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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (vol 50, pg 1412, 2018)

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NATURE GENETICS 2018年第12期50卷 1755-1755页

作者： Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Karaman, Ibrahim Fu Liang Ng Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Magi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stephanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Theriault, Sebastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renee Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Noordam, Raymond Pare, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Goncalo Amin, Najaf Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John C. Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco, Fabiola M. Demirkale, Cumhur Yusuf Dorr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Franberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen Department of Epidemiology and Biostatistics Imperial College London London UK Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina Greece William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK National Institute for Health Research Barts Cardiovascular Biomedical Research Center Queen Mary University of London London UK MRC-PHE Centre for Environment and Health Imperial College London London UK Department of Mathematics Imperial College London London UK Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Medical Center Tennessee Valley Healthcare System (626)/Vanderbilt University Nashville TN USA Vanderbilt Genetics Institute Vanderbilt Epidemiology Center Department of Obstetrics and Gynecology Vanderbilt University Medical Center Tennessee Valley Health Systems VA Nashville TN USA Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA Department of Biomedical Informatics Emory University School of Medicine Atlanta GA USA Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA Division of Aging Department of Medicine Brigham and Women’s Hospital Department of Medicine Harvard Medical School Boston MA USA Atlanta VAMC and Emory Clinical Cardiovascular Research Institute Atlanta GA USA VA Palo Alto Health Care System Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Nephrology Section Memphis VA Medical Center and University of Tennessee Health Science Center Memphis TN USA Estonian Genome Center University of Tartu Tartu Estonia Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Department Clinical Sciences Malmö Lund University Malmö Sweden MRC Human Genetics Un

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

关键词： Cardiovascular diseases Genome informatics Genome-wide association studies

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Author Correction: Why rankings of biomedical image analysis competitions should be interpreted with care

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Nature communications 2019年第1期10卷 588页

作者： Lena Maier-Hein Matthias Eisenmann Annika Reinke Sinan Onogur Marko Stankovic Patrick Scholz Tal Arbel Hrvoje Bogunovic Andrew P Bradley Aaron Carass Carolin Feldmann Alejandro F Frangi Peter M Full Bram van Ginneken Allan Hanbury Katrin Honauer Michal Kozubek Bennett A Landman Keno März Oskar Maier Klaus Maier-Hein Bjoern H Menze Henning Müller Peter F Neher Wiro Niessen Nasir Rajpoot Gregory C Sharp Korsuk Sirinukunwattana Stefanie Speidel Christian Stock Danail Stoyanov Abdel Aziz Taha Fons van der Sommen Ching-Wei Wang Marc-André Weber Guoyan Zheng Pierre Jannin Annette Kopp-Schneider Division of Computer Assisted Medical Interventions (CAMI) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. l.maier-hein@dkfz.de. Division of Computer Assisted Medical Interventions (CAMI) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. Centre for Intelligent Machines McGill University Montreal QC H3A0G4 Canada. Christian Doppler Laboratory for Ophthalmic Image Analysis Department of Ophthalmology Medical University Vienna 1090 Vienna Austria. Science and Engineering Faculty Queensland University of Technology Brisbane QLD 4001 Australia. Department of Electrical and Computer Engineering Department of Computer Science Johns Hopkins University Baltimore MD 21218 USA. CISTIB - Center for Computational Imaging & Simulation Technologies in Biomedicine The University of Leeds Leeds Yorkshire LS2 9JT UK. Department of Radiology and Nuclear Medicine Medical Image Analysis Radboud University Center 6525 GA Nijmegen The Netherlands. Institute of Information Systems Engineering TU Wien 1040 Vienna Austria. Complexity Science Hub Vienna 1080 Vienna Austria. Heidelberg Collaboratory for Image Processing (HCI Heidelberg University 69120 Heidelberg Germany. Centre for Biomedical Image Analysis Masaryk University 60200 Brno Czech Republic. Electrical Engineering Vanderbilt University Nashville TN 37235-1679 USA. Institute of Medical Informatics Universität zu Lübeck 23562 Lübeck Germany. Division of Medical Image Computing (MIC) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. Institute for Advanced Studies Department of Informatics Technical University of Munich 80333 Munich Germany. Information System Institute HES-SO Sierre 3960 Switzerland. Departments of Radiology Nuclear Medicine and Medical Informatics Erasmus MC 3015 GD Rotterdam The Netherlands. Department of Computer Science University of Warwick Coventry CV4 7AL UK. Department of Radiation Oncology Massachusetts General Hospital Boston MA

In the original version of this Article the values in the rightmost column of Table 1 were inadvertently shifted relative to the other columns. This has now been corrected in the PDF and HTML versions of the Article.

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Reports of the AAAI 2014 conference workshops

Reports of the AAAI 2014 conference workshops

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作者： Albrecht, Stefano V. Barreto, André M. S. Braziunas, Darius Buckeridge, David L. Cuayáhuitl, Heriberto Dethlefs, Nina Endres, Markus Farahmand, Amir-Massoud Fox, Mark Frommberger, Lutz Ganzfried, Sam Guillet, Sébastien Gil, Yolanda Hunter, Lawrence E. Jhala, Arnav Kersting, Kristian Konidaris, George Lecue, Freddy McIlraith, Sheila Natarajan, Sriraam Noorian, Zeinab Poole, David Ronfard, Rémi Saffiotti, Alessandro Shaban-Nejad, Arash Srivastava, Biplav Tesauro, Gerald Uceda-Sosa, Rosario Van Den Broeck, Guy Van Otterlo, Martijn Wallace, Byron C. Weng, Paul Wiens, Jenna Zhang, Jie School of Informatics University of Edinburgh United Kingdom Department of Applied and Computational Mathematics Brazilian National Laboratory Brazil Big Data Group Kobo Inc. Brazil Department of Epidemiology and Biostatistics McGill University Canada School of Mathematical and Computer Sciences Heriot-Watt University in Edinburgh United Kingdom University of Augsburg Germany Carnegie Mellon University United States University of Toronto Canada Cognitive Systems Group University of Bremen Germany LIARA UQAC Chicoutimi Canada Information Sciences Institute University of Southern California Computer Science Department United States Center for Computational Pharmacology University of Colorado School of Medicine United States Department of Computational Media University of California Santa Cruz United States Computer Science Department Technical University of Dortmund Germany MIT Computer Science and Artificial Intelligence Laboratory CambridgeMA United States IBM Research - Smarter Cities Technology Centre Dubline Ireland School of Informatics and Computing Indiana University United States Department of Computer Science University of Saskatchewan Canada University of British Columbia Canada INRIA University of Grenoble France Orebro University Sweden McGill Clinical and Health Informatics Group McGill University Canada IBM Research United States Cognitive Computing Department IBM Research Yorktown HeightsNY United States Computer Science Department Katholieke Universiteit Leuven Belgium Cognitive Artificial Intelligence Department Radboud University Nijmegen Netherlands University of Texas Austin United States Pierre and Marie Curie University Paris France University of Michigan United States School of Computer Engineering Nanyang Technological University Singapore

The AAAI-14 Workshop program was held Sunday and Monday, July 27-28, 2014, at the Québec City Convention Centre in Québec, Canada. The AAAI-14 workshop program included 15 workshops covering a wide range of topics in artificial intelligence. The titles of the workshops were Artificial Intelligence and Robotics;Artificial Intelligence Applied to Assistive Technologies and Smart Environments;Cognitive computing for Augmented Human Intelligence;Computer Poker and Imperfect Information;Discovery Informatics;Incentives and Trust in Electronic Communities;Intelligent Cinematography and Editing;Machine Learning for Interactive systems: Bridging the Gap Between Perception, Action, and Communication;Modern Artificial Intelligence for Health Analytics;Multiagent Interaction Without Prior Coordination;Multidisciplinary Workshop on Advances in Preference Handling;Semantic Cities - Beyond Open data to Models, Standards, and Reasoning;Sequential Decision Making with big data;Statistical Relational AI;and the World Wide Web and Public Health Intelligence. This article presents short summaries of those events. © 2015, Association for the Advancement of Artificial Intelligence. All rights reserved.

关键词： Decision making

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Efficient Distributed Skyline Queries for Mobile Applications

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计算机科学技术学报（英文版） 2010年第3期25卷 523-536页

作者： Ying-Yuan Xiao Yue-Guo Chen Tianjin Key Laboratory of Intelligence Computing and Novel Software Technology Tianjin University of Technology Tianjin 300191China Key Laboratory of Computer Vision and System Tianjin University of TechnologyTianjin 300191China School of Computing National University of Singapore117417Singapore Key Laboratory of Data Engineering and Knowledge Engineering Renmin University of ChinaBeijing 100872China

In this paper,we consider skyline queries in a mobile and distributed environment,where data objects are distributed in some sites(database servers)which are interconnected through a high-speed wired network,and queries are issued by mobile units(laptop,cell phone,etc.)which access the data objects of database servers by wireless *** inherent properties of mobile computing environment such as mobility,limited wireless bandwidth,frequent disconnection,make skyline queries more *** show how to efficiently perform distributed skyline queries in a mobile environment and propose a skyline query processing approach,called efficient distributed skyline based on mobile computing(EDS-MC).In EDS-MC,a distributed skyline query is decomposed into five processing phases and each phase is elaborately designed in order to reduce the network communication,network delay and query response *** conduct extensive experiments in a simulated mobile database system,and the experimental results demonstrate the superiority of EDS-MC over other skyline query processing techniques on mobile computing.

关键词： skyline distributed query processing mobile database system

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Effcient Distributed Skyline Queries for Mobile Applications

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Journal of Computer Science & technology 2010年第3期25卷 523-536页

作者：肖迎元陈跃国 Tianjin Key Laboratory of Intelligence Computing and Novel Software Technology Tianjin University of Technology Key Laboratory of Computer Vision and System Tianjin University of Technology School of Computing National University of Singapore Key Laboratory of Data Engineering and Knowledge Engineering Renmin University of China

In this paper, we consider skyline queries in a mobile and distributed environment, where data objects are distributed in some sites （database servers） which are interconnected through a high-speed wired network, and queries are issued by mobile units （laptop, cell phone, etc.） which access the data objects of database servers by wireless channels. The inherent properties of mobile computing environment such as mobility, limited wireless bandwidth, frequent disconnection, make skyline queries more complicated. We show how to efficiently perform distributed skyline queries in a mobile environment and propose a skyline query processing approach, called efficient distributed skyline based on mobile computing （EDS-MC）. In EDS-MC, a distributed skyline query is decomposed into five processing phases and each phase is elaborately designed in order to reduce the network communication, network delay and query response time. We conduct extensive experiments in a simulated mobile database system, and the experimental results demonstrate the superiority of EDS-MC over other skyline query processing techniques on mobile computing.

关键词： skyline distributed query processing mobile database system

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AMSPM: Adaptive Model Selection and Partition Mechanism for Edge Intelligence-driven 5G Smart City with Dynamic computing Resources

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ACM Transactions on Sensor Networks 1000年

作者： Xin Niu Xuejiao Cao Chen Yu Hai Jin National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Technology Huazhong University of Science and Technology Wuhan China

With the help of 5G network, edge intelligence (EI) can not only provide distributed, low-latency, and high-reliable intelligent services, but also enable intelligent maintenance and management of smart city. However, the constantly changing available computing resources of end devices and edge servers cannot continuously guarantee the performance of intelligent inference. In order to guarantee the sustainability of intelligent services in smart city, we propose the Adaptive Model Selection and Partition Mechanism (AMSPM) in 5G smart city where EI provides services, which mainly consists of Adaptive Model Selection (AMS) and Adaptive Model Partition (AMP). In AMSPM, the model selection and partition of deep neural network (DNN) are formulated as an optimization problem. Firstly, we propose a recursive-based algorithm named AMS based on the computing resources of edge devices to derive an appropriate DNN model that satisfies the latency demand of intelligent services. Then, we adaptively partition the selected DNN model according to the computing resources of edge devices. The experimental results demonstrate that, when compared with state-of-the-art model selection and partition mechanisms, AMSPM not only reduces latency but also enhances computing resource utilization.

关键词： Edge intelligence changing available computing resources adaptive model selection and partition smart city sustainable intelligent services

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Contrastive Learning based Speech Spoofing Detection for Multimedia Security in Edge Intelligence

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ACM Transactions on Multimedia computing, Communications, and Applications 1000年

作者： Jiaqi Sun Xianjun Deng Shenghao liu Xiaoxuan Fan Yongling Huang Yuanyuan He Celimuge Wu Jong Hyuk Park Hubei Key Laboratory of Distributed System Security Hubei Engineering Research Center on Big Data Security School of Cyber Science and Engineering Huazhong University of Science and Technology China The University of Electro-Communications Japan Seoul National University of Science and Technology South Korea

Artificial intelligence (AI) empowered edge computing has given rise to a new paradigm and effectively facilitated the promotion and development of multimedia applications. The speech assistant is one of the significant services provided by multimedia applications, which aims to offer intelligent interactive experiences between humans and machines. However, malicious attackers may exploit spoofed speeches to deceive speech assistants, posing great challenges to the security of multimedia applications. The limited resources of multimedia terminal devices hinder their ability to effectively load speech spoofing detection models. Furthermore, processing and analyzing speech in the cloud can result in poor real-time performance and potential privacy risks. Existing speech spoofing detection methods rely heavily on annotated data and exhibit poor generalization capabilities for unseen spoofed speeches. To address these challenges, this paper first proposes the Coordinate Attention Network (CA2Net) that consists of coordinate attention blocks and Res2Net blocks. CA2Net can simultaneously extract temporal and spectral speech feature information and represent multi-scale speech features at a granularity level. Besides, a contrastive learning-based speech spoofing detection framework named GEMINI is proposed. GEMINI can be effectively deployed on edge nodes and autonomously learn speech features with strong generalization capabilities. GEMINI first performs data augmentation on speech signals and extracts conventional acoustic features to enhance the feature robustness. Subsequently, GEMINI utilizes the proposed CA2Net to further explore the discriminative speech features. Then, a tensor-based multi-attention comparison model is employed to maximize the consistency between speech contexts. GEMINI continuously updates CA2Net with contrastive learning, which enables CA2Net to effectively represent speech signals and accurately detect spoofed speeches. Extensive experiments on

关键词： Edge intelligence Multimedia applications Speech spoofing detection Contrastive learning Coordinate attention

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Automate Legibility through Inverse Reinforcement Learning

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ACM Transactions on Autonomous and Adaptive systems 1000年

作者： Buxin Zeng Yinghui Pan Jing Tang Yifeng Zeng Department of Computer and Information Sciences Northumbria University UK School of Artificial Intelligence & National Engineering Laboratory for Big Data System Computing Technology Shenzhen University China Newcastle Business School Northumbria University UK

When intelligent agents act in a stochastic environment, the principle of maximizing expected rewards is used to optimize their policies. The rationality of the maximum rewards becomes a single objective when agents’ decision problems are solved in most cases. This sometimes leads to the agents’ behaviors (the optimal policies for solving the decision problems) that are not legible. In other words, it is difficult for users (or other agents and even humans) to understand the agents’ intentions when they are executing the optimal policies. Hence, it becomes pertinent to consider the legibility of agents’ decision problems. The key challenge lies in formulating a proper legibility function in the problems. Using domain experts’ inputs leans to be subjective and inconsistent in specifying legibility values, and the manual approach quickly becomes infeasible in a complex problem domain. In this article, we aim to learn such a legibility function parallel to developing a (conventional) reward function. We adopt inverse reinforcement learning techniques to automate a legibility function in agents’ decision problems. We first demonstrate the effectiveness of the inverse reinforcement learning technique when legibility is solely considered in a decision problem. Things become complicated when both the reward and legibility functions are to be found. We develop a multi-objective inverse reinforcement learning method to automate the two functions in a good balance simultaneously. We vary problem domains in the performance study and provide empirical results in support.

关键词： Legibility Inverse Reinforcement Learning Decision Making

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Cheetah: Accelerating Dynamic Graph Mining with Grouping Updates

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ACM Transactions on Architecture and Code Optimization 1000年

作者： Yi Zhang Xiaomeng Yi Yu Huang Jingrui Yuan Chuangyi Gui Dan Chen Long Zheng Jianhui Yue Xiaofei Liao Hai Jin Jingling Xue National Engineering Research Center for Big Data Technology and System Service Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Technology Huazhong University of Science and Technology Wuhan China Zhejiang Lab Hangzhou China National Engineering Research Center for Big Data Technology and System Service Computing Technology and System Lab Cluster and Grid Computing Lab School of Software Engineering Huazhong University of Science and Technology Wuhan China Eastern Institute of Technology Ningbo China National University of Singapore Singapore Singapore Michigan Technological University Houghton United States School of Computer Science and Engieering UNSW Sydney Kensington Australia

Graph pattern mining is essential for deciphering complex networks. In the real world, graphs are dynamic and evolve over time, necessitating updates in mining patterns to reflect these changes. Traditional methods use fine-grained incremental computation to avoid full re-mining after each update, which improves speed but often overlooks potential gains from examining inter-update interactions holistically, thus missing out on overall efficiency *** this paper, we introduce Cheetah, a dynamic graph mining system that processes updates in a coarse-grained manner by leveraging exploration domains. These domains exploit the community structure of real-world graphs to uncover data reuse opportunities typically missed by existing approaches. Exploration domains, which encapsulate extensive portions of the graph relevant to updates, allow multiple updates to explore the same regions efficiently. Cheetah dynamically constructs these domains using a management module that identifies and maintains areas of redundancy as the graph changes. By grouping updates within these domains and employing a neighbor-centric expansion strategy, Cheetah minimizes redundant data accesses. Our evaluation of Cheetah across five real-world datasets shows it outperforms current leading systems by an average factor of 2.63 ×.

关键词： Graph mining system dynamic graph incremental computing

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