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Ultrasound Stimulation Potentiates Management of Diabetic Hyperglycemia

Ultrasound in Medicine and Biology 2023年第5期49卷 1259-1267页

作者： Chang, Chia-Hsuan Fan, Kang-Chih Cheng, Yuan-Pin Chen, Jung-Chih Chen, Gin-Shin Graduate Degree Program of the College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu City Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County Taiwan Division of Endocrinology and Metabolism Department of Internal Medicine National Taiwan University Hospital Hsinchu Branch Hsinchu City Taiwan Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei City Taiwan Electronic Systems Research Division National Chung-Shan Institute of Technology Taoyuan City Taiwan Institute of Biomedical Engineering National Yang Ming Chiao Tung University Hsinchu City Taiwan Department of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu City Taiwan Catholic Mercy Hospital Catholic Mercy Medical Foundation Hsinchu County Taiwan Medical Device Innovation & Translation Center National Yang Ming Chiao Tung University Hsinchu City Taiwan

Objective: Glucose homeostasis is the only way to manage diabetic progression as all medications used do not cure diabetes. This study was aimed at verifying the feasibility of lowering glucose with non-invasive ultrasonic stimulation. Methods: The ultrasonic device was homemade and controlled via a mobile application on the smartphone. Diabetes was induced in Sprague–Dawley rats through high-fat diets followed by streptozotocin injection. The treated acupoint CV12 was at the middle of the xiphoid and umbilicus of the diabetic rats. Parameters of ultrasonic stimulation were an operating frequency of 1 MHz, pulse repetition frequency of 15 Hz, duty cycle of 10% and sonication time of 30 min for a single treatment. Discussion: The diabetic rats exhibited a significant decrease of 11.5% ± 3.6% in blood glucose in 5 min of ultrasonic stimulation (p © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Glucose

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Solid State Electrolyte to Enable Structural Supercapacitors

Solid State Electrolyte to Enable Structural Supercapacitors

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IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS)

作者： Nandu Koripally Lulu Yao Jason D. Azoulay Tse Nga Ng Department of Electrical and Computer Engineering University of California San Diego La Jolla CA USA Materials Science Engineering Program University of California San Diego La Jolla CA USA Chemisty Department Georgia Institute of Technology Atlanta GA USA

ISBN: (数字)9798350383263

ISBN: (纸本)9798350383270

Supercapacitors are known for longer cycle life and faster charging rate compared to batteries. However, the energy density of supercapacitors requires improvement to expand their application space. To raise the energy density of structural supercapacitors, this work demonstrates a low resistance and mechanically strong solid-state electrolyte.

关键词： Resistance Supercapacitors Electrolytes Sensor systems Sensors Batteries

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Distributed 3D-Map Matching and Merging on Resource-Limited Platforms Using Tomographic Features

Distributed 3D-Map Matching and Merging on Resource-Limited ...

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European Conference on Mobile Robots (ECMR)

作者： Halil Utku Unlu Anthony Tzes Prashanth Krishnamurthy Farshad Khorrami Electrical & Computer Engineering Department New York University Brooklyn NY USA Electrical Engineering Program New York University Abu Dhabi Abu Dhabi UAE Center for Artificial Intelligence and Robotics New York University Abu Dhabi Abu Dhabi UAE

A fast, robust, resource-efficient, and distributed 3D map matching and merging algorithm utilizing extracted tomographic features is studied. Instead of depending on 3D features and descriptors, 2D features are extracted from 2D projections of horizontal sections of gravity-aligned local maps and matched with slices from the other map at different height differences, enabling the estimation of four degrees of freedom. The proposed algorithm is observed to provide order-of-magnitude improvements in memory and time efficiency over state-of-the-art feature extraction and registration pipelines, rendering it useful for near real-time map merging tasks in resource-limited platforms (e.g. UAVs).

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UAV- Navigation Using Map Slicing and Safe Path Computation

UAV- Navigation Using Map Slicing and Safe Path Computation

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International Conference on Autonomous Robots and Agents, ICARA

作者： Halil Utku Unlu Dimitris Chaikalis Athanasios Tsoukalas Anthony Tzes Electrical & Computer Engineering Department New York University Brooklyn NY USA Electrical Engineering Program New York University Abu Dhabi Abu Dhabi UAE Center for Artificial Intelligence and Robotics New York University Abu Dhabi Abu Dhabi UAE

This paper is concerned with the safe path planning of a drone while exploring an unknown space. The drone is localized by fusing measurements from sensors including an IMU, RGB-D sensor, and an optical flow system, while executing an RTAB-Map SLAM algorithm. The 3D-occupancy Octomap is generated online and a slicing algorithm is employed to compute 2D-maps. The maps' traversible coordinates are identified and used as potential points for the drone intermediate navigation to the destination. The final segment corresponds to a shortest Chebyshev-length path between all frontier pixels and the endpoint over the unexplored map region. The drone's path is computed using a skeletal path between the identified map boundaries so that the drone moves from its current location through the free map coordinates to the destination point. Simulation studies using within the interior of an apartment indicate the efficiency and effectiveness of the proposed method.

关键词： Simultaneous localization and mapping Target tracking Navigation Robot kinematics Chebyshev approximation Sensor systems Space exploration

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Joint Source Decomposition of Concurrent EEG-FMRI Data in Epilepsy and Control Groups

Joint Source Decomposition of Concurrent EEG-FMRI Data in Ep...

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IEEE International Symposium on Biomedical Imaging

作者： J. Mason Harding Haatef Pourmotabbed Yamin Li Kimberly Rogge-Obando Kate Wang Sarah E. Goodale Shiyu Wang Camden Bibro Bergen Allee Caroline Martin Victoria L. Morgan Dario J. Englot Catie Chang Department of Electrical and Computer Engineering Vanderbilt University Department of Biomedical Engineering Vanderbilt University Department of Computer Science Vanderbilt University Neuroscience Graduate Program Vanderbilt University Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Department of Neurological Surgery Vanderbilt University Medical Center Department of Radiology Vanderbilt University Medical Center

ISBN: (数字)9798331520526

ISBN: (纸本)9798331520533

EEG and fMRI are complementary, noninvasive technologies for investigating human brain function. These modalities have been used to uncover large-scale functional networks and their disruptions in clinical populations. Given the high temporal resolution of EEG and high spatial resolution of fMRI, integrating these modalities can provide a more holistic understanding of brain activity. This work explores a multimodal source decomposition technique for extracting shared modes of temporal variation between fMRI BOLD signals and EEG spectral power fluctuations in the resting state. The resulting components are then compared between patients with focal epilepsy and controls, revealing multimodal network differences between groups.

关键词： Neuroimaging Brain Fluctuations Epilepsy Functional magnetic resonance imaging Electroencephalography Pattern recognition Hemodynamics Spatial resolution Signal resolution

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Abnormal skeletal muscle and myocardial vasoreactivity manifests prior to heart failure in a diabetic cardiomyopathy rat model

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Discover medicine 2025年第1期2卷 2页

作者： Sadi Loai Hai-Ling Margaret Cheng Institute of Biomedical Engineering University of Toronto Toronto ON Canada. Translational Biology & Engineering Program Ted Rogers Centre for Heart Research 661 University Avenue Room 1433 Toronto ON M5G 1M1 Canada. The Edward S. Rogers Sr. Department of Electrical and Computer Engineering University of Toronto Toronto ON Canada.

Background:Microvascular dysfunction (MVD) is a recognized sign of disease in heart failure progression. Intact blood vessels exhibit abnormal vasoreactivity in early stage, subsequently deteriorating to rarefaction and reduced perfusion. In managing heart failure with preserved ejection fraction (HFpEF), earlier diagnosis is key to improving management. In this study, we applied a steady-state blood-pool magnetic resonance imaging (MRI) method to investigate if it can sensitively detect abnormal leg muscle vasoreactivity, a sign of MVD, posited to manifest before structural and functional cardiac changes emerge in a diabetes model of HFpEF. Methods:Male and female Sprague-Dawley rats were maintained on either a high-fat, high-sugar diet or a control diet for 6 months after the induction of diabetes ( = 5 per group). Beginning at month 1 or 2 post-diabetes and every 2 months thereafter, rats underwent steady-state blood-pool MRI to assess vasoreactivity in the heart or skeletal muscle, respectively. A T1-reducing blood-pool agent was administered and the T1 relaxation time dynamically measured as animals breathed in elevated CO levels to modulate vessels. Results:In male rats, the normally unresponsive heart to 10% CO revealed a pro-vasoconstriction response beginning at 5 months post-diabetes. Abnormal leg skeletal muscle vasoreactivity appeared even earlier, at 2 months: the usual vasodilatory response to 5% CO was interrupted with periods of vasoconstriction in diseased rats. In female rats, differences were observed between healthy and diseased animals only in the first 2 months post-diabetes and not later. In the heart, vasodilation to 10% CO seen in healthy females was abolished in diabetic females. In skeletal muscle, 5% CO was suboptimal in inducing reproducible vasoreactivity, but young diabetic females responded by vasodilation only. Conclusions:Abnormal vasoreactivity presented earlier than overt functional changes in both heart and skeletal muscle in dia

关键词： Blood-pool T1 imaging Diabetes Gadofosveset Heart Hypercapnia Microvascular dysfunction Skeletal muscle Vasoreactivity

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Analysis of DFIG differential protection based on Park transform

Analysis of DFIG differential protection based on Park trans...

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2021 IEEE PES Innovative Smart Grid Technologies Conference - Latin America, ISGT Latin America 2021

作者： De Queiroz, Janailson Maciel Barros, Luciano Sales Barbosa, Daniel Graduate Program on Electrical and Computer Engineering Federal Un. of Rio Grande Do Norte Natal Brazil Federal Un. of Paraíba João Department of Computer Systems Pessoa Brazil

ISBN: (纸本)9781665444217

In recent years, the use of wind energy in the world has grown. Consequently, the need for studies related to the impact of wind turbines on the electrical system has increased including protection of them and associated equipment. For DFIG-based wind turbines, differential protection has recently been proposed, however, there are few studies on this type of application and in this paper it proposes criteria in the decision-making using the Park transform in which, in addition to the restriction current, voltage level and current direction at the stator terminals are considered. In a DFIG operating with 1.51 MW tests of faults internal and external to the protection zone were made, of the single-phase and three-phase type with various levels of voltage drops. Interturn faults in the rotor and stator of the machine were also tested with various levels of defects. So, with the proper definition of the operating logic, it was possible to show the effectiveness of the protection. © 2021 IEEE.

关键词： Wind power

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Tunable Source of Quantum-Correlated Photons with Integrated Pump Rejection in a Silicon CMOS Platform

Tunable Source of Quantum-Correlated Photons with Integrated...

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Frontiers in Optics + Laser Science 2021, FiO+LS 2021 - Part of Frontiers in Optics, FiO 2021

作者： Fargas Cabanillas, Josep M. Kramnik, Danielius Ramesh, Anirudh Gentry, Cale M. Stojanović, Vladimir Kumar, Prem Popović, Miloš A. Department of Electrical and Computer Engineering Photonics Center Boston University BostonMA02215 United States Department of Electrical Engineering and Computer Science UC Berkeley BerkeleyCA94720 United States Graduate Program in Applied Physics Northwestern University EvanstonIL60208 United States Department of Electrical Computer and Energy Engineering University of Colorado BoulderCO80309 United States Center for Photonic Communication and Computing Dept. of Electrical and Computer Eng. Northwestern University EvanstonIL60208 United States

ISBN: (纸本)9781557528209

A wavelength-tunable, silicon photon-pair source based on spontaneous four-wave mixing, integrated with a pump rejection filter in a single, flip-chip packaged CMOS chip, is demonstrated with a coincidence-to-accidentals ratio of 9.1 with no off-chip pump filtering. Frontiers in Optics / Laser Science © Optica Publishing Group 2021.

关键词： CMOS integrated circuits

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Phortex: Physically-Informed Operational Robotic Trajectories for Scientific Expeditions

IEEE Transactions on Field Robotics

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IEEE Transactions on Field Robotics 2024年 1卷 446-475页

作者： Victoria L. Preston Genevieve E. Flaspohler John W. Fisher Anna P. M. Michel Nicholas Roy Applied Ocean Physics and Engineering Massachusetts Institute of Technology and Woods Hole Oceanographic Institution Joint Program Cambridge MA USA Olin College of Engineering Needham MA USA Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA Rhiza Research Oakland CA USA Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge MA USA Applied Ocean Physics and Engineering Woods Hole Oceanographic Institution Woods Hole MA USA

Mobile robots are increasingly used to collect valuable in situ samples during scientific expeditions. However, many phenomena of scientific interest—deep-sea hydrothermal plumes, algal blooms, warm-core eddies, and lava flows—are spatiotemporal distributions that evolve on spatial and temporal scales that complicate sample collection. Here, we consider the problem of charting the space-time dynamics of deep-sea hydrothermal plumes with the state-of-the-art autonomous underwater vehicle (AUV) Sentry. In the hydrothermal plume charting problem, the plume state is driven by complicated and unobserved dynamics in the deep sea. To effectively sample the moving plume, an autonomy system must infer plume dynamics from sparse, point observations, while respecting operational constraints of AUV Sentry that restrict the set of possible trajectories to nonadaptive, uniform-coverage patterns. We frame the plume charting problem as a sequential decision-making problem, and formulate a mission planner Phortex: physically-informed operational robotic trajectories for expeditions that strategically designs full mission trajectories for Sentry, where each mission plan is informed by the observations of the last. Phortex is composed of a trajectory optimizer that maximizes expected samples collected within a moving plume, and Phumes: physically-informed uncertainty models for environment spatiotemporality, a modeling framework that leverages an embedded simulator of idealized plume physics as an inductive bias to enable dynamics learning from extreme partial observations and few Sentry deployments. In both simulation and in field trials at a hydrothermal site in the Gulf of California, we demonstrate that Sentry using Phortex learns to track a moving hydrothermal plume and gather samples that significantly improve upon baseline spatial and temporal diversity for use in downstream science tasks.

关键词： Trajectory Robots Robot sensing systems Vehicle dynamics Spatiotemporal phenomena Predictive models Decision making Uncertainty Data models

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Temperature Dependent Anomalous Threshold Voltage Modulation of a-IGZO TFT by Incorporating Variant Gate Stresses

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ECS Journal of Solid State Science and Technology 2024年第6期13卷 065008-065008页

作者： Aslam, Muhammad Chang, Shu-Wei Chen, Yi-Ho Lee, Yao-Jen Li, Yiming Lee, Wen-Hsi Electrical Engineering and Computer Science International Graduate Program National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Department of Electrical Engineering National Cheng Kung University Tainan 701401 Taiwan Graduate Degree Program of College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Institute of Pioneer Semiconductor Innovation Industry Academic Innovation School National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan

Amorphous indium gallium zinc oxide (a-IGZO) has recently made significant advancement as a key material for electronic component design owing to its compatibility with complementary metal oxide semiconductor technologies. A comprehensive analysis of reliability-related issues is required to determine the true potential of a-IGZO-based devices for next-generation electronics applications. To address this objective, we electrically characterize scaled-channel a-IGZO thin film transistors (TFTs) under positive bias (temperature) stress (PB(T)S). Both PBS and PBTS are characterized by positive and negative V_th shift, respectively, during the various gate stresses. In particular, the negative V_th shift is explained by the generation of donor-like traps stimulated by ionization of oxygen vacancy/hydrogen at elevated temperature. The TFTs exhibit relatively decent stability during the PBS operation. The analysis of devices with variant channel dimensions implies that long-channel devices exhibit relatively higher stability and performance compared to the short-channel ones. We also observe that the V_th can be controllably adjusted by employing the top gate (TG) with bottom gate sweep. Moreover, the stress-induced partial recovery mechanism is experimentally observed owing to detrapping of charges. Generally, the reported results infer a perceptive understanding of scaled-channel a-IGZO-TFTs which helps with shaping performance-enhancement strategies. © 2024 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited

关键词： amorphous IGZO-TFT electrical instabilities hydrogen-impact scaling impact on reliability

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