检索结果-内蒙古大学图书馆

PD-L1 Aptamer-Functionalized Metal–Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety

引用

Angewandte Chemie 2022年第5期135卷

作者： Dr. Jingfang Zhang Dr. Wenzhe Li Dr. Yafei Qi Dr. Guorong Wang Prof. Lele Li Prof. Zhengyu Jin Prof. Jie Tian Prof. Yang Du Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing 100083 China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191 China CAS Key Laboratory of Molecular Imaging Beijing Key Laboratory of Molecular Imaging the State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 China Department of Radiology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Medicine Beihang University Beijing 100191 China

Immune checkpoint blockade has become a paradigm-shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti-PD-L1 antibody (α-PD-L1), often shows unsatisfactory immune responses and lead to severe immune-related adverse effects (irAEs). Herein, we develop a PD-L1 aptamer-based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal–organic framework nanoparticle core and a dense shell of aptPD-L1 (denoted as M@O-A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O-A shows scarcely any systemic immunotoxicity in a clinical irAEs-mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo-immunotherapy against cancer with enhanced safety.

关键词： DNA Nanotechnology Immunotherapy Metal–Organic Frameworks PD-L1 Aptamer Spherical Nucleic Acids (SNAs)

来源：评论

学校读者我要写书评

暂无评论

Secure analysis of dynamic networks under pinning attacks against synchronization

arXiv

引用

arXiv 2019年

作者： Li, Yuzhe Shi, Dawei Chen, Tongwen State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Shenyang110004 State Key Laboratory of Intelligent Control and Decision of Complex Systems School of Automation Beijing Institute of Technology Beijing100081 China Department of Electrical and Computer Engineering University of Alberta EdmontonABT6G 1H9 Canada

In this paper, we first consider a pinning node selection and control gain co-design problem for complex networks. A necessary and sufficient condition for the synchronization of the pinning controlled networks at a homogeneous state is provided. A quantitative model is built to describe the pinning costs and to formulate the pinning node selection and control gain design problem for different scenarios into the corresponding optimization problems. Algorithms to solve these problems efficiently are presented. Based on the developed results, we take the existence of a malicious attacker into consideration and a resource allocation model for the defender and the malicious attacker is described. We set up a leader-follower Stackelberg game framework to study the behaviour of both sides and the equilibrium of this security game is investigated. Numerical examples and simulations are presented to demonstrate the main results. Copyright © 2019, The Authors. All rights reserved.

关键词： complex networks

来源：评论

学校读者我要写书评

暂无评论

Current controller Based on Recurrent Neural Network for Grid-Connected Converter

Current Controller Based on Recurrent Neural Network for Gri...

引用

Chinese control Conference (CCC)

作者： Xuefen Wang Hongbin Wang Qingyi Wang Min Ding Quan Yin Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan China State Grid Corporation of China Wuhan China School of Automation Huazhong University of science and technology Wuhan China

Three-phase grid-connected converters are widely used in renewable and electric power system applications. Due to system nonlinearity and time-variant characteristic, there are limitations in standard decoupled d-q vector control mechanism. To mitigate these limitations, a RNN vector controller trained with Levenberg-Marquardt and FATT(Forward accumulation through time) algorithm is designed. The simulation is researched by using MATLAB software, and the results show that training neural-network algorithm is effective and the system using RNN vector control method outperforms the system using conventional PI control method under low sampling rate conditions.

关键词： Mathematical model Training Artificial neural networks Recurrent neural networks Voltage control Convergence

来源：评论

学校读者我要写书评

暂无评论

Review on Teacher's Online Practice in Community

Review on Teacher's Online Practice in Community

引用

IEEE International Conference on Service Operations and Logistics, and Informatics, SOLI

作者： Xinzhu Wang Xiaoyan Gong Xiwei Liu Yan Yan Nan Zhang Jie Luo Faculty of Education Beijing Normal University Beijing China Institute of Smart Education Qingdao Academy of Intelligent Industries Qingdao China The State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing China Chinese Association of Automation Beijing China The State Key Laboratory of Software Development Environment Beihang University Beijing China

Teacher's Online Practice in Community (TOPIC) is an informal and practical online learning community that improves teachers' professional development. Domestic researches on TOPIC have begun to take shape. By sorting out relevant literature retrieved from China National Knowledge Infrastructure (CNKI), this article summarizes research topics such as knowledge management, teacher professional development, and community management and summarizes qualitative and quantitative research methods commonly used by domestic researches. This article finally puts forward some limitations of current researches in this field and forecasts the possible future research directions.

关键词： Knowledge transfer Training Reflection Organizations Focusing

来源：评论

学校读者我要写书评

暂无评论

Analysis and Maximum Efficiency Design for Wireless Power Transfer systems

Analysis and Maximum Efficiency Design for Wireless Power Tr...

引用

Chinese control Conference

作者： Bing Cao Hongbin Wang Qingyi Wang Min Ding Quan Yin Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan China State Grid Corporation of China Wuhan China School of Automation Huazhong University of science and technology Wuhan China

How to stabilize the output voltage while ensuring the maximum charging efficiency of the system is a problem faced by the development of wireless power transfer(WPT). Especially in the dynamic environment, the change of system coupling coefficient or load resistance will have a huge impact on the system. In this paper, a two-stage DC-DC converter control mode is used to control the system with the goal of dynamic charging demand. Among them, the system achieves impedance matching through the receiver DC-DC converter to ensure the transmission efficiency of the system, and in order to match the impedance, the voltage and current information in the coil is used to calculate the coupling coefficient, then, the coupling coefficient can be used to achieve maximum efficiency. The system output voltage is stabilized by using the transmitter DC-DC converter. The simulation experiment shows that the control mode can stabilize the output voltage well, and is more efficient than the single receiver closed loop control(SRCLP) system.

关键词： Resistance Couplings DC-DC power converters control systems Voltage control Receivers Frequency control

来源：评论

学校读者我要写书评

暂无评论

Analysis of Influencing Factors on Carbon Monoxide Utilization Rate of Blast Furnace Based on Multi-Timescale Characteristics 36

Analysis of Influencing Factors on Carbon Monoxide Utilizati...

引用

第36届中国控制会议

作者： Jianqi An Yuwan Yang Min Wu Takao Terano School of Automation China University of Geosciences Hubei key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Department of Computer Science School of ComputingTokyo Institute of Technology

ISBN: (纸本)9781538629185

In the blast furnace,due to the different changing frequency of different operations,and the different reaction time of gas,liquid and solid materials,there exists multi-timescale characteristics in the iron-making ***,not enough attention has been paid to this characteristic,most of the analyses on the blast furnace state before are under a fixed time ***,this paper makes a analysis of influencing factors on carbon monoxide utilization rate of blast furnace based on multi-timescale ***,the factors that affect the carbon monoxide utilization rate are analyzed from different time ***,in the short time scale,the individual influencing time scale of the permeability index,total pressure difference and top temperature is found by the support vector machine（SVM） *** in the long time scale,the influencing time scale of burdening is *** the validity of each model is verified by the field data of the blast furnace.

关键词： Multi-time scales Carbon monoxide utilization Support vector machine Blast furnace

来源：评论

学校读者我要写书评

暂无评论

Consensus of discrete-time second-order multi-agent systems with delayed and noisy measurements under balanced digraphs 29

Consensus of discrete-time second-order multi-agent systems ...

引用

第29届中国控制与决策会议

作者： Xiaofeng Zong Tao Li School of Automation China University of Geosciences Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Department of Mathematics East China Normal University Shanghai Key Laboratory of Power Station Automation Technology

ISBN: (纸本)9781509046584

This paper studies mean square and almost sure consensus of discrete-time second-order multi-agent systems with time-delays and multiplicative noises in the information exchange with *** using the stochastic stability theorem of discrete-time stochastic delay systems,we find sufficient conditions for mean square and almost sure consensus explicitly related to the network and control *** is shown that if the network graph is balanced and strongly connected,then the weighted-average type control protocol can be properly designed to ensure mean square and almost sure consensus for any given time-delays and noise intensity coefficients.

关键词： Second-order multi-agent system Multiplicative noise Time-delay Consensus

来源：评论

学校读者我要写书评

暂无评论

D-S Data Fusion and Efficiency Evaluation for Drilling Process

D-S Data Fusion and Efficiency Evaluation for Drilling Proce...

引用

Chinese control Conference (CCC)

作者： Haipeng Fan Xuzhi Lai Min Wu Hubei Key Labortory of Advanced Control and Intelligent Automation for Complex System Wuhan P. R. China

Due to the unknown complexity of geological conditions, drilling operations are difficult to carry out. It is of great value to implement drilling measurement while drilling. However, due to the poor working conditions underground, information transmission for the drilling process may be affected, which leads to the loss and conflicts of the data. It is necessary to use effective method to deal with the data and to make evaluation for the drilling process. In this paper, we present a D-S data fusion method and use fused data to form a framework to evaluate efficiency for the drilling process. We can efficiently analyze the entire drilling process and optimize the drilling parameters based on this framework.

关键词： Drilling machines Data integration Torque Pollution measurement Wireless sensor networks Sensor fusion

来源：评论

学校读者我要写书评

暂无评论

Robust Iterative Learning control for Alloy Batch Weighing Process in Refining Furnace 36

Robust Iterative Learning Control for Alloy Batch Weighing P...

引用

第36届中国控制会议

作者： Yibo Huang Jianqi An Yong He Min Wu Takao Terano School of Automation China University of Geosciences Hubei key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Department of Computer Science School of ComputingTokyo Institute of Technology

ISBN: (纸本)9781538629185

This paper proposes a robust iterative learning control method for the refining furnace alloy weighing process to solve the problem of the poor control accuracy and stability caused by the changing of alloy properties and the frequency of the vibration feeder. First, a two dimensional（2D） weighing model was established based on the analysis of the dynamic characteristics of alloy weighing process. Second, a control scheme is proposed for the 2D model of alloy weighing ***, a robust iterative learning controller is developed and a stability condition of the 2D system is derived through linear matrix inequality（LMI） obtained by a 2D Lyapunov-Krasovskii function. Finally, the simulation results show that the proposed method can sufficiently improve the control precision of the alloy weighing process.

关键词： Iterative learning control 2D weighing model Batch process Alloy weighing process Robust control

来源：评论

学校读者我要写书评

暂无评论

Load Frequency control in Power systems via A Sampled-Data controller

Load Frequency Control in Power Systems via A Sampled-Data C...

引用

Chinese control Conference (CCC)

作者： Xing Chen Shang Guau Yong He Lin Jiang China University of Geosciences Wuhan Hubei CN Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan P. R. China University of Liverpool Liverpool UK

In modern power systems, load frequency control (LFC) scheme usually operates in the discrete mode, while the most existing LFC schemes are designed in the continuous mode, such that those LFC schemes do not work usually in their best manner in practice. In this paper, a method of state-feedback controller design of load frequency control (LFC) for one-area system is discussed in continuous-discrete mode via sampled-data control scheme. At first, the model of LFC is constructed in continuous-discrete mode by using the input delay method. Then, a new method is present to design a state-feedback controller. Finally, a case study is given to show the effectiveness and the benefits of the proposed method.

关键词： Delays Symmetric matrices Frequency control Generators control systems Power system dynamics

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：