Bacterial wound infections are a growing challenge in healthcare,posing severe risks like systemic infection,organ failure,and sepsis,with projections predicting over 10 million deaths annually by *** hydrogels,with a...
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Bacterial wound infections are a growing challenge in healthcare,posing severe risks like systemic infection,organ failure,and sepsis,with projections predicting over 10 million deaths annually by *** hydrogels,with adaptable extracellular matrix-like features,are emerging as promising solutions for treating infectious ***,the antibacterial properties of most of these hydrogels are largely attributed to extrinsic agents,and their mechanisms of action remain poorly *** we introduce for the first time,modified imidazolidinyl urea(IU)as the polymeric backbone for developing tissue-like antibacterial ***-designed hydrogels behave tissue-like mechanical features,outstanding antifreeze behavior,and rapid self-healing *** dynamics(MD)simulation and density functional theory(DFT)calculation were employed to well-understand the extent of H-bonding and metal-ligand coordination to finetune hydrogels’*** vitro studies suggest good biocompatibility of hydrogels against mouse fibroblasts&human skin,lung,and red blood cells,with potential wound healing ***,the hydrogels exhibit good 3D printability and remarkable antibacterial activity,attributed to concentration dependent ROS genera-tion,oxidative stress induction,and subsequent disruption of bacterial *** top of that,in vitro biofilm studies confirmed that developed hydrogels are effective in preventing biofilm ***,these tissue-mimetic hydrogels present a promising and effective platform for accelerating wound healing while simulta-neously controlling bacterial infections,offering hope for the future of wound care.
Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, ...
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Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.
This book is written to serve as textbook on biomaterials and biopolymers for faculty and students and thus contains a broad introduction and basic terms, followed by major developments over the years with some ...
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ISBN:
(数字)9783031361357
ISBN:
(纸本)9783031361340;9783031361371
This book is written to serve as textbook on biomaterials and biopolymers for faculty and students and thus contains a broad introduction and basic terms, followed by major developments over the years with some emphasis on recent developments and future prospects.;It provide a comprehensive overview in biomaterials and biopolymers. All relevant aspects of modern biomaterials, including: synthesis and characterization, biocompatibility and host response, the implementation of novel manufacturing processes, and advanced medical and biotechnological applications. Each chapter provides an overview of a specific field, its importance, the chemistry of biomaterials and the relations between chemical structure and the applications. Each chapter ends with a future prospective/concepts and a friendly quiz/multiple answer questions with answers that serves as a resource to provide guided additional practice.
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