检索结果-内蒙古大学图书馆

arXiv 2024年

作者： Audard, Marc Awaki, Hisamitsu Ballhausen, Ralf Bamba, Aya Behar, Ehud Boissay-Malaquin, Rozenn Brenneman, Laura Brown, Gregory V. Corrales, Lia Costantini, Elisa Cumbee, Renata Diaz-Trigo, Maria Done, Chris Dotani, Tadayasu Ebisawa, Ken Eckart, Megan Eckert, Dominique Enoto, Teruaki Eguchi, Satoshi Ezoe, Yuichiro Foster, Adam Fujimoto, Ryuichi Fujita, Yutaka Fukazawa, Yasushi Fukushima, Kotaro Furuzawa, Akihiro Gallo, Luigi García, Javier A. Gu, Liyi Guainazzi, Matteo Hagino, Kouichi Hamaguchi, Kenji Hatsukade, Isamu Hayashi, Katsuhiro Hayashi, Takayuki Hell, Natalie Hodges-Kluck, Edmund Hornschemeier, Ann Ichinohe, Yuto Ishida, Manabu Ishikawa, Kumi Ishisaki, Yoshitaka Kaastra, Jelle Kallman, Timothy Kara, Erin Katsuda, Satoru Kanemaru, Yoshiaki Kelley, Richard Kilbourne, Caroline Kitamoto, Shunji Kobayashi, Shogo Kohmura, Takayoshi Kubota, Aya Leutenegger, Maurice Loewenstein, Michael Maeda, Yoshitomo Markevitch, Maxim Matsumoto, Hironori Matsushita, Kyoko McCammon, Dan McNamara, Brian Mernier, François Miller, Eric D. Miller, Jon M. Mitsuishi, Ikuyuki Mizumoto, Misaki Mizuno, Tsunefumi Mori, Koji Mukai, Koji Murakami, Hiroshi Mushotzky, Richard Nakajima, Hiroshi Nakazawa, Kazuhiro Ness, Jan-Uwe Nobukawa, Kumiko Nobukawa, Masayoshi Noda, Hirofumi Odaka, Hirokazu Ogawa, Shoji Ogorzalek, Anna Okajima, Takashi Ota, Naomi Paltani, Stephane Petre, Robert Plucinsky, Paul Porter, Frederick Scott Pottschmidt, Katja Sato, Kosuke Sato, Toshiki Sawada, Makoto Seta, Hiromi Shidatsu, Megumi Simionescu, Aurora Smith, Randall Suzuki, Hiromasa Szymkowiak, Andrew Takahashi, Hiromitsu Takeo, Mai Tamagawa, Toru Tamura, Keisuke Tanaka, Takaaki Tanimoto, Atsushi Tashiro, Makoto Terada, Yukikatsu Terashima, Yuichi Tsuboi, Yohko Tsujimoto, Masahiro Tsunemi, Hiroshi Tsuru, Takeshi G. Uchida, Hiroyuki Uchida, Nagomi Uchida, Yuusuke Uchiyama, Hideki Ueda, Yoshihiro Uno, Shinichiro Vink, Jacco Watanabe, Shin Williams, Brian J. Yamada, Satoshi Yamada, Shinya Yamaguchi, Hiroya Yamaoka, Kazutaka Yamasaki, Noriko Yamauchi, Makoto Yamauchi, S Department of Astronomy University of Geneva VersoixCH-1290 Switzerland Department of Physics Ehime University Ehime790-8577 Japan Department of Astronomy University of Maryland College ParkMD20742 United States NASA Goddard Space Flight Center GreenbeltMD20771 United States GreenbeltMD20771 United States Department of Physics University of Tokyo Tokyo113-0033 Japan Department of Physics Technion Technion City Haifa3200003 Israel BaltimoreMD21250 United States Center for Astrophysics | Harvard-Smithsonian MA02138 United States Lawrence Livermore National Laboratory CA94550 United States Department of Astronomy University of Michigan MI48109 United States SRON Netherlands Institute for Space Research Leiden Netherlands ESO Karl-Schwarzschild-Strasse 2 Garching bei Munchen85748 Germany Centre for Extragalactic Astronomy Department of Physics University of Durham South Road DurhamDH1 3LE United Kingdom Kanagawa252-5210 Japan Department of Physics Kyoto University Kyoto606-8502 Japan Department of Economics Kumamoto Gakuen University Kumamoto862-8680 Japan Department of Physics Tokyo Metropolitan University Tokyo192-0397 Japan Department of Physics Hiroshima University Hiroshima739-8526 Japan Department of Physics Fujita Health University Aichi470-1192 Japan Department of Astronomy and Physics Saint Mary's University Nova ScotiaB3H 3C3 Canada Cahill Center for Astronomy and Astrophysics California Institute of Technology PasadenaCA91125 United States Noordwijk2200 AG Netherlands Faculty of Engineering University of Miyazaki Miyazaki889-2192 Japan RIKEN Nishina Center Saitama351-0198 Japan Leiden Observatory University of Leiden P.O. Box 9513 LeidenNL-2300 RA Netherlands Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology MA02139 United States Department of Physics Saitama University Saitama338-8570 Japan Department of Physics Rikkyo University Tokyo171-8501 Japa

Sagittarius A East is a supernova remnant with a unique surrounding environment, as it is located in the immediate vicinity of the supermassive black hole at the Galactic center, Sagittarius A∗. The X-ray emission of the remnant is suspected to show features of overionized plasma, which would require peculiar evolutionary paths. We report on the first observation of Sagittarius A East with X-Ray Imaging and Spectroscopy Mission (XRISM). Equipped with a combination of high-resolution microcalorimeter spectrometer and large field-of-view CCD imager, we for the first time resolved the Fe XXV K-shell lines into fine structure lines and measured the forbidden-to-resonance intensity ratio to be 1.39±0.12, which strongly suggests the presence of overionized plasma. We obtained a reliable constraint on the ionization temperature just before the transition into the overionization state, to be > 4 keV. The recombination timescale was constrained to be 11 cm−3 s. The small velocity dispersion of 109 ±6 km s−1 indicates a low Fe ion temperature −1. The high initial ionization temperature and small recombination timescale suggest that either rapid cooling of the plasma via adiabatic expansion from dense circumstellar material or intense photoionization by Sagittarius A∗ in the past may have triggered the overionization. © 2024, CC BY.

关键词： Supernovae

来源：评论

学校读者我要写书评

暂无评论

The XRISM First Light Observation: Velocity Structure and Thermal Properties of the Supernova Remnant N132D

arXiv

引用

arXiv 2024年

作者： Audard, Marc Awaki, Hisamitsu Ballhausen, Ralf Bamba, Aya Behar, Ehud Boissay-Malaquin, Rozenn Brenneman, Laura Brown, Gregory V. Corrales, Lia Costantini, Elisa Cumbee, Renata Diaz-Trigo, Maria Done, Chris Dotani, Tadayasu Ebisawa, Ken Eckart, Megan Eckert, Dominique Enoto, Teruaki Eguchi, Satoshi Ezoe, Yuichiro Foster, Adam Fujimoto, Ryuichi Fujita, Yutaka Fukazawa, Yasushi Fukushima, Kotaro Furuzawa, Akihiro Gallo, Luigi Garcia, Javier A. Gu, Liyi Guainazzi, Matteo Hagino, Kouichi Hamaguchi, Kenji Hatsukade, Isamu Hayashi, Katsuhiro Hayashi, Takayuki Hell, Natalie Hodges-Kluck, Edmund Hornschemeier, Ann Ichinohe, Yuto Ishida, Manabu Ishikawa, Kumi Ishisaki, Yoshitaka Kaastra, Jelle Kallman, Timothy Kara, Erin Katsuda, Satoru Kanemaru, Yoshiaki Kelley, Richard Kilbourne, Caroline Kitamoto, Shunji Kobayashi, Shogo Kohmura, Takayoshi Kubota, Aya Leutenegger, Maurice Loewenstein, Michael Maeda, Yoshitomo Markevitch, Maxim Matsumoto, Hironori Matsushita, Kyoko McCammon, Dan McNamara, Brian Mernier, François Miller, Eric D. Miller, Jon M. Mitsuishi, Ikuyuki Mizumoto, Misaki Mizuno, Tsunefumi Mori, Koji Mukai, Koji Murakami, Hiroshi Mushotzky, Richard Nakajima, Hiroshi Nakazawa, Kazuhiro Ness, Jan-Uwe Nobukawa, Kumiko Nobukawa, Masayoshi Noda, Hirofumi Odaka, Hirokazu Ogawa, Shoji Ogorzalek, Anna Okajima, Takashi Ota, Naomi Paltani, Stephane Petre, Robert Plucinsky, Paul Porter, Frederick Scott Pottschmidt, Katja Sato, Kosuke Sato, Toshiki Sawada, Makoto Seta, Hiromi Shidatsu, Megumi Simionescu, Aurora Smith, Randall Suzuki, Hiromasa Szymkowiak, Andrew Takahashi, Hiromitsu Takeo, Mai Tamagawa, Toru Tamura, Keisuke Tanaka, Takaaki Tanimoto, Atsushi Tashiro, Makoto Terada, Yukikatsu Terashima, Yuichi Tsuboi, Yohko Tsujimoto, Masahiro Tsunemi, Hiroshi Tsuru, Takeshi G. Uchida, Hiroyuki Uchida, Nagomi Uchida, Yuusuke Uchiyama, Hideki Ueda, Yoshihiro Uno, Shinichiro Vink, Jacco Watanabe, Shin Williams, Brian J. Yamada, Satoshi Yamada, Shinya Yamaguchi, Hiroya Yamaoka, Kazutaka Yamasaki, Noriko Yamauchi, Makoto Yamauchi, S Department of Astronomy University of Geneva VersoixCH-1290 Switzerland Department of Physics Ehime University Ehime790-8577 Japan Department of Astronomy University of Maryland College ParkMD20742 United States NASA / Goddard Space Flight Center GreenbeltMD20771 United States GreenbeltMD20771 United States Department of Physics University of Tokyo Tokyo113-0033 Japan Department of Physics Technion Technion City Haifa3200003 Israel BaltimoreMD21250 United States Center for Astrophysics Harvard-Smithsonian MA02138 United States Lawrence Livermore National Laboratory CA94550 United States Department of Astronomy University of Michigan MI48109 United States SRON Netherlands Institute for Space Research Leiden Netherlands ESO Karl-Schwarzschild-Strasse 2 Garching bei München85748 Germany Centre for Extragalactic Astronomy Department of Physics University of Durham South Road DurhamDH1 3LE United Kingdom Kanagawa252-5210 Japan Department of Physics Kyoto University Kyoto606-8502 Japan Department of Economics Kumamoto Gakuen University Kumamoto862-8680 Japan Department of Physics Tokyo Metropolitan University Tokyo192-0397 Japan Department of Physics Hiroshima University Hiroshima739-8526 Japan Department of Physics Fujita Health University Aichi470-1192 Japan Department of Astronomy and Physics Saint Mary’s University Nova ScotiaB3H 3C3 Canada Cahill Center for Astronomy and Astrophysics California Institute of Technology PasadenaCA91125 United States Noordwijk2200 AG Netherlands Faculty of Engineering University of Miyazaki Miyazaki889-2192 Japan RIKEN Nishina Center Saitama351-0198 Japan Leiden Observatory University of Leiden P.O. Box 9513 LeidenNL-2300 RA Netherlands Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology MA02139 United States Department of Physics Saitama University Saitama338-8570 Japan Department of Physics Rikkyo University Tokyo171-8501 Japa

We present an initial analysis of the X-Ray Imaging and Spectroscopy Mission (XRISM) first-light observation of the supernova remnant (SNR) N132D in the Large Magellanic Cloud. The Resolve microcalorimeter has obtained the first high-resolution spectrum in the 1.6–10 keV band, which contains K-shell emission lines of Si, S, Ar, Ca, and Fe. We find that the Si and S lines are relatively narrow, with a broadening represented by a Gaussian-like velocity dispersion of σv ∼ 450 km s−1. The Fe Heα lines are, on the other hand, substantially broadened with σv ∼ 1670 km s−1. This broadening can be explained by a combination of the thermal Doppler effect due to the high ion temperature and the kinematic Doppler effect due to the SNR expansion. Assuming that the Fe Heα emission originates predominantly from the supernova ejecta, we estimate the reverse shock velocity at the time when the bulk of the Fe ejecta were shock heated to be −1000 ∼ Vrs [km s−1] ∼ 3300 (in the observer frame). We also find that Fe Lyα emission is redshifted with a bulk velocity of ∼ 890 km s−1, substantially larger than the radial velocity of the local interstellar medium surrounding N132D. These results demonstrate that high-resolution X-ray spectroscopy is capable of providing constraints on the evolutionary stage, geometry, and velocity distribution of SNRs. Copyright © 2024, The Authors. All rights reserved.

关键词： Supernovae

来源：评论

学校读者我要写书评

暂无评论

Twitter and facebook posts about COVID-19 are less likely to spread false and low-credibility content compared to other health topics

arXiv

引用

arXiv 2020年

作者： Broniatowski, David A. Kerchner, Daniel Farooq, Fouzia Huang, Xiaolei Jamison, Amelia M. Dredze, Mark Quinn, Sandra Crouse Department of Engineering Management and Systems Engineering School of Engineering and Applied Science George Washington University WashingtonDC20052 United States Institute for Data Democracy and Politics The George Washington University WashingtonDC20052 United States George Washington University Libraries The George Washington University WashingtonDC20052 United States Department of Epidemiology Graduate School of Public Health University of Pittsburgh PittsburghPA15260 United States Department of Computer Science University of Memphis MemphisTN38152 United States Department of Family Science Center for Health Equity School of Public Health University of Maryland College ParkMD20742 United States Department of Computer Science Whiting School of Engineering Johns Hopkins University BaltimoreMD21218 United States

On February 2, 2020, the World Health Organization declared a COVID-19 social media "infodemic", with special attention to misinformation - frequently understood as false claims. To understand the infodemic's scope and scale, we analyzed over 500 million posts from Twitter and Facebook about COVID-19 and other health topics, between March 8 and May 1, 2020. Following prior work (Lazer et al., 2019), we assumed URL source credibility is a proxy for false content, but we also tested this assumption. Contrary to expectations, we found that messages about COVID-19 were more likely to contain links to more credible sources. Additionally, messages linking to government sources, and to news with intermediate credibility, were shared more often, on average, than links to non-credible sources. These results suggest that more ambiguous forms of misinformation about COVID-19 may be more likely to be disseminated through credible sources when compared to other health topics. Furthermore, the assumption that credibility is an adequate proxy for false content may overestimate the prevalence of false content online: less than 25% of posts linking to the least credible sources contained false content. Our results emphasize the importance of distinguishing between explicit falsehoods and more ambiguous forms of misinformation due to the search for meaning in an environment of scientific uncertainty. © 2020, CC BY-NC-ND.

关键词： Social networking (online)

来源：评论

学校读者我要写书评

暂无评论

The XRISM /Resolve view of the Fe K region of Cyg X-3

arXiv

引用

arXiv 2024年

作者： Audard, Marc Awaki, Hisamitsu Ballhausen, Ralf Bamba, Aya Behar, Ehud Boissay-Malaquin, Rozenn Brenneman, Laura Brown, Gregory V. Corrales, Lia Costantini, Elisa Cumbee, Renata Diaz Trigo, Maria Done, Chris Dotani, Tadayasu Ebisawa, Ken Eckart, Megan E. Eckert, Dominique Eguchi, Satoshi Enoto, Teruaki Ezoe, Yuichiro Foster, Adam Fujimoto, Ryuichi Fujita, Yutaka Fukazawa, Yasushi Fukushima, Kotaro Furuzawa, Akihiro Gallo, Luigi García, Javier A. Gu, Liyi Guainazzi, Matteo Hagino, Kouichi Hamaguchi, Kenji Hatsukade, Isamu Hayashi, Katsuhiro Hayashi, Takayuki Hell, Natalie Hodges-Kluck, Edmund Hornschemeier, Ann Ichinohe, Yuto Ishida, Manabu Ishikawa, Kumi Ishisaki, Yoshitaka Kaastra, Jelle Kallman, Timothy Kara, Erin Katsuda, Satoru Kanemaru, Yoshiaki Kelley, Richard Kilbourne, Caroline Kitamoto, Shunji Kobayashi, Shogo Kohmura, Takayoshi Kubota, Aya Leutenegger, Maurice Loewenstein, Michael Maeda, Yoshitomo Markevitch, Maxim Matsumoto, Hironori Matsushita, Kyoko McCammon, Dan McNamara, Brian Mernier, François Miller, Eric D. Miller, Jon M. Mitsuishi, Ikuyuki Mizumoto, Misaki Mizuno, Tsunefumi Mori, Koji Mukai, Koji Murakami, Hiroshi Mushotzky, Richard Nakajima, Hiroshi Nakazawa, Kazuhiro Ness, Jan-Uwe Nobukawa, Kumiko Nobukawa, Masayoshi Noda, Hirofumi Odaka, Hirokazu Ogawa, Shoji Ogorzalek, Anna Okajima, Takashi Ota, Naomi Paltani, Stephane Petre, Robert Plucinsky, Paul Porter, Frederick S. Pottschmidt, Katja Sato, Kosuke Sato, Toshiki Sawada, Makoto Seta, Hiromi Shidatsu, Megumi Simionescu, Aurora Smith, Randall Suzuki, Hiromasa Szymkowiak, Andrew Takahashi, Hiromitsu Takeo, Mai Tamagawa, Toru Tamura, Keisuke Tanaka, Takaaki Tanimoto, Atsushi Tashiro, Makoto Terada, Yukikatsu Terashima, Yuichi Tsuboi, Yohko Tsujimoto, Masahiro Tsunemi, Hiroshi Tsuru, Takeshi Uchida, Hiroyuki Uchida, Nagomi Uchida, Yuusuke Uchiyama, Hideki Ueda, Yoshihiro Uno, Shinichiro Vink, Jacco Watanabe, Shin Williams, Brian J. Yamada, Satoshi Yamada, Shinya Yamaguchi, Hiroya Yamaoka, Kazutaka Yamasaki, Noriko Yamauchi, Makoto Yamauchi, Shig Department of Astronomy University of Geneva VersoixCH-1290 Switzerland Department of Physics Ehime University Ehime790-8577 Japan Department of Astronomy University of Maryland College ParkMD20742 United States NASA Goddard Space Flight Center GreenbeltMD20771 United States GreenbeltMD20771 United States Department of Physics University of Tokyo Tokyo113-0033 Japan Department of Physics Technion Technion City Haifa3200003 Israel BaltimoreMD21250 United States Center for Astrophysics — Harvard-Smithsonian MA02138 United States Lawrence Livermore National Laboratory CA94550 United States Department of Astronomy University of Michigan MI48109 United States SRON Netherlands Institute for Space Research Leiden Netherlands ESO Karl-Schwarzschild-Strasse 2 Garching bei München85748 Germany Centre for Extragalactic Astronomy Department of Physics University of Durham South Road DurhamDH1 3LE United Kingdom Kanagawa252-5210 Japan Department of Economics Kumamoto Gakuen University Kumamoto862-8680 Japan Department of Physics Kyoto University Kyoto606-8502 Japan Department of Physics Tokyo Metropolitan University Tokyo192-0397 Japan Department of Physics Hiroshima University Hiroshima739-8526 Japan Department of Physics Fujita Health University Aichi470-1192 Japan Department of Astronomy and Physics Saint Mary’s University Nova ScotiaB3H 3C3 Canada California Institute of Technology PasadenaCA91125 United States Noordwijk2200 AG Netherlands Faculty of Engineering University of Miyazaki 1-1 Gakuen-Kibanadai-Nishi Miyazaki Miyazaki889-2192 Japan RIKEN Nishina Center Saitama351-0198 Japan Leiden Observatory University of Leiden P.O. Box 9513 LeidenNL-2300 RA Netherlands Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology MA02139 United States Department of Physics Saitama University Saitama338-8570 Japan Department of Physics Rikkyo University Tokyo171-8501 Japan Facult

The X-ray binary system Cygnus X-3 (4U 2030+40, V1521 Cyg) is luminous but enigmatic owing to the high intervening absorption. High-resolution X-ray spectroscopy uniquely probes the dynamics of the photoionized gas in the system. In this paper we report on an observation of Cyg X-3 with the XRISM/Resolve spectrometer which provides unprecedented spectral resolution and sensitivity in the 2–10 keV band. We detect multiple kinematic and ionization components in absorption and emission, whose superposition leads to complex line profiles, including strong P-Cygni profiles on resonance lines. The prominent Fe XXV Heα and Fe XXVI Lyα emission complexes are clearly resolved into their characteristic fine structure transitions. Self-consistent photoionization modeling allows us to disentangle the absorption and emission components and measure the Doppler velocity of these components as a function of binary orbital phase. We find a significantly higher velocity amplitude for the emission lines than for the absorption lines. The absorption lines generally appear blueshifted by ∼ − 500–600 km s−1. We show that the wind decomposes naturally into a relatively smooth and large scale component, perhaps originating with the background wind itself, plus a turbulent more dense structure located close to the compact object in its orbit. Copyright © 2024, The Authors. All rights reserved.

关键词： Photoionization

来源：评论

学校读者我要写书评

暂无评论

OTHR-04. DEVELOPMENT OF A FUNCTIONAL PLATFORM FOR REAL-TIME PERSONALIZED DRUG SENSITIVITY PROFILING OF PATIENT-DERIVED 3D FRESH TUMOR TISSUE CULTURES IN THE PEDIATRIC PRECISION ONCOLOGY PROGRAM INFORM

引用

Neuro-Oncology 2023年第SUPPLEMENT_1期25卷 i74–i75页

作者： Heike Peterziel Nora Jamaladdin Dina ElHarouni Xenia F Gerloff Sonja Herter Petra Fiesel Yannick Berker Mirjam Blattner-Johnson Kathrin Schramm Barbara C Jones David Reuss Laura Turunen Aileen Friedenauer Tim Holland-Letz Martin Sill Lena Weiser Christopher Previti Gnanaprakash Balasubramanian Nicolas U Gerber Johannes Gojo Caroline Hutter Ingrid Øra Olli Lohi Antonis Kattamis Bram de Wilde Frank Westermann Stephan Tippelt Norbert Graf Michaela Nathrath Monika Sparber-Sauer Astrid Sehested Christof M Kramm Uta Dirksen Olli Kallioniemi Stefan M Pfister Cornelis M van Tilburg David T W Jones Jani Saarela Vilja Pietiäinen Natalie Jäger Matthias Schlesner Annette Kopp-Schneider Sina Oppermann Till Milde Olaf Witt Ina Oehme Hopp Children’s Cancer Center Heidelberg (KiTZ) Heidelberg Germany Clinical Cooperation Unit Pediatric Oncology German Cancer Research Center (DKFZ) National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Consortium (DKTK) Heidelberg Germany Bioinformatics and Omics Data Analytics German Cancer Research Center (DKFZ) Division of Pediatric Neurooncology German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany Clinical Cooperation Unit Neuropathology German Cancer Research Center (DKFZ) Heidelberg Germany Division of Pediatric Glioma Research German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany Division of Pediatric Glioma Research German Cancer Research Center (DKFZ) Department of Pediatric Oncology Hematology Immunology and Pulmonology Heidelberg University Hospital and German Cancer Consortium (DKTK) Heidelberg Germany Department Neuropathology at Institute of Pathology Heidelberg University Hospital Heidelberg Germany Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki Finland Division of Biostatistics German Cancer Research Center (DKFZ) Heidelberg Heidelberg Germany Division of Pediatric Neurooncology German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany Core Facility Omics IT and Data Management (ODCF) German Cancer Research Center (DKFZ) Heidelberg Germany Department of Oncology University Children’s Hospital Zürich Zürich Switzerland Department of Pediatrics and Adolescent Medicine Comprehensive Cancer Center and Comprehensive Center for Pediatrics Medical University of Vienna Vienna Austria St. Anna Children’s Hospital Department of Pediatrics and Adolescent Medicine Medical University of Vienna and St. Anna Children’s Cancer Research Institute (CCRI) Vienna Austria Children’s Hospital Pediatric Oncology Skåne University Hospital Lund &amp Karolinska Univ

The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75-78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on multicellular fresh tumor tissue spheroid cultures in 384-well plates with an overall mean processing time of three weeks. In 89 cases (67%), sufficient viable tissue was received; 69 (78%) passed internal quality controls. The DSP results matched the identified molecular targets, including BRAF, ALK, MET and TP53 status. Drug vulnerabilities were identified in 80% of cases lacking actionable (very) high-evidence molecular events, adding value to the molecular data. Striking parallels between clinical courses and the DSP results were observed in selected patients. Overall, DSP in clinical real-time is feasible in international multicenter precision oncology programs.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Augmentation of wastewater-based epidemiology with machine learning to support global health surveillance

Nature Water

引用

Nature Water 2025年 1-11页

作者： Eva Aßmann Christopher Irrgang Hugues Richard Martin Hölzer Timo Greiner Alexander Ullrich Matthew Wade Shelesh Agrawal Susanne Lackner Fabian Amman Sindy Böttcher Markus Landthaler Emanuel Wyler Serghei Mangul Viorel Munteanu Fotis Psomopoulos Maureen Smith Maria Trofimova Max von Kleist Centre for Artificial Intelligence in Public Health Research (ZKI-PH) Robert Koch Institute Berlin Germany Genome Competence Center (MF1) Robert Koch Institute Berlin Germany Department of Infectious Disease Epidemiology Robert Koch Institute Berlin Germany Chief Data Officer Group UK Health Security Agency London UK Chair of Water and Environmental Biotechnology Institute IWAR Department of Civil and Environmental Engineering Sciences Technical University of Darmstadt Darmstadt Germany CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria Institute for Hygiene and Applied Immunology Medical University of Vienna Vienna Austria Gastroenteritis and Hepatitis Pathogens and Enteroviruses (FG15) Robert Koch Institute Berlin Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Berlin Germany Institute for Biology Humboldt-Universität zu Berlin Berlin Germany Titus Family Department of Clinical Pharmacy USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences University of Southern California Los Angeles CA USA Department of Biological and Morphofunctional Sciences College of Medicine and Biological Sciences Stefan cel Mare University of Suceava Suceava Romania Department of Computers Informatics and Microelectronics Technical University of Moldova Chisinau Moldova Institute of Applied Biosciences Center for Research and Technology Hellas Thessaloniki Greece Systems Medicine of Infectious Disease (P5) Robert Koch Institute Berlin Germany Department of Mathematics and Computer Science Freie Universität Berlin Berlin Germany

Wastewater-based epidemiology (WBE) has proven to be a valuable tool for monitoring the evolution and spread of global health threats, from pathogens to antimicrobial resistances. Throughout the COVID-19 pandemic, multiple wastewater surveillance programmes have advanced statistical and machine learning methods for detecting pathogens from wastewater sequencing data and correlating measured targets with the represented population to infer meaningful conclusions for public health. Integrating contextual data can account for measurement uncertainties across the WBE workflow that affect the reliability of analyses. However, the broader availability and harmonization of data are major obstacles to method development. Here we review the benefits and limitations of wastewater-related data streams, highlighting the potential of machine learning to leverage these streams for normalization and other WBE applications. We emphasize the relevance of developing global frameworks for integrating WBE with other health surveillance systems and discuss next steps to address current and foreseeable challenges for robust and interpretable machine learning-enhanced WBE.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Ten quick tips for deep learning in biology

arXiv

引用

arXiv 2021年

作者： Lee, Benjamin D. Gitter, Anthony Greene, Casey S. Raschka, Sebastian Maguire, Finlay Titus, Alexander J. Kessler, Michael D. Lee, Alexandra J. Chevrette, Marc G. Stewart, Paul Allen Britto-Borges, Thiago Cofer, Evan M. Yu, Kun-Hsing Carmona, Juan Jose Fertig, Elana J. Kalinin, Alexandr A. Signal, Beth Lengerich, Benjamin J. Triche, Timothy J. Boca, Simina M. In-Q-Tel Labs School of Engineering and Applied Sciences Harvard University Department of Genetics Harvard Medical School United States Department of Biostatistics and Medical Informatics University of Wisconsin-Madison MadisonWI United States Morgridge Institute for Research MadisonWI United States Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Biochemistry and Molecular Genetics University of Colorado School of Medicine AuroraCO United States Center for Health AI University of Colorado School of Medicine AuroraCO United States Department of Statistics University of Wisconsin Madison United States Faculty of Computer Science Dalhousie University Canada University of New Hampshire Bioeconomy.XYZ United States Department of Oncology Johns Hopkins University United States Institute for Genome Sciences University of Maryland School of Medicine United States Genomics and Computational Biology Graduate Program University of Pennsylvania United States Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania United States Wisconsin Institute for Discovery Department of Plant Pathology University of Wisconsin-Madison United States Department of Biostatistics and Bioinformatics Moffitt Cancer Center TampaFL United States Section of Bioinformatics and Systems Cardiology Klaus Tschira Institute for Integrative Computational Cardiology University Hospital Heidelberg Germany University Hospital Heidelberg Germany Lewis-Sigler Institute for Integrative Genomics Princeton University PrincetonNJ United States Graduate Program in Quantitative and Computational Biology Princeton University PrincetonNJ United States Department of Biomedical Informatics Harvard Medical School United States Department of Pathology Brigham and Women's Hospital United States Philips Healthcare CambridgeMA United States Philips Research

Machine learning is a modern approach to problem-solving and task automation. In particular, machine learning is concerned with the development and applications of algorithms that can recognize patterns in data and use them for predictive modeling. Artificial neural networks are a particular class of machine learning algorithms and models that evolved into what is now described as deep learning. Given the computational advances made in the last decade, deep learning can now be applied to massive data sets and in innumerable contexts. Therefore, deep learning has become its own subfield of machine learning. In the context of biological research, it has been increasingly used to derive novel insights from high-dimensional biological data. To make the biological applications of deep learning more accessible to scientists who have some experience with machine learning, we solicited input from a community of researchers with varied biological and deep learning interests. These individuals collaboratively contributed to this manuscript's writing using the GitHub version control platform and the Manubot manuscript generation toolset. The goal was to articulate a practical, accessible, and concise set of guidelines and suggestions to follow when using deep learning. In the course of our discussions, several themes became clear: the importance of understanding and applying machine learning fundamentals as a baseline for utilizing deep learning, the necessity for extensive model comparisons with careful evaluation, and the need for critical thought in interpreting results generated by deep learning, among others. © 2021, CC BY.

关键词： Learning algorithms

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations

引用

Nature communications 2023年第1期14卷 6611页

作者： Elena V Feofanova Michael R Brown Taryn Alkis Astrid M Manuel Xihao Li Usman A Tahir Zilin Li Kevin M Mendez Rachel S Kelly Qibin Qi Han Chen Martin G Larson Rozenn N Lemaitre Alanna C Morrison Charles Grieser Kari E Wong Robert E Gerszten Zhongming Zhao Jessica Lasky-Su Bing Yu Human Genetics Center School of Public Health The University of Texas Health Science Center Houston TX USA. Center for Precision Health School of Biomedical Informatics The University of Texas Health Science Center at Houston Houston TX USA. Department of Biostatistics Harvard T.H. Chan School of Public Health Boston MA USA. Division of Cardiovascular Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA. Department of Biostatistics and Health Data Science Indiana University School of Medicine Indianapolis IN USA. Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA USA. Retina Service Massachusetts Eye and Ear Harvard Medical School 243 Charles Street Boston MA USA. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Biostatistics Boston University School of Public Health Boston MA USA. Cardiovascular Health Research Unit Departments of Medicine Epidemiology and Health Systems and Population Health University of Washington Seattle WA USA. Metabolon Inc. Morrisville NC USA. Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WA USA. Broad Institute of Harvard and MIT Cambridge MA USA. Human Genetics Center School of Public Health The University of Texas Health Science Center Houston TX USA. Bing.Yu@uth.tmc.edu.

来源：评论

学校读者我要写书评

暂无评论

The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study

引用

The Lancet Microbe 2025年 101098页

作者： Crandell, Jameson Monteiro, Valter Silva Pischel, Lauren Fang, Zhenhao Conde, Luciana Zhong, Yi Lawres, Lauren de Asis, Gustavo Meira Maciel, Gabriela Zaleski, Agnieszka Lira, Guilherme S Higa, Luiza M Breban, Mallery I Vogels, Chantal B F Caria, Joao Pinto, Ana Raquel Almeida, Vasco Maltez, Fernando Cordeiro, Rita Póvoas, Diana Grubaugh, Nathan D Aoun-Barakat, Lydia Grifoni, Alba Sette, Alessandro Castineiras, Terezinha M Chen, Sidi Yildirim, Inci Vale, Andre M Omer, Saad B Lucas, Carolina Department of Immunobiology Yale School of Medicine Yale University New Haven CT United States Department of Genetics Yale School of Medicine Yale University New Haven CT United States Comprehensive Cancer Center Yale School of Medicine Yale University New Haven CT United States Stem Cell Center Yale School of Medicine Yale University New Haven CT United States Center for Biomedical Data Science Yale School of Medicine Yale University New Haven CT United States Section of Infectious Diseases Department of Medicine Yale School of Medicine Yale University New Haven CT United States System Biology Institute Yale University West Haven CT United States Center for Cancer Systems Biology Yale University West Haven CT United States Laboratorio de Biologia de Linfócitos Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Yale Center for Clinical Investigation Yale University New Haven CT United States Department of Ecology and Evolutionary Biology Yale University New Haven CT United States Yale Institute for Global Health Yale University New Haven CT United States Center for Infection and Immunity Yale University New Haven CT United States Departamento de Doenças Infecciosas e Parasitarias Faculdade de Medicina Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Department of Epidemiology of Microbial Diseases Yale School of Public Health New Haven CT United States Infectious Diseases Unit Hospital de Curry Cabral Unidade Local de Saúde São José Lisbon Portugal Instituto de Saúde Ambiental-Faculdade de Medicina da Universidade de Lisboa Lisbon Portugal Infectious Diseases Department National Institute of Health Dr Ricardo Jorge Lisbon Portugal Lymphocyte Physiology Instituto Gulbenkian de Ciência Lisbon Portugal Center for Vaccine Innovation La Jolla Institute for Immunology La Jolla CA United States Division of Infectious Diseases and Global Public Health University of Californi

Background: Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbreak control. We aimed to assess the magnitude, specificity, and durability of cross-reactive immune responses elicited by smallpox vaccines and mpox virus infection. Methods: We did a multicohort observational study involving participants from the USA, Brazil, and Portugal across four groups: Dryvax (first-generation smallpox vaccine) recipients vaccinated 40–80 years ago, JYNNEOS (third-generation smallpox vaccine) recipients vaccinated within the past year, a cohort receiving both vaccines, and patients infected with clade IIb mpox. Samples were analysed for systemic and mucosal humoral responses, neutralising antibody titres, viral antigen structural analysis, and T-cell cross-reactivity to vaccina virus, cowpox virus, and mpox virus. Statistical analyses included correlation assessments and comparisons across cohorts to determine the magnitude, longevity, and breadth of immune responses. Findings: Between July 7, 2022, and Aug 3, 2023, 262 participants were recruited, resulting in analysis of 378 samples. Both first-generation and third-generation smallpox vaccines elicited vaccinia virus-reactive and mpox virus-reactive antibodies, with the strongest responses targeting the less conserved extracellular virion antigens B5 and A33. Despite high concentrations of anti-mpox virus antibodies in the plasma, cross-neutralisation activity correlated with viral antigenic distance. Higher neutralisation was observed for cowpox virus than for mpox virus, which has lower antigenic conservation with vaccina virus. Complement-mediated neutralisation enhanced mpox virus neutralisation, overcoming the limitations of antigenic distance. Dryvax recipients sustained vaccina virus neutralisation titres for over 80 years, whereas cross-reactive responses did not show this durability. JYNNEOS-induced responses waned within a

关键词：

来源：评论

学校读者我要写书评

暂无评论

The XRISM/Resolve View of the Fe K Region of Cyg X-3

引用

Astrophysical Journal Letters 2024年第2期977卷 L34-L34页

作者： Audard, Marc Awaki, Hisamitsu Ballhausen, Ralf Bamba, Aya Behar, Ehud Boissay-Malaquin, Rozenn Brenneman, Laura Brown, Gregory V. Corrales, Lia Costantini, Elisa Cumbee, Renata Trigo, María Díaz Done, Chris Dotani, Tadayasu Ebisawa, Ken Eckart, Megan E. Eckert, Dominique Eguchi, Satoshi Enoto, Teruaki Ezoe, Yuichiro Foster, Adam Fujimoto, Ryuichi Fujita, Yutaka Fukazawa, Yasushi Fukushima, Kotaro Furuzawa, Akihiro Gallo, Luigi García, Javier A. Gu, Liyi Guainazzi, Matteo Hagino, Kouichi Hamaguchi, Kenji Hatsukade, Isamu Hayashi, Katsuhiro Hayashi, Takayuki Hell, Natalie Hodges-Kluck, Edmund Hornschemeier, Ann Ichinohe, Yuto Ishida, Manabu Ishikawa, Kumi Ishisaki, Yoshitaka Kaastra, Jelle Kallman, Timothy Kara, Erin Katsuda, Satoru Kanemaru, Yoshiaki Kelley, Richard Kilbourne, Caroline Kitamoto, Shunji Kobayashi, Shogo Kohmura, Takayoshi Kubota, Aya Leutenegger, Maurice Loewenstein, Michael Maeda, Yoshitomo Markevitch, Maxim Matsumoto, Hironori Matsushita, Kyoko McCammon, Dan McNamara, Brian Mernier, François Miller, Eric D. Miller, Jon M. Mitsuishi, Ikuyuki Mizumoto, Misaki Mizuno, Tsunefumi Mori, Koji Mukai, Koji Murakami, Hiroshi Mushotzky, Richard Nakajima, Hiroshi Nakazawa, Kazuhiro Ness, Jan-Uwe Nobukawa, Kumiko Nobukawa, Masayoshi Noda, Hirofumi Odaka, Hirokazu Ogawa, Shoji Ogorzalek, Anna Okajima, Takashi Ota, Naomi Paltani, Stephane Petre, Robert Plucinsky, Paul Porter, Frederick S. Pottschmidt, Katja Sato, Kosuke Sato, Toshiki Sawada, Makoto Seta, Hiromi Shidatsu, Megumi Simionescu, Aurora Smith, Randall Suzuki, Hiromasa Szymkowiak, Andrew Takahashi, Hiromitsu Takeo, Mai Tamagawa, Toru Tamura, Keisuke Tanaka, Takaaki Tanimoto, Atsushi Tashiro, Makoto Terada, Yukikatsu Terashima, Yuichi Tsuboi, Yohko Tsujimoto, Masahiro Tsunemi, Hiroshi Tsuru, Takeshi Uchida, Hiroyuki Uchida, Nagomi Uchida, Yuusuke Uchiyama, Hideki Ueda, Yoshihiro Uno, Shinichiro Vink, Jacco Watanabe, Shin Williams, Brian J. Yamada, Satoshi Yamada, Shinya Yamaguchi, Hiroya Yamaoka, Kazutaka Yamasaki, Noriko Yamauchi, Makoto Yamauchi, Shig Department of Astronomy University of Geneva Versoix CH-1290 Switzerland Department of Physics Ehime University Ehime 790-8577 Japan Department of Astronomy University of Maryland College Park 20742 MD United States NASA Goddard Space Flight Center Greenbelt 20771 MD United States Center for Research and Exploration in Space Science and Technology NASA GSFC (CRESST II) Greenbelt 20771 MD United States Department of Physics University of Tokyo Tokyo 113-0033 Japan Department of Physics Technion Technion City Haifa 3200003 Israel Center for Space Sciences and Technology University of Maryland Baltimore County (UMBC) Baltimore 21250 MD United States Center for Astrophysics-Harvard-Smithsonian 02138 MA United States Lawrence Livermore National Laboratory 94550 CA United States Department of Astronomy University of Michigan 48109 MI United States SRON Netherlands Institute for Space Research Leiden Netherlands ESO Karl-Schwarzschild-Strasse 2 Garching bei München 85748 Germany Centre for Extragalactic Astronomy Department of Physics University of Durham South Road Durham DH1 3LE United Kingdom Institute of Space and Astronautical Science (ISAS) Japan Aerospace Exploration Agency (JAXA) Kanagawa 252-5210 Japan Department of Economics Kumamoto Gakuen University Kumamoto 862-8680 Japan Department of Physics Kyoto University Kyoto 606-8502 Japan Department of Physics Tokyo Metropolitan University Tokyo 192-0397 Japan Department of Physics Hiroshima University Hiroshima 739-8526 Japan Department of Physics Fujita Health University Aichi 470-1192 Japan Department of Astronomy and Physics Saint Mary's University B3H 3C3 NS Canada California Institute of Technology Pasadena 91125 CA United States European Space Agency (ESA) European Space Research and Technology Centre (ESTEC) Noordwijk 2200AG Netherlands Faculty of Engineering University of Miyazaki 1-1 Gakuen-Kibanadai-Nishi Miyazaki Miyazaki 889-2192 Japan RIKEN Nishina Ce

The X-ray binary system Cygnus X-3 (4U 2030+40, V1521 Cyg) is luminous but enigmatic owing to the high intervening absorption. High-resolution X-ray spectroscopy uniquely probes the dynamics of the photoionized gas in the system. In this Letter, we report on an observation of Cyg X-3 with the XRISM/Resolve spectrometer, which provides unprecedented spectral resolution and sensitivity in the 2-10 keV band. We detect multiple kinematic and ionization components in absorption and emission whose superposition leads to complex line profiles, including strong P Cygni profiles on resonance lines. The prominent Fe XXV Hea and Fe XXVI Lya emission complexes are clearly resolved into their characteristic fine-structure transitions. Self-consistent photoionization modeling allows us to disentangle the absorption and emission components and measure the Doppler velocity of these components as a function of binary orbital phase. We find a significantly higher velocity amplitude for the emission lines than for the absorption lines. The absorption lines generally appear blueshifted by ∼-500-600 km s^-1. We show that the wind decomposes naturally into a relatively smooth and large-scale component, perhaps associated with the background wind itself, plus a turbulent, denser structure located close to the compact object in its orbit. © 2024. The Author(s). Published by the American Astronomical Society.

关键词： High mass x-ray binary stars High resolution spectroscopy

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：