge Laboratory University of Liverpool Liverpool UK 13.Institute of Physics University of Belgrade Belgrade Serbia 126.Laboratorio de Instrumentacao e Fisica Experimental de Particulas LIP Lisbon Portugal 215.Departamento de Fisica Teorica y del Cosmos and CAFPE Universidad de Granada Granada Spain 17.Albert Einstein Center for Fundamental Physics and Laboratory for High Energy Physics University of Bern Bern Switzerland 22.Department of Physics Boston University Boston MA USA 65.Joint Institute for Nuclear Research JINR Dubna Dubna Russia 134.INFN Sezione di Roma Tor Vergata Rome Ita

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Accelerated oxidation of silicon due to x-ray irradiation

Accelerated oxidation of silicon due to x-ray irradiation

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European Conference on Radiation and its Effects on Components and Systems (RADECS)

作者： Shweta Bhandaru En Xia Zhang Daniel M. Fleetwood Robert A. Reed Robert A. Weller Sharon M. Weiss Interdisciplinary Graduate Program in Material Science Vanderbilt University Nashville TN USA Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN USA

关键词： Silicon Radiation effects Oxidation Atomic measurements Temperature measurement Optical sensors Atomic layer deposition

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