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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51, pg 659, 2019)

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NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

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Parametric sensitivity analysis of cOptBees optimal clustering algorithm 14

Parametric sensitivity analysis of cOptBees optimal clusteri...

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2014 14th international Conference on Intelligent Systems Design and Applications, ISDA 2014

作者： Cruz, Dávila Patrícia Ferreira Maia, Renato Dourado De Castro, Leandro Nunes Graduate Program in Electrical Engineering Mackenzie University São Paulo Brazil Computer Science Department State University of Montes Claros Montes Claros MG Brazil

ISBN: (纸本)9781479979387

Clustering is one of the most important tasks in data mining and can be defined as the process of partitioning objects into groups or clusters, such that objects in the same group are more similar to one another than to objects belonging to other groups. Many algorithms to solve data clustering problems have been presented in the literature. Recently, bee-inspired clustering algorithms have been proposed, presenting good performance to find groups in data. This paper aims to present the parametric sensitivity analysis of cOptBees, a bee-inspired clustering algorithm designed to find optimal clusters in datasets. The algorithm was run for different parameter configurations to assess the influence of each parameter in its performance. © 2014 IEEE.

关键词： Clustering algorithms

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Fat percentage equation for children with cerebral palsy: A novel approach

Fat percentage equation for children with cerebral palsy: A ...

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13th Mediterranean Conference on Medical and Biological engineering and Computing 2013, MEDICON 2013

作者： Neves, E.B. Krueger, E. Rosário, B.R. Oliveira, M.C.N. Pol, S. Ripka, W.L. Campos de Andrade University Center Vitória Research Center Curitiba Brazil Federal Technological University of Paraná Graduate Program in Electrical Engineering and Computer Science Curitiba Brazil Federal Technological University of Paraná Graduate Program in Biomedical Engineering Curitiba Brazil

ISBN: (纸本)9783319008455

Nutritional changes are commonly related to children with cerebral palsy (CP), since these are problems as: dysphagia, vomiting and gastrointestinal reflux. For nutritional monitoring, body composition has become an important tool and has been present in this population assessments routine. In this sense, the aim of this study was to develop an equation for body composition estimate for children with cerebral palsy, aged between 5 and 6 years, using skinfolds, from the results of body composition obtained by Dual Energy X-rays Absormetry (DEXA). The study included 10 male children with cerebral palsy, aged between five and six-years-old, who participated in the physical therapy intensive program in Vitória research center, Curitiba, Brazil. Participants were assessed by: the Gross Motor Function Classification System;DEXA;and skinfold thickness. The skinfolds that showed better correlation with the total fat percentage and segmental fat percentage were: biceps and abdominal. The results of the regression analysis obtained equations to estimate the fat percentage by skinfold thickness with R2: 1.000 and 0.971, to seven and two skinfold thickness, respectively. In this sense, it is recommended to use the equation that utilizes the biceps and abdominal skinfolds thickness to estimate fat percentage of children with cerebral palsy, as this presents good estimation indicators. © Springer international Publishing Swit zerland 2014.

关键词： Biochemistry

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Measurement of the Soft-Drop Jet Mass in pp Collisions at s=13 TeV with the ATLAS Detector

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Physical Review Letters 2018年第9期121卷 092001-092001页

作者： M. Aaboud G. Aad B. Abbott O. Abdinov B. Abeloos S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu R. Abreu Y. Abulaiti B. S. Acharya S. Adachi L. Adamczyk J. Adelman M. Adersberger T. Adye A. A. Affolder Y. Afik C. Agheorghiesei J. A. Aguilar-Saavedra S. P. Ahlen F. Ahmadov G. Aielli S. Akatsuka H. Akerstedt T. P. A. Åkesson E. Akilli A. V. Akimov G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini S. C. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob B. Ali M. Aliev G. Alimonti J. Alison S. P. Alkire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. A. Alshehri M. I. Alstaty B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio Y. Amaral Coutinho C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi A. Angerami A. V. Anisenkov N. Anjos A. Annovi C. Antel M. Antonelli A. Antonov D. J. Antrim F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque V. Araujo Ferraz A. T. H. Arce R. E. Ardell F. A. Arduh J-F. Arguin S. Argyropoulos M. Arik A. J. Armbruster L. J. Armitage O. Arnaez H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Artz S. Asai N. Asbah A. Ashkenazi L. Asquith K. Assamagan R. Astalos M. Atkinson N. B. Atlay K. Augsten G. Avolio B. Axen M. K. Ayoub G. Azuelos A. E. Baas M. J. Baca H. Bachacou K. Bachas M. Backes P. Bagnaia M. Bahmani H. Bahrasemani J. T. Baines M. Bajic O. K. Baker P. J. Bakker E. M. Baldin P. Balek F. Balli W. K. Balunas E. Banas A. Bandyopadhyay Sw. Banerjee A. A. E. Bannoura L. Barak E. L. Barberio D. Barberis M. Barbero T. Barillari M-S Barisits J. T. Barkeloo T. Barklow N. Barlow S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska-Blenessy A. Baroncelli G. Barone A. J. Barr L. Barranco Navarro F. Barreiro J. Barreiro Guimarães da Costa R. Bartoldus A. E. Barton P. Bartos A. Basalaev A. Bassalat R. L. Bates Faculté des Sciences Université Mohamed Premier and LPTPM Oujda Morocco CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Univ. Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Ontario Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel Center for High Energy Physics University of Oregon Eugene Oregon USA Department of Physics Stockholm University Sweden The Oskar Klein Centre Stockholm Sweden INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Laboratório de Instrumentação e Física Experimental de Partículas—LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos Universidad de Granada Granada Spain Department of Physics Boston University Boston Massachusetts USA Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN Sezione di Roma Tor Vergata Roma Italy Dipartimento di Fisica Università di Roma Tor Vergata Roma Italy Faculty of Sci

Jet substructure observables have significantly extended the search program for physics beyond the standard model at the Large Hadron Collider. The state-of-the-art tools have been motivated by theoretical calculations, but there has never been a direct comparison between data and calculations of jet substructure observables that are accurate beyond leading-logarithm approximation. Such observables are significant not only for probing the collinear regime of QCD that is largely unexplored at a hadron collider, but also for improving the understanding of jet substructure properties that are used in many studies at the Large Hadron Collider. This Letter documents a measurement of the first jet substructure quantity at a hadron collider to be calculated at next-to-next-to-leading-logarithm accuracy. The normalized, differential cross section is measured as a function of log10ρ2, where ρ is the ratio of the soft-drop mass to the ungroomed jet transverse momentum. This quantity is measured in dijet events from 32.9 fb−1 of s=13 TeV proton-proton collisions recorded by the ATLAS detector. The data are unfolded to correct for detector effects and compared to precise QCD calculations and leading-logarithm particle-level Monte Carlo simulations.

关键词： Perturbative QCD Quark & gluon jets

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Search for a Structure in the Bs0π± Invariant Mass Spectrum with the ATLAS Experiment

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Physical Review Letters 2018年第20期120卷 202007-202007页

作者： M. Aaboud G. Aad B. Abbott O. Abdinov B. Abeloos S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya S. Adachi L. Adamczyk J. Adelman M. Adersberger T. Adye A. A. Affolder Y. Afik C. Agheorghiesei J. A. Aguilar-Saavedra S. P. Ahlen F. Ahmadov G. Aielli S. Akatsuka H. Akerstedt T. P. A. Åkesson E. Akilli A. V. Akimov G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini S. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob B. Ali M. Aliev G. Alimonti J. Alison S. P. Alkire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. A. Alshehri M. I. Alstaty B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio Y. Amaral Coutinho C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi A. Angerami A. V. Anisenkov N. Anjos A. Annovi C. Antel M. Antonelli A. Antonov D. J. Antrim F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque V. Araujo Ferraz A. T. H. Arce R. E. Ardell F. A. Arduh J-F. Arguin S. Argyropoulos M. Arik A. J. Armbruster L. J. Armitage O. Arnaez H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Artz S. Asai N. Asbah A. Ashkenazi L. Asquith K. Assamagan R. Astalos M. Atkinson N. B. Atlay K. Augsten G. Avolio B. Axen M. K. Ayoub G. Azuelos A. E. Baas M. J. Baca H. Bachacou K. Bachas M. Backes P. Bagnaia M. Bahmani H. Bahrasemani J. T. Baines M. Bajic O. K. Baker P. J. Bakker D. Bakshi Gupta E. M. Baldin P. Balek F. Balli W. K. Balunas E. Banas A. Bandyopadhyay Sw. Banerjee A. A. E. Bannoura L. Barak E. L. Barberio D. Barberis M. Barbero T. Barillari M-S Barisits J. T. Barkeloo T. Barklow N. Barlow S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska-Blenessy A. Baroncelli G. Barone A. J. Barr L. Barranco Navarro F. Barreiro J. Barreiro Guimarães da Costa R. Bartoldus A. E. Barton P. Bartos A. Basalaev A. Bassalat R. L. B Faculté des Sciences Université Mohamed Premier and LPTPM Oujda Morocco CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Univ. Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Ontario Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel Department of Physics Stockholm University Sweden The Oskar Klein Centre Stockholm Sweden INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Laboratório de Instrumentação e Física Experimental de Partículas - LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos Universidad de Granada Granada Portugal Department of Physics Boston University Boston Massachusetts USA Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN Sezione di Roma Tor Vergata Italy Dipartimento di Fisica Università di Roma Tor Vergata Roma Italy Faculty of Science Kyoto University Kyoto Japan Fysiska institutionen Lunds universit

A search for the narrow structure, X(5568), reported by the D0 Collaboration in the decay sequence X→Bs0π±, Bs0→J/ψϕ, is presented. The analysis is based on a data sample recorded with the ATLAS detector at the LHC corresponding to 4.9 fb−1 of pp collisions at 7 TeV and 19.5 fb−1 at 8 TeV. No significant signal was found. Upper limits on the number of signal events, with properties corresponding to those reported by D0, and on the X production rate relative to Bs0 mesons, ρX, were determined at 95% confidence level. The results are N(X)<382 and ρX<0.015 for Bs0 mesons with transverse momenta above 10 GeV, and N(X)<356 and ρX<0.016 for transverse momenta above 15 GeV. Limits are also set for potential Bs0π± resonances in the mass range 5550 to 5700 MeV.

关键词： Exotic mesons Hadron colliders

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Search for High-Mass Resonances Decaying to τν in pp Collisions at s=13 TeV with the ATLAS Detector

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Physical Review Letters 2018年第16期120卷 161802-161802页

作者： M. Aaboud G. Aad B. Abbott O. Abdinov B. Abeloos S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya S. Adachi L. Adamczyk J. Adelman M. Adersberger T. Adye A. A. Affolder Y. Afik C. Agheorghiesei J. A. Aguilar-Saavedra S. P. Ahlen F. Ahmadov G. Aielli S. Akatsuka T. P. A. Åkesson E. Akilli A. V. Akimov G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini S. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob B. Ali M. Aliev G. Alimonti J. Alison S. P. Alkire C. Allaire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. A. Alshehri M. I. Alstaty B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio Y. Amaral Coutinho L. Ambroz C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso C. S. Amrouche C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi A. Angerami A. V. Anisenkov A. Annovi C. Antel M. T. Anthony M. Antonelli D. J. Antrim F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque V. Araujo Ferraz R. Araujo Pereira A. T. H. Arce R. E. Ardell F. A. Arduh J-F. Arguin S. Argyropoulos A. J. Armbruster L. J. Armitage O. Arnaez H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Artz S. Asai N. Asbah A. Ashkenazi E. M. Asimakopoulou L. Asquith K. Assamagan R. Astalos R. J. Atkin M. Atkinson N. B. Atlay K. Augsten G. Avolio R. Avramidou B. Axen M. K. Ayoub G. Azuelos A. E. Baas M. J. Baca H. Bachacou K. Bachas M. Backes P. Bagnaia M. Bahmani H. Bahrasemani J. T. Baines M. Bajic O. K. Baker P. J. Bakker D. Bakshi Gupta E. M. Baldin P. Balek F. Balli W. K. Balunas E. Banas A. Bandyopadhyay Sw. Banerjee A. A. E. Bannoura L. Barak W. M. Barbe E. L. Barberio D. Barberis M. Barbero T. Barillari M-S Barisits J. T. Barkeloo T. Barklow N. Barlow R. Barnea S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska-Blenessy A. Baroncelli G. Barone A. J. Barr L. Barranco Navarro F. Barreiro J. B Faculté des Sciences Université Mohamed Premier and LPTPM Oujda Morocco CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Univ. Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Ontario Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel High Energy Physics Division Argonne National Laboratory Argonne Illinois USA INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Laboratório de Instrumentação e Física Experimental de Partículas - LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos Universidad de Granada Granada Spain Department of Physics Boston University Boston Massachusetts USA Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN Sezione di Roma Tor Vergata Roma Italy Dipartimento di Fisica Università di Roma Tor Vergata Roma Italy Faculty of Science Kyoto University Kyoto Japan Fysiska institutionen Lunds universitet Lund Swede

A search for high-mass resonances decaying to τν using proton-proton collisions at s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb−1. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W′ bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2–3.8 TeV depending on the coupling in the nonuniversal G(221) model are excluded at the 95% credibility level.

关键词： Extensions of gauge sector Particle production Hypothetical gauge bosons Hadron colliders

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Search for the Decay of the Higgs Boson to Charm Quarks with the ATLAS Experiment

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Physical Review Letters 2018年第21期120卷 211802-211802页

作者： M. Aaboud G. Aad B. Abbott O. Abdinov B. Abeloos S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya S. Adachi L. Adamczyk J. Adelman M. Adersberger T. Adye A. A. Affolder Y. Afik C. Agheorghiesei J. A. Aguilar-Saavedra S. P. Ahlen F. Ahmadov G. Aielli S. Akatsuka T. P. A. Åkesson E. Akilli A. V. Akimov G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini S. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob B. Ali M. Aliev G. Alimonti J. Alison S. P. Alkire C. Allaire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. A. Alshehri M. I. Alstaty B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio Y. Amaral Coutinho L. Ambroz C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi A. Angerami A. V. Anisenkov A. Annovi C. Antel M. Antonelli A. Antonov D. J. Antrim F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque V. Araujo Ferraz R. Araujo Pereira A. T. H. Arce R. E. Ardell F. A. Arduh J-F. Arguin S. Argyropoulos A. J. Armbruster L. J. Armitage O. Arnaez H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Artz S. Asai N. Asbah A. Ashkenazi L. Asquith K. Assamagan R. Astalos R. J. Atkin M. Atkinson N. B. Atlay K. Augsten G. Avolio R. Avramidou B. Axen M. K. Ayoub G. Azuelos A. E. Baas M. J. Baca H. Bachacou K. Bachas M. Backes P. Bagnaia M. Bahmani H. Bahrasemani J. T. Baines M. Bajic O. K. Baker P. J. Bakker D. Bakshi Gupta E. M. Baldin P. Balek F. Balli W. K. Balunas E. Banas A. Bandyopadhyay Sw. Banerjee A. A. E. Bannoura L. Barak E. L. Barberio D. Barberis M. Barbero T. Barillari M-S Barisits J. T. Barkeloo T. Barklow N. Barlow R. Barnea S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska-Blenessy A. Baroncelli G. Barone A. J. Barr L. Barranco Navarro F. Barreiro J. Barreiro Guimarães da Costa R. Bartoldus A. E. Bart Faculté des Sciences Université Mohamed Premier and LPTPM Oujda Morocco CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Univ. Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Ontario Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel High Energy Physics Division Argonne National Laboratory Argonne Illinois USA INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Laboratório de Instrumentação e Física Experimental de Partículas—LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos Universidad de Granada Granada Portugal Department of Physics Boston University Boston Massachusetts USA Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN Sezione di Roma Tor Vergata Roma Italy Dipartimento di Fisica Università di Roma Tor Vergata Roma Italy Faculty of Science Kyoto University Kyoto Japan Fysiska institutionen Lunds universitet Lund

A direct search for the standard model Higgs boson decaying to a pair of charm quarks is presented. Associated production of the Higgs and Z bosons, in the decay mode ZH→ℓ+ℓ−cc¯ is studied. A data set with an integrated luminosity of 36.1 fb−1 of pp collisions at s=13TeV recorded by the ATLAS experiment at the LHC is used. The H→cc¯ signature is identified using charm-tagging algorithms. The observed (expected) upper limit on σ(pp→ZH)×B(H→cc¯) is 2.7 (3.9−1.1+2.1) pb at the 95% confidence level for a Higgs boson mass of 125 GeV, while the standard model value is 26 fb.

关键词： Spontaneous symmetry breaking Charm quark Higgs bosons

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Single-cell morphological analysis for rapid antimicrobial susceptibility test

Single-cell morphological analysis for rapid antimicrobial s...

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international Conference on Solid State Sensors and Actuators (TRANSDUCERS)

作者： J. Choi J. Yoo M. Lee E.-G. Kim J. S. Lee S. Lee S. Joo S. H. Song E.-C. Kim J. C. Lee H. C. Kim Y.-G. Jung S. Kwon Department of Electrical Engineering and Computer Science Seoul National University Seoul Republic of Korea QuantaMatrix Inc. Republic of Korea Interdisciplinary Program of Bioengineering Seoul National University Graduate School Seoul Republic of Korea Department of Laboratory Medicine School of Medicine” Incheon Republic of Korea Department of Laboratory Medicine Seoul National-University Hospital Seoul Republic of Korea Institute of Medical and Biological Engineering Seoul National University Seoul Republic of Korea

A rapid antibiotic susceptibility test (AST) is desperately needed in clinical settings for fast and appropriate antibiotic administration. Traditional ASTs, which rely on cell culture, are not suitable for urgent cases of bacterial infection and antibiotic resistance owing to their relatively long test times. Here, we describe a novel AST called single-cell morphological analysis (SCMA) that can determine antimicrobial susceptibility by automatically analyzing and categorizing morphological changes in single bacterial cells under various antimicrobial conditions. The SCMA was tested with four Clinical and Laboratory Standards Institute standard bacterial strains and 189 clinical samples from hospitals. The results were compared with the gold standard broth microdilution test. The SCMA results were obtained in less than 4 hours with 91.5% categorical agreement and 6.51% minor, 2.56% major, and 1.49% very major discrepancies. Thus, SCMA provides rapid and accurate antimicrobial susceptibility data.

关键词： Microorganisms Antibiotics Strain Immune system Microfluidics Standards Imaging

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Erratum to: Measurement of the W-boson mass in pp collisions at with the ATLAS detector

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The European Physical Journal C 2018年第11期78卷 1-14页

作者： Aaboud, M. Aad, G. Abbott, B. Abdallah, J. Abdinov, O. Abeloos, B. Abidi, S. H. AbouZeid, O. S. Abraham, N. L. Abramowicz, H. Abreu, H. Abreu, R. Abulaiti, Y. Acharya, B. S. Adachi, S. Adamczyk, L. Adams, D. L. Adelman, J. Adersberger, M. Adye, T. Affolder, A. A. Agatonovic-Jovin, T. Agheorghiesei, C. Aguilar-Saavedra, J. A. Ahlen, S. P. Ahmadov, F. Aielli, G. Akatsuka, S. Akerstedt, H. Åkesson, T. P. A. Akimov, A. V. Alberghi, G. L. Albert, J. Alconada Verzini, M. J. Aleksa, M. Aleksandrov, I. N. Alexa, C. Alexander, G. Alexopoulos, T. Alhroob, M. Ali, B. Aliev, M. Alimonti, G. Alison, J. Alkire, S. P. Allbrooke, B. M. M. Allen, B. W. Allport, P. P. Aloisio, A. Alonso, A. Alonso, F. Alpigiani, C. Alshehri, A. A. Alstaty, M. Alvarez Gonzalez, B. Álvarez Piqueras, D. Alviggi, M. G. Amadio, B. T. Amaral Coutinho, Y. Amelung, C. Amidei, D. Amor Dos Santos, S. P. Amorim, A. Amoroso, S. Amundsen, G. Anastopoulos, C. Ancu, L. S. Andari, N. Andeen, T. Anders, C. F. Anders, J. K. Anderson, K. J. Andreazza, A. Andrei, V. Angelidakis, S. Angelozzi, I. Angerami, A. Anghinolfi, F. Anisenkov, A. V. Anjos, N. Annovi, A. Antel, C. Antonelli, M. Antonov, A. Antrim, D. J. Anulli, F. Aoki, M. Aperio Bella, L. Arabidze, G. Arai, Y. Araque, J. P. Araujo Ferraz, V. Arce, A. T. H. Ardell, R. E. Arduh, F. A. Arguin, J-F. Argyropoulos, S. Arik, M. Armbruster, A. J. Armitage, L. J. Arnaez, O. Arnold, H. Arratia, M. Arslan, O. Artamonov, A. Artoni, G. Artz, S. Asai, S. Asbah, N. Ashkenazi, A. Asquith, L. Assamagan, K. Astalos, R. Atkinson, M. Atlay, N. B. Augsten, K. Avolio, G. Axen, B. Ayoub, M. K. Azuelos, G. Baas, A. E. Baca, M. J. Bachacou, H. Bachas, K. Backes, M. Backhaus, M. Bagiacchi, P. Bagnaia, P. Baines, J. T. Bajic, M. Baker, O. K. Baldin, E. M. Balek, P. Balestri, T. Balli, F. Balunas, W. K. Banas, E. Banerjee, Sw. Bannoura, A. A. E. Barak, L. Barberio, E. L. Barberis, D. Barbero, M. Barillari, T. Barisits, M-S. Barklow, T. Barlow, N. Barnes, S. L. Barnett, B. M. Barnett, R. M. Barnovska-Blenessy, Z. Baroncelli, A. Barone, G. Faculté des Sciences Université Mohamed Premier and LPTPM Oujda Morocco CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman USA Department of Physics The University of Texas at Arlington Arlington USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Univ. Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz USA Department of Physics and Astronomy University of Sussex Brighton UK Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel Center for High Energy Physics University of Oregon Eugene USA Department of Physics Stockholm University Stockholm Sweden The Oskar Klein Centre Stockholm Sweden INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan Faculty of Physics and Applied Computer Science AGH University of Science and Technology Kraków Poland Physics Department Brookhaven National Laboratory Upton USA Department of Physics Northern Illinois University DeKalb USA Fakultät für Physik Ludwig-Maximilians-Universität München Munich Germany Particle Physics Department Rutherford Appleton Laboratory Didcot UK Institute of Physics University of Belgrade Belgrade Serbia Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest Romania Laboratório de Instrumentação e Física Experimental de Partículas-LIP Lisbon Portugal Departamento de Fisica Teorica y del Cosmos and CAFPE Universidad de Granada Granada Spain Department of Physics Boston University Boston USA Joint Institute for Nuclear Research JINR Dubn

It has been found that Figure 30 shows the 68% and 99% confidence-level contours for the W boson and top quark mass measurements, instead of the 68% and 95% confidence-level contours, as stated in the legend.

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Search for top squarks decaying to tau sleptons in pp collisions at s=13 TeV with the ATLAS detector

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Physical Review D 2018年第3期98卷 032008-032008页

作者： M. Aaboud G. Aad B. Abbott O. Abdinov B. Abeloos S. H. Abidi O. S. Abouzeid N. L. Abraham H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya S. Adachi L. Adamczyk J. Adelman M. Adersberger T. Adye A. A. Affolder Y. Afik C. Agheorghiesei J. A. Aguilar-Saavedra F. Ahmadov G. Aielli S. Akatsuka T. P. A. Åkesson E. Akilli A. V. Akimov G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini S. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob B. Ali M. Aliev G. Alimonti J. Alison S. P. Alkire C. Allaire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. A. Alshehri M. I. Alstaty B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio Y. Amaral Coutinho L. Ambroz C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi A. Angerami A. V. Anisenkov A. Annovi C. Antel M. T. Anthony M. Antonelli A. Antonov D. J. A. Antrim F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque V. Araujo Ferraz R. Araujo Pereira A. T. H. Arce R. E. Ardell F. A. Arduh J-F. Arguin S. Argyropoulos A. J. Armbruster L. J. Armitage O. Arnaez H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Artz S. Asai N. Asbah A. Ashkenazi L. Asquith K. Assamagan R. Astalos R. J. Atkin M. Atkinson N. B. Atlay K. Augsten G. Avolio R. Avramidou B. Axen M. K. Ayoub G. Azuelos A. E. Baas M. J. Baca H. Bachacou K. Bachas M. Backes P. Bagnaia M. Bahmani H. Bahrasemani J. T. Baines M. Bajic O. K. Baker P. J. Bakker D. Bakshi Gupta E. M. Baldin P. Balek F. Balli W. K. Balunas E. Banas A. Bandyopadhyay Sw. Banerjee A. A. E. Bannoura L. Barak W. M. Barbe E. L. Barberio D. Barberis M. Barbero T. Barillari M-S Barisits J. Barkeloo T. Barklow N. Barlow R. Barnea S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska-Blenessy A. Baroncelli G. Barone A. J. Barr L. Barranco Navarro F. Barreiro J. Barreiro Guimarães da Costa R. Bartol Faculté des Sciences Université Mohamed Premier and LPTPM Oujda CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Université Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Ontario Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel High Energy Physics Division Argonne National Laboratory Argonne Illinois USA INFN Gruppo Collegato di Udine Sezione di Trieste Udine ICTP Trieste International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Departamento de Fisica Teorica y del Cosmos Universidad de Granada Granada (Spain) Laboratório de Instrumentação e Física Experimental de Partículas - LIP Lisboa Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN Sezione di Roma Tor Vergata Roma Italy Dipartimento di Fisica Università di Roma Tor Vergata Roma Italy Faculty of Science Kyoto University Kyoto Japan Fysiska institutionen Lunds universitet Lund Sweden Departement de Physique Nucléaire et Corpusculaire Université de Genève Geneva Switzerland P.N. Lebede

A search for direct pair production of top squarks in final states with two tau leptons, b-jets, and missing transverse momentum is presented. The analysis is based on proton-proton collision data at s=13 TeV corresponding to an integrated luminosity of 36.1 fb−1 recorded with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. Two exclusive channels with either two hadronically decaying tau leptons or one hadronically and one leptonically decaying tau lepton are considered. No significant deviation from the Standard Model predictions is observed in the data. The analysis results are interpreted in terms of model-independent limits and used to derive exclusion limits on the masses of the top squark t˜1 and the tau slepton τ˜1 in a simplified model of supersymmetry with a nearly massless gravitino. In this model, masses up to m(t˜1)=1.16 TeV and m(τ˜1)=1.00 TeV are excluded at 95% confidence level.

关键词： Supersymmetric models Superpartners Tau leptons Top quark Particle data analysis

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