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Proceedings of the 41st International Conference on Machine Learning

作者： Cong Hua Qianqian Xu Shilong Bao Zhiyong Yang Qingming Huang Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing China and School of Computer Science and Technology University of Chinese Academy of Sciences Beijing China Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing China Institute of Information Engineering Chinese Academy of Sciences Beijing China and School of Cyber Security University of Chinese Academy of Sciences Beijing China School of Computer Science and Technology University of Chinese Academy of Sciences Beijing China School of Computer Science and Technology University of Chinese Academy of Sciences Beijing China and Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing China and Key Laboratory of Big Data Mining and Knowledge Management Chinese Academy of Sciences Beijing China

This paper explores a novel multi-modal alternating learning paradigm pursuing a reconciliation between the exploitation of uni-modal features and the exploration of cross-modal interactions. This is motivated by the fact that current paradigms of multi-modal learning tend to explore multi-modal features simultaneously. The resulting gradient prohibits further exploitation of the features in the weak modality, leading to modality competition, where the dominant modality overpowers the learning process. To address this issue, we study the modality-alternating learning paradigm to achieve reconcilement. Specifically, we propose a new method called ReconBoost to update a fixed modality each time. Herein, the learning objective is dynamically adjusted with a reconcilement regularization against competition with the historical models. By choosing a KL-based reconcilement, we show that the proposed method resembles Friedman's Gradient-Boosting (GB) algorithm, where the updated learner can correct errors made by others and help enhance the overall performance. The major difference with the classic GB is that we only preserve the newest model for each modality to avoid overfitting caused by ensembling strong learners. Furthermore, we propose a memory consolidation scheme and a global rectification scheme to make this strategy more effective. Experiments over six multi-modal benchmarks speak to the efficacy of the method. We release the code at https://***/huacong/ReconBoost.

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Multi-Object Localization and Irrelevant-Semantic Separation for Nuclei Segmentation in Histopathology Images 48

Multi-Object Localization and Irrelevant-Semantic Separation...

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48th IEEE International Conference on Acoustics, Speech and signal processing, ICASSP 2023

作者： Tang, Ya Ye, Xiongjun Li, Xuanya Chen, Zhineng Xiangtan University Key Laboratory of Intelligent Computing and Information Processing Ministry of Education Xiangtan411105 China Chinese Academy of Medical Sciences Peking Union Medical College National Cancer Center Cancer Hospital Beijing100021 China Baidu Inc. Beijing100085 China Fudan University School of Computer Science Shanghai200438 China

ISBN: (纸本)9781728163277

Automated segmentation of nuclei in histopathology images is critical for cancer diagnosis and prognosis. Due to the high variability of nuclei morphology, numerous nuclei overlapping, and the wide existence of nuclei clusters, this task still remains challenging. In this paper, we propose an effective nuclei segmentation method for histopathology images based on a novel neural network for multi-object localization and irrelevant-semantic separation (MI-Net), which includes a multi-object localization module (MOLM), a deep boundary awareness module (DBAM), and an irrelevant semantic separation module (ISSM). Specifically, the MOLM is used to calibrate features to capture more comprehensive information about the location of nuclei. It alleviates the problem of cell adhesion in histopathology images. The DBAM is intended to extract boundary information and solve the blurred boundary problem effectively. The ISSM is used to separate foreground features from background features and effectively address the problem of complex backgrounds in histopathology images. It also solves the low contrast problem between the target objects and the background. We evaluate MI-Net on the famous MoNuSeg dataset and compare it with ten state-of-the-art methods. MI-Net surpasses the best-performed method by margins from 1.12% to 2.29% over standard evaluation metrics, showing its effectiveness on nuclei segmentation. © 2023 IEEE.

关键词： Semantics

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Generalized Self-Adaption Network for Domain Adaptation

Generalized Self-Adaption Network for Domain Adaptation

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Artificial Intelligence and intelligent Information processing (AIIIP), International Conference on

作者： Yongheng Bian Xiao Ke Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing College of Computer and Data Science Fuzhou University Fuzhou China Key Laboratory of Spatial Data Mining & Information Sharing Ministry of Education Fuzhou China

The purpose of domain adaptation is to transfer knowledge learned in the labeled source domain to unlabeled but related target domains without requiring a large number of target domain labels. The latest method of domain adaptation mainly adjusts the distribution of the source and target domains to adapt to the target domain. Despite significant success, when there are significant distribution differences between the source and target domains, the adaptability in the target domain still decreases, which may be due to insufficient exploration of domain specific features leading to domain offset issues. To address this issue, we propose the GSA-NET framework in this article. We designed an adversarial dropout method to improve the generalization performance of the model in the target domain by pushing the decision boundary away from the feature dense region. At the same time, in order to effectively match the distribution of advanced features across domains, we deploy feature adaptation modules before the classification layer, which can significantly reduce domain differences. Our experiments on two cross domain benchmarks, Office Home and Office-31, have shown that the proposed method is significantly superior to existing methods.

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Hierarchical Policies of Subgoals for Safe Deep Reinforcement Learning 2nd

Hierarchical Policies of Subgoals for Safe Deep Reinforcem...

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2nd International Conference on Ubiquitous Security, UbiSec 2022

作者： Yu, Fumin Gao, Feng Yuan, Yao Xing, Xiaofei Dai, Yinglong College of Information Science and Engineering Hunan Normal University Changsha410081 China School of Computer Science and Cyber Engineering Guangzhou University Guangzhou510006 China College of Liberal Arts and Sciences National University of Defense Technology Changsha410073 China Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing Changsha410081 China

ISBN: (纸本)9789819902712

Reinforcement learning is a machine learning method that relies on the agent to learn by trial and error to solve decision optimization problems. It is well known that an agent based on deep reinforcement learning in complex environments is difficult to train. Moreover, the agent will generate unsafe and strange actions due to the lack of sufficient reward feedback from the environment. To make the agent converge to a better policy and make its behavior safer and more controllable under sparse rewards, we propose a subgoal embedding method based on prior knowledge and hierarchical strategy that can make the training process converge faster. The subgoal embedding method can be combined with existing reinforcement learning methods. In this paper, we combine the subgoal embedding method with REINFORCE algorithm and PPO(Proximal Policy Optimization) algorithm to test the method in the MiniGrid-Doorkey game environment of the gym platform. The experiments demonstrate the effectiveness of the subgoal embedding method. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Reinforcement learning

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Research on Critical Illness Fundraising Methods Based on Blockchain and Smart Contracts 7th

Research on Critical Illness Fundraising Methods Based on Bl...

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7th International Conference on Artificial Intelligence and Security, ICAIS 2021

作者： Tang, Huanrong Jiang, Aoyun Ouyang, Jianquan Key Laboratory of Intelligent Computing Information Processing Ministry of Education School of Computer Science and School of Cyberspace Science Xiangtan University Xiangtan Hunan411100 China

ISBN: (纸本)9783030786144

At present, with the development of science and medical level, more and more diseases can be cured. However, the cost of treating some diseases is high, and for many families with limited financial resources, it is difficult to spend so much money on treatment in a short period of time. As a result, more and more people are launching fundraising projects through third-party platforms such as Water Drops and Easy Fundraising, using the money raised to treat diseases. However, these third-party platforms have many problems, such as easy to disclose the private information of people who seeking help, the fundraising process is complex and slow, the use of project funds is difficult to timely monitor, the release of false fundraising projects for fundraising fraud, and so on. For these reasons, fewer members of the public will believe the authenticity of fundraising projects, so that it is not easy to donate to fundraising projects, which also makes it difficult for people who really need to raise funds to treat diseases. In view of this situation, this paper puts forward a blockchain and smart contract-based fundraising system for critical diseases, which can solve the problems existing in third-party platforms, and can help helpers quickly raise funds to cure diseases, it also can avoid the abuse of fundraising funds, false fundraising and other acts. Not only improve the transparency of fundraising behavior, but also enhance the enthusiasm of public participation in donations. © 2021, Springer Nature Switzerland AG.

关键词： Smart contract

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Deep Representation Learning for Electron Ionization Mass Spectra Retrieval

Deep Representation Learning for Electron Ionization Mass Sp...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Shibo Liu Xuan Zhang Anlei Jiao Shiwei Sun Longyang Dian Xuefeng Cui School of Computer Science and Technology Shandong University Qingdao China Key Lab of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing China State Key Laboratory of Microbial Technology Shandong University Qingdao China

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

The task of retrieving and analyzing mass spectra is indispensable for the identification of compounds in mass spectrometry (MS). This methodology is of critical importance as it enables researchers to correlate observed spectra with established databases, thereby precisely determining the chemical composition of samples. The primary challenges to its efficacy lie in optimizing the balance between retrieval accuracy and processing speed. Empirical studies have demonstrated that by converting mass spectra into embeddings via deep learning, it is possible to achieve both high accuracy and speed in retrieval. Nevertheless, there are complex challenges associated with employing deep learning for spectral embedding, particularly within the domain of electron ionization mass spectrometry (EI-MS). In this paper, we introduce a novel representation learning technique termed EI-MS2VEC for EI-MS retrieval. Our spectrum retrieval methodology surpasses current state-of-the-art techniques such as FastEI. For the in-silico library, we attain hit rate@1 and hit rate@10 of 43.6% and 84.5%, respectively, compared to FastEI’s 36.7% and 80.4%. Moreover, our retrieval approach operates with an order of magnitude greater speed than FastEI. The source code is available on Github (https://***/xfcui/EI-MS2VEC).

关键词： Representation learning Deep learning Accuracy Databases Source coding Ionization Predictive models Mass spectroscopy Electrons Software development management

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How to Train Your Neural Network for Molecular Structure Generation from Mass Spectra?

How to Train Your Neural Network for Molecular Structure Gen...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Kai Zhao Yanmin Liu Longyang Dian Shiwei Sun Xuefeng Cui School of Computer Science and Technology Shandong University Qingdao China State Key Laboratory of Microbial Technology Shandong University Qingdao China Key Lab of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing China

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

Mass spectrometry serves as a pivotal tool for the analysis of small molecules through an examination of their mass-to-charge ratios. Recent advancements in deep learning have markedly enhanced the analysis of mass spectrometric data, facilitating the prediction of novel small molecule structures without the necessity of extensive databases. Nonetheless, the paucity of annotated datasets impedes the efficacious training of molecular generation models predicated on MS 2 spectra. To mitigate this limitation, we introduce ctMSNovelist, an avant-garde method that amalgamates pre-training, fine-tuning, and co-training techniques to construct a more precise model for the generation of molecular structures from tandem mass spectrometry data. This novel approach augments both the training regimen and the predictive accuracy of the MSNovelist model, thereby surmounting the obstacle of limited data. The methodology commences with the pretraining of a Variational Autoencoder (VAE) to generate molecular fingerprints derived from SMILES strings. Subsequently, it undergoes fine-tuning to emulate noisy fingerprints originating from mass spectrometry (MS) data. Concurrently, MSNovelist is co-trained utilizing these simulated fingerprints, inclusive of the highly noisy variants produced in the early stages of VAE training. The incorporation of a substantial volume of noisy data serves to enhance model accuracy and avert overfitting. We evaluated ctMSNovelist using the GNPS dataset and attained a SMILES prediction accuracy of 48.8%, representing a 4.1% enhancement over MSNovelist. It is pertinent to note that the sole distinction between ctMSNovelist and MSNovelist in this experiment was the training process. The code and models are publicly available at https://***/xfcui/ctMSNovelist.

关键词： Training Solid modeling Accuracy Biological system modeling Fingerprint recognition Predictive models Mass spectroscopy Data models Noise measurement Overfitting

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DEGSTalk: Decomposed Per-Embedding Gaussian Fields for Hair-Preserving Talking Face Synthesis

DEGSTalk: Decomposed Per-Embedding Gaussian Fields for Hair-...

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International Conference on Acoustics, Speech, and signal processing (ICASSP)

作者： Kaijun Deng Dezhi Zheng Jindong Xie Jinbao Wang Weicheng Xie Linlin Shen Siyang Song Computer Vision Institute School of Computer Science and Software Engineering Shenzhen University National Engineering Laboratory for Big Data System Computing Technology Shenzhen University Guangdong Provincial Key Laboratory of Intelligent Information Processing Department of Computer Science University of Exeter

ISBN: (数字)9798350368741

ISBN: (纸本)9798350368758

Accurately synthesizing talking face videos and capturing fine facial features for individuals with long hair presents a significant challenge. To tackle these challenges in existing methods, we propose a decomposed per-embedding Gaussian fields (DEGSTalk), a 3D Gaussian Splatting (3DGS)-based talking face synthesis method for generating realistic talking faces with long hairs. Our DEGSTalk employs Deformable Pre-Embedding Gaussian Fields, which dynamically adjust pre-embedding Gaussian primitives using implicit expression coefficients. This enables precise capture of dynamic facial regions and subtle expressions. Additionally, we propose a Dynamic Hair-Preserving Portrait Rendering technique to enhance the realism of long hair motions in the synthesized videos. Results show that DEGSTalk achieves improved realism and synthesis quality compared to existing approaches, particularly in handling complex facial dynamics and hair preservation. Our code is available at https://***/CVI-SZU/DEGSTalk.

关键词： Hair Training Three-dimensional displays Dynamics signal processing Rendering (computer graphics) Noise measurement Speech processing Faces Videos

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DSPE: An End-to-End Drug Synergy Combination Prediction Algorithm for Echinococcosis

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Current Bioinformatics 2025年

作者： Li, Haitao Jiang, Liyuan Chu, Yuanyuan Liu, Yuansheng Zheng, Chunhou Su, Yansen Key Laboratory of Intelligent Computing and Signal Processing School of Artificial Intelligence Anhui University 111 Jiulong Road Hefei230601 China Institute of Artificial Intelligence Hefei Comprehensive National Science Center 5089 Wangjiang West Road Anhui Hefei230088 China College of Computer Science and Electronic Engineering Hunan University China

Background: Echinococcosis, a parasitic disease caused by the larvae of the Echinococcus parasite, poses a serious threat to human health. Medication is an indispensable means of treatment for Echinococcosis;however, due to the less satisfactory efficacy of single drugs, identifying effective drug combinations for the treatment of Echinococcosis is essential. Yet, current predictive models for drug synergy in Echinococcosis face accuracy challenges due to data scarcity, method limitations, and insufficient feature representation. Objective: This work aims to design an end-to-end method to predict drug synergistic combinations, which enables efficient and accurate identification of drug combinations against Echinococcosis. Methods: In this work, an end-to-end method, named DSPE, is proposed for predicting anti-Echinococcosis drug synergistic combinations. In DSPE, a dataset of Echinococcosis drug synergistic combinations is constructed by retrieving and extracting information from related scientific articles. Further, DSPE employs a residual graph attention network to deeply analyze drug characteristics and their interactions, thereby enhancing the performance of deep learning models. It also explores the protein-protein interaction network related to Echinococcosis, using node2vec combined with an attention mechanism to efficiently encode disease features. Finally, it predicts the synergy of drug combinations based on the Bliss score by integrating drug combinations and disease features. Results: Experimental evidence shows that DSPE outperforms five state-of-the-art algorithms in predicting drug combination effects by leveraging disease-target information and single-agents for the treatment. Conclusion: DSPE improves prediction accuracy and addresses the issue of data scarcity for new diseases, offering new insights and methods for the development of treatment plans for parasitic diseases in the future. © 2025 Bentham Science Publishers.

关键词： Diseases

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Multiscale Feature-guided Adversarial Examples Quality Assessment via Hierarchical Perception of Human Visual System

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IEEE Transactions on Big Data 2024年

作者： Wen, Wenying Huang, Minghui Dong, Li Zhang, Yushu Fang, Yuming Jiangxi University of Finance and Economics School of Computing and Artificial Intelligence Jiangxi Nanchang China Jiangxi Provincial Key Laboratory of Multimedia Intelligent Processing Jiangxi Nanchang China Ningbo University Faculty of Electrical Engineering and Computer Science Zhejiang Ningbo China

Deep neural networks (DNNs) reveal significant robustness deficiencies due to their susceptibility to being misled by small and imperceptible adversarial examples, thus it is crucial to improve the robustness of DNNs against such harmful perturbations. The current Lp specification ignores differences in human visual perception when measuring similarity, and most existing image quality assessment (IQA) methods and adversarial example datasets lack subjective scores for evaluation. In this paper, we construct a new database of adversarial examples, called the AED, which contains 35 original images, 1050 adversarial examples, and the corresponding subjective scores of adversarial examples. Then, a novel full-reference IQA model for the quality evaluation of the adversarial examples is proposed by taking into full consideration the hierarchical perception of human visual system (HVS) and the outstanding capabilities of the multi-scale feature extraction network in feature extraction. Specifically, a feature encoding network that uses continuous convolution layers to pre-extract features and expand the receptive field of the image is employed. To simulate the HVS hierarchical perception, the features of different scales are further obtained by designing a multi-scale feature extraction network. The structural similarity scores of the feature maps at different scales are calculated for jointly arriving at the final IQA score of the adversarial examples. Experimental results have demonstrated that our proposed model is closer to the perception of HVS in small imperceptible distortions evaluation of adversarial examples compared with other classical and state-of- the-art models. © 2015 IEEE.

关键词： Adversarial examples HVS hierarchical perception Lp norms multiscale feature

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