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PD-L1 Aptamer-Functionalized Metal–Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety

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Angewandte Chemie 2022年第5期135卷

作者： Dr. Jingfang Zhang Dr. Wenzhe Li Dr. Yafei Qi Dr. Guorong Wang Prof. Lele Li Prof. Zhengyu Jin Prof. Jie Tian Prof. Yang Du Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing 100083 China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191 China CAS Key Laboratory of Molecular Imaging Beijing Key Laboratory of Molecular Imaging the State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 China Department of Radiology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Medicine Beihang University Beijing 100191 China

Immune checkpoint blockade has become a paradigm-shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti-PD-L1 antibody (α-PD-L1), often shows unsatisfactory immune responses and lead to severe immune-related adverse effects (irAEs). Herein, we develop a PD-L1 aptamer-based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal–organic framework nanoparticle core and a dense shell of aptPD-L1 (denoted as M@O-A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O-A shows scarcely any systemic immunotoxicity in a clinical irAEs-mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo-immunotherapy against cancer with enhanced safety.

关键词： DNA Nanotechnology Immunotherapy Metal–Organic Frameworks PD-L1 Aptamer Spherical Nucleic Acids (SNAs)

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Design of lower extremity rehabilitation robots with magnetorheological dampers and wire-driven system

Design of lower extremity rehabilitation robots with magneto...

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2018 IEEE International Conference on Information and Automation, ICIA 2018

作者： Xu, Jiajun Xu, Linsen Li, Youfu Liu, Jinfu Li, Xiaohu Lu, Linlin University of Science and Technology of China No. 96 Jinzhai Road Hefei Anhui Province China City University of Hong Tat Chee Avenue Kowloon Hong Kong Hefei Institutes of Physical Science CAS Changzhou China Key Laboratory of Biomimetic Sensing and Advanced Robot Technology Anhui Province China

ISBN: (纸本)9781538680698

Lower extremity rehabilitation robots play significantly important role in rehabilitation medicine, which aims to bring back the capabilities of patients' lower limbs because of illness, injury and disease. However, controllability, energy consumption and control precision of the robot motion remain difficult to solve out. In many cases, electric motors are required to have high output torque to move the entire machine legs along with human legs, while extravagant motor torque may lead to excessive bending, fracture or other secondary damages. And the motors would generate the braking torque to prevent this at the cost of consuming large armature current. Controllable braking torque also counts while patients' active anti-resistance training. Smart materials have provided inspiration and magneto-rheological (MR) fluids vary in rheological behavior with responding to applied magnetic field. Based on the characteristics, magnetorheological dampers (MR dampers) were developed and have realized variable damping resistance according to different magnetic field. Besides, wire-driven system is another guarantee of safety and controllability due to its flexible structure and compliant control. So, with combination of MR dampers and wire-driven system, the lower extremity rehabilitation robot would perform better, more efficiently and more safely. Actually, such robot can hardly be seen in previous related research or publication. In this paper, three kinds of rehabilitation robots with MR dampers and wire-driven system are introduced. They are standing/walking rehabilitation robot with cylindrical dampers, standing/walking rehabilitation robot with discal dampers and sitting/lying rehabilitation robot with discal dampers. Their advantages and drawbacks are also explained. © 2018 IEEE.

关键词： Energy utilization

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Survey on Bioinspired Adhesive Methods and Design and Implementation of A Multi-Mode biomimetic Wall-Climbing robot

Survey on Bioinspired Adhesive Methods and Design and Implem...

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IEEE/ASME (AIM) International Conference on advanced Intelligent Mechatronics

作者： Jiajun Xu Linsen Xu Jinfu Liu Xiaohu Li Xuan Wu School of Engineering Science University of Science and Technology of China Hefei China CAS The Key Laboratory of Biomimetic Sensing and Advanced Robot Technology Changzhou China University of Science and Technology of China Hefei China CAS Hefei Institutes of Physical Science Changzhou China

Wall-climbing robot is an essential branch of robotics, and the adhesive method is the key technology. Nowadays, suction cups, magnets and grippers are three conventional modes for adhering. However, there are many limitations of the traditional methods, which make it difficult for the wall-climbing robots to adapt to most of the complicated environments. Bionics gives us inspiration to solve the limitation problems of conventional wall-climbing robots, and biomimetic wall-climbing robots have become a hot research area. Spiny feet and dry adhesives are two main bioinspired adhesive methods applied into wall-climbing robots, and relevant research status and development situation have been surveyed. In order to improve the adaption of biomimetic wall-climbing robots to both smooth and rough surfaces, we have developed a brand new multi-mode biomimetic wall-climbing robot employing four modes: spiny wheels, adhesive treads, spiny treads and a suction cup, which can switch different modes to conform to different terrains. The robot employs spiny wheels and spiny treads while meeting with rough surfaces and employs adhesive treads while encountering smooth surfaces. And a suction cup is applied all the time for assistive adhesive function. Design and prototype experiment about this robot have been represented.

关键词： Mobile robots Wheels Switches Rough surfaces Surface roughness Foot

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Flexible micro-perforated panels prepared by CNC machining

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IOP Conference Series: Earth and Environmental Science 2019年第4期358卷

作者： Dongyue Xie Xiaoning Tang Ming Hu Deyi Kong Yujie Qian Hefei University of Technology Hefei 230601 China State Key Laboratory Cultivation Base for New Textile Materials and Advanced Processing Technology School of Textile Science and Engineering Wuhan Textile University Wuhan 430200 China State Key Laboratory of Transducer Technology Key Laboratory of Biomimetic Sensing and Advanced Robot Technology of Anhui Province Institute of Intelligent Machines Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei 230031 China IOT Engineering College Hohai University Changzhou 213022 China

With the advantages of light weight, thin thickness and environment friendly, the micro-perforated panel (MPP) has been widely studied for noise reduction. Maa's model pointed out that the MPP could obtain higher sound absorption over broader frequency band when the perforations were reduced to less than 100 μm. However, it is challenging to manufacture MPPs with the aperture of approximate 100 μm, thus its potential application has been restricted. In this study, we used a computer numerical control (CNC) milling machine to process MPP. Four different kinds of raw materials including paperboard, polyethylene terephthalate (PET), polyvinyl chloride (PVC), and polycarbonate (PC) were taken to prepare micro-perforated panels (MPPs). It has been indicated that MPPs with good sound absorption properties were successfully prepared by this facile method.

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RETRACTED ARTICLE: A dynamic simulation of force in the movement of ameba based on COSMOS

RETRACTED ARTICLE: A dynamic simulation of force in the move...

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作者： Chen, Lei Luo, Minzhou Mei, Tao Key Laboratory of Biomimetic Sensing and Advanced Robot Technology Hefei Institute of Intelligent Machines CAS Hefei 230031 China Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei 230026 China

ISBN: (纸本)9780769540467

Imitation amoeba robot entering the space whose nominal size is smaller than itself can complete can perform many tasks inaccessible to other robots or humans such as surveillance, inspection, repair, cleaning, and exploration. Parameterized solid models of amoeba are established by using *** simulation analysis of the movement and the force situation in the movement is completed by using the software of COSMOS. The change of Amoeba entities that based on deformation of the ipmc material in effect ofthe control unit is researched. © 2010 IEEE.

关键词： Computer software

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The research of pulse wave signal denosing based on EMD and ICA

The research of pulse wave signal denosing based on EMD and ...

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3rd International Joint Conference on Computational Sciences and Optimization, CSO 2010: Theoretical Development and Engineering Practice

作者： Zheng, Yingying Zhang, Yongliang Liu, Yanli Key Laboratory of Biomimetic Sensing and Advanced Robot Technology Institute of Intelligent Machines Chinese Academy of Science 230031 China Department of Automation University of Science and Technology of China 230027 China Anhui Institute of Architecture and Industry Hefei 230601 China

ISBN: (纸本)9780769540306

Pulse wave is easily contaminated by noise when being sampled and processed. In order to extract and analyze the useful information involved, the paper presents a novel denoising algorithm based on empirical mode decomposition (EMD) and independent component analysis (ICA).First, the signal is decomposed by EMD ,then a series of intrinsic mode functions (IMFs) and the remainder can be obtained. Second, ICA will be performed to separate independent components from IMFs. At last, these independent components will be used to reconstruct the pulse wave signal. By using the method, we are able to separate noise and estimate desired source signals from pulse wave signal. Experimental results substantiate the strong potential of the proposed method for pulse wave signal noise separation. © 2010 IEEE.

关键词： Empirical mode decomposition

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The research of pulse wave signal denosing based on EMD and ICA

The research of pulse wave signal denosing based on EMD and ...

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The Third International Joint Conference on Computational Science and Optimization(第三届计算科学与优化国际大会 CSO 2010)

作者： Yingying Zheng Yongliang Zhang Yanli Liu Key Laboratory of Biomimetic Sensing and Advanced Robot Technology Institute of Intelligent Machine Anhui institute of Architecture & Industry Hefei 230601 China

关键词： Empirical mode decomposition independent component analysis pulse wave signal

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Predicting Arterial Stiffness from radial Pulse Waveform using support vector machines

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Procedia Engineering 2010年 7卷 458-462页

作者： Yingying Zheng Yongliang Zhang Zuchang Ma Yining Sun Key Laboratory of Biomimetic Sensing and Advanced Robot Technology Institute of Intelligent machines Chinese Academy of Sciences Hefei 230031 China Department of Automation University of Science and Technology of China Hefei 230027 China

Cardiovascular disease (CVD) is a larger cause of mortality in the developed country; hence, the early detection of its onset is vital for effective prevention. Arterial stiffness as measured by radial augmentation index (AIx) has been shown to be an independent predictor of CVD; however, the measurement of AIx is complex and not easily obtained precisely. A new approach based on the implementation of support vector machine (SVM) is presented for classification of radial pulse waveform. The radial pulse signals was decomposed into time-frequency representations using discrete wavelet transform (DWT) and wavelet scale-energy were calculated to represent the signals. The purpose is to predict an optimum classification scheme. The result demonstrated that the wavelet scale-energy are the features which well represent the radial Pulse Waveforms and the SVM trained on these features achieved high classification accuracies.

关键词： Arterial stiffness Support vector machine Discrete wavelet transform Wavelet packet energy entropy

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Performance of optimized TVOCs sensor

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Procedia Engineering 2010年 7卷 392-398页

作者： Fumin Peng Tao Luoa Yupeng Yuan Lingguang Qiu Laboratory of Advanced Porous Materials and College of Chemistry and Chemical Engineering Anhui University Anhui Hefei 230039 China Key Laboratory of Biomimetic Sensing and Advanced Robot Technology Hefei Institute of Intelligent Machines Chinese Academy of Sciences Anhui Hefei 230031 China

In this paper, an improved TVOCs (total volatile organic compounds) sensor construction was studied. Base on this new construction, the optimized flow rate, the responding character and the linear range of detector were studied. The effect of different electrode positions on the signal intensity was tested at different voltages. Compared with traditional PID — axial PID3, the construction of this perpendicular PID could make the sensitivity loss decreased by a factor of 40%. Especially, a newly adopted automatic cleaning technique was tested, which could decrease the drift greatly and make the signal of the detector almost unchanged after two weeks of continuous detection. Due to this new construction, the response time was decreased and the accuracy consequently was improved. When coupled with automatic cleaning technique, labor intensive daily calibration and frequent lamp cleaning were eliminated. The improvements in this new design made the detector more compatible with field uses.

关键词： Photoionization detector Direct-reading and automated cleaning Total volatile organic compounds

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The influence of X-ray wavelength and the simulative human skin and muscle obstruction on the detection of human body-hidden drugs by non-intrusive X-ray diffraction method

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Procedia Engineering 2010年 7卷 195-202页

作者： Bai Sun Minqiang Li Fang Zhang Yu Zhong Daoyang Yu Wei Lu Guoqiang Pan Jinhuai Liu The Key Laboratory of Biomimetic Sensing and Advanced Robot Technology Anhui Province Institute of Intelligent Machines Chinese Academy of Sciences Hefei 230031 PR China National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 PR China

In order to detect the body-hidden drugs non-intrusively and rapidly, the influence of the X-ray wavelength and covering of the simulative skin and muscle on the detection of methamphetamine sample by synchrotron radiation X-ray diffraction (SR-XRD) technique have been investigated. Synchrotron radiation based X-ray with three different wavelengths (1.29 Å, 1.54 Å, 1.80 Å) has been chosen as the X-ray source. The results indicate that the intensities as well as the number of the diffraction peaks of methamphetamine sample covered by simulative muscle decreased with the increasing of the X-ray wavelength from 1.29 Åto 1.80 Å. In addition, the intensities of the diffraction peaks for methamphetamine will be seriously affected by the covered simulative skin or muscle due to the X-ray absorption. Furthermore, the absorption of X-ray by the simulative muscle seems much stronger than that of the simulative skin. Moreover, the specific molecular structure of the methamphetamine sample has been obtained by X-ray diffraction method.

关键词： Drug detection SR-XRD Methamphetamine Molecular structure

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