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Obesity alters pathology and treatment response in inflammatory disease

四川生理科学杂志 2022年第3期44卷 446-446页

作者： Sagar P Bapat NOMIS Center for Immunobiology and Microbial Pathogenesis The Salk Institute for Biological Studies La Jolla CA USA Gene Expression Laboratory The Salk Institute for Biological Studies La Jolla CA USA Medical Scientist Training Program University of California San Diego La Jolla CA USA Department of Laboratory Medicine University of California San Francisco San Francisco CA USA Department of Microbiology and Immunology University of California San Francisco San Francisco CA USA Diabetes Center University of California San Francisco San Francisco CA USA Medical Scientist Training Program University of California San Francisco CA USA Division of Pulmonary Critical Care Allergy and Sleep Department of Medicine University of California San Francisco San Francisco CA USA School of Pharmaceutical Sciences Xiamen University Xiamen China Department of Dermatology University of California San Diego La Jolla CA USA Department of Surgery University of California San Francisco San Francisco CA USA Department of Medicine University of California San Francisco San Francisco CA USA Sandler Asthma Basic Research Center University of California San Francisco San Francisco CA USA School of Medicine Wake Forest University Winston–Salem NC USA Department of Dermatology Icahn School of Medicine at Mount Sinai New York NY USA Lung Biology Center Department of Medicine University of California San Francisco San Francisco CA USA Department of Biomedical Science Graduate School Kyungpook National University Kyungpook National University Hospital Daegu South Korea Department of Dermatology University of California San Francisco San Francisco CA USA Department of Pathology University of California San Francisco San Francisco CA USA Department of Internal Medicine Division of Pulmonary Critical Care and Sleep Medicine University of Kentucky Lexington KY USA Pulmonary Critical Care Section Department of Medicine Veterans Affairs San Diego Hea

Decades of work have elucidated cytokine signalling and transcriptional pathways that control T cell differentiation and have led the way to targeted biologic therapies that are effective in a range of autoimmune,allergic and inflammatory *** evidence indicates that obesity and metabolic disease can also influence the immune system1-7,although the mechanisms and effects on immunotherapy outcomes remain largely ***,using two models of atopic dermatitis,we show that lean and obese mice mount markedly different immune *** converted the classical type 2 T helper(TH2)-predominant disease associated with atopic dermatitis to a more severe disease with prominent TH17 *** also observed divergent responses to biologic therapies targeting TH2 cytokines,which robustly protected lean mice but exacerbated disease in obese ***-cell RNA sequencing coupled with genome-wide binding analyses revealed decreased activity of nuclear receptor peroxisome proliferator-activated receptor-γ(PPARγ)in TH2 cells from obese mice relative to lean mice.

关键词： dermatitis inflammatory allergic

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Current Methods for Hyperpolarized [1-13C]pyruvate MRI Human Studies

arXiv

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arXiv 2023年

作者： Larson, Peder E.Z. Bernard, Jenna M.L. Bankson, James A. Bøgh, Nikolaj Bok, Robert A. Chen, Albert P. Cunningham, Charles H. Gordon, Jeremy Hövener, Jan-Bernd Laustsen, Christoffer Mayer, Dirk McLean, Mary A. Schilling, Franz Slater, James Vanderheyden, Jean-Luc von Morze, Cornelius Vigneron, Daniel B. Xu, Duan Hansen, Esben Søvsø Szocska Miller, Jack Bertelsen, Lotte Bonde Vaeggemose, Michael Lin, Gigin Capozzi, Andrea Fuetterer, Max Chen, Albert Leftin, Avi Schulte, Rolf Rius, Irene Marco Booth, Thomas C. Mishkovsky, Mor Walker, Christopher Michael Keshari, Kayvan Woitek, Ramona Takado, Yuhei Vasquez, Crystal Müller, Christoph Floyd, Joel Grashei, Martin Topping, Geoff van Heijster, Frits Che, Jenny Kim, Yaewon Kurhanewicz, John Ohliger, Michael Sriram, Renuka Chaumeil, Myriam Bock, Michael Schmidt, Andreas Gallagher, Ferdia Chowdhury, Rafat Gong, Yangcan Punwani, Shonit Merritt, Matthew Grist, James Tyler, Damian Khashami, Fatemeh Malloy, Craig Park, Jae Mo Zaha, Vlad Department of Radiology and Biomedical Imaging University of California San FranciscoCA94143 United States UC Berkeley-UCSF Graduate Program in Bioengineering University of California San Francisco United States University of California BerkeleyCA94143 United States Department of Imaging Physics MD Anderson Medical Center HoustonTX United States The MR Research Center Department of Clinical Medicine Aarhus University Aarhus Denmark GE Healthcare Menlo ParkCA United States Sunnybrook Research Institute TorontoON Canada Department of Medical Biophysics University of Toronto TorontoON Canada Kiel University Am Botanischen Garten 14 Kiel24118 Germany Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of Medicine BaltimoreMD United States Greenebaum Cancer Center University of Maryland School of Medicine BaltimoreMD United States Department of Radiology University of Cambridge Cambridge United Kingdom Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Center Cambridge United Kingdom Department of Nuclear Medicine School of Medicine Klinikum Rechts der Isar Technical University of Munich Munich81675 Germany JLVMI Consulting LLC DousmanWI United States Department of Radiology Washington University St. LouisMO United States Aarhus University Aarhus Denmark Chang Gung Memorial Hospital Taoyuan Taiwan Technical University of Denmark Copenhagen Denmark ETH Zurich Zurich Switzerland GE Healthcare WaukeshaWI United States Institute for Bioengineering of Catalonia Barcelona Spain Kings College London London United Kingdom École Polytechnique Fédérale de Lausanne Lausanne Switzerland MD Anderson Cancer Center HoustonTX United States Memorial Sloan Kettering Cancer Center New YorkNY United States Danube Private University Kerns-Stein an der Donau Austria National Institutes for Quantum Science and Technology Chiba Japan National Institutes Health National Cancer Institute Bethe

MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, with recent rapid growth in studies largely based on increasing availability of hyperpolarized agent preparation methods suitable for use in humans. This paper aims to capture the current successful practices for HP MRI human studies with [1-13C]pyruvate - by far the most commonly used agent, which sits at a key metabolic junction in glycolysis. The paper is divided into four major topic areas: (1) HP 13C-pyruvate preparation, (2) MRI system setup and calibrations, (3) data acquisition and image reconstruction, and (4) data analysis and quantification. In each area, we identified the key components for a successful study, summarized both published studies and current practices, and discuss evidence gaps, strengths, and limitations. This paper is the output of the "HP 13C MRI Consensus Group" as well as the ISMRM Hyperpolarized Media MR and Hyperpolarized Methods & Equipment study groups. It further aims to provide a comprehensive reference for future consensus building as the field continues to advance human studies with this metabolic imaging modality. © 2023, CC BY.

关键词： Magnetic resonance imaging

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A comparison of coil combination strategies in 3D multi-channel MRSI reconstruction for patients with brain tumors (vol 31, e3929, 2018)

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NMR IN BIOMEDICINE 2018年第12期31卷 e3929-e3929页

作者： Vareth, M. Lupo, J. M. Larson, P. E. Z. Nelson, S. J. UC Berkeley-UCSF Graduate Program in Bioengineering University of California Berkeley and University of California San Francisco California USA Surbeck Laboratory of Advanced Imaging Department of Radiology and Biomedical Imaging University of California San Francisco California USA UC Berkeley-UCSF Graduate Program in Bioengineering University of California Berkeley and University of California San Francisco California USA Surbeck Laboratory of Advanced Imaging Department of Radiology and Biomedical Imaging University of California San Francisco California USA UC Berkeley-UCSF Graduate Program in Bioengineering University of California Berkeley and University of California San Francisco California USA Surbeck Laboratory of Advanced Imaging Department of Radiology and Biomedical Imaging University of California San Francisco California USA UC Berkeley-UCSF Graduate Program in Bioengineering University of California Berkeley and University of California San Francisco California USA Surbeck Laboratory of Advanced Imaging Department of Radiology and Biomedical Imaging University of California San Francisco California USA

The goal of this study was to find the most robust algorithm for a phase‐sensitive coil combination of 3D single‐cycle and lactate‐edited, multi‐channel H‐1 point‐resolved spectroscopy (PRESS) localized echo planar spectroscopic imaging (EPSI) data for clinical applications in the brain. Data were acquired over 5-10 minutes at 3T using 8‐ or 32‐channel array coils. Peak referencing with residual water and N‐acetyl‐aspartate, first‐point phasing, generalized least squared (GLS) and whitened singular‐value decomposition (WSVD) combination algorithms were evaluated relative to unsuppressed water with data from a phantom, six volunteers and 55 patients with brain tumors. Comparison metrics were signal‐to‐noise ratio, coefficient of variance and percent signal increase. Where residual water was present, using it as a reference peak for phasing and weighting factors from an imaging calibration scan gave the best overall performance. Greater improvement was seen for large selected volumes (>720 cm³) and for the 32‐channel array (25%) compared with the 8‐channel array (19%). Applying voxel‐by‐voxel phase corrections produced a larger increase in performance for the 32‐ versus 8‐channel coil. We conclude that, for clinically relevant 3D H‐1 PRESS localized EPSI studies, the most robust technique employed individual phase maps generated from high residual water and individual amplitude maps generated from calibration scans.

关键词： coil combination techniques first‐point phasing GLS lactate editing multichannel EPSI peak referencing PRESS localization WSVD

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Performance evaluation and comparison of two triple-nuclear RF resonators for 1H/19F/31PMR imaging at 9.4T

Performance evaluation and comparison of two triple-nuclear ...

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2019 IEEE International Conference on Real-Time Computing and Robotics, RCAR 2019

作者： Du, Feng Liu, Shengping Li, Nan Liu, Congcong Chen, Qiaoyan Zhang, Shuai Wang, Haifeng Zhang, Xiaoliang Li, Ye Research Center for Biomedical Imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Guang Dong China Chongqing University of Technology Department of Biomedical Engineering Chongqing China Department of Radiology and Biomedical Imaging University of California San Francisco San FranciscoCA94158 United States UCSF/UC Berkeley Joint Graduate Group in Bioengineering San FranciscoCA94158 United States

ISBN: (纸本)9781728137261

Radio frequency (RF) coils are critical devices in magnetic resonance (MR) systems for transmitting and receiving magnetic resonance signals. However, the required high operating frequency at ultrahigh magnetic fields makes the design of highly efficient radio frequency (RF) transmit or receive coils technically challenging. This is particularly true in the double-tuned or triple-tuned RF coils usually required in heteronuclear MRI and MRS where multiple nuclei, such as 1H, 19F, and 31P, are involved. The performance of RF coils is a critically important factor for realizing the high sensitivity provided by ultrahigh magnetic fields to contribute towards the advancement of a novel human in vivo application at 9.4T. In this work, two different configurations of novel triple-nuclear (1H/19F/31P) RF resonators were proposed for the ultrahigh field 9.4T applications. We also reported on the design and construction, and a field-circuit co-simulation was used to obtain the S-parameters, B1+ field and specific absorption rate (SAR) distributions to evaluate and compare their performance. And the characteristics and advantages of the proposed two different configurations of triple-nuclear RF resonators in the applications of 1H/19F/31P at ultrahigh magnetic field were investigated. © 2019 IEEE.

关键词： Magnetic resonance

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Novel techniques for large-scale manipulations of cortical networks in non-human primates

Novel techniques for large-scale manipulations of cortical n...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Azadeh Yazdan-Shahmorad Daniel B. Silversmith Philip N. Sabes University of California San Francisco San Francisco CA US UC Berkeley – UCSF Graduate Program in Bioengineering San Francisco CA 94158 USA

Optogenetics is a powerful tool that enables millisecond-level control of the activity of specific groups of neurons. Furthermore, it has the great advantage of artifact free recordings. These characteristics make this technique ideal for relating brain function to behavior in animals with great behavioral capabilities such as non-human primates (NHPs). We recently introduced a practical, stable interface for optogenetic stimulation and recording of large-scale cortical circuits in NHPs. Here we present the various potentials of this interface for studying circuits and connectivity at a large-scale and for relating it to behavior.

关键词： Frequency modulation Oscillators Time series analysis Couplings Electrical stimulation

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Publisher Correction: Modular and tunable biological feedback control using a de novo protein switch

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Nature 2020年第7798期579卷 E8页

作者： Andrew H Ng Taylor H Nguyen Mariana Gómez-Schiavon Galen Dods Robert A Langan Scott E Boyken Jennifer A Samson Lucas M Waldburger John E Dueber David Baker Hana El-Samad Department of Biochemistry and Biophysics University of California San Francisco San Francisco CA USA. Department of Bioengineering University of California Berkeley Berkeley CA USA. The UC Berkeley-UCSF Graduate Program in Bioengineering UC Berkeley Berkeley CA USA. Cell Design Initiative University of California San Francisco CA USA. Department of Biochemistry University of Washington Seattle WA USA. Institute for Protein Design University of Washington Seattle WA USA. Graduate Program in Biological Physics Structure and Design University of Washington Seattle WA USA. Howard Hughes Medical Institute University of Washington Seattle WA USA. Department of Biochemistry and Biophysics University of California San Francisco San Francisco CA USA. hana.el-samad@ucsf.edu. Cell Design Initiative University of California San Francisco CA USA. hana.el-samad@ucsf.edu. Chan-Zuckerberg Biohub San Francisco CA USA. hana.el-samad@ucsf.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Correction to: Toward Automatic Detection of Radiation-Induced Cerebral Microbleeds Using a 3D Deep Residual Network

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Journal of digital imaging 2019年第5期32卷 898页

作者： Yicheng Chen Javier E Villanueva-Meyer Melanie A Morrison Janine M Lupo UCSF-UC Berkeley Graduate Program in Bioengineering San Francisco USA. Department of Radiology and Biomedical Imaging University of California San Francisco San Francisco USA. UCSF-UC Berkeley Graduate Program in Bioengineering San Francisco USA. Janine.Lupo@ucsf.edu. Department of Radiology and Biomedical Imaging University of California San Francisco San Francisco USA. Janine.Lupo@ucsf.edu.

This paper was published inadvertently as open access. It has been corrected online.

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Drug Delivery: Injectable Drug‐Releasing Microporous Annealed Particle Scaffolds for Treating Myocardial Infarction (Adv. Funct. Mater. 43/2020)

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Advanced Functional Materials 2020年第43期30卷

作者： Jun Fang Jaekyung Koh Qizhi Fang Huiliang Qiu Maani M. Archang Mohammad Mahdi Hasani‐Sadrabadi Hiromi Miwa Xintong Zhong Richard Sievers Dong‐Wei Gao Randall Lee Dino Di Carlo Song Li Department of Bioengineering University of California Los Angeles CA 90095 USA Department of Medicine University of California Los Angeles CA 90095 USA Department of Medicine Cardiovascular Research Institute and Institute for Regeneration Medicine University of California San Francisco CA 94143 USA California NanoSystems Institute (CNSI) University of California Los Angeles CA 90095 USA UC Berkeley‐UCSF Graduate Program in Bioengineering University of California San Francisco San Francisco CA 94158 USA Department of Mechanical and Aerospace Engineering University of California Los Angeles CA 90095 USA Jonsson Comprehensive Cancer Centre University of California Los Angeles CA 90024 USA

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Cytocompatible magnetostrictive microstructures for nano- A nd microparticle manipulation on linear strain response piezoelectrics

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Multifunctional Materials 2018年第1期1卷

作者： Xiao, Zhuyun Khojah, Reem Chooljian, Marc Conte, Roberto Lo Schneider, Joseph D. Fitzell, Kevin Chopdekar, Rajesh V. Wang, Yilian Scholl, Andreas Chang, Jane Carman, Gregory P. Bokor, Jeffrey Carlo, Dino Di Candler, Rob N. Department of Electrical and Computer Engineering University of California Los Angeles United States Department of Bioengineering University of California Los Angeles United States University of California Berkeley UCSF Graduate Program in Bioengineering Berkeley United States Department of Electrical Engineering and Computer Sciences University of California Berkeley United States Department of Mechanical and Aerospace Engineering University of California Los Angeles United States Department of Chemical and Biomolecular Engineering University of California Los Angeles United States Advanced Light Source Lawrence Berkeley National Laboratory Berkeley United States California Nanosystems Institute Los Angeles United States

In this work, we investigate polycrystalline Ni and FeGamagnetostrictivemicrostructures on prepoled (011)-cut single crystal [Pb(Mg1/3Nb2/3)O3]1-x-[PbTiO3]x (PMN-PT, x ≈ 0.31) with linear strain profile versus applied electric field. Magnetostrictive microstructure arrays with various geometries are patterned on PMN-PT. Functionalizedmagnetic beads are trapped by localized stray fields originating fromthe microstructures. With an applied electric field, themagnetic domains are actuated, inducing the motion of the coupled particles with sub-micrometer precision. This work shows promise of using energy-efficient electric-field-controlled magnetostrictivemicro- A nd nanostructures formanipulatingmagnetic beads via a linear strain response. The work also demonstrates the viability of cells suspended in solution on these structures when subject to applied electric fields, proving the cytocompatibility of the platform for live cell sorting applications. © 2018 IOP Publishing Ltd.

关键词： Electric fields

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Author Correction: lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements

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Nature protocols 2021年第7期16卷 3736页

作者： M Grace Gordon Fumitaka Inoue Beth Martin Max Schubach Vikram Agarwal Sean Whalen Shiyun Feng Jingjing Zhao Tal Ashuach Ryan Ziffra Anat Kreimer Ilias Georgakopoulos-Soares Nir Yosef Chun Jimmie Ye Katherine S Pollard Jay Shendure Martin Kircher Nadav Ahituv Department of Bioengineering and Therapeutic Sciences University of California San Francisco San Francisco CA USA. Institute for Human Genetics University of California San Francisco San Francisco CA USA. Biological and Medical Informatics Graduate Program University of California San Francisco San Francisco CA USA. Department of Bioengineering and Therapeutic Sciences University of California San Francisco San Francisco CA USA. fumitaka.inoue@ucsf.edu. Institute for Human Genetics University of California San Francisco San Francisco CA USA. fumitaka.inoue@ucsf.edu. Berlin Institute of Health (BIH) Berlin Germany. Department of Genome Sciences University of Washington Seattle WA USA. Calico Life Sciences LLC South San Francisco CA USA. Gladstone Institutes San Francisco CA USA. Department of Electrical Engineering and Computer Sciences and Center for Computational Biology University of California Berkeley Berkeley CA USA. Chan-Zuckerberg Biohub San Francisco CA USA. Division of Rheumatology Department of Medicine University of California San Francisco San Francisco CA USA. Institute for Computational Health Sciences University of California San Francisco San Francisco California USA. Department of Epidemiology and Biostatistics and Institute of Computational Health Sciences University of California San Francisco San Francisco CA USA. Department of Genome Sciences University of Washington Seattle WA USA. shendure@uw.edu. Howard Hughes Medical Institute Seattle WA USA. shendure@uw.edu. Brotman Baty Institute for Precision Medicine University of Washington Seattle WA USA. shendure@uw.edu. Berlin Institute of Health (BIH) Berlin Germany. martin.kircher@bihealth.de. Charité-Universitätsmedizin Berlin Berlin Germany. martin.kircher@bihealth.de. Department of Bioengineering and Therapeutic Sciences University of California San Francisco San Francisco CA USA. nadav.ahituv@ucsf.edu. Institute for Human Genetics University of California San

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