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Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach

PLoS Computational Biology 2025年第5期21卷 e1013067页

作者： Vahdat, Zahra Gambrell, Oliver Fisch, Jonas Friauf, Eckhard Singh, Abhyudai Department of Electrical and Computer Engineering University of Delaware NewarkDE United States Animal Physiology Group Department of Biology University of Kaiserslautern Kaiserslautern Germany Department of Biomedical Engineering University of Delaware NewarkDE United States University of Delaware NewarkDE United States Interdisciplinary Neuroscience Program University of Delaware NewarkDE United States

Quantal parameters of synapses are fundamental for the temporal dynamics of neurotransmitter release, which is the basis of interneuronal communication. We formulate a general class of models that capture the stochastic dynamics of quantal content (QC), defined as the number of SV fusion events triggered by a single action potential (AP). Considering the probabilistic and time-varying nature of SV docking, undocking, and AP-triggered fusion, we derive an exact statistical distribution for the QC over time. Analyzing this distribution at steady-state and its associated autocorrelation function, we show that QC fluctuation statistics can be leveraged for inferring key presynaptic parameters, such as the probability of SV fusion (release probability) and SV replenishment at empty docking sites (refilling probability). Our model predictions are tested with electrophysiological data obtained from 50-Hz stimulation of auditory MNTB-LSO synapses in brainstem slices from juvenile mice. Our results show that while synaptic depression can be explained by low and constant refilling/release probabilities, this scenario is inconsistent with the statistics of the electrophysiological data, which show a low QC Fano factor and almost uncorrelated successive QCs. Our systematic analysis yields a model that couples a high release probability to a time-varying refilling probability to explain both the synaptic depression and its associated statistical fluctuations. In summary, we provide a general approach that exploits stochastic signatures in QCs to infer neurotransmission regulating processes that cannot be distinguished from simple analysis of averaged synaptic responses. © 2025 Vahdat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

关键词： Distribution functions

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Development of Flexible Sendust Composite Sheets with Enhanced Magnetic Permeability for Microwave Absorbers and Antennas

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IEEE Transactions on Magnetics 2025年

作者： Whalen, Matthew P. Plouff, David T. Shevchenko, Nicholas B. Mirotznik, Mark Xiao, John Q. University of Delaware Quantum Science and Engineering Program NewarkDE19716 United States University of Delaware Department of Physics and Astronomy NewarkDE19716 United States University of Delaware Center for Composite Materials NewarkDE19716 United States University of Delaware Department of Electrical and Computer Engineering NewarkDE19716 United States

The demand for high-frequency soft magnetic composites with elevated permeability and flexibility is growing for applications in microwave absorbers and magnetodielectric antennas. However, balancing high permeability with mechanical flexibility remains challenging. This study presents flexible Sendust (FeSiAl) composite sheets, fabricated with a hot-pressing technique that aligns flakes within an acrylic rubber and epoxy resin matrix. The alignment significantly enhances relative permeability at high frequencies, achieving single-layer film properties of μr' = 14.8 and μr"= 20.4 at 1 GHz, alongside high saturation magnetization (118 eμg) and high hesitivity (44.7 kΩ m-1), outperforming commonly used materials such as NiZn ferrite. Our method supports customizable thickness without sacrificing permeability, establishing a versatile platform for advanced conformal microwave absorber and antenna applications. © 2025 IEEE.

关键词： Saturation magnetization

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Spectral Extremal Connectivity of Two-State Seizure Brain Waves

arXiv

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arXiv 2025年

作者： Talento, Mara Sherlin D. Richards, Jordan Pinto-Orellana, Marco Huser, Raphael Ombao, Hernando C. Statistics Program Computer Electrical and Mathematical Science & Engineering Division King Abdullah University of Science and Technology 23955 - 6900 Saudi Arabia Neuro-AI Laboratory Computer Electrical and Mathematical Science & Engineering Division King Abdullah University of Science and Technology 23955 - 6900 Saudi Arabia School of Mathematics Maxwell Institute for Mathematical Sciences University of Edinburgh EdinburghEH9 3FD United Kingdom Department of Biomedical Engineering University of California Irvine92697 United States

Coherence analysis plays a vital role in the study of functional brain connectivity. However, coherence captures only linear spectral associations, and thus can produce misleading findings when ignoring variations of connectivity in the tails of the distribution. This limitation becomes important when investigating extreme neural events that are characterized by large signal amplitudes. The focus of this paper is to examine connectivity in the tails of the distribution, as this reveals salient information that may be overlooked by standard methods. We develop a novel notion of spectral tail association of periodograms to study connectivity in the network of electroencephalogram (EEG) signals of seizure-prone neonates. We further develop a novel non-stationary extremal dependence model for multivariate time series that captures differences in extremal dependence during different brain phases, namely burst-suppression and non-burst-suppression. One advantage of our proposed approach is its ability to identify tail connectivity at key frequency bands that could be associated with outbursts of energy which may lead to seizures. We discuss these novel scientific findings alongside a comparison of the extremal behavior of brain signals for epileptic and non-epileptic patients. © 2025, CC BY.

关键词： Electroencephalography

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AVTENet: A Human-Cognition-Inspired Audio-Visual Transformer-Based Ensemble Network for Video Deepfake Detection

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IEEE Transactions on Cognitive and Developmental Systems 2025年

作者： Hashmi, Ammarah Shahzad, Sahibzada Adil Lin, Chia-Wen Tsao, Yu Wang, Hsin-Min Taiwan International Graduate Program Academia Sinica Social Networks and Human-Centered Computing Program Taipei11529 Taiwan National Tsing Hua University Institute of Information Systems and Applications Hsinchu30013 Taiwan National Chengchi University Department of Computer Science Taipei11605 Taiwan National Tsing Hua University Department of Electrical Engineering Institute of Communications Engineering Hsinchu300044 Taiwan Academia Sinica Research Center for Information Technology Innovation Taipei11529 Taiwan

The recent proliferation of hyper-realistic deepfake videos has drawn attention to the threat of audio and visual forgeries. Most previous studies on detecting artificial intelligence-generated fake videos only utilize visual modality or audio modality. While some methods exploit audio and visual modalities to detect forged videos, they have not been comprehensively evaluated on multimodal datasets of deepfake videos involving acoustic and visual manipulations, and are mostly based on convolutional neural networks with low detection accuracy. Considering that human cognition instinctively integrates multisensory information including audio and visual cues to perceive and interpret content and the success of transformer in various fields, this study introduces the audio-visual transformer-based ensemble network (AVTENet). This innovative framework tackles the complexities of deepfake technology by integrating both acoustic and visual manipulations to enhance the accuracy of video forgery detection. Specifically, the proposed model integrates several purely transformer-based variants that capture video, audio, and audio-visual salient cues to reach a consensus in prediction. For evaluation, we use the recently released benchmark multimodal audio-video FakeAVCeleb dataset. For a detailed analysis, we evaluate AVTENet, its variants, and several existing methods on multiple test sets of the FakeAVCeleb dataset. Experimental results show that the proposed model outperforms all existing methods and achieves state-of-the-art performance on Testset-I and Testset-II of the FakeAVCeleb dataset. We also compare AVTENet against humans in detecting video forgery. The results show that AVTENet significantly outperforms humans. © 2016 IEEE.

关键词： audio-visual AVTENet Deepfake detection

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Visual Control and Mapping for UAV-Based Platform Inspection

Visual Control and Mapping for UAV-Based Platform Inspection

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International Conference on Unmanned Aircraft Systems (ICUAS)

作者： Leonardo A. Fagundes Carlos M. Soria Raquel F. Vassallo Alexandre S. Brandão Department of Electrical Engineering Graduate Program on Computer Science Federal University of Viçosa Viçosa MG Brazil Facultad de Ingeniería Instituto de Automática Universidad Nacional de San Juan Argentine Department of Electric Engineering Federal University of Espirito Santo Vitória ES Brazil

ISBN: (数字)9798331513283

ISBN: (纸本)9798331513290

Autonomous take-off and landing capabilities are crucial in UAV vision-based missions, ensuring adaptive navigation, especially in challenging environments where realtime identification and interaction with a variety of landing platforms are required. In this context, this paper presents a servo-visual controller that uses pattern detection and color segmentation techniques to identify take-off/landing platforms and estimate their current orientation. The proposed system was subjected to experimental validation with four platforms positioned in different orientations, heights, and positions, demonstrating its versatility in various conditions. Our study addresses the Flying Robots Trial League challenge, which emulates mapping and inspection tasks in offshore platforms.

关键词： Visualization Offshore installations Navigation Color Inspection Autonomous aerial vehicles Aircraft Drones Aerospace control

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Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts

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Advanced Science 2025年第0期 e2417003页

作者： Jin, Yifu He, Fei Rathore, Haad Sun, Yingchu Zhang, Jia-ao Li, Xinyu Yin, Rongkang Zhu, Hanlin Xie, Chong Luan, Lan Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Neuroengineering Initiative Rice University HoustonTX77005 United States Applied Physics Program Rice University HoustonTX77005 United States Department of Bioengineering Rice University HoustonTX77005 United States

Microinfarcts, the "invisible lesions", are prevalent in aged and injured brains and associated with cognitive impairments, yet their neurophysiological impact remains largely unknown. Using a multimodal chronic neural platform that combines functional microvasculature imaging with spatially resolved neural recording, the neurovascular effect of a single microinfarct is investigated. Unlike larger strokes, microinfarcts induced only temporary suppression of neural activity with minimal cell death, with recovery paralleling vasculature remodeling at the infarct core. Neural activity is more severely suppressed at the shallower cortical layer despite milder vascular damage compared to deeper layers, and the excitability of fast-spiking interneurons attenuation is accompanied by heightened bursting of regular spiking neurons. Spike phase locking at the low-gamma band is disrupted, indicating a lasting impairment of long-range assembly communication. These results highlight the subtle yet significant neurovascular disruptions of a single microinfarct. © 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH.

关键词： Flexible electronics

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Unavoidable multilevel biaxial symmetry breaking in chiral hybrid liquid crystals

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Physical Review E 2025年第4期111卷 045410-045410页

作者： Jin-Sheng Wu Marina Torres Lázaro Souvik Ghosh Haridas Mundoor Henricus H. Wensink Ivan I. Smalyukh Department of Physics and Chemical Physics Program University of Colorado Boulder Colorado 80309 USA Laboratoire de Physique des Solides–UMR 8502 Université Paris-Saclay and CNRS 91405 Orsay France International Institute for Sustainability with Knotted Chiral Meta Matter Hiroshima University Higashihiroshima Japan Department of Electrical Computer and Energy Engineering Materials Science and Engineering Program and Soft Materials Research Center University of Colorado Boulder Colorado 80309 USA Renewable and Sustainable Energy Institute National Renewable Energy Laboratory and University of Colorado Boulder Colorado 80309 USA

Chiral nematic or cholesteric liquid crystals (LCs) are fluid mesophases with long-ranged orientational order featuring a quasilayered periodicity imparted by a helical director configuration but lacking long-range positional order. Doping molecular cholesteric LCs with strongly anisotropic uniaxial colloidal particles adds another level of complexity because of the interplay between weak surface-anchoring boundary conditions and bulk-based elastic distortions near the particle-LC interface. Using cylindrical colloidal disks and rods with different geometric shapes and surface conditions, we demonstrate that these colloidal inclusions generically exhibit biaxial orientational probability distributions which may impart anomalously strong local biaxiality onto the hybrid cholesteric LC structure. Unlike nonchiral hybrid molecular-colloidal LCs, where biaxial order emerges only at critical colloid volume fractions exceeding some uniaxial-biaxial transition value, the orientational probability of the colloidal inclusions immersed in chiral nematic hosts is unambiguously biaxial even at infinite dilution. We demonstrate that the colloids induce local biaxial perturbations within the molecular orientational order of the LC host medium which strongly enhances the weak but native biaxial order of chiral nematic LC induced by the chiral symmetry breaking of the director field. With the help of analytical modeling and computer simulations based on the Landau–de Gennes free energy of the host LC around the colloids, we rationalize the observed multilevel biaxial order and conclude that it is not only unavoidable but also strongly enhanced compared to both achiral hybrid LCs and purely molecular cholesteric LCs.

关键词： Cholesteric liquid crystals

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Bayesian Inference for Non-Synchronously Observed Diffusions

arXiv

引用

arXiv 2025年

作者： Jasra, Ajay Kamatani, Kengo Wu, Amin School of Data Science The Chinese University of Hong Kong Shenzhen Shenzhen China Institute of Statistical Mathematics Tokyo190-0014 Japan Statistics Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia

We consider the problem of Bayesian inference for bi-variate data observed in time but with observation times which occur non-synchronously. In particular, this occurs in a wide variety of applications in finance, such as high-frequency trading or crude oil futures trading. We adopt a diffusion model for the data and formulate a Bayesian model with priors on unknown parameters along with a latent representation for the the so-called missing data. We then consider computational methodology to fit the model using Markov chain Monte Carlo (MCMC). We have to resort to time-discretization methods as the complete data likelihood is intractable and this can cause considerable issues for MCMC when the data are observed in low frequencies. In a high frequency observation frequencies we present a simple particle MCMC method based on an Euler–Maruyama time discretization, which can be enhanced using multilevel Monte Carlo (MLMC). In the low frequency observation regime we introduce a novel bridging representation of the posterior in continuous time to deal with the issues of MCMC in this case. This representation is discretized and fitted using MCMC and MLMC. We apply our methodology to real and simulated data to establish the efficacy of our methodology. © 2025, CC BY.

关键词： Crude oil

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Dynamics of COVID-19 Misinformation: An Analysis of Conspiracy Theories, Fake Remedies, and False Reports

arXiv

引用

arXiv 2025年

作者： Thakur, Nirmalya Shao, Mingchen Knieling, Victoria Su, Vanessa Bian, Andrew Jeong, Hongseok Department of Electrical Engineering and Computer Science South Dakota School of Mines and Technology Rapid CitySD57701 United States Department of Computer Science Emory University AtlantaGA30322 United States Program in Linguistics Emory University AtlantaGA30322 United States Goizueta Business School Emory University AtlantaGA30322 United States

This paper makes four scientific contributions to the area of misinformation detection and analysis on digital platforms, with a specific focus on investigating how conspiracy theories, fake remedies, and false reports emerge, propagate, and shape public perceptions in the context of COVID-19. A dataset of 5,614 posts on the internet that contained misinformation about COVID-19 was used for this study. These posts were published in 2020 on 427 online sources (such as social media platforms, news channels, and online blogs) from 193 countries and in 49 languages. First, this paper presents a structured, three-tier analytical framework that investigates how multiple motives - including fear, politics, and profit - can lead to a misleading claim. Second, it emphasizes the importance of narrative structures, systematically identifying and quantifying the thematic elements that drive conspiracy theories, fake remedies, and false reports. Third, it presents a comprehensive analysis of different sources of misinformation, highlighting the varied roles played by individuals, state-based organizations, media outlets, and other sources. Finally, it discusses multiple potential implications of these findings for public policy and health communication, illustrating how insights gained from motive, narrative, and source analyses can guide more targeted interventions in the context of misinformation detection on digital platforms. © 2025, CC BY.

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The growing memristor industry

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Nature 2025年第8059期640卷 613-622页

作者： Lanza, Mario Pazos, Sebastian Aguirre, Fernando Sebastian, Abu Le Gallo, Manuel Alam, Syed M. Ikegawa, Sumio Yang, J. Joshua Vianello, Elisa Chang, Meng-Fan Molas, Gabriel Naveh, Ishai Ielmini, Daniele Liu, Ming Roldan, Juan B. Department of Materials Science and Engineering National University of Singapore Singapore Singapore Institute for Functional Intelligent Materials National University of Singapore Singapore Singapore Centre for Advanced 2D Materials (CA2DM) National University of Singapore Singapore Singapore Materials Science and Engineering Program Physical Science and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia Intrinsic Semiconductor Technologies London United Kingdom IBM Research – Zurich Rüschlikon Switzerland Everspin Technologies Chandler AZ United States Department of Electrical and Computer Engineering University of Southern California Los Angeles CA United States CEA-Leti Université Grenoble Alpes Grenoble France Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan Weebit Nano Hod Hasharon Israel Dipartimento di Elettronica Informazione e Bioingegneria (DEIB) Politecnico di Milano and *** Milano Italy Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing China Departamento de Electrónica y Tecnología de Computadores Universidad de Granada Facultad de Ciencias Granada Spain

The semiconductor industry is experiencing an accelerated transformation to overcome the scaling limits of the transistor and to adapt to new requirements in terms of data storage and computation, especially driven by artificial intelligence applications and the Internet of Things. In this process, new materials, devices, integration strategies and system architectures are being developed and optimized. Among them, memristive devices and circuits—memristors are two-terminal memory devices that can also mimic some basic bioelectronic functions—offer a potential approach to create more compact, energy-efficient or better-performing systems. The memristor industry is growing quickly, raising abundant capital investment, creating new jobs and placing advanced products in the market. Here we analyse the status and prospects of the memristor industry, focusing on memristor-based products that are already commercially available, prototypes with a high technological readiness level that might affect the market in the near future, and discuss obstacles and pathways to their implementation. © Springer Nature Limited 2025.

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