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3D Image Acquisition and Display: Technology, Perception and Applications, 3D 2016

作者： Johnson, Paul V. Parnell, Jared A.Q. Kim, Joohwan Saunter, Christopher D. Banks, Martin S. Love, Gordon D. UC Berkeley UCSF Graduate Program in Bioengineering BerkeleyCA94720 United States Durham University Dept. of Physics DurhamDH1 3LE United Kingdom Vision Science Program School of Optometry University of California BerkeleyCA94720 United States

We describe two new methods of reducing the accommodation-vergence conflict using lenses between the viewer and the screen and assess their performance in terms of discomfort and time to complete a task. © OSA 2016.

ISBN: (纸本)9781943580156

关键词： Beam splitters Differential absorption lidar Eyes Fusion Presbyopia Stereoscopic displays

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Theoretical design and evaluation of endoluminal ultrasound applicators for thermal therapy of pancreatic cancer under image guidance

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AIP Conference Proceedings 2017年第1期1821卷

作者： Matthew Adams Serena Scott Vasant Salgaonkar Graham Sommer Chris Diederich 1Thermal Therapy Research Group University of California San Francisco 2340 Sutter Street S341 San Francisco CA 94109 USA 2Joint Graduate Program in Bioengineering UC Berkeley and UC San Francisco USA 3Stanford Medical Center 300 Pasteur Drive Stanford CA 94305 USA

An image-guided endoluminal ultrasound applicator has been proposed for palliative and potential curative thermal therapy of pancreatic tumors. By considering a directional transducer array of planar, tubular, or curvilinear transducers, this design offers the potential for fast volumetric therapy and 3D spatial control over the energy deposition profile. Treatment of pancreatic tumor tissue would be performed in a minimally invasive fashion with the applicator positioned in the gastrointestinal (GI) lumen, and sparing of the luminal wall would be achieved with a water-cooled balloon surrounding the transducers. A theoretical evaluation of this design was performed by developing a 3D acoustic and bioheat transfer model, with temperature and thermal dose solutions obtained using a FEM solver (COMSOL Multiphysics). Parametric studies were performed on a generalized anatomical model of the pancreas, tumor, and adjacent luminal wall to determine preferred transducer configurations and frequencies for maximizing lesion volume and penetration while sparing the luminal wall. Patient-specific models of pancreatic tumors were generated from CT studies and used to assess the feasibility of performing thermal ablation or hyperthermia on small (∼2 cm diameter) pancreatic head tumors with an endoluminal applicator positioned within the duodenum. Simulation results indicate lower transducer operating frequencies (1-3 MHz) are necessary to mitigate damage to the luminal wall, and a tradeoff between penetration depth and lesion volume emerges as the degree of focusing increases. For patient-specific ablation modeling of tumors within 30 mm of the luminal wall, approximately 95% of the volume could be ablated within 15 min using a planar or lightly focused transducer configuration without duodenal damage. Over 90% of the volume could be elevated above 40°C at steady state for hyperthermia applications (e.g., radiation sensitization, drug delivery) using a tubular transducer. For tum

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Detection of Isoforms Differing by a Single Charge Unit in Individual Cells

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Angewandte Chemie 2016年第40期128卷

作者： Augusto M. Tentori Kevin A. Yamauchi Amy E. Herr The UC Berkeley/UCSF Graduate Program in Bioengineering Berkeley CA USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Bioengineering UC Berkeley 308B Stanley Hall Berkeley CA 94720 USA

To measure protein isoforms in individual mammalian cells, we report single‐cell resolution isoelectric focusing (scIEF) and high‐selectivity immunoprobing. Microfluidic design and photoactivatable materials establish the tunable pH gradients required by IEF and precisely control the transport and handling of each 17‐pL cell lysate during analysis. The scIEF assay resolves protein isoforms with resolution down to a single‐charge unit, including both endogenous cytoplasmic and nuclear proteins from individual mammalian cells.

关键词： Einzelzellanalyse Immunassays Isoelektrische Fokussierung Lab-on-a-Chip Proteomik

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Towards a Full-Field Strain Sensor for Guiding Hernia Repairs

Towards a Full-Field Strain Sensor for Guiding Hernia Repair...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Amy Liao Hobart W. Harris Michel M. Maharbiz the UC Berkeley/UCSF Joint Bioengineering Program Berkeley CA 94709 USA UCSF Department of Surgery San Francisco CA 77005 USA. the Electrical Engineering Department and Bioengineering Department UC Berkeley Berkeley CA 94720 USA

ISBN: (纸本)9781424492695

Each year, approximately 400,000 ventral hernia repairs are performed in the United States [1], [2]. Large ventral hernias (hernias that occur in the abdominal wall) are typically treated by suturing in a surgical mesh to cover and overlap the hernia defect. However, in 10-20% of patients, the hernia repair fails, resulting in recurrence of the hernia, along with other complications including infection and intestinal obstruction [3], [4]. One potential cause of hernia recurrence is the unequal distribution of stress across the mesh resulting in high stress concentrations at the tissue-mesh interface, particularly at the site of mesh fixation to the abdominal wall muscles[5], [6]. Strain across the mesh can be used as an indicator for how evenly stress is distributed across the surface of the mesh. To this end, we have built a full-field, 3D strain measurement system to enable physicians to actively identify and address areas of high strain during the surgery, thus decreasing the rate of hernia recurrence. The strain sensor uses an optical technique, called the grid method, in conjunction with the defocused particle image velocimetry (DPIV) technique to measure the 3D strain distribution across the mesh. The system can achieve a limit of detection down to 0.4% strain and across a 50 cm range z-axis displacement using a Canon EOS 7D camera with a pinhole aperture mask.

关键词： Towards Full-Field Strain Sensor Guiding Hernia Repairs

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Experimental investigations of an endoluminal ultrasound applicator for MR-guided thermal therapy of pancreatic cancer

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AIP Conference Proceedings 2017年第1期1821卷

作者： Matthew Adams Vasant Salgaonkar Peter Jones Juan Plata Henry Chen Kim Butts Pauly Graham Sommer Chris Diederich 1Thermal Therapy Research Group University of California San Francisco 2340 Sutter Street S341 San Francisco CA 94109 USA 2Joint Graduate Program in Bioengineering UC Berkeley and UC San Francisco USA 3Radiological Sciences Laboratory Stanford University 1201 Welch Road Palo Alto CA 94304 USA 4Stanford Medical Center 300 Pasteur Drive Stanford CA 94305 USA

An MR-guided endoluminal ultrasound applicator has been proposed for palliative and potential curative thermal therapy of pancreatic tumors. Minimally invasive ablation or hyperthermia treatment of pancreatic tumor tissue would be performed with the applicator positioned in the gastrointestinal (GI) lumen, and sparing of the luminal tissue would be achieved with a water-cooled balloon surrounding the ultrasound transducers. This approach offers the capability of conformal volumetric therapy for fast treatment times, with control over the 3D spatial deposition of energy. Prototype endoluminal ultrasound applicators have been fabricated using 3D printed fixtures that seat two 3.2 or 5.6 MHz planar or curvilinear transducers and contain channels for wiring and water flow. Spiral surface coils have been integrated onto the applicator body to allow for device localization and tracking for therapies performed under MR guidance. Heating experiments with a tissue-mimicking phantom in a 3T MR scanner were performed and demonstrated capability of the prototype to perform volumetric heating through duodenal luminal tissue under real-time PRF-based MR temperature imaging (MRTI). Additional experiments were performed in ex vivo pig carcasses with the applicator inserted into the esophagus and aimed towards liver or soft tissue surrounding the spine under MR guidance. These experiments verified the capacity of heating targets up to 20-25 mm from the GI tract. Active device tracking and automated prescription of imaging and temperature monitoring planes through the applicator were made possible by using Hadamard encoded tracking sequences to obtain the coordinates of the applicator tracking coils. The prototype applicators have been integrated with an MR software suite that performs real-time device tracking and temperature monitoring.

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Corrigendum: Rapid and visual Chlamydia trachomatis detection using loop-mediated isothermal amplification and hydroxynaphthol blue

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Letters in applied microbiology 2017年第4期65卷 343页

作者： I Choopara N Arunrut W Kiatpathomchai D Dean N Somboonna Program in Biotechnology Faculty of Science Chulalongkorn University Bangkok Thailand. Bioengineering and Sensing Technology Laboratory National Center for Genetic Engineering and Biotechnology Khlong Nueng Khlong Luang Pathum Thani Thailand. Center for Immunobiology and Vaccine Development UCSF Benioff Children's Hospital Oakland Research Institute Oakland CA USA. Department of Medicine University of California San Francisco CA USA. Joint Graduate Program in Bioengineering University of California Berkeley CA USA. Department of Microbiology Faculty of Science Chulalongkorn University Bangkok Thailand.

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Enabling closed-loop neurostimulation research with downloadable firmware upgrades

Enabling closed-loop neurostimulation research with download...

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IEEE Biomedical Circuits and Systems (BIOCAS)

作者： Preeya Khanna Scott Stanslaski Yizi Xiao Terry Ahrens Duane Bourget Nicole Swann Philip Starr Jose M. Carmena Timothy Denison UC Berkeley/UCSF Joint Graduate Group in Bioengineering Neuromodulation Technology PLC Department of Neurological Surgery University of California San Francisco University of California Berkeley Berkeley CA US

We present a simulated case study using investigational, downloadable firmware updates to configure an existing implanted deep brain stimulator. With the upgrade, closed-loop algorithm parameters affecting stimulation state classification and stimulation timing can be embedded within the device to allow for chronic investigation of closed-loop concepts both flexibly and incrementally. The system can be outfitted with either cortical sensing electrodes or depth electrodes to explore a variety of closed-loop paradigms. The prototype case study presented here uses motor intention signals to titrate stimulation, a relevant use case for treatment of movement disorders, though the technology is extensible to other neurological disorders. To highlight the translational capabilities of this tool, the key technology considerations of battery power usage, chronic sensitivity and stability of biomarkers, and parameter tuning are discussed using representative testing and data sources.

关键词： Algorithm design and analysis Electrodes Microprogramming Satellite broadcasting Classification algorithms Sensors Computers

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Open-top selective plane illumination microscope compatible with standard sample holders

Open-top selective plane illumination microscope compatible ...

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Novel Techniques in Microscopy, NTM 2015

作者： McGorty, Ryan Liu, Harrison Kamiyama, Daichi Huang, Bo Deparment of Pharmaceutical Chemistry University of California San Francisco San FranciscoCA94158 United States UC Berkeley - UCSF Graduate Program in Bioengineering University of California San Francisco San FranciscoCA94158 United States Department of Biochemistry and Biophysics University of California San Francisco San FranciscoCA94158 United States

Selective plane illumination microscopy (SPIM) has emerged recently as a powerful tool in optically sectioning tissue samples. We have designed a new SPIM that allows samples to be mounted in a variety of common metho... 详细信息

ISBN: (纸本)9781557529541

关键词： Aberration correction Cylindrical lenses Laser beams Light sheet microscopy Selective plane illumination microscopy Spatial resolution

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Chemical shift separation with controlled aliasing for hyperpolarized 13C metabolic imaging

Chemical shift separation with controlled aliasing for hyper...

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作者： Shin, Peter J. Larson, Peder E.Z. Uecker, Martin Reed, Galen D. Kerr, Adam B. Tropp, James Ohliger, Michael A. Nelson, Sarah J. Pauly, John M. Lustig, Michael Vigneron, Daniel B. Department of Radiology and Biomedical Imaging University of California at San Francisco 1700 4th Street San FranciscoCA94158 United States UC Berkeley - UCSF Graduate Program in Bioengineering CA United States Department of Electrical Engineering and Computer Sciences University of California at Berkeley BerkeleyCA United States Magnetic Resonance Systems Research Laboratory Department of Electrical Engineering Stanford University StanfordCA United States General Electric Healthcare FremontCA United States

Purpose A chemical shift separation technique for hyperpolarized 13C metabolic imaging with high spatial and temporal resolution was developed. Specifically, a fast three-dimensional pulse sequence and a reconstruction method were implemented to acquire signals from multiple 13C species simultaneously with subsequent separation into individual images. Theory and Methods A stack of flyback echo-planar imaging readouts and a set of multiband excitation radiofrequency pulses were designed to spatially modulate aliasing patterns of the acquired metabolite images, which translated the chemical shift separation problem into parallel imaging reconstruction problem. An eight-channel coil array was used for data acquisition and a parallel imaging method based on nonlinear inversion was developed to separate the aliased images. Results Simultaneous acquisitions of pyruvate and lactate in a phantom study and in vivo rat experiments were performed. The results demonstrated successful separation of the metabolite distributions into individual images having high spatial resolution. Conclusion This method demonstrated the ability to provide accelerated metabolite imaging in hyperpolarized 13C MR using multichannel coils, tailored readout, and specialized RF pulses. © 2014 Wiley Periodicals, Inc.

关键词： Separation

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Motion artifacts on 240Hz OLED stereoscopic 3D displays

Motion artifacts on 240Hz OLED stereoscopic 3D displays

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2014 SID International Symposium

作者： Johnson, Paul Kim, Joohwan Hoffman, David M. Vargas, Andres Banks, Martin S. UC Berkeley - UCSF Graduate Program in Bioengineering United States University of California Berkeley Vision Science Program 360 Minor Hall Berkeley CA United States Samsung Display Americas Lab San Jose CA United States

We examined the visibility of motion artifacts-judder, motion blur, and edge banding-on a Samsung 240Hz stereoscopic 3D (S3D) OLED display. We determined the relative contributions of the frame rate of the content, update rate of the panel, duty cycle, and flash number. We compared the visibility of artifacts on the Samsung display with those on a 60Hz S3D LCD. Short duty cycles and low flash numbers reduce the visibility of motion artifacts. © 2014 SID.

关键词： Visibility

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