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Development of label-free triboelectric nanosensors as screening platforms for anti-tumor drugs

Nano Energy 2024年 125卷

作者： Cheng, Yu-Ying Ganguly, Anindita Cheng, Yi-Yun Ortiz, Christopher Llynard D. Pal, Arnab Shah, Pramod Kaswan, Kuldeep Yang, Lee-Wei Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan Praexisio Taiwan Inc. New Taipei221425 Taiwan Institute of Bioinformatics and Structural Biology National Tsing Hua University Hsinchu300044 Taiwan Chemical Biology and Molecular Biophysics Program Taiwan International Graduate Program Institute of Biological Chemistry Academia Sinica Taipei115 Taiwan Department of Chemistry National Tsing Hua University Hsinchu300044 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu300044 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu300044 Taiwan Biomedical Artificial Intelligence PhD Program National Tsing Hua University Hsinchu300044 Taiwan Physics Division National Center for Theoretical Sciences Taipei Taiwan

This study introduces a general label-free drug screening platform with potential to support high-throughput drug screening for any protein target. Its innovation lies in quantifying the affinity of molecule-molecule interactions via voltage output variation, which achieves unprecedented selectivity and sensitivity. It combines computational analysis complemented by experimental substantiation with a solid-liquid triboelectric nanosensor. Owing to its high binding affinity, FKBP-rapamycin is used as a model system to demonstrate the platform's sensitivity. Subsequently, the research is extended to study drug interactions with an oncogenic protein ATG4B. The findings unveil the binding of S130 and Tioconazole to ATG4B, a critical cysteine protease involved in autophagy, while revealing that Dexamethasone does not bind ATG4B. This binding exerts a specific inhibitory effect on autophagic flux and triggers cancer cell apoptosis. The results support the previously verified inhibitory effects of these drugs and the effectiveness of a newly developed self-powered drug screening platform, leveraging the principles of solid-liquid contact electrification. This approach adeptly confronts enduring challenges in traditional drug development methods where biochemical assays need to be designed for each individual protein target or only time-consuming and concentration-demanding molecular interaction measurements were made available. © 2024 Elsevier Ltd

关键词： Nanosensors

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Structural and magnetic properties of molecular beam epitaxy (MnSb2Te4)x(Sb2Te3)1-x topological materials with exceedingly high Curie temperature

arXiv

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arXiv 2023年

作者： Forrester, Candice R. Testelin, Christophe Wickramasinghe, Kaushini Levy, Ido Demaille, Dominique Hrabovski, David Ding, Xiaxin Krusin-Elbaum, Lia Lopez, Gustavo E. Tamargo, Maria C. Department of Chemistry The City College of New York New YorkNY10031 United States PhD Program in Chemistry CUNY Graduate Center New YorkNY10016 United States Department of Chemistry Lehman College BronxNY10468 United States Sorbonne Université CNRS Institut des NanoScience de Paris ParisF-75005 France Department of Physics New York University New YorkNY10003 United States Sorbonne Université MPBT Platform 4 Place Jussieu Paris75252 France Department of Physics The City College of New York New YorkNY10031 United States PhD Program in Physics CUNY Graduate Center New YorkNY10016 United States

Tuning magnetic properties of magnetic topological materials is of interest to realize elusive physical phenomena such as quantum anomalous hall effect (QAHE) at higher temperatures and design topological spintronic devices. However, current topological materials exhibit Curie temperature (TC) values far below room temperature. In recent years, significant progress has been made to control and optimize TC, particularly through defect engineering of these structures. Most recently we showed evidence of TC values up to 80K for (MnSb2Te4)x(Sb2Te3)1-x, where 0.7 ≤ x ≤ 0.85, by controlling the compositions and Mn content in these structures. Here we show further enhancement of the TC, as high as 100K, by maintaining high Mn content and reducing the growth rate from 0.9 nm/min to 0.5 nm/min. Derivative curves reveal the presence of two TC components contributing to the overall value and propose TC1 and TC2 have distinct origins: excess Mn in SLs and Mn in Sb2-yMnyTe3QLs alloys, respectively. In pursuit of elucidating the mechanisms promoting higher Curie temperature values in this system, we show evidence of structural disorder where Mn is occupying not only Sb sites but also Te sites, providing evidence of significant excess Mn and a new crystal structure:(Mn1+ySb2-yTe4)x(Sb2-yMnyTe3)1-x. Our work shows progress in understanding how to control magnetic defects to enhance desired magnetic properties and the mechanism promoting these high TC in magnetic topological materials such as (Mn1+ySb2-yTe4)x(Sb2-yMnyTe3)1-x Copyright © 2023, The Authors. All rights reserved.

关键词： Topology

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Mechanistic insights of evaporation-induced actuation in supramolecular crystals (Sept, 10.1038/s41563-020-0799-0, 2020)

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NATURE MATERIALS 2021年第3期20卷 434-434页

作者： Piotrowska, Roxana Hesketh, Travis Wang, Haozhen Martin, Alan R. G. Bowering, Deborah Zhang, Chunqiu Hu, Chunhua T. McPhee, Scott A. Wang, Tong Park, Yaewon Singla, Pulkit McGlone, Thomas Florence, Alastair Tuttle, Tell Ulijn, Rein V. Chen, Xi Advanced Science Research Center (ASRC) at the Graduate Center of the City University of New York New York NY USA PhD Program in Chemistry The Graduate Center of the City University of New York New York NY USA Department of Pure and Applied Chemistry University of Strathclyde Glasgow UK PhD Program in Physics The Graduate Center of the City University of New York New York NY USA EPSRC Continuous Manufacturing and Crystallisation Future Research Hub c/o Strathclyde Institute of Pharmacy and Biomedical Sciences Technology Innovation Centre University of Strathclyde Glasgow UK Department of Chemistry New York University New York NY USA Department of Chemistry and Biochemistry Hunter College City University of New York New York NY USA Department of Chemical Engineering The City College of New York New York NY USA

A Correction to this paper has been published: https://***/10.1038/s41563-021-00950-3.

关键词： Condensed-matter physics Materials science Soft materials

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Novel (Ce,Mo) Co-Doped Bivo4 with Enhanced Photocatalytic Activity for the Degradation of Methyl Orange

SSRN

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SSRN 2023年

作者： Sriwichai, Surassa Sakulsermsuk, Sumet Wetchakun, Khatcharin Wetchakun, Natda PhD’s Degree Program in Materials Science Faculty of Science Chiang Mai University Chiang Mai50200 Thailand Department of Physics and Materials Science Faculty of Science Chiang Mai University Chiang Mai50200 Thailand Faculty of Science Ubon Ratchathani Rajabhat University Ubon Ratchathani34000 Thailand

Novel (Ce,Mo) co-doped BiVO4 is synthesized via the hydrothermal method. The effect of Ce and Mo ions co-doping on the physicochemical and photocatalytic characteristics of BiVO4 is investigated. The presence of Ce and Mo in BiVO4 induces a tetragonal zircon phase, rod-like morphology, and wide band gap. The synergistic effect of optimal Ce and Mo allows (0.0312Ce, 0.0312Mo) co-doped BiVO4 to show a ~15-fold increase in the methyl orange (MO) degradation. The enhanced photocatalytic performance of (Ce,Mo) co-doped BiVO4 is attributed to the increased surface adsorption ability, increased band gap, and improved effective separation of the photogenerated electron and hole pairs. Furthermore, active species trapping experiments reveal that h+ is the dominant radical in the photodegradation process. © 2023, The Authors. All rights reserved.

关键词： Morphology

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A `Rosetta stone' for the population dynamics of spiking neuron networks

arXiv

引用

arXiv 2021年

作者： Vinci, Gianni V. Mattia, Maurizio Natl. Center for Radioprotection and Computational Physics Istituto Superiore di Sanità Roma00169 Italy PhD Program in Physics "Tor Vergata" University of Rome Roma00133 Italy

Populations of spiking neuron models have densities of their microscopic variables (e.g., single-cell membrane potentials) whose evolution fully capture the collective dynamics of biological networks, even outside equilibrium. Despite its general applicability, the Fokker-Planck equation governing such evolution is mainly studied within the borders of the linear response theory, although alternative spectral expansion approaches offer some advantages in the study of the out-of-equilibrium dynamics. This is mainly due to the difficulty in computing the state-dependent coefficients of the expanded system of differential equations. Here, we address this issue by deriving analytic expressions for such coefficients by pairing perturbative solutions of the Fokker-Planck approach with their counterparts from the spectral expansion. A tight relationship emerges between several of these coefficients and the Laplace transform of the inter-spike interval density (i.e., the distribution of first-passage times). ‘Coefficients’ like the current-to-rate gain function, the eigenvalues of the Fokker-Planck operator and its eigenfunctions at the boundaries are derived without resorting to integral expressions. For the leaky integrate-and-fire neurons, the coupling terms between stationary and nonstationary modes are also worked out paving the way to accurately characterize the critical points and the relaxation timescales in networks of interacting populations. © 2021, CC BY.

关键词： Eigenvalues and eigenfunctions

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A mechanistically interpretable model of the retinal neural code for natural scenes with multiscale adaptive dynamics 55

A mechanistically interpretable model of the retinal neural ...

引用

55th Asilomar Conference on Signals, Systems and Computers, ACSSC 2021

作者： Ding, Xuehao Lee, Dongsoo Grant, Satchel Stein, Heike McIntosh, Lane Maheswaranathan, Niru Baccus, Stephen Stanford University Department of Applied Physics Stanford United States Stanford University Neurosciences PhD Program Stanford United States Stanford University Department of Psychology Stanford United States University of Barcelona August Pi i Sunyer Biomedical Research Institute Barcelona Spain Stanford University Neurobiology Department Stanford United States

ISBN: (纸本)9781665458283

The visual system processes stimuli over a wide range of spatiotemporal scales, with individual neurons receiving input from tens of thousands of neurons whose dynamics range from milliseconds to tens of seconds. This poses a challenge to create models that both accurately capture visual computations and are mechanistically interpretable. Here we present a model of salamander retinal ganglion cell spiking responses recorded with a multielectrode array that captures natural scene responses and slow adaptive dynamics. The model consists of a three-layer convolutional neural network (CNN) modified to include local recurrent synaptic dynamics taken from a linear-nonlinear-kinetic (LNK) model [1]. We presented alternating natural scenes and uniform field white noise stimuli designed to engage slow contrast adaptation. To overcome difficulties fitting slow and fast dynamics together, we first optimized all fast spatiotemporal parameters, then separately optimized recurrent slow synaptic parameters. The resulting full model reproduces a wide range of retinal computations and is mechanistically interpretable, having internal units that correspond to retinal interneurons with biophysically modeled synapses. This model allows us to study the contribution of model units to any retinal computation, and examine how long-term adaptation changes the retinal neural code for natural scenes through selective adaptation of retinal pathways. © 2021 IEEE.

关键词： Dynamics

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Correction: Comparative study on formic acid sensing properties of flame-made Zn2SnO4 nanoparticles and its parent metal oxides

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Physical Chemistry Chemical physics 2023年第27期25卷 18497-18498页

作者： Matawee Punginsang Kanittha Inyawilert Mameaseng Siriwalai Anurat Wisitsoraat Adisorn Tuantranont Chaikarn Liewhiran Department of Physics and Materials Science Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand PhD Program in Nanoscience and Nanotechnology (International Program/Interdisciplinary) Faculty of Science Chiang Mai University Chiang Mai Thailand Graduate School Chiang Mai University Chiang Mai Thailand Center of Excellence in Materials Science and Technology Chiang Mai University Chiang Mai 50200 Thailand National Security and Dual-Use Technology Center National Science and Technology Development Agency (NSTDA) Klong Luang Phathum Thani 12120 Thailand

Correction for ‘Comparative study on formic acid sensing properties of flame-made Zn2SnO4 nanoparticles and its parent metal oxides’ by Matawee Punginsang et al., Phys. Chem. Chem. Phys., 2023, 25, 15407–15421, htt...

Correction for ‘Comparative study on formic acid sensing properties of flame-made Zn₂SnO₄ nanoparticles and its parent metal oxides’ by Matawee Punginsang et al., Phys. Chem. Chem. Phys., 2023, 25, 15407–15421, https://***/10.1039/D3CP00845B.

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Space mishap as a stimulus context for thermal conduction exploration in secondary school

Space mishap as a stimulus context for thermal conduction ex...

引用

GIREP-ICPE-EPEC 2017 Conference

作者： Komáromi, A. Physics Education PhD Program of Eötvös University Budapest Hungary

A large body of literature underlines the relevance of personal involvement and in-context assignments in increasing student engagement in physics education at secondary level. The research-based teaching/learning experience offers different kinds of suggestions for physics education on the level of curricular proposals, on the level of feasibility of inquiry-based learning approaches, on the level of strategies and methods for learning environment settings, and on the level of conceptual understanding of students. During the activities, students find a good opportunity to discuss how heat is transferred, both on Earth and in space. Students discover through their own exploration what types of radiation space objects are exposed to in near-Earth orbits. By means of a "flipped classroom" methodology the students analyse radiant heat absorption and reflection. The activity was extended to learn about heat radiation incident on Earth and emitted by Earth. It was interesting to see the reaction of students when they realized that "radiant heat" has a wavelength, and that it is part of the electromagnetic wave spectrum. Tutorials and post-tests were used in order to gauge the students' understanding of the processes involved, and in particular what their conception of heat is. Students proposed different materials for heat shields used in the experiment, and in this way we touched on the subjects of thermal insulation and heat capacity. This leads us to examine the inner structure of materials, and essentially the link between macro- and micro-world. Discussion of heat absorption is a way to introduce the concept of energy, and consequently the role of macro-micro models in material science processes description. Characteristics and main results of the intervention module will be presented together with data of the monitored learning process. © Published under licence by IOP Publishing Ltd.

关键词： Students

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Directed discovery of high-loading nanoaggregates enabled by drug-matched oligo-peptide excipients

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Chem 2025年

作者： Berisha, Naxhije Farahpour, Atena Ramakrishnan, Maithreyi Chen, Chen McPhee, Scott A. Wang, Tong Li, Tai-De Hema, Kuntrapakam Panagiotakopoulou, Magdalini Athiyarath, Vignesh Coste, Maeva Marciano, Yaron Sherman, Emmet Ulijn, Rein V. Heller, Daniel A. Nanoscience Initiative Advanced Science Research Center CUNY Graduate Center City University of New York New York 10031 NY United States Department of Chemistry and Biochemistry Hunter College City University of New York New York 10065 NY United States PhD Program in Chemistry CUNY Graduate Center City University of New York New York 10016 NY United States Molecular Pharmacology Program Memorial Sloan Kettering Cancer Center New York 10065 NY United States Tri-Institutional PhD Program in Chemical Biology Memorial Sloan Kettering Cancer Center New York 10065 NY United States Department of Physics City College of New York City University of New York New York 10031 NY United States Department of Chemistry Brooklyn College City University of New York 2900 Bedford Avenue Brooklyn 11210 NY United States PhD Program in Biochemistry CUNY Graduate Center City University of New York New York 10016 NY United States Weill Cornell Medicine Cornell University New York 10065 NY United States

Nanoparticles can improve drug pharmacokinetics, but low loading efficiencies can limit treatment efficacy. Drug-aggregation-based nanoparticles have demonstrated improved loadings of up to 90%, but few excipients facilitate efficient co-assembly. We investigated peptides as designer excipients because of their diverse chemical space and inherent biodegradability. We designed pentapeptide scaffolds to mimic the structure of known indocyanine excipients by modulating aromaticity, rigidity, and charge. We screened 184 formulations by using diverse drug cargoes. We found drug-peptide combinations that formed nanoparticles with up to 98% drug loading. Molecular dynamics simulations and mass spectrometry analysis demonstrated that tryptophan-drug interactions and solvent exposure of charged amino acid residues drove the formation of core-shell structures. Peptide-drug formulations containing the JAK2/FLT3 inhibitor lestaurtinib were investigated in acute myeloid leukemia models, resulting in enhanced anti-tumor efficacy. This work found that oligopeptides can be designed to efficiently co-assemble with therapeutic cargoes to result in high-loading nanoparticles that improve anti-tumor efficacy. © 2024

关键词： co-assembly directed discovery drug delivery excipient nanocarrier design nanoparticle oligopeptides SDG3: Good health and well-being

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Systematic designs of single metal compounds synthesized using ammonia fluoride-based complex as structure directing agents for energy storage

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Journal of Colloid and Interface Science 2023年第PartA期652卷 294-304页

作者： Kuo, Tsung-Rong Zher Yu, You Wu, Chung-Hsien Lee, Pin-Yan Kongvarhodom, Chutima Chen, Hung-Ming Husain, Sadang Yougbaré, Sibidou Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso

Tailoring morphology and composition of metal organic frameworks (MOF) can improve energy storage by establishing high surface area, large porosity and multiple redox states. Structure directing agents (SDA) is functional of designing surface properties of electroactive materials. Ammonium fluoride has functional abilities for designing MOF derivatives with excellent energy storage abilities. Systematic design of MOF derivatives using ammonia fluoride-based complex as SDA can essentially create efficient electroactive materials. Metal species can also play significant roles on redox reactions, which are the main energy storage mechanism for battery-type electrodes. In this work, 2-methylimidazole, two novel SDAs of NH4BF4 and NH4HF2, and six metal species of Al, Mn, Co, Ni, Cu and Zn are coupled to synthesize MOF derivatives for energy storage. Metal species-dependent compositions including hydroxides, oxides, and hydroxide nitrates are observed. The nickel-based derivative (Ni-HBF) shows the highest specific capacitance (CF) of 698.0F/g at 20 mV/s, due to multiple redox states and advanced flower-like surface properties. The diffusion and capacitive-control contributions of MOF derivatives are also analyzed. The battery supercapacitor hybrid with Ni-HBF electrode shows a maximum energy density of 27.9 Wh/kg at 325 W/kg. The CF retention of 170.9% and Coulombic efficiency of 93.2% are achieved after 10,000 cycles. © 2023 Elsevier Inc.

关键词： Supercapacitor

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