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19th International Conference on Advanced Data Mining and Applications, ADMA 2023

作者： Wan, Peng Liu, Chunrui Zhang, Daoqiang Key Laboratory of Brain-Machine Intelligence Technology Ministry of Education College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing China Department of Ultrasound Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China

ISBN: (纸本)9783031466632

Dual-view contrast-enhanced ultrasound (CEUS) has been widely applied in lesion detection and characterization due to the provided anatomical and functional information of lesions. Accurate delineation of lesion contour is important to assess lesion morphology and perfusion dynamics. Although the last decade has witnessed the unprecedented progress of deep learning methods in 2D ultrasound imaging segmentation, there are few attempts to discriminate tissue perfusion discrepancy using dynamic CEUS imaging. Combined with the side-by-side gray-scale US view, we propose a novel anatomical-functional fusion network (AFF-Net) to fuse complementary imaging characteristics from dual-view dynamic CEUS imaging. Towards a comprehensive characterization of lesions, our method mainly tackles with two challenges: 1) how to effectively represent and aggregate enhancement features of the dynamic CEUS view;2) how to efficiently fuse them with the morphology features of the US view. Correspondingly, we design the channel-wise perfusion (PE) gate and anatomical-functional fusion (AFF) module with the goal to exploit dynamic blood flow characteristics and perform layer-level fusion of the two modalities, respectively. The effectiveness of the AFF-Net method on lesion segmentation is validated on our collected thyroid nodule dataset with superior performance compared with existing methods. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Deep learning

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Safe reinforcement learning using finite-horizon gradient-based estimation 24

Safe reinforcement learning using finite-horizon gradient-ba...

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Proceedings of the 41st International Conference on machine Learning

作者： Juntao Dai Yaodong Yang Qian Zheng Gang Pan College of Computer Science and Technology and The State Key Lab of Brain-Machine Intelligence Zhejiang University Hangzhou China Center for AI Safety and Governance Peking University Beijing China

A key aspect of Safe Reinforcement Learning (Safe RL) involves estimating the constraint condition for the next policy, which is crucial for guiding the optimization of safe policy updates. However, the existing Advantage-based Estimation (ABE) method relies on the infinite-horizon discounted advantage function. This dependence leads to catastrophic errors in finite-horizon scenarios with non-discounted constraints, resulting in safety-violation updates. In response, we propose the first estimation method for finite-horizon non-discounted constraints in deep Safe RL, termed Gradient-based Estimation (GBE), which relies on the analytic gradient derived along trajectories. Our theoretical and empirical analyses demonstrate that GBE can effectively estimate constraint changes over a finite horizon. Constructing a surrogate optimization problem with GBE, we developed a novel Safe RL algorithm called Constrained Gradient-based Policy Optimization (CGPO). CGPO identifies feasible optimal policies by iteratively resolving sub-problems within trust regions. Our empirical results reveal that CGPO, unlike baseline algorithms, successfully estimates the constraint functions of subsequent policies, thereby ensuring the efficiency and feasibility of each update.

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Alleviating the semantic gap for generalized fMRI-to-image reconstruction 23

Alleviating the semantic gap for generalized fMRI-to-image r...

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Proceedings of the 37th International Conference on Neural Information Processing Systems

作者： Tao Fang Qian Zheng Gang Pan College of Computer Science and Technology Zhejiang University Hangzhou China and The State Key Lab of Brain-Machine Intelligence Zhejiang University Hangzhou China

Although existing fMRI-to-image reconstruction methods could predict high-quality images, they do not explicitly consider the semantic gap between training and testing data, resulting in reconstruction with unstable and uncertain semantics. This paper addresses the problem of generalized fMRI-to-image reconstruction by explicitly alleviates the semantic gap. Specifically, we leverage the pre-trained CLIP model to map the training data to a compact feature representation, which essentially extends the sparse semantics of training data to dense ones, thus alleviating the semantic gap of the instances nearby known concepts (i.e., inside the training super-classes). Inspired by the robust low-level representation in fMRI data, which could help alleviate the semantic gap for instances that far from the known concepts (i.e., outside the training super-classes), we leverage structural information as a general cue to guide image reconstruction. Further, we quantify the semantic uncertainty based on probability density estimation and achieve Generalized fMRI-to-image reconstruction by adaptively integrating Expanded Semantics and Structural information (GESS) within a diffusion process. Experimental results demonstrate that the proposed GESS model outperforms state-of-the-art methods, and we propose a generalized scenario split strategy to evaluate the advantage of GESS in closing the semantic gap. Our codes are available at https://***/duolala1/GESS.

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FP3O: Enabling Proximal Policy Optimization in Multi-Agent Cooperation with Parameter-Sharing Versatility

arXiv

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arXiv 2023年

作者： Feng, Lang Xing, Dong Zhang, Junru Pan, Gang College of Computer Science and Technology Zhejiang University Hangzhou China The State Key Lab of Brain-Machine Intelligence Zhejiang University Hangzhou China

Existing multi-agent PPO algorithms lack compatibility with different types of parameter sharing when extending the theoretical guarantee of PPO to cooperative multi-agent reinforcement learning (MARL). In this paper, we propose a novel and versatile multi-agent PPO algorithm for cooperative MARL to overcome this limitation. Our approach is achieved upon the proposed full-pipeline paradigm, which establishes multiple parallel optimization pipelines by employing various equivalent decompositions of the advantage function. This procedure successfully formulates the interconnections among agents in a more general manner, i.e., the interconnections among pipelines, making it compatible with diverse types of parameter sharing. We provide a solid theoretical foundation for policy improvement and subsequently develop a practical algorithm called Full-Pipeline PPO (FP3O) by several approximations. Empirical evaluations on MultiAgent MuJoCo and StarCraftII tasks demonstrate that FP3O outperforms other strong baselines and exhibits remarkable versatility across various parameter-sharing configurations. Copyright © 2023, The Authors. All rights reserved.

关键词： Approximation algorithms

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EvSTVSR: Event Guided Space-Time Video Super-Resolution 39

EvSTVSR: Event Guided Space-Time Video Super-Resolution

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39th Annual AAAI Conference on Artificial intelligence, AAAI 2025

作者： Yan, Haojie Lu, Zhan Chen, Zehao Ma, De Tang, Huajin Zheng, Qian Pan, Gang The State Key Lab of Brain-Machine Intelligence Zhejiang University China College of Computer Science and Technology Zhejiang University China School of Electrical and Electronic Engineering Nanyang Technological University Singapore

ISBN: (纸本)157735897X

In the domain of space-time video super-resolution, it is typically challenging to handle complex motions (including large and nonlinear motions) and varying illumination scenes due to the lack of inter-frame information. Leveraging the dense temporal information provided by event signals offers a promising solution. Traditional event-based methods typically rely on multiple images, using motion estimation and compensation, which can introduce errors. Accumulated errors from multiple frames often lead to artifacts and blurriness in the output. To mitigate these issues, we propose EvSTVSR, a method that uses fewer adjacent frames and integrates dense temporal information from events to guide alignment. Additionally, we introduce a coordinate-based feature fusion upsampling module to achieve spatial super-resolution. Experimental results demonstrate that our method not only outperforms existing RGB-based approaches but also excels in handling large motion scenarios. Copyright © 2025, Association for the Advancement of Artificial intelligence (***). All rights reserved.

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EvHDR-GS: Event-guided HDR Video Reconstruction with 3D Gaussian Splatting 39

EvHDR-GS: Event-guided HDR Video Reconstruction with 3D Gaus...

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39th Annual AAAI Conference on Artificial intelligence, AAAI 2025

作者： Chen, Zehao Lu, Zhan Ma, De Tang, Huajin Jiang, Xudong Zheng, Qian Pan, Gang The State Key Lab of Brain-Machine Intelligence Zhejiang University China College of Computer Science and Technology Zhejiang University China School of Electrical and Electronic Engineering Nanyang Technological University Singapore

ISBN: (纸本)157735897X

High Dynamic Range (HDR) video reconstruction seeks to accurately restore the extensive dynamic range present in real-world scenes and is widely employed in downstream applications. Existing methods typically operate on one or a small number of consecutive frames, which often leads to inconsistent brightness across the video due to their limited perspective on the video sequence. Moreover, supervised learning-based approaches are susceptible to data bias, resulting in reduced effectiveness when confronted with test inputs exhibiting a domain gap relative to the training data. To address these limitations, we present an event-guided HDR video reconstruction method through building 3D Gaussian Splatting (3DGS), to ensure consistent brightness imposed by 3D consistency. We introduce HDR 3D Gaussians capable of simultaneously representing HDR and low-dynamic-range (LDR) colors. Furthermore, we incorporate a learnable HDR-to-LDR transformation optimized by input event streams and LDR frames to eliminate the data bias. Experimental results on both synthetic and real-world datasets demonstrate that the proposed method achieves state-of-the-art performance. © 2025, Association for the Advancement of Artificial intelligence (***). All rights reserved.

关键词： Supervised learning

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Inter-Channel Correlation-Based EMI Noise Removal (ICER) for Shielding-Free Low-Field MRI

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IEEE Transactions on Biomedical Engineering 2025年 PP卷 PP页

作者： Huang, Yiman Qu, Shuxian Xie, Yushu Wang, Hanlei Zhang, Xinlin Zhang, Xiaotong Zhejiang University College of Electrical Engineering MOE Frontier Science Center for Brain Science and Brain-machine Integration Hangzhou China Zhejiang University College of Biomedical Engineering & Instrument Science MOE Frontier Science Center for Brain Science and Brain-machine Integration Hangzhou China Fuzhou University College of Physics and Information Engineering Fujian Key Lab of Medical Instrumentation & Pharmaceutical Technology Fuzhou China Zhejiang University College of Electrical Engineering the Second Affiliated Hospital of Zhejiang University School of Medicine the State Key Lab of Brain-Machine Intelligence MOE Frontier Science Center for Brain Science and Brain-machine Integration Hangzhou China

Objective: For low-field magnetic resonance imaging (MRI) in unshielded environment, existing methods have been proposed to eliminate electromagnetic interference (EMI) noise in each single radio-frequency (RF) receive coil. In the present study, we propose to use the EMI information from multiple MRI receive coils collectively in EMI denoising. Methods: The proposed method leverages the information of inter-channel correlation, including EMI detectors and RF receive coils to remove EMI noise. Calibration signals from both EMI detectors and RF receivers are concatenated to determine a de-correlation matrix, which is then used to denoise MRI signals. Results: Saline phantom and in vivo experiments demonstrated the efficacy of the proposed method in EMI elimination, showing that the proposed method outperformed advanced EMI elimination methods with up to 16.34% improvement in EMI noise removal percentage (NRP) and 1.58dB improvement in signal-to-noise ratio (SNR), along with reduced computational times. Conclusion: The proposed method effectively removes EMI noise and shows improved performance by using information from all receive coils. Significance: This method allows for the design of multi-receive coils for low-field MRI such as phased-arrays, which have the potential to enhance the performance in noise removal and improve the SNR in MRI signal acquisition. © 2025 IEEE.

关键词： Signal to noise ratio

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Perivascular spaces relate to the course and cognition of Huntington’s disease

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Translational Neurodegeneration 2023年第1期12卷 546-549页

作者： Xiao-Yan Li Juan-Juan Xie Jin-Hong Wang Yu-Feng Bao Yi Dong Bin Gao Ting Shen Pei-Yu Huang Hao-Chao Ying Han Xu Anna Wang Roe Hsin-Yi Lai Zhi-Ying Wu Department of Medical Genetics and Center for Rare Diseases Department of Neurology in Second Affiliated HospitalKey Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhouChina Interdisciplinary Institute of Neuroscience and Technology College of Biomedical Engineering and Instrument ScienceKey Laboratory for Biomedical Engineering of Ministry of EducationZhejiang UniversityHangzhouChina College of Computer Science and Technology Zhejiang UniversityHangzhouChina Department of Radiology Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina School of Public Health Zhejiang UniversityHangzhouChina MOE Frontier Science Center for Brain Research and Brain-Machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhouChina CAS Center for Excellence in Brain Science and Intelligence Technology ShanghaiChina

Huntington’s disease(HD)is an autosomal dominant neurodegenerative disease that is caused by a cytosine-adenine-guanine(CAG)expansion in the first exon of the huntingtin(HTT)gene,which codes for the hun-tingtin *** typically manifests with a triad of symptoms,including motor disorders,cognitive impair-ment and psychiatric disturbances[1].HD primar-ily affects the basal ganglia(BG),especially the caudate and putamen,after which it extends to more widespread gray and white matter[2].Perivascular spaces(PVSs)are fluid-filled extensions of the subarachnoid spaces that enclose cerebral blood vessels and extend from the cer-ebral cortex through the brain *** physi-ological role of PVSs is the drainage of brain interstitial fluid into perivascular pathways for the elimination of waste products through the glymphatic drainage *** increasing number of studies have demonstrated that enlarged PVSs indicate glymphatic dysfunction and are associated with many neurological diseases,such as Alzheimer’s disease,Parkinson’s disease and small vessel disease[3].With the advantage of strong field strengths,7.0 T images show superior resolution and signal-to-noise ratios than 3.0 T,which facilitate the visualization of *** automated segmentation methods could accurately identify PVS in a short time with no inter-rater *** the current study,we used U-shaped networks(U-net),a class of deep learning methods,to explore the PVS distribution in HD and *** date,PVS distribution in HD is still *** two studies have investigated PVSs in HD,and both dem-onstrated increased visible PVS burden in manifest HD compared to controls[4,5].However,whether PVS bur-den increases in premanifest HD(pre-HD)individuals remains unknown,and the relationship of PVS with cog-nitive decline has never been studied.

关键词： Huntington filled elimination

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EAS-SNN: End-to-End Adaptive Sampling and Representation for Event-based Detection with Recurrent Spiking Neural Networks

arXiv

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arXiv 2024年

作者： Wang, Ziming Wang, Ziling Li, Huaning Qin, Lang Jiang, Runhao Ma, De Tang, Huajin College of Computer Science and Technology Zhejiang University Hangzhou310027 China State Key Laboratory of Brain-Machine Intelligence Zhejiang University Hangzhou310027 China

Event cameras, with their high dynamic range and temporal resolution, are ideally suited for object detection in scenarios with motion blur and challenging lighting conditions. However, while most existing approaches prioritize optimizing spatiotemporal representations with advanced detection backbones and early aggregation functions, the crucial issue of adaptive event sampling remains largely unaddressed. Spiking Neural Networks (SNNs), operating on an event-driven paradigm, align closely with the behavior of an ideal temporal event sampler. Motivated by this, we propose a novel adaptive sampling module that leverages recurrent convolutional SNNs enhanced with temporal memory, facilitating a fully end-to-end learnable framework for event-based detection. Additionally, we introduce Residual Potential Dropout (RPD) and Spike-Aware Training (SAT) to regulate potential distribution and address performance degradation encountered in spike-based sampling modules. Empirical evaluation on neuromorphic detection datasets demonstrates that our approach outperforms existing state-of-the-art spike-based methods with significantly fewer parameters and time steps. For instance, our method yields a 4.4% mAP improvement on the Gen1 dataset, while requiring 38% fewer parameters and only three time steps. Moreover, the applicability and effectiveness of our adaptive sampling methodology extend beyond SNNs, as demonstrated through further validation on conventional non-spiking models. Code is available at Github. Copyright © 2024, The Authors. All rights reserved.

关键词： Object detection

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Tumor Micro-Environment Interactions Guided Graph Learning for Survival Analysis of Human Cancers from Whole-Slide Pathological Images

Tumor Micro-Environment Interactions Guided Graph Learning f...

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Conference on computer Vision and Pattern Recognition (CVPR)

作者： Wei Shao YangYang Shi Daoqiang Zhang JunJie Zhou Peng Wan Ministry of Education College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Key Laboratory of Brain-Machine Intelligence Technology Nanjing China MIIT Key Laboratory of Pattern Analysis and Machine Intelligence Nanjing China

ISBN: (数字)9798350353006

ISBN: (纸本)9798350353013

The recent advance of deep learning technology brings the possibility of assisting the pathologist to predict the patients' survival from whole-slide pathological images (WSIs). However, most of the prevalent methods only worked on the sampled patches in specifically or randomly selected tumor areas of WSIs, which has very limited capability to capture the complex interactions between tumor and its surrounding micro-environment components. As a matter of fact, tumor is supported and nurtured in the heterogeneous tumor micro-environment(TME), and the detailed analysis of TME and their correlation with tumors are important to in-depth analyze the mechanism of cancer development. In this paper, we considered the spatial interactions among tumor and its two major TME components (i.e., lymphocytes and stromal fibrosis) and presented a Tumor Micro-environment Interactions Guided Graph Learning (TMEGL) algorithm for the prognosis prediction of human cancers. Specifically, we firstly selected different types of patches as nodes to build graph for each WSI. Then, a novel TME neighborhood organization guided graph embedding algorithm was proposed to learn node representations that can preserve their topological structure information. Finally, a Gated Graph Attention Network is applied to capture the survival-associated intersections among tumor and different TME components for clinical outcome prediction. We tested TMEGL on three cancer cohorts derived from The Cancer Genome Atlas (TCGA), and the experimental results indicated that TMEGL not only outperforms the existing WSI-based survival analysis models, but also has good explainable ability for survival prediction.

关键词： Pathology Analytical models Organizations Predictive models Semisupervised learning Prediction algorithms Pattern recognition

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