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2011 11th IEEE International Conference on Nanotechnology, NANO 2011

作者： Brandigampala, Savindra Feikert, Paige Vattipalli, Krishna Prasad, Shalini Department of Electrical Enginering and Computer Science Wichita State University Wichita KS 67206 United States Bio-Engineering Program College of Engineering Wichita State University Wichita KS 67206 United States

ISBN: (纸本)9781457715143

The goal of this work is to understand the role of nano confinement in designing molecular biosensors. We have been investigating micro devices incorporated with nanoporous membranes as molecular bio-sensor platforms. Ultra low detection of biomolecules is the key expectation from the new class of molecular biosensors utilizing nanomaterial. In this paper we have evaluated the role of the physical attributes of nano-porous aluminum oxide membranes in nanoconfinement and enhancing sensitivity of detection of protein biomolecules. In this biosensor configuration we have generated a sandwich assay in a high density array of nanoscale confined spaces generated by overlaying the nanoporous alumina membrane over metallic microscale sensing sites. The binding of the biomolecules results in the perturbation of the electrical double layer due to the binding of the test protein (C-reactive protein). Using electrical impedance spectroscopy (EIS), the capacitance changes in the electrical double layer associated with specific protein binding has been evaluated. The sensor performance metrics of sensitivity and dynamic range have been analyzed with changes in the pore diameter. © 2011 IEEE.

关键词： Biomolecules

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Design Management Review 2014年第3期25卷

作者： John Maeda Steven Heller Tim Hoover Has been a design partner at Kleiner Perkins Caufield & Byers since January 2014 helping entrepreneurs and portfolio companies to build design into their company cultures. He served as the president of Rhode Island School of Design for six years through 2013 and also served as an associate director of research at the MIT Media Lab. Maeda has been a practicing designer since 1990 and his work is in the permanent collections of the Museum of Modern Art San Francisco Museum of Modern Art and the Cartier Foundation. He serves on the boards of several corporations including Sonos and Wieden + Kennedy and is chair of eBay's Design Advisory Board. His four published books include The Laws of Simplicity and Redesigning Leadership. Maeda is the recipient of a variety of international awards for his creative work including induction into the Art Director's Club Hall of Fame. In 2001 he received the White House National Design Award in 2002 he received the Mainichi Design Prize in Japan and in 2005 he was awarded the Raymond Loewy Foundation Prize in Germany. Maeda earned a BS and an MS from MIT in computer science and electrical engineering. He received a PhD in design science from the University of Tsukuba Institute of Art and Design in Japan as well as an MBA from Arizona State University. Co‐chair and co‐founder of the MFA Designer as Author and Entrepreneur program at the School of Visual Arts in New York. He was the art director of The New York Times Book Review and now writes the VISUALS column for the NYTBR. He also writes “The Daily Heller” at *** a weekly online design column for Atlantic magazine. He is author co‐author and editor of more than 165 books on the history and practice of graphic design illustration and satiric art. His forthcoming books include 100 Classic Graphic Design Magazines (Laurence King Publishers) and Raw Data: The Process Behind Information Graphics (Thames + Hudson). Heller was the 2011 recipient of the Smithsonian National Design Award for Design Mind. He has also writ

John Maeda is a past president of Rhode Island School of Design and an internationally known designer. He's now involved in helping entrepreneurs build design into their company cultures. Writer and educator Steven Heller pairs up with Tim Hoover, head of product and design at Canary, to talk about designer CEOs, start‐ups, and cutting out the middleman.

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Enhanced detection of cardiovascular biomarker proteins: A detailed study of nanoconfinement in nanoporous membrane

Enhanced detection of cardiovascular biomarker proteins: A d...

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2011 MRS Spring Meeting

作者： Brandigampala, Savindra Feikert, Paige Vattipalli, Krishna Prasad, Shalini Department of Electrical Engineering and Computer Science Wichita State University 1845 Fairmount St Wichita KS 67260 United States Bio-Engineering Program College of Engineering Wichita State University 1845 Fairmount St Wichita KS 67260 United States

ISBN: (纸本)9781627482004

The goal of this work is to understand the role of nano-confinement in designing an inexpensive and user friendly 'point- of- care' (POC) protein biosensor. We used printed circuit board based gold chips and integrated them with nanoporous alumina membranes in generating high density arrays of nano scale confined spaces. We initially tested the role of a nanomembrane in achieving signal enhancement through size based confinement of proteins. As a later part of the experiment, we studied the role of pore size on achieving signal enhancement by using membranes of two different pore sizes of 100 and 200 nm. It is critical that ultralow detection of biomolecules be achieved as they have significant impact in designing diagnostics platforms for early disease diagnosis. Commercially available nano-porous membranes made out of anodized alumina were evaluated for their role in nano-confinement and enhancing sensitivity of detection. In this biosensor configuration sandwich assay, an electrical double layer is formed between a test protein (C-reactive protein) and the gold surface underneath the porous membrane. Using electrical impedance spectroscopy, the capacitance/impedance changes in the electrical double layer, was analyzed which translated to identifying the sensitivity and the linear dose response of the sensor for two specific conditions (a) with nano confinement and (b) for varying size of confined spaces. © 2012 Materials Research Society.

关键词： Proteins

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Casier: Structures for composing tangibles and complementary interactors for use across diverse systems

Casier: Structures for composing tangibles and complementary...

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5th International Conference on Tangible Embedded and Embodied Interaction, TEI'11

作者： Ullmer, Brygg Dell, Christian Gill, Claudia Toole Jr., Cornelius Wiley, Cole Dever, Zachary Rogge, Landon Bradford, Rachel Riviere, Guillaume Sankaran, Rajesh Liu, Kexi Freeman, Chase Wallace Jr., Alvin DeLatin, Michael Washington, Christian Reeser, Alex Branton, Christopher W. Parker, Rod Louisiana State University Dept. of Computer Science United States United States Dept. of Electrical Engineering United States Graphic Design Program United States Hillsdale College United States ESTIA United States

ISBN: (纸本)9781450306287

Casiers are a class of tangible interface elements that structure the physical and functional composition of tangibles and complementary interactors (e.g., buttons and sliders). Casiers allow certain subsets of interactive functionality to be accessible across diverse interactive systems (with and without graphical mediation, employing varied sensing capabilities and supporting software). We illustrate examples of casiers in use, including iterations around a custom walk-up-and-use kiosk, as well as casiers operable across commercial platforms of widely varying cost and capability. © 2011 ACM.

关键词： Interactive computer systems

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Digital library 2.0 for educational resources

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Lecture Notes in computer science

作者： Akbar, Monika Fan, Weiguo Shaffer, Clifford A. Chen, Yinlin Cassel, Lillian Delcambre, Lois Garcia, Daniel D. Hislop, Gregory W. Shipman, Frank Furuta, Richard Carpenter II, B. Stephen Hsieh, Haowei Siegfried, Bob Fox, Edward A. Department of Computer Science Virginia Tech. Blacksburg VA United States Department of Computing Sciences Villanova University Villanova PA United States Department of Computer Science Portland State University Portland OR United States Electrical Engineering and Computer Science UC Berkeley Berkeley CA United States Department of Computer Science Drexel University Philadelphia PA United States Department of Computer Science Texas A and M College Station TX United States Art Education Program Pennsylvania State University State College PA United States School of Library and Information Science Univ. of Iowa Iowa City IA United States

ISBN: (纸本)9783642244681

We report on focus group feedback regarding the services provided by existing education-related Digital Libraries (DL). Participants provided insight into how they seek educational resources online, and what they perceive to be the shortcomings of existing educational DLs. Along with useful content, social interactions were viewed as important supplements for educational DLs. Such interactions lead to both an online community and new forms of content such as reviews and ratings. Based on our analysis of the focus group feedback, we propose DL 2.0, the next generation of digital library, which integrates social knowledge with DL content. © 2011 Springer-Verlag.

关键词： Digital libraries

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Online correction of orientation estimates using spatial memory in a neuromorphic head direction system

Online correction of orientation estimates using spatial mem...

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IEEE International Symposium on Circuits and Systems (ISCAS)

作者： Tarek M. Massoud Timothy K. Horiuchi Electrical and Computer Engineering Department Institute of Systems Research University of Maryland College Park MD USA Electrical and Computer Engineering Department Institute of Systems Research Neuroscience and Cognitive Science Program University of Maryland College Park MD USA

Many animals are known to maintain an internal estimate of their orientation in the environment. In the absence of external sensory cues, this estimate inevitably exhibits drift. When sensory information is available, associations between sensory landmarks and the internal estimate can be used to correct for drift. In this paper we present a neuromorphic system to model such associations between sensory landmarks in the environment (as provided by sonar) and the activity of a hardware-based head direction cell system (HDS) that continuously integrates angular velocity signals to maintain an estimate of the orientation. These associations are shown to correct for drift errors that are encountered in the HDS.

关键词： High definition video Robot sensing systems Neurons Navigation Sonar detection Neuromorphics

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BioN∅T: A searchable database of biomedical negated sentences

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BMC Bioinformatics 2011年第1期12卷 1-7页

作者： Agarwal, Shashank Yu, Hong Kohane, Issac Medical Informatics College of Engineering and Applied Sciences University of Wisconsin-Milwaukee 3200 N. Cramer St. Milwaukee WI 53201-0784 United States Department of Computer Science and Electrical Engineering College of Engineering and Applied Sciences University of Wisconsin-Milwaukee 3200 N. Cramer St. Milwaukee WI 53201-0784 United States Department of Health Sciences College of Health Science University of Wisconsin-Milwaukee 2400 E. Hartford Ave. Milwaukee WI 53211 United States Children's Hospital Informatics Program Children's Hospital 300 Longwood Ave. Enders-6 Boston MA 02115 United States

Background: Negated biomedical events are often ignored by text-mining applications;however, such events carry scientific significance. We report on the development of BioN∅T, a database of negated sentences that can be used to extract such negated ***: Currently BioN∅T incorporates ≈32 million negated sentences, extracted from over 336 million biomedical sentences from three resources: ≈2 million full-text biomedical articles in Elsevier and the PubMed Central, as well as ≈20 million abstracts in PubMed. We evaluated BioN∅T on three important genetic disorders: autism, Alzheimer's disease and Parkinson's disease, and found that BioN∅T is able to capture negated events that may be ignored by ***: The BioN∅T database can be a useful resource for biomedical researchers. BioN∅T is freely available at http://***/. In future work, we will develop semantic web related technologies to enrich BioN∅T. © 2011 Agarwal et al;licensee BioMed Central Ltd.

关键词： Database systems

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LOW-FREQUENCY ELECTRONIC NOISE IN GRAPHENE TRANSISTORS: COMPARISON WITH CARBON NANOTUBES

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International Journal of High Speed Electronics and Systems 2011年第1期20卷 161-170页

作者： GUANXIONG LIU WILLIAM STILLMAN SERGEY RUMYANTSEV MICHAEL SHUR ALEXANDER A. BALANDIN Nano-Device Laboratory Department of Electrical Engineering Materials Science and Engineering Program Bourns College of Engineering University of California – Riverside Riverside California 92521 USA Center for Integrated Electronics and Department of Electrical Computer and Systems Engineering Rensselaer Polytechnic Institute Troy New York 12180 USA Ioffe Physico-Technical Institute Russian Academy of Sciences St. Petersburg 194021 Russia Nano-Device Laboratory Department of Electrical Engineering and Materials Science Engineering Program Bourns College of Engineering University of California – Riverside Riverside California 92521 USA

We report results of the experimental investigation of the low-frequency noise in graphene transistors. The graphene devices were measured in three-terminal configuration. The measurements revealed low flicker noise levels with the normalized noise spectral density close to 1/f (f is the frequency) and the Hooge parameter α H ~10 -3 . Both top-gate and back-gate devices were studied. The analysis of the noise spectral-density dependence on the gate biases helped us to elucidate the noise sources in these devices. We compared the noise performance of graphene devices with that of carbon nanotube devices. It was determined that graphene devices works better than carbon nanotube devices in terms of the low-frequency noise. The obtained results are important for graphene electronic, communication and sensor applications.

关键词： graphene 1/ f noise carbon nanotubes low-frequency noise graphene transistors

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An automated bottle filling and capping project for freshman engineering students

An automated bottle filling and capping project for freshman...

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2010 ASEE Annual Conference and Exposition

作者： Meah, Kala Garrison, Timothy Kearns, James Link, Gregory Garrison, Laura Blanding, Wayne Celik, Emine Kuchnicki, Stephen Dawson, Jennifer McFarland, Barry Department of Physical Science York College of Pennsylvania United States Mechanical Engineering Program York College of Pennsylvania United States Department of Electrical and Computer Engineering York College of Pennsylvania United States Department of Thermal Sciences Freshmen Design Courses and Computer Programming York College of Pennsylvania United States Department of Electrical Engineering York College of Pennsylvania United States York College of Pennsylvania United States Department of Mechanical Engineering York College of Pennsylvania United States

All freshman engineering students at York college participate in a spring semester design challenge as part of a year-long, two-course introduction to engineering. This paper describes the course organization, the project goals, and project itself and how it supports the broader engineering curriculum goals of engaging freshman engineering students in a design project, exposing them in an interesting way to the breath of engineering, and motivating them in their engineering studies. The students work in small teams and have roughly 12 weeks to design an automated electromechanical system that first transports three empty Snapple bottles, three tennis balls, and 36 oz. of water to a 2/x3/ operational zone. The machine must fill each bottle with 12 oz. of water, cap each bottle by covering the top with a tennis ball, and then deliver the capped and filled bottles to an area outside of the operational zone. The bottle-filling project serves as the second of two interdisciplinary engineering design experiences during the freshman year. It introduces aspects of computer, electrical, and mechanical engineering, including the following five primary knowledge areas: (i) machining and fabrication;(ii) electronic circuit prototyping and programming;(iii) sensor and actuator applications;(iv) mechanical design;(v) project planning;and (vi) presentation skills. A project demonstration at the end of the semester determines the relative effectiveness of each machine based upon a number of quantitative factors, including the total time required to complete the overall process, the volume of water in each bottle, the number of bottles successfully capped, the amount of water spilled, and approximate manufacturing cost. Some qualitative factors considered are simplicity, creativity, and aesthetics. Student interest in this substantial hands-on experience, as measured by surveys and exhibited by attendance, enthusiasm, productivity, and success, appears to be high through the three y

关键词： Bottles

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Study of parallel AC and DC electrical distribution in the all-electric ship

Study of parallel AC and DC electrical distribution in the a...

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Grand Challenges in Modeling and Simulation Symposium, GCMS 2010, Part of the 2010 Summer Simulation Multiconference, SummerSim 2010

作者： Chalfant, Julie S. Chryssostomidis, Chryssostomos Angle, Matthew G. Design Laboratory MIT Sea Grant College Program United States Research Laboratory of Electronics Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA United States

ISBN: (纸本)9781617387043

Medium-voltage DC electrical distribution is envisioned as a possible system for the warship of the future, bringing numerous advantages including a very power-dense architecture. This system takes the AC power produced by generators, immediately rectifies all power to DC and distributes it throughout the ship, requiring inversion back to AC for all AC loads. The question then arises whether it makes sense instead to route two parallel buses: an AC bus for all 60 Hz. AC loads and a DC bus to service all other loads. We model these two theoretical distribution systems in a notional destroyer using a preliminary design tool under development in our laboratory and find that the two-bus system is more efficient and lighter.

关键词： Electric drives

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