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Superhydrophobic photothermal coatings based on candle soot for prevention of bioﬁlm formation

Journal of materials Science & Technology 2023年第1期132卷 18-26页

作者： Yuancheng Lin Haixin Zhang Yi Zou Kunyan Lu Luohuizi Li Yan Wu Jingjing Cheng Yanxia Zhang Hong Chen Qian Yu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Soochow UniversitySuzhou 215007China Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function Soochow UniversitySuzhou 215123China

Bacterial biofilms formed on the material surfaces have posed a series of serious problems for human health and *** treatment of mature biofilms is particularly difficult because they are inher-ently highly resistant against antibiotics and other adverse *** prevention is strategically advan-tageous over the treatment,and thus the development of innovative surfaces with capability to inhibit biofilm formation is highly *** this work,we developed a superhydrophobic photothermal coating for prevention of biofilm formation,which was based on candle soot with hierarchical structure and excellent light-to-heat conversion *** coating was fabricated by deposition of a candle soot layer on the substrate,followed by sequential chemical vapor deposition of tetraethoxysilane and immo-bilization of fluorinated silane to make the coating robust and *** resulted coating could repel a majority of bacteria from the surface at the early stage,and then eradicate a small number of bacteria remained on the surface under a short-term irradiation of near-infrared *** combi-nation of anti-adhesive property and photothermal bactericidal property endowed the coating with good antibiofilm property to prevent biofilm formation for at least 2 *** coating is facile for deposition on various substrates with good storage stability,showing great potential for diverse practical applications to solve the biofilm-associated problems of materials and devices.

关键词： Antibiofilm Candle soot Superhydrophobic surface Anti-adhesive Photothermal surface

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An injectable alginate/fibrin hydrogel encapsulated with cardiomyocytes and VEGF for myocardial infarction treatment

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Journal of materials Science & Technology 2023年第12期143卷 198-206页

作者： Chunxia Liu Yong Wu Hong Yang Kunyan Lu Haixin Zhang Yuanyuan Wang Jingjing Wang Linan Ruan Zhenya Shen Qian Yu Yanxia Zhang Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215000China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function Soochow UniversitySuzhou 215123China

Myocardial infarction(MI)is one of the typical cardiovascular diseases,which persist as the leading cause of death *** to the poor regenerative capability of endogenous cardiomyocytes(CMs),the transplantation of exogenous CMs becomes a promising option for MI ***,the low retention and survival of transplanted cells still limit the clinical translation of cell ***,an alginate/fibrin-based injectable hydrogel was prepared for the delivery of neonatal CMs and an angiogen-esis agent vascular endothelial growth factor(VEGF)locally to the infarcted area of the *** hydro-gel combined the specific advantages of alginate and fibrin with proper mechanical properties and cell affinity,showing good biocompatibility to support the retention and integration of the transplanted CMs to the host ***,the delivered VEGF was favorable for the blood recovery to mitigate the ischemic microenvironment of the infarcted area and thus improved the survival of the transplanted *** injection of this hydrogel to the infarcted area of the heart promoted angiogenesis,inhibited fibrosis,and improved cardiac function,exhibiting great potential for MI treatment.

关键词： Injectable hydrogel Alginate Fibrin Cardiomyocytes VEGF Myocardial infarction

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Bioactive fibrous scaffolds with programmable release of polypeptides regulate inflammation and extracellular matrix remodeling

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Regenerative Biomaterials 2023年第1期10卷 522-532页

作者： Zehong Xiang Xinghua Guan Zhifang Ma Qiang Shi Mikhail Panteleev Fazly I.Ataullakhanov State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin 130022China University of Science and Technology of China HefeiAnhui 230026China Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function Soochow UniversitySuzhou 215123China Dmitry Rogachev National Research Center of Pediatric Hematology Oncology and ImmunologyMoscow 117198Russia Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Russia

Inflammation manipulation and extracellular matrix(ECM)remodeling for healthy tissue regeneration are critical requirements for tissue engineering *** this end,the bioactive polycaprolactone(PCL)-based scaffolds are fabricated to release aprotinin and thymosinβ4(Tβ4)in a programmable *** core part of the fiber is composed of hyaluronic acid and Tβ4,and the shell is PCL,which is further coated with heparin/gelatin/aprotinin to enhance *** in vitro assay demonstrates that the controlled release of aprotinin prevents initial excessive *** subsequent release of Tβ4 after 3 days induces the transition of macrophages from M1 into M2 *** manipulation of inflammatory response further controls the expression of transforming growth factor-βand fibroblast activation,which oversee the quantity and quality of ECM *** addition,the gradual degradation of the scaffold allows cells to proliferate within the *** vivo implant evaluation convinces that PCL-based scaffolds possess the high capability to control the inflammatory response and restore the ECM to normal ***,our work paves a new way to develop tissue engineering scaffolds for inflammation manipulation and ECM remodeling with peptide-mediated reactions.

关键词： bioactive scaffolds inflammation control extracellular matrix remodeling polypeptide release electrospinning

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Preparation of Lipid‒Polymer Conjugates by Photoiniferter Polymerization and Application to Cell Surface Modification

SSRN

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SSRN 2024年

作者： Xia, Wenjuan Liu, Shengjie Yu, Yijia Wang, Wenjin Wu, Zhaoqiang Chen, Hong Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou215123 China

As the demand for lipid‒polymer conjugates (LPCs) grows in the biomedical field, developing a simple, rapid, efficient, and cost-effective method for the synthesis of LPCs is important. In this study, a novel Y-type photoiniferter reagent (Lipid-PIT) with a diethyldithiocarbamate functional group at one end and a diacylglycerol group at the other end was first synthesized. Then, conjugated vinyl monomers such as oligo(ethylene glycol) methacrylate (OEGMA), N,N-dimethylacrylamide (DMA), tert-butyl acrylate (tBA), and n-butyl acrylate (nBA) were rapidly initiated by the photoiniferter Lipid-PIT under UV irradiation at room temperature to efficiently prepare LPCs. The 1H NMR results revealed that the diethyldithiocarbamate and diacylglycerol moieties were located at the end of the molecular chain of the prepared LPCs. The kinetic data of the polymerization of the monomer DMA showed that the molecular weight (Mn) of the resulting polymers increased linearly with increasing light exposure time, and the polydispersity coefficient (Đ) was less than 1.50, which demonstrated good controllability of the polymerization process. In addition, owing to the controllable polymerization activity of the photoiniferter, the prepared LPC can also be used to prepare different block copolymers via a secondary chain extension reaction. Finally, the in vitro bioassay results showed that Lipid-PIT-POF prepared from OEGMA monomers not only could successfully modify the surface of L929 and HeLa cells but also had good biocompatibility. Overall, this study not only provides a rapid and efficient method for the synthesis of LPCs but also has broad application prospects in the field of biomedical applications. © 2024, The Authors. All rights reserved.

关键词： Conjugated polymers

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肽基多孔材料及其应用

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Science China materials 2023年第2期66卷 470-484页

作者：王跃飞闵继伟魏豪刘佳羽梁耀宇苏荣欣张弓张伟王跃飞齐崴 State Key Laboratory of Chemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China State Key Laboratory of Component-based Chinese Medicine Haihe Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin UniversityTianjin 300072China Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function Soochow UniversitySuzhou 215123China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou Industrial ParkSuzhou 215123China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

多肽自组装形成的多孔结构是新一代多孔材料,在催化、传感、分离和药物递送等领域具有很好的应用前景.肽基多孔材料的孔内充满氨基酸侧链,因此可以通过合理设计或修改肽序列来调节其孔径大小和性能.功能基团和金属离子的引入进一步扩展... 详细信息

多肽自组装形成的多孔结构是新一代多孔材料,在催化、传感、分离和药物递送等领域具有很好的应用前景.肽基多孔材料的孔内充满氨基酸侧链,因此可以通过合理设计或修改肽序列来调节其孔径大小和性能.功能基团和金属离子的引入进一步扩展了多肽基多孔材料的结构与性能.在这篇综述中,我们讨论了肽基多孔材料的设计、合成、组装及其性能,并综述了近年来其在不同领域的应用.

关键词：多孔材料药物递送氨基酸侧链自组装多孔结构功能基团金属离子孔径大小

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Construction of a transparent, water-resistant anti-fog coating by benzophenone-functionalized polyvinyl alcohol

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materials Today Communications 2025年 47卷

作者： Sijia Yang Ran Wei Xiao Song Shengjie Liu Zhaoqiang Wu The Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 PR China

Polyethylene terephthalate (PET) is widely used in the fields of medical protection, food packaging and agriculture because of its excellent comprehensive performance, but the problem of decreased light transmittance due to fog on its surface severely restricts its practical application. In this study, to address the shortcomings of weak interfacial adhesion and poor water resistance between existing polyvinyl alcohol (PVA) antifog coatings and PET substrates, an antifog coating strategy based on benzophenone-functionalized polyvinyl alcohol (PVA) to construct transparent, water-resistant and rub-resistant materials was proposed. First, the amino functional group of 4-aminobenzophenone (ABP) is activated by N,N′-carbonyldiimidazole (CDI), and then it is coupled and grafted to the PVA side chain to construct the PVA-ABP x polymer. Finally, the PVA-ABP x polymer aqueous solution was coated on the PET substrate via the wire rod coating method, and the anti-fog coating was obtained via UV curing. The benzophenone hydrophobic group in the PVA-ABP x coating can covalently bond to the PET substrate during the UV curing process, which greatly improves the adhesion of the coating. In addition, its hydrophobicity effectively inhibits the swelling of the coating because of excessive water absorption. The experimental results show that the resulting transparent coating has excellent anti-fog performance. The coating has no traces of shedding after cross-cutting, quartz sand abrasion and nonwoven cloth dipped in water back-and-forth wipe tests. After immersion in 80 °C water for 60 min, 87 % light transmittance and no shedding phenomenon are maintained, and the coating has good water resistance and stability.

关键词： Antifog coating Benzophenone Polyethylene terephthalate Polyvinyl alcohol Transparent

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Bioactive engineered scaffolds based on PCL-PEG-PCL and tumor cell-derived exosomes to minimize the foreign body reaction

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Biomaterials and Biosystems 2022年 7卷 100055页

作者： Xiang, Zehong Guan, Xinghua Ma, Zhifang Shi, Qiang Panteleev, Mikhail Ataullakhanov, Fazly I. State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Jilin Changchun 130022 China University of Science and Technology of China Anhui Hefei 230026 China Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function Soochow University Suzhou 215123 China Dmitry Rogachev Natl Res Ctr Pediat Hematol Oncol 1 Samory Mashela St Moscow 117198 Russian Federation Faculty of Physics Lomonosov Moscow State University Leninskie Gory 1 build. 2 GSP-1 Moscow 119991 Russian Federation

Long-term presence of M1 macrophages causes serious foreign body reaction (FBR), which is the main reason for the failure of biological scaffold integration. Inducing M2 polarization of macrophages near scaffolds to reduce foreign body response has been widely researched. In this work, inspired by the special capability of tumor exosomes in macrophages M2 polarization, we integrate tumor-derived exosomes into biological scaffolds to minimize the FBR. In brief, breast cancer cell-derived exosomes are loaded into polycaprolactone-b-polyethylene glycol-b-polycaprolactone (PCL-PEG-PCL) fiber scaffold through physical adsorption and entrapment to constructed bioactive engineered scaffold. In cellular experiments, we demonstrate bioactive engineered scaffold based on PCL-PEG-PCL and exosomes can promote the transformation of macrophages from M1 to M2 through the PI3K/Akt signaling pathway. In addition, the exosomes release gradually from scaffolds and act on the macrophages around the scaffolds to reduce FBR in a subcutaneous implant mouse model. Compared with PCL-PEG-PCL scaffolds without exosomes, bioactive engineered scaffolds reduce significantly inflammation and fibrosis of tissues around the scaffolds. Therefore, cancer cell-derived exosomes show the potential for constructing engineered scaffolds in inhibiting the excessive inflammation and facilitating tissue formation. © 2022

关键词： Engineered scaffolds Exosomes Inflammation Macrophages Polarization

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Alternating Donor-Acceptor Ladder-Type Heteroarene for Efficient Photothermal Conversion via Boosting Non-Radiative Decay

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Angewandte Chemie 2024年第6期137卷

作者： Nan Luo Lingxiu Liu Jinyang Luo Zhaoqiong Zhou Prof. Chun-Lin Sun Xinqiang Hua Liang Luo Prof. Jianguo Wang Prof. Hua Geng Xiangfeng Shao Prof. Hao-Li Zhang Prof. Zitong Liu State Key Laboratory of Applied Organic Chemistry (SKLAOC) Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China College of Chemistry and Chemical Engineering College of Biomedical Sciences Inner Mongolia Key Laboratory of Synthesis and Application of Organic Functional Molecules Inner Mongolia University Hohhot 010021 China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of Chemistry Capital Normal University Beijing 100048 China

The development of novel ladder-type conjugated molecules is crucial for advancing supramolecular chemistry and material science. In this study, we report a straightforward synthesis of new alternating donor-acceptor (D-A) ladder-type heteroarene, FCDTDPP , and demonstrate its application as photothermal agent for imaging and cancer therapy. FCDTDPP is constructed by vinylene bridge between cyclopentadithiophene (D) and diketopyrrolopyrrole (A) through intramolecular Friedel–Crafts type reaction. FCDTDPP exhibits unique combination of good molecular planarity, efficient intra-/intermolecular mixed D-A interactions, and local aromaticity. These features collectively contribute to its broad and intense absorptions with narrow band gap in red band of the spectra, coupled with multiple vibrational absorption feature, thereby enhancing non-radiative decay process and resulting in efficient photothermal conversion property. FCDTDPP and its nanoparticles (NPs) exhibit superior photothermal conversion performance and stability under 660 nm laser irradiation. Moreover, in vitro studies reveal that FCDTDPP NPs possess excellent biocompatibility, low cytotoxicity, and robust photothermal therapeutic efficacy, a finding further corroborated by preliminary in vivo experiments in tumor-bearing mice. This work charts a novel course for the molecular engineering of organic photothermal conversion systems, propelling relevant research forward.

关键词： cyclopentadithiophene diketopyrrolopyrrole ladder-type conjugated molecule non-radiative decay photothermal conversion

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