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A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme

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Bioactive Materials 2023年第3期21卷 547-565页

作者： Fei Wei Craig J.Neal Tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa Minh Ta Samuel Moxon Marco Molinari Jackson Asiatico Michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup Biionix Cluster Department of Internal MedicineCollege of MedicineUniversity of Central FloridaOrlandoFLUSA Advanced Materials Processing and Analysis Centre Nanoscience Technology Center(NSTC)Materials Science and EngineeringCollege of MedicineUniversity of Central FloridaOrlandoFLUSA CMC Materials 870 North CommonsDrAuroraILUSA Department of Chemistry Oakland UniversityRochesterMIMIUSA School of Applied Sciences Department of Chemical SciencesUniversity of HuddersfieldUK Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA Engineering Research Center for Revolutionizing Biomaterials North Carolina A&T UniversityGreensboroNCUSA Department of Automatic Control and Systems Engineering Insigneo Institute for In Silico MedicineUniversity of SheffieldSheffieldS13JDUK

The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy *** radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing *** demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic *** reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic *** properties make cerium oxide nanomaterials *** show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and *** investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in ***,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in *** findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials.

关键词： Ionizing radiation Osteoporosis Nanozyme Cerium oxide Bone strength Bone resorption

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Sharing and Collaborating When Teaching Automatic control: An Experience-Based Needs analysis

Sharing and Collaborating When Teaching Automatic Control: A...

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Mediterranean Conference on control and Automation (MED)

作者： Steffi Knorn Anja Garone Damiano Varagnolo Emanuele Garone Department of Control Technische Universität Berlin Germany Brussels Institute for Advanced Studies Belgium Department of Engineering Cybernetics Norwegian University of Science and Technology Norway Department of Information Engineering University of Padova Italy Department of Automation and Systems Analysis Free University of Brussels Belgium

ISBN: (数字)9798350395440

ISBN: (纸本)9798350395457

We discuss two specific issues that affected the workflows in our career as automatic control teachers and that are related to how teachers may establish teaching-oriented collaborations with colleagues from the same or different institutions. The first issue we identify is the systematic difficulty that one encounters when wanting to exchange instructional material with colleagues, while the second is the complexity of establishing students exchange programs across different institutions and nations. We discuss the nature and structure of the two problems, discuss why and how they are connected, and draw practical examples of how these problems may affect workflows. We then present a strategy that aims at solving these issues based on the introduction of an opportune indexing of instructional material in terms of contents and complexity of such contents, and how this information may be graphically displayed so to ease human and machine interpretability. We further discuss how this approach was used on a smaller scale to ease collaborations among close colleagues, and how it may be extended and adopted on a larger scale.

关键词： Visualization Systematics Engineering profession Databases Education Buildings Collaboration

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Swarm of satellites initial formation maintenance using impulsive and low thrust maneuvers

Swarm of satellites initial formation maintenance using impu...

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Accelerating Space Commerce, Exploration, and New Discovery Conference, ASCEND 2020

作者： Karimi, Reza R. Peterson, Joseph T.A. Rahmani, Amir Chung, Soon-Jo Junkins, John L. Hadaeagh, Fred Outer Planet Mission Analysis Group Jet Propulsion Laboratory PasadenaCA91109 United States Aerospace Engineering Department Texas A&M University College StationTX77843 United States Mobility and Robotic Systems Group Jet Propulsion Laboratory PasadenaCA91109 United States Department of Aerospace Engineering Coordinated Science Laboratory California Institute of Technology CA91125 United States Hagler Institute for Advanced Study Texas A&M University College StationTX77843 United States Jet Propulsion Laboratory PasadenaCA91109 United States

ISBN: (纸本)9781624106088

Emerging science and on-orbit service missions require a number of satellites in formation to maintain various shapes with given tolerances appropriate for the mission and onboard instruments;therefore, swarm station keeping plays a significant role in the success of the mission. In this work, we propose two techniques to maintain the desired initial swarm configurations, 1) based on determining a set of optimized deputy initial conditions such that the initial swarm experiences the least amount of deconfiguration due to both the dynamics of the deputies relative motion and also J2 and atmospheric drag perturbations. For extended missions, periodic maintenance is required by performing designed impulsive maneuvers to ensure that the swarm initial configuration is preserved as much as possible, and 2) based on a LQR algorithm in which the deputies relative motion is linearized about Chief’s orbit (HCW equations) and the low thrust maneuvers are designed to track the desired deputies reference trajectories. For case studies, two formations were considered, an equilateral triangle planar configuration with three deputies with Chief in the center and a tetrahedron formation with four deputies at the vertices with Chief at the centroid of the configuration. Results showed that the triangular formation maintenance is cheap in general, but for Tetrahedron, since we are dealing with out-of-plane motions, a tight formation maintenance would be expensive using impulsive maneuvers, while for small size tetrahedron configurations, LQR yields compelling solutions using continues low thrust maneuvers. © 2020 The MITRE Corporation. All Rights Reserved.

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Scaling reduction of port-Hamiltonian systems for numerical calculation

Scaling reduction of port-Hamiltonian systems for numerical ...

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ICROS-SICE International Joint Conference 2009, ICCAS-SICE 2009

作者： Nishida, Gou Ichishima, Daiji Kashima, Kenji Fujimoto, Kenji Yamakita, Masaki Maschke, Bernhard Ikeura, Ryojun Robotic Motion Lab. Advanced Science Institute RIKEN Japan Research and Development Center Sumitomo Heavy Industries Ltd. Japan Department of Mechanical and Environmental Informatics Graduate School of Information Science and Engineering Tokyo Institute of Technology Japan Department of Mechanical Science and Engineering Graduate School of Engineering Nagoya University Japan Department of Mechanical and Control Systems Engineering Tokyo Institute of Technology Japan Laboratoire d'Automatique et de Génie des Procédés UMR CNRS 5007 Université Claude Bernard Lyon 1 France Department of Mechanical Engineering Mie University Denmark

ISBN: (纸本)9784907764333

We present a novel reduction method of port-Hamiltonian systems by a renormalization group. The reduced system is suitable for a fast numerical calculation in a mesoscopic scale. Especially, we aim at the development of renormalized molecular dynamics with controls. First, we define a renormalized Hamiltonian with coarse graining. Next, we introduce a renormalized canonical Hamiltonian system. Moreover, we clarify the relationship between the renormalized Hamiltonian system and a Dirac structure. Finally, we obtain necessary conditions of boundary connections for each renormalized Hamiltonian system with different scales. © 2009 SICE.

关键词： Hamiltonians

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Computer vision based wheel sinkage detection for robotic lunar exploration tasks

Computer vision based wheel sinkage detection for robotic lu...

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IEEE International Conference on Mechatronics and Automation

作者： GuruPrasad Hegde Christopher J. Robinson Cang Ye Ashley Stroupe Edward Tunstel Department of Applied Science University of Arkansas at Little Rock Little Rock AR USA Department of Systems Engineering University of Arkansas at Little Rock Little Rock AR USA Advanced Robotic Control Group Jet Propulsion Laboratory Pasadena CA USA Space Department Johns Hopkins University Applied Physics Laboratory Laurel MD USA

This paper presents a wheel sinkage detection method that may be used in robotic lunar exploration tasks. The method extracts the boundary line between a robot wheel and lunar soil by segmenting the wheel-soil images captured from a video camera that monitors wheel-soil interaction. The detected boundary is projected onto the soil-free image of the robot wheel to determine the depth of wheel sinkage. The segmentation method is based on graph theory. It first clusters a wheel-soil image into homogeneous regions called superpixels and constructs a graph on the superpixels. It then partitions the graph into segments by using normalized cuts. Compared with the existing methods, the proposed algorithm is more robust to illumination condition, shadows and dust (covering the wheel). The method's efficacy has been validated by experiments under various conditions.

关键词： Wheels Image segmentation Mobile robots Soil Moon Pixel

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MODELING GROUND-WATER QUALITY SAMPLING DECISIONS

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GROUND WATER MONITORING AND REMEDIATION 1988年第4期8卷 121-134页

作者： HSUEH, YW RAJAGOPAL, R Ya-Wen Hsueh received undergraduate training in liberal arts at the National Taiwan University and a master's degree in geography with an emphasis in water resources from the University of Iowa. Her major research interests are in the fields of water resources Systems analysis environmental impact assessment and geographic information Systems. Her current affiliation at the National Taiwan University (Department of Environmental Science Taiwan Republic of China) includes research dealing with an assessment of state-of-the-art applications and management of Geographic Information Systems in the Department of Interior of the Government of Taiwan. R. Rajagopal received undergraduate and graduate education in mathematics and statistics from the University of Bombay a master's degree in operations research from the University of Florida and a Ph.D. in resource management with an emphasis on ground water pollution control from the University of Michigan. He is a professor of geography and civil and environmental engineering at the University of Iowa. He is currently a visiting scientist in the Advanced Monitoring Systems Division Environmental Monitoring Systems Laboratory P.O. Box 93478 U.S. Environmental Protection Agency Las Vegas NV 89193.

Questions such as what, where, when, and how often to sample play a central role in the development of monitoring strategies. Limited resources will not permit sampling for many contaminants at the same frequency at all well sites. Therefore, a resource allocation strategy is necessary to arrive at answers for the preceding types of questions. Such a strategy for a ground water quality monitoring program is formulated as an integer programming model (an optimization model). The model will be of use in the process of deciding what constituents to sample and where to sample them so as to maximize a given objective, subject to a set of budget, sampling, and regulatory constraints. The maximization objective in the model is defined as a weighted function of population exposure to a scaled measure of observed chemical concentrations. The sampling constraints are based on the observed variability of contaminants in the aquifer, needed precision in estimates, a chosen level of significance, the available budget for implementing the program, and selected regulatory constraints. The model is tested with field data obtained for 10 selected constituents from more than 650 wells in the Cambrian-Ordovician aquifer in Iowa. Results from two alternative formulations of the model are compared, analyzed, and discussed. Further avenues for research are briefly outlined.

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Transient Modeling and control of DFIG with Fault Ride Through Capability

Transient Modeling and Control of DFIG with Fault Ride Throu...

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IEEE Innovative Smart Grid Technologies - Asia

作者： Likin Simon Naina, P. M. Shanti Swarup Universidad Politécnica de Madrid Universidad Politécnica de Madrid Madrid Spain Department for Analysis and Control of Advanced Robotic Systems German Aerospace Center Oberpfaffenhofen Germany Department for Perception and Cognition German Aerospace Center Oberpfaffenhofen Germany

ISBN: (纸本)9781538642924

The scarcity in the electrical power generation and huge demand of power promotes more renewable energy integration to the grid. This paper proposes a solution for Fault/Low Voltage Ride through (LVRT) problem with dynamic crowbar operation for grid connected Doubly Fed Induction Generator (DFIG) based Wind Energy Conversion systems (WECS). Stator and rotor equations are developed in dq frame which makes possible to control active and reactive powers independently. Crowbar resister is connected at the rotor terminals to limit the rotor currents to protect the converters during low voltage or fault conditions. During abnormal condition, the crow bar connected in series with the rotor windings dissipate the rotor energy and limit the converter currents. This paper proposes an adaptive crowbar resistance which can dynamically change the resistance value to control the amount of rotor power to be dissipated. A set of comprehensive simulation case studies are done to verify the proposed control strategy.

关键词： Rotors Stators Doubly fed induction generators Torque Reactive power Voltage control Circuit faults

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DAFNI: A computational platform to support infrastructure systems research

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Proceedings of the Institution of Civil Engineers: Smart Infrastructure and Construction 2023年第3期176卷 108-116页

作者： Matthews, Brian Hall, Jim Batty, Michael Blainey, Simon Cassidy, Nigel Choudhary, Ruchi Coca, Daniel Hallett, Stephen Harou, Julien J James, Phil Lomax, Nik Oliver, Peter Sivakumar, Aruna Tryfonas, Theodoros Varga, Liz Scientific Computing Department Science and Technology Facilities Council Didcot United Kingdom School of Geography and the Environment University of Oxford Oxford United Kingdom Centre for Advanced Spatial Analysis University College London London United Kingdom Transportation Research Group Faculty of Engineering and Physical Sciences University of Southampton Southampton United Kingdom Department of Civil Engineering University of Birmingham Birmingham United Kingdom Department of Engineering University of Cambridge Cambridge United Kingdom Department of Automatic Control and Systems Engineering University of Sheffield Sheffield United Kingdom Centre for Environmental and Agricultural Informatics Cranfield University Cranfield United Kingdom Department of Mechanical Aerospace and Civil Engineering University of Manchester Manchester United Kingdom School of Engineering Newcastle University Newcastle United Kingdom School of Geography University of Leeds Leeds United Kingdom Department of Civil and Environmental Engineering Imperial College London London United Kingdom Department of Civil Engineering University of Bristol Bristol United Kingdom Department of Civil Environmental and Geomatic Engineering University College London London United Kingdom

Research into the engineering of infrastructure systems is increasingly data intensive. Researchers build computational models to explore scenarios such as investigating the merits of infrastructure plans, analysing historical data to inform system operations or assessing the impacts of infrastructure on the environment. Models are more complex, at higher resolution and with larger coverage. Researchers also require a 'multi-systems' approach to explore interactions between systems, such as energy and water with urban development, and across scales, from buildings and streets to regions or nations. Consequently, researchers need enhanced computational resources to support cross-institutional collaboration and sharing at scale. The Data and Analytics Facility for National Infrastructure (DAFNI) is an emerging computational platform for infrastructure systems research. It provides high-throughput compute resources so larger data sets can be used, with a data repository to upload data and share these with collaborators. Users' models can also be uploaded and executed using modern containerisation techniques, giving platform independence, scaling and sharing. Further, models can be combined into workflows, supporting multi-systems modelling and generating visualisations to present results. DAFNI forms a central resource accessible to all infrastructure systems researchers in the UK, supporting collaboration and providing a legacy, keeping data and models available beyond the lifetime of a project. © 2023 Emerald Publishing Limited: All rights reserved.

关键词： Urban growth

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A COMPUTER INTEGRATED ENGINEERING SYSTEM FOR DESIGN AND LIFE-CYCLE MANAGEMENT

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NAVAL ENGINEERS JOURNAL 1986年第3期98卷 115-121页

作者： NICKODEMUS, GH YANUS, ID Irwin D. Yanusgraduated from the University of Pennsylvania with a bachelor's degree in arts and science in 1960 and a bachelor of science degree in mechanical engineering in 1961. In 1963 he received a master of science degree in mechanical engineering from Carnegie-Mellon University. Mr. Yanus is presently the manager of naval systems engineering in the Computer Aided Engineering Department of the Plant Engineering Division of Westinghouse Electric Corporation. His prior experience includes 19 years at the Bettis Atomic Power Laboratory where he performed assignments of increasing responsibility in design analysis development and procurement of nuclear reactor components for naval applications. As the manager of reactor mechanical design he was responsible for the mechanical design of theNimitzclass reactor components and control drive mechanism technology development. Mr. Yanus is a member of the American Society of Mechanical Engineers and the Society of Naval Architects and Marine Engineers. Glen H. Nickodemusgraduated from Michigan State University in 1964 with a bachelor of science degree in civil engineering. He joined the Pittsburgh-Des Moines Corporation in July of the same year. A master of science degree in civil engineering was obtained from Carnegie-Mellon University in 1973. In 1969 Mr. Nickodemus joined the Advanced Reactors Division of the Westinghouse Electric Corporation where he performed design and structural analysis functions for the development of the Fast Flux Test Facility and Clinch River Breeder Reactor Plant (CRBRP). As manager of CRBRP reactor engineering stress analysis he was responsible for the reactor vessel internals closure head control rod drivelines and miscellaneous guard vessels and head access area components. He is currently the manager of software development for the Computer Aided Engineering Department of the Plant Engineering Division. Mr. Nickodemus is a member of the American Society of Mechanical Engineers and is a registered professional engineer in Penn

This paper describes a computer integrated engineering system for design and life cycle management of weapons systems, ships and other multidisciplined systems. All engineering data are stored in a central engineering database. Individual application databases define and process information necessary for specific discipline evaluations. Interface modules between the application databases and the engineering database ensure that the entered data are complete, consistent, compatible, and in compliance with requirements. Conflicts are immediately identified and efficiently resolved. Implementation of the system improves design quality and reduces costs by minimizing the number of design iterations, reducing the effort to implement changes, providing effective storage and retrieval, and reducing the need for ship checks prior to modifications and alterations.

关键词： MILITARY ENGINEERING

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Scaling reduction of port-Hamiltonian systems for numerical calculation

Scaling reduction of port-Hamiltonian systems for numerical ...

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SICE Annual Conference

作者： Gou Nishida Daiji Ichishima Kenji Kashima Kenji Fujimoto Masaki Yamakita Bernhard Maschke Ryojun Ikeura Robotic Motion Laboratory RTC Advanced Science Institute RIKEN Japan Research and Development Center Sumitomo Heany Industries Limited Japan Department of Mechanical and Environmental Informatics Graduate School of Information Science and Engineering Tokyo Institute of Technology Japan Department of Mechanical Science and Engineering Graduate School of Engineering University of Nagoya Japan Department of Mechanical and Control Systems Engineering Tokyo Institute of Technology Japan Laboratoire dAutomatique et de Génie des Procédés UMR CNRS 5007 Université Claude Bemard Lyon 1 France Department of Mechanical Engineering Mie University Japan

关键词： Microscopy Solids control systems Robot motion Research and development Electrical equipment industry Informatics Information science systems engineering and theory Mechanical engineering

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