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IEEE Electron Device Letters 2025年第5期46卷 705-708页

作者： Chen, Yi-Ho Chu, Fu-Chuan Aslam, Muhammad Lee, Yao-Jen Li, Yiming Samukawa, Seiji National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Graduate Degree Program of College of Electrical and Computer Engineering Hsinchu300093 Taiwan National Chung-Shan Institute of Science and Technology Solid State Devices Section Electronic System Research Division Taoyuan325 Taiwan National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program Hsinchu300093 Taiwan Institute of Pioneer Semiconductor Innovation National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Institute of Pioneer Semiconductor Innovation Institute of Artificial Intelligence Innovation National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Institute of Biomedical Engineering Department of Electronics and Electrical Engineering Institute of Communications Engineering Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Institute of Communications Engineering Department of Electronics and Electrical Engineering Hsinchu300093 Taiwan

Recess gate etching is a critical technique for achieving enhancement-mode (E-mode) AlGaN/GaN high-electron mobility transistors (HEMTs) because the interface is susceptible to the etching damage. This study fabricates recess gates using the neutral beam etching (NBE) technique. By adjusting the aperture thickness in the NBE apparatus, we simulate both NB-mode and plasma-mode etching. The electrical characteristics of E-mode HEMTs fabricated using these two modes are analyzed and compared through DC, noise, and pulsed IV measurements. The results demonstrate that NB-recessed HEMTs exhibit superior performance. © 1980-2012 IEEE.

关键词： Aluminum gallium nitride

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Comparative Analysis of Quantum Support Vector Machines and Variational Quantum Classifiers for B-cell Epitope Prediction in Vaccine Design

arXiv

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arXiv 2025年

作者： Hwang, Chi-Chuan Su, Cheng-Fang Hong, Yi-Ang Department of Engineering Science National Cheng Kung University Tainan City701 Taiwan Department of Applied Mathematics National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan Undergraduate Degree Program of Systems Engineering and Technology National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan Chung Cheng Institute of Technology National Defense University Taoyuan City33551 Taiwan

Quantum computing offers new opportunities for addressing complex classification tasks in biomedical applications. This study investigates two quantum machine learning models-the Quantum Support Vector Machine (QSVM) and the Variational Quantum Classifier (VQC)-in the context of B-cell epitope prediction, a key step in modern vaccine design. QSVM builds upon the classical SVM framework by using quantum circuits to encode nonlinear kernel computations, while VQC replaces the entire classification pipeline with trainable quantum circuits optimized variationally. A benchmark dataset from the Immune Epitope Database (IEDB) is used for model evaluation. Each epitope is represented by 10 physicochemical features, and dimensionality reduction via Principal Component Analysis (PCA) is applied to assess model performance across different feature spaces. We also examine the effect of sample size on prediction outcomes. Experimental results show that QSVM performs well under limited data conditions, while VQC achieves higher accuracy in larger datasets. These findings highlight the potential of quantum-enhanced models for bioinformatics tasks, particularly in supporting efficient and scalable epitope-based vaccine development. Copyright © 2025, The Authors. All rights reserved.

关键词： Epitopes

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Relativistic Quantum Simulation of Hydrogen Sulfide for Hydrogen Energy via Hybrid Quantum-Classical Algorithms

arXiv

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arXiv 2025年

作者： Hwang, Chi-Chuan Su, Cheng-Fang Yang, Jung-Fan Department of Engineering Science National Cheng Kung University Tainan City701 Taiwan Department of Applied Mathematics National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan Undergraduate Degree Program of Systems Engineering and Technology National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan Chung Cheng Institute of Technology National Defense University Taoyuan City33551 Taiwan

We present a hybrid quantum-classical computational framework for simulating relativistic quantum chemical systems using the variational quantum eigensolver (VQE). Our approach integrates relativistic electron integrals derived from the Dirac–Coulomb Hamiltonian with quantum circuit models constructed via Jordan–Wigner transformation. By employing both heuristic and chemistry-inspired ansätze, we compute ground-state energies and potential energy surfaces (PES) for benchmark molecules including H2, H2O, and H2S. Active-space reduction and Hartree–Fock embedding techniques are used to minimize the number of qubits and Pauli terms, enabling efficient simulation on near-term quantum devices. Our results demonstrate that VQE can reproduce classical full-configuration-interaction energies with millihartree-level accuracy, even under relativistic Hamiltonians. We observe consistent relativistic energy shifts and orbital contraction effects, particularly for the sulfur-containing H2S molecule. The constructed PES allow for equilibrium geometry prediction and activation energy analysis. This work highlights the feasibility and scalability of applying quantum algorithms to relativistic electronic structure problems, paving the way for future simulations of heavier-element systems in quantum chemistry. Copyright © 2025, The Authors. All rights reserved.

关键词： Molecular orbitals

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Gait proficiency index in children aged 3.5 to 9.5 years old

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Research on Biomedical engineering 2021年第2期37卷 429-437页

作者： das Neves, Ana Maria Bender Seidenfuss de Souza, Leandro Daniel Aires, Andréia Gomes Souza, Thalita Borges Giacomazzi, Leandro Peserico Dachi, Édison Pereira Baptista, Rafael Reimann School of Technology Graduate Program in Electrical Engineering PUCRS Porto Alegre Brazil School of Health and Life Sciences Undergraduate Program in Physical Education PUCRS Porto Alegre Brazil School of Technology Undergraduate Program in Electrical Engineering PUCRS Porto Alegre Brazil School of Technology Associate Degree Program in Industrial Automation and Embedded Systems SENAI Porto Alegre Brazil School of Technology and School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul Av. Ipiranga 6681 Partenon Porto Alegre90619-900 Brazil

Introduction: The purpose of this study is to present a novel approach for gait assessment called gait proficiency index (GPI) using only ground reaction forces (GRF)-derived parameters. Material and methods: Barefoot gait from 51 healthy children was evaluated with the GPI in this study. The participants walked at their self-selected speed along a 6-m walkway with 8 force platforms placed in pairs. The force-time analysis resulted in a dynamic symmetry assessment (DSA) that is the result of vertical GRF component distribution for all gait cycles both the left and right foot. DSA and impulse calculation from GRF led to the calculation of the GPI, which is the relationship between the impulse of load response and mid-stance and impulse of terminal stance and pre-swing of both right and left feet multiplied by the DSA index. The children were divided into three groups with 17 participants each and classified according to age (mean age ± standard deviation): G1 (4.39 ± 0.511), G2 (6.33 ± 0.639), G3 (8.49 ± 0.636). Results: The results show that as children mature, the GPI seems to increase from G1 to G2 and decreases from G2 to G3 and that both the standard deviations and coefficient of variation decrease with the increase of age. Conclusions: This can be an indicative that the index can assess improvements in gait quality through age. However, there was no statistical significance between the groups in this variable. Also, the correlation between either DSA and age or GPI and age found is weak to make other conclusions but that the study of adults should be included to either validate or refute the use of GPI. © 2021, Sociedade Brasileira de Engenharia Biomedica.

关键词： Biophysics

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Wide Temperature Range and High Thermal Sensitivity Radiometer Image Sensor Using CMOS SPAD Array

Wide Temperature Range and High Thermal Sensitivity Radiomet...

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2022 International Symposium on VLSI technology, systems and Applications, VLSI-TSA 2022

作者： Tsai, Hui-Chen Liu, Chun-Hsien Lin, Sheng-Di Tsai, Chia-Ming Wu, Jau-Yang National Yang Ming Chiao Tung University Institute of Electronics Hsinchu Taiwan National Yang Ming Chiao Tung University Undergraduate Degree Program of Systems Engineering and Technology Hsinchu Taiwan

ISBN: (纸本)9781665409230

We demonstrate a wide temperature range and high thermal sensitivity radiometry image sensor by using a 32x32 pixels SPAD imager sensor with a time gated active reset circuit. The temperature range with upper limit of 1050 °C and lower limit of 280 °C can be detected with low noise, thanks to the high sensitivity performed by short deadtime and adjustable summed output of multi-pixel readout technology. The thermal image is detected with high spatial resolution of about 100 µm. © 2022 IEEE.

关键词： Image sensors

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Sasirangan Cloth Recognition and Shopping Experience Simulation Based on Virtual Reality Game with Non-Player Character Integration 8

Sasirangan Cloth Recognition and Shopping Experience Simulat...

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8th International HCI and UX Conference in Indonesia, CHIuXiD 2022

作者： Subandi, Subandi Syahidi, Aulia Akhrian Zakiah, Siti Kiyokawa, Kiyoshi Riyadi, Ahmad Noor, M. Helmy Politeknik Negeri Banjarmasin Smart City Information System Applied Undergraduate Program Banjarmasin Indonesia Universitas Brawijaya Informatics Engineering Undergraduate Program Faculty of Computer Science Malang Indonesia Nara Institute of Science and Technology Cybernetics and Reality Engineering Laboratory Ikoma Japan Politeknik Negeri Banjarmasin Informatics Engineering Diploma Program Banjarmasin Indonesia

ISBN: (纸本)9781665476645

Sasirangan cloth is one of the traditional cloths owned by Indonesia and is a typical cloth originating from the province of South Kalimantan. This Sasirangan cloth has many motifs and is unique. Sasirangan cloth is also one of the potentials that can attract local and foreign tourists to visit South Kalimantan. However, in recent years, tourist visits to South Kalimantan have decreased due to the impact of the COVID-19 pandemic. Then it also has an impact on the delay in the implementation of the Banjarmasin Sasirangan Festival which is usually held annually. The next impact is a decrease in turnover and interest in shopping for Sasirangan cloth, so that employees who work for Sasirangan cloth craftsmen are dismissed and reduce people's income. So the purpose of this study is to report the results of the development of a Virtual Reality Game application called VR-SasiranganKu by integrating the interaction of Non-Player Character (NPC) behavior with the type of narrative in the simulation genre game. VR-SasiranganKu is recommended to introduce and at the same time promote Sasirangan cloth to users, then justify the reaction to knowledge and shopping experience, and evaluate user experience using the UX Honeycomb method. Respondents involved as many as 100 people who are local and national tourists. The results show that the interaction of NPC behavior can provide good direction to users regarding the introduction of Sasirangan cloth by presenting an appropriate interaction design based on the narrative and the theme of the NPC that has been adopted, the results of justification using VR-SasiranganKu can provide knowledge reaction and very good shopping experience, and based on user experience evaluation that VR-SasiranganKu has adopted a very good UX with an average score of 4.91. © 2022 IEEE.

关键词： Virtual reality

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Effect of an antiferromagnetic order on tailoring Dzyaloshinskii- Moriya interaction in Pt/Co/IrMn trilayer

Effect of an antiferromagnetic order on tailoring Dzyaloshin...

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2023 IEEE International Magnetic Conference - Short Papers, INTERMAG Short Papers 2023

作者： Chen, Sheng-Huai Yang, Chao-Yao Lai, Chih-Huang National Tsing Hua University Department of Materials Science and Engineering Hsinchu300044 Taiwan National Yang Ming Chiao Tung University Department of Materials Science and Engineering Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Undergraduate Degree Program of Systems Engineering and Technology Hsinchu300093 Taiwan

ISBN: (纸本)9798350338362

Antiferromagnet (AFM) has currently participated in the spin-orbit torque (SOT) magnetoresistive random access memory (MRAM) technolopgy due to its great potential to be applied to the field-free SOT switching and promote the thermal stability of MRAM. However, effect of the introduction of AFM into the basic structure of SOT-MRAM composed of a heavy metal/ferromagnet (FM) bilayer was still not comprehensively understood. This work reports the effect of how an antiferromagnetic (AFM) order modifies the strength of Dzyaloshinskii-Moriya interaction (DMI) in a heavy metal (Pt)/FM (Co)/AFM (IrMn) trilayer, studied by SOT switching and loop-shift method. Increasing the AFM order reflected on exchange bias (Hex) through increasing the thickness of IrMn appears to significantly reduce the DMI strength of the trilayer, which leads to the reduction of the external field for yielding a complete SOT switching. The reduced DMI strength may ascribe to the Hex-hosted uni-directional anisotropy suppressing the neighboring spin canting in the FM layer. This stabilization for the magnetic moments via the Hex-hosted uni-directional anisotropy also improved the stability of SOT switching on the random read/write characterization, in which the strong AFM order would promote the memristivity for neuromorphic application and the weak AFM order would give rise to the stochasticity for the purpose of physically unclonable functionality. This work demonstrates the significance of an intrinsic tuning over the AFM order would serve as a switch to turn the SOT device into a stochastic/memristive cell to bridge probabilistic and neuromorphic computing. © 2023 IEEE.

关键词： Stochastic systems

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Revisiting a hidden order at an ferromagnet/antiferromagnet interface and its switching dynamics

Revisiting a hidden order at an ferromagnet/antiferromagnet ...

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2023 IEEE International Magnetic Conference - Short Papers, INTERMAG Short Papers 2023

作者： Yang, Chao-Yao Chen, Sheng-Huai Lai, Chih-Huang National Yang Ming Chiao Tung University Department of Materials Science and Engineering Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Undergraduate Degree Program of Systems Engineering and Technology Hsinchu300093 Taiwan National Tsing Hua University Department of Materials Science and Engineering Hsinchu300044 Taiwan

ISBN: (纸本)9798350338362

Study on the exchange bias (Hex) switching in a ferromagnet (FM)/antiferromagnet (AFM) bilayer driven by the spin-orbit torque (SOT) has been an explicit research field and current focus has been devoted to determining the approaches to drive the Hex switching along with specific SOT applications. Hex is magnetically dominant but only reveals the partial facet of IrMn, which is only responsible for the ferromagnetic component at the interface of AFM. Therefore, the complete facet of AFM and its interaction with SOT at an FM/AFM interface is still not fully uncovered. This research reports an SOT-driven hidden order transition behind Hex in a heavy metal (Pt)/FM (Co)/AFM (IrMn) trilayer along with the issue of switching activity at Co/IrMn interface. The exchange coupling across Co/IrMn interface allows a long-range spin order in the form of an exchange-spring configuration, yielding two kinds of order in IrMn: a canting-induced ferromagnetic order for hosting Hex and a hidden Néel order for preserving the antiferromagnetic nature. The former appears to be strongly coupled to the magnetization state of Co during the SOT switching, so it can be reversibly switched with Co on the Hex switching. On the contrary, the hidden Néel order transition re-orientated to the current direction appears to be irreversibly driven by SOT and independent on the current polarity, which can reflect on the magnetoresistance (MR) measurement and X-ray magnetic linear dichroism (XMLD) spectroscopy. Finally, a micromagnetic simulation reveals the dynamic IrMn spins are mainly based on a canting type interface instead of an uncompensated type via an exchange-spring coupling with Co. © 2023 IEEE.

关键词： Binary alloys

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One-step flow synthesis of size-controlled polymer nanogels in a fluorocarbon microfluidic chip

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RSC Advances 2024年第16期14卷 11258-11265页

作者： Montalbo, Reynaldo Carlos K. Wu, Meng-Jie Tu, Hsiung-Lin Institute of Chemistry Academia Sinica Taipei11529 Taiwan Nanoscience and Technology Taiwan International Graduate Program Academia Sinica Taipei11529 Taiwan Department of Engineering and System Science National Tsing-Hua University Hsinchu300044 Taiwan Department of Chemistry National Cheng-Kung University Tainan70101 Taiwan Genome and Systems Biology Degree Program Academia Sinica and National Taiwan University Taiwan

Synthetic polymer nanoparticles (NPs) with biomimetic properties are ideally suited for different biomedical applications such as drug delivery and direct therapy. However, bulk synthetic approaches can suffer from poor reproducibility and scalability when precise size control or multi-step procedures are required. Herein, we report an integrated microfluidic chip for the synthesis of polymer NPs. The chip could sequentially perform homopolymer synthesis and subsequent crosslinking into NPs without intermediate purification. This was made possible by fabrication of the chip with a fluorinated elastomer and incorporation of two microfluidic mixers. The first was a long channel with passive mixing features for the aqueous RAFT synthesis of stimuli-responsive polymers in ambient conditions. The polymers were then directly fed into a hydrodynamic flow focusing (HFF) junction that rapidly mixed them with a crosslinker solution to produce NPs. Compared to microfluidic systems made of PDMS or glass, our chip had better compatibility and facile fabrication. The polymers were synthesized with high monomer conversion and the NP size was found to be influenced by the flow rate ratio between the crosslinker solution and polymer solution. This allowed for the size to be predictably controlled by careful adjustment of the fluid flow rates. The size of the NPs and their stimuli-responses were studied using DLS and SEM imaging. This microfluidic chip design can potentially streamline and provide some automation for the bottom-up synthesis of polymer NPs while offering on-demand size control. © 2024 The Royal Society of Chemistry.

关键词： Microfluidic chips

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A New Tree Structure for Local Diagnosis

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Journal of Information Science and engineering 2024年第2期40卷 231-244页

作者： Chen, Meirun Li, Xiao-Yan Lin, Cheng-Kuan Pai, Kung-Jui School of Mathematics and Statistics Xiamen University of Technology Xiamen361024 China College of Computer and Data Science Fuzhou University Fuzhou350108 China Department of Computer Science National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Undergraduate Degree Program of Systems Engineering and Technology National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Computer Science and Information Engineering Chung Cheng Institute of Technology National Defense University Taoyuan30010 Taiwan Department of Industrial Engineering and Management Ming Chi University of Technology New Taipei City243303 Taiwan

Diagnosability is an important parameter to measure the fault tolerance of a multiprocessor system. If we only care about the state of a node, instead of doing the global diagnosis, Hsu and Tan proposed the idea of local diagnosis. Chiang and Tan provided an extended star structure to diagnose a node under comparison model. In this work, we evaluate the local diagnosability better by proposing a tree structure around this node. We provide the corresponding algorithm to diagnose the node. Simulation results are presented for different failure probability of a node in the tree and different percentage of faulty nodes in the tree, showing the performance of our algorithm. © 2024 Institute of Information Science. All rights reserved.

关键词： comparison model diagnosis algorithm fault diagnosis local diagnosability tree

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