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作者： Butler, David L. Lewis, Jack L. Frank, Cyril B. Banes, Albert J. Caplan, Arnold I. De Deyne, Patrick G. Dowling, Mary-Ann Fleming, Braden C. Glowacki, Julie Guldberg, Robert E. Johnstone, Brian Kaplan, David L. Levenston, Marc E. Lotz, Jeffrey C. Ed, Yiling Lu Lumelsky, Nadya Mao, Jeremy J. Mauck, Robert L. McDevitt, Cahir A. Mejia, Lito C. Murray, Martha Ratcliffe, Anthony Spindler, Kurt P. Tashman, Scott Wagner, Christopher T. Weisberg, Elijah M. Williams, Chrysanthi Zhang, Renwen Department of Biomedical Engineering University of Cincinnati 840 Engineering Research Center 2901 Woodside Drive Cincinnati OH 45221-0048 United States Department of Biomedical Engineering University of Cincinnati Cincinnati OH United States Department of Orthopaedic Surgery University of Minnesota Minneapolis MN United States Division of Orthopaedic Surgery Department of Surgery University of Calgary Calgary AB Canada Joint Department of Biomedical Engineering University of North Carolina Raleigh NC United States Flexcell International Corp. Department of Biology Case Western Reserve University Cleveland OH United States Preclinical Biology Johnson and Johnson Regenerative Therapeutics Raynham MA United States Smith and Nephew Research Centre York United Kingdom Department of Orthopaedic Surgery Brown University Providence RI United States Departments of Orthopedic Surgery and Oral and Maxillofacial Surgery Harvard Schools of Medicine and Dental Medicine Boston MA United States George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology Atlanta GA United States Department of Orthopaedics and Rehabilitation Oregon Health and Science University Portland OR United States Department of Biomedical Engineering Tufts University Medford MA United States Department of Mechanical Engineering Stanford University Stanford CA United States Department of Orthopaedic Surgery University of California San Francisco San Francisco CA United States Johnson and Johnson Regenerative Therapeutics Raynham MA United States Tissue Engineering and Dental and Craniofacial Regenerative Medicine Research Program National Institute of Dental and Craniofacial Research Bethesda MD United States Columbia University New York NY United States Department of Orthopaedic Surgery University of Pennsylvania Philadelphia PA United States Department of Biomedical Engineering Cleveland Clinic Foundation Cleveland OH United States Bose Corporation Ed

Over the past 20 years, tissue engineering (TE) has evolved into a thriving research and commercial development field. However, applying TE strategies to musculoskeletal (MSK) and craniofacial tissues has been particularly challenging since these tissues must also transmit loads during activities of daily living. To address this need, organizers invited a small group of bioengineers, surgeons, biologists, and material scientists from academia, industry, and government to participate in a 21/2-day conference to develop general and tissue-specific criteria for evaluating new concepts and tissue-engineered constructs, including threshold values of success. Participants were assigned to four breakout groups representing commonly injured tissues, including tendon and ligament, articular cartilage, meniscus and temporomandibular joint, and bone and intervertebral disc. Working in multidisciplinary teams, participants first carefully defined one or two important unmet clinical needs for each tissue type, including current standards of care and the potential impact of TE solutions. The groups then sought to identify important parameters for evaluating repair outcomes in preclinical studies and to specify minimally acceptable values for these parameters. The importance of in vitro TE studies was then discussed in the context of these preclinical studies. Where data were not currently available from clinical, preclinical, or culture studies, the groups sought to identify important areas of preclinical research needed to speed the development process. This report summarizes the findings of the conference. © Copyright 2008, Mary Ann Liebert, Inc.

关键词： Tissue engineering

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Abstracts for the 6th Congress of Asian Sleep Research Society

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Sleep and Biological Rhythms 2009年第4期7卷 A1-A49页

作者： Seog Ju Kim In Kyoon Lyoo Yu-Jin Lee Do-Un Jeong Hirohiko Kanai Masanori Ookubo Atsushi Yoshimura Masako Okawa Noto Yamada Takeshi Munezawa Yoshitaka Kaneita Yoneatsu Osaki Hideyuki Kanda Tadahiro Ohtsu Masumi Minowa Kenji Suzuki Susumu Hijuchi Hiroyuki Suzuki Takashi Ohida Takashi Abe Yoko Komada Shoichi Asaoka Yuichi Inoue Jin-Seong Lee Sang-Yong Cho Deependra Kumar Hruda N. Mallick Velayudhan M. Kumar Mahesh K. Kaushik Akihiro Karashima Noiihiro Katayama Mitsuyuki Nakao Ravindra P. Nagendra Sathiamma Sulekha Sathyaprabha T. Narasappa Pradhan Nityanadan Bindu M. Kutty M. Nirmala P. N. Ravindra Basavaraj Ramappa Tubaki T. N. Sathyaprabha D. Sudhakar G. S. Lavekar C. R. Chandrashekar Kazuyoshi Kitaoka Mika Shimizu Sachiko Chikahisa Kazuo Yoshizaki Hiroyoshi Sei Jong-Won Kim Misa Takegami Shin Yamazaki Yasuaki Hayashino Rei Ono Koji Otani Miho Sekiguchi Shinichi Konno Shunichi Fukuhara Antonia J. Jakobson Paul Fitzgerald Russell Conduit Xin Shirley Li Siu Ping Joyce Lam Wai Man Mandy Yu Yun Kwok Wing Kazue Okamoto-Mizuno Koh Mizuno Mituaki Yamamoto Shuichiro Shirakawa Hirokazu Doi Mikako Kato Kazuyuki Shinohara Masako Tamaki Shiori Matsuda Katsuo Yamazaki Tadao Hori Keiko Ogawa Kazumi Takahashi Kunio Kitahama Katuo Yamazaki Yoshimasa Koyama Kohei Shioda Yugo Ueda Yukiko Nakamura Clara Inoue Kazushige Goto Sunao Uchida Yuko Morita Yoshiko Honda Tohru Kodama Mari Hagihara Toru Nakajima Masato Saito Yoshihiko Koga Shinichiro Tanaka Hiroshi Yamadera Madoka Takahara Sachiko Suwa Minoru Onozuka Sadao Sato Fumiharu Togo Taiki Komatsu Takeshi Mitani Jongbae Choi Bin Zhang Taeko Sasai Hiromi Mitsubayashi Mitsuhiro Ohtsu Isao Hasegawa Tatsuya Ishii Akira Komori Asami Suzuki Yue Nakahara Mitsuyasu Hiroki Mariko Nakauma Nobuo Someya Tomomasa Ochiai Shouhei Komori Rayleigh Ping-Ying Chiang Zai-Ting Yeh Seong T. Kim Seung H. Yoon Jeong S. Kwon Jong H. Choi Hyung J. Ahn Youngsoo Kim Bolortuya Yunren Lichao Chen Radhika Basheer Robert W. Mccarley Robert E. Strecker Makoto Honda Tetsuaki Arai Miyuki Fukazawa Yutaka Honda Kuniaki T Department of Psychiatry Gachon University of Medicine and Science Incheon Republic of Korea Department of Psychiatry Seoul National University Seoul Republic of Korea Department of Neuropsychiatry and Center for Sleep and Chronobiology Seoul National University Hospital Seoul Republic of Korea Department of Neuropsychiatry Seoul National University Hospital Seoul Republic of Korea Seoul National University Hospital Seoul Republic of Korea Department of Psychiatry Shiga University of Medical Science Otsu Japan Division of Public Health Department of Social Medicine Nihon University School of Medicine Tokyo Japan Department of Public Health Nihon University School of Medicine Tokyo Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan Department of Public Health Showa University School of Medicine Tokyo Japan Faculty of Humanities Seitoku University Matsudo Japan Section on Behavioral Science Division of Clinical Research National Hospital Organization Kurihama Alcoholism Center Yokosuka Japan Department of Otolaryngology Second Hospital Fujita Health University Nagoya Japan National Hospital Organization Kurihama Alcoholism Center Kanagawa Japan Metropolitan Police Department Criminal Investigation Laboratory Tokyo Japan Japan Somnology Center Neuropsychiatrie Research Institute Tokyo Japan Department of Somnology Tokyo Medical University Tokyo Japan Japan Somnology Center Neuropsychiatric Research Institute Tokyo Japan Department of Somnology Tokyo Medical and Dental University Tokyo Japan Center for Sleep and Chronobiology Department of Psychiatry and Behavioral Science Seoul National University College of Medicine Seoul Republic of Korea Department of Psychiatry and Behavioral Science Center for Sleep and Chronobiology Seoul Republic of Korea Department of Physiology Al

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Invited Commentary

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Physical Therapy 2007年第5期87卷 569-570页

作者： Madhavan, Sangeetha Shields, Richard K S Madhavan PT MA is a doctoral student Graduate Program in Physical Therapy and Rehabilitation Science Carver College of Medicine The University of Iowa Iowa City Iowa RK Shields PT PhD FAPTA is Professor and Director Graduate Program in Physical Therapy and Rehabilitation Science Carver College of Medicine The University of Iowa 1–252 Medical Education Building Iowa City IA 52242

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Dynamic analysis of lower limb during swing phase in chronic SCI patients for functional electrical stimulation

Dynamic analysis of lower limb during swing phase in chronic...

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2005 Summer Bioengineering Conference

作者： Kim, Yongchul Schmit, Brian D. Youm, Youngil Department of the Mechanical Engineering Pohang University of Science and Technology Pohang Korea Republic of Department of Biomedical Engineering Marquette University Milwaukee WI Sensory Motor Performance Program Rehabilitation Institute of Chicago Chicago IL Department of Physical Medicine and Rehabilitation Northwestern University Medical School Chicago IL

ISBN: (纸本)0974249211

The aim of this study was to develop the dynamic model of lower limb using static and dynamic reflex properties of flexion reflex. Identification of torque response associated with hip angle and angular velocity was tested in 6 subjects with chronic SCI. Each subject placed in a supine position and lower leg was fixed with the knee at 155°±12 and the ankle at 126°±14. The hip was aligned with the axis of the Biodex motor in order to impose hip movements to the leg. A train of 10 stimulus pulses (50mA, 1ms) as reference pulse were applied at 200Hz to the skin of the medial arch to trigger flexion reflex reflexes. From this experiment, we identified the torque response as linear function of hip angle and angular velocity. In order to simulate the lower limb of spinal cord injured patients for functional electrical stimulation, we developed two dimensional dynamic model with three segments, thigh, shank and foot. Influences of stimulation parameters such as amplitude, frequency and duration time of pulse train were investigated with Taguchi method to obtain best results.

关键词： Physiological models

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A parametric investigation of swing motion triggered by electrical stimulation in paraplegic patients using response surface method

A parametric investigation of swing motion triggered by elec...

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2005 27th Annual International Conference of the engineering in Medicine and Biology Society, IEEE-EMBS 2005

作者： Kim, Yongchul Youm, Youngil Schmit, Brian D. Department of Mechanical Engineering Pohang University of Science and Technology Pohang Korea Republic of Department of Biomedical Engineering Marquette University Milwaukee WI United States Sensory Motor Performance Program Rehabilitation Institute of Chicago Chicago IL United States Department of Physical Medicine and Rehabilitation Northwestern University Medical School Chicago IL United States

ISBN: (纸本)0780387406

We identified torque response of flexion reflex associated with hip angle and angular velocity in 6 subjects with chronic SCI and developed two dimensional dynamic model with three segments, thigh, shank and foot. Influences of stimulation parameters such as amplitude, frequency and duration time of pulse train for producing swing motion of lower limb were investigated with response surface method to obtain optimal solutions. The initial hip flexion velocity (F-value > 19.0) and knee flexion velocity (F-value > 9.0) were clearly significant, while the initial hip angle was indistinguishable from the estimated amount of error. When the limb motion was simulated with initial hip and knee flexion velocity, the stimulation amplitude was increased 53%, the frequency was decreased 37% and the duration time was decreased 33% with respect to no initial condition. © 2005 IEEE.

关键词： Motion estimation

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Proximal femoral density patterns are consistent with bicentric joint loads

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Computer Methods in Biomechanics and Biomedical engineering 1999年第4期2卷 271-283页

作者： Fischer, Kenneth J. Jacobs, Christopher R. Levenston, Marc E. Cody, Dianna D. Carters, Dennis R. Musculoskeletal Research Center Department of Orthopaedic Surgery University of Pittsburgh Pittsburgh PA 15213 United States Department of Orthopaedics Musculoskeletal Research Laboratory Pennsylvania State University School of Medicine Hershey PA 17033 United States Department of Electrical Engineering and Computer Science Continuum Elect romechanics Mhoratory Massachusetts Institute of Technology Hershey MA 02139 United States Department of Diagnostic Radiology Division of Radiologic Physics and Engineering Henry Ford Hospital Detroit MI 48202 United States Department of Veterans Affairs Medical Center Rehabilitation Research and Development Center Palo Alto CA 94304-1200 United States Department of Mechanical Engineering Stanford University Biomechanical Engineering Program Stanford CA 94305-402 United States

We developed an alternate method for density-based load estimation and applied it to estimate hip joint load distributions for two femora. Two-dimensional finite element models were constructed from single energy quantitative computed tomography (QCT) data. Load estimation was performed using five loading regions on the femoral head. Within each loading region, individual nodal loads, normal to the local surface, were supplied as input to the load estimation. An optimization procedure independently adjusted individual nodal load magnitudes in each region, and the magnitudes of muscle forces on the greater trochanter, such that the applied tissue stimulus approached the reference stimulus throughout the model. Dominant estimated load resultant directions were generally consistent with published experimental data for loads during gait. The estimated loads also suggested that loads near the extremes of the articulating surface may be important (even required) for development and maintenance of normal bone architecture. Estimated load distributions within nearly all regions predicted bicentric loading patterns, which are consistent with observations of hip joint incongruity. Remodeling simulations with the estimated loads predicted density distributions with features qualitatively similar to the QCT data sets. This study illustrates how applications of density-based bone load estimation can improve understanding of dominant loading patterns in other bones and joints. The prediction of bicentric loading suggests a very fine level of local adaptation to details of joint loading. © 1999 OPA (Overseas Publishers Association) N.V.

关键词： Finite element method

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MEASUREMENT OF ISOMETRIC FORCE IN CHILDREN WITH AND WITHOUT DUCHENNES MUSCULAR-DYSTROPHY AND INTRARATER RELIABILITY OF MANUAL MUSCLE TEST (medical-RESEARCH-COUNCIL SCALE) GRADES IN DUCHENNES MUSCULAR-DYSTROPHY - REPLY

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PHYSICAL THERAPY 1992年第2期72卷 124-124页

作者： BRUSSOCK, CM CM Brussock MS PT is Instructor Physical Therapy Program Department of Developmental and Rehabilitative Sciences School of Health Related Professions University of Medicine and Dentistry of New Jersey/Rutgers 401 Haddon Ave Camden NJ 08103-1506 (USA). At the time of completion of the study she was Supervisor Neuromuscular Research Unit New England Medical Center 750 Washington St Boston MA 02111. This study was completed in partial fulfillment of Ms Brussock's Master of Science degree at the MGH Institute of Health Professions. SM Haley PhD PT is Director of Research Medical Rehabilitation Research and Training Center in Rehabilitation and Childhood Trauma New England Medical Center Hospital 75 Kneeland St 5th Fl Boston MA 02111 and Assistant Professor Tufts University School of Medicine 136 Harrison Ave Boston MA 02111. TL Munsat MD is Director Neuromuscular Research Unit New England Medical Center and Professor of Neurology and Pharmacology Tufts University School of Medicine. DB Bernhardt EdD PT was Assistant Professor Department of Health Sciences Sargent College of Allied Health Professions and Director Program in Athletic Training Boston University Boston MA 02215 when the study was completed. She is now in private practice Northern Rockies Athletic Rehabilitation and Training Center Missoula MT 59801.

The purpose of this study was to examine the consistency of measurements of maximal isometric force production in children using an electronic strain gauge. A standardized protocol of force testing from the Tufts Quantitative Neuromuscular Examination was adapted to obtain isometric force measurements in seven muscle groups bilaterally. Ten children with Duchenne's muscular dystrophy (DMD) and 10 age-matched children without DMD were recruited for the study. A generalizability framework was used to examine variations in measurements attributable to group differences, test occasions within the same day, and extremity side. Intertester reliability estimates were also completed on a subsample of children with and without DMD. A three-way analysis of variance between groups, sides, and test occasions demonstrated a significant group main effect for all muscle groups. In general, significant main effects were not present for side or test occasion. Test-retest intraclass correlation coefficients (ICCs) for all muscle groups ranged from .88 to .99 for the children with DMD and from .85 to .98 for the children without DMD. Intertester ICCs were slightly lower, ranging from .74 to .97 for the children with DMD and from .71 to .98 for the children without DMD. The results indicate that the electronic strain-gauge protocol produces reproducible force measurements in seven selected muscle groups in children with and without DMD.

关键词： Isometric force Measurement Muscular dystrophy Pediatrics Reliability

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