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arXiv 2022年

作者： Rodriguez, Joseph E. Quinn, Samuel N. Vanderburg, Andrew Zhou, George Eastman, Jason D. Thygesen, Erica Cale, Bryson Ciardi, David R. Reed, Phillip A. Oelkers, Ryan J. Collins, Karen A. Bieryla, Allyson Latham, David W. Gonzales, Erica J. Gaudi, B. Scott Hellier, Coel Jones, Matías I. Brahm, Rafael Sokolovsky, Kirill Schulte, Jack Srdoc, Gregor Kielkopf, John Horta, Ferran Grau Massey, Bob Evans, Phil Stephens, Denise C. McLeod, Kim K. Chazov, Nikita Krushinsky, Vadim Ghachoui, Mourad Safonov, Boris S. Dedrick, Cayla M. Conti, Dennis Laloum, Didier Giacalone, Steven Ziegler, Carl Serra, Pere Guerra Nogues, Ramon Naves Murgas, Felipe Michaels, Edward J. Ricker, George R. Vanderspek, Roland K. Seager, Sara Winn, Joshua N. Jenkins, Jon M. Addison, Brett Alfaro, Owen Anderson, D.R. Aydi, Elias Beatty, Thomas G. Bedding, Timothy R. Belinski, Alexander A. Benkhaldoun, Zouhair Berlind, Perry Blake, Cullen H. Bowen, Michael J. Bowler, Brendan P. Boyle, Andrew W. Branson, Dalton Briceño, César Calkins, Michael L. Campbell, Emma Christiansen, Jessie L. Chomiuk, Laura Collins, Kevin I. Cornachione, Matthew A. Daassou, Ahmed Dressing, Courtney D. Esquerdo, Gilbert A. Feliz, Dax L. Fong, William Fukui, Akihiko Gan, Tianjun Gill, Holden Goliguzova, Maria V. Hansen, Jarrod Henning, Thomas Hintz, Eric G. Hobson, Melissa J. Horner, Jonathan Huang, Chelsea X. James, David J. Jensen, Jacob S. Johnson, Samson A. Jordán, Andrés Kane, Stephen R. Barkaoui, Khalid Kim, Myung-Jin Kim, Kingsley Kuhn, Rudolf B. Law, Nicholas Lewin, Pablo Liu, Hui-Gen Lund, Michael B. Mann, Andrew W. McCrady, Nate Mengel, Matthew W. Mink, Jessica Murphy, Lauren G. Narita, Norio Newman, Patrick Okumura, Jack Osborn, Hugh P. Paegert, Martin Palle, Enric Pepper, Joshua Plavchan, Peter Popov, Alexander A. Rabus, Markus Ranshaw, Jessica Rodriguez, Jennifer A. Roh, Dong-Goo Reefe, Michael A. Savel, Arjun B. Schwarz, Richard P. Shporer, Avi Siverd, Robert J. Sliski, David H. Stassun, Keivan G. Stevens, Daniel J. Soubkiou, Abderahmane Ting, Eric B. Tinney, C.G. Vow Center for Data Intensive and Time Domain Astronomy Department of Physics and Astronomy Michigan State University East LansingMI48824 United States Center for Astrophysics | Harvard & Smithsonian 60 Garden St CambridgeMA02138 United States Department of Physics Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States Centre for Astrophysics University of Southern Queensland West Street ToowoombaQLD4350 Australia Caltech IPAC NASA Exoplanet Science Institute 1200 E. California Ave PasadenaCA91125 United States Department of Physical Sciences Kutztown University KutztownPA19530 United States George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy Texas A&M University College StationTX77843 United States Charles R. & Judith G. Munnerlyn Astronomical Laboratory Department of Physics & Astronomy Texas A&M University College StationTX77843 United States Center for Gravitational Wave Astronomy The University of Texas Rio Grande Valley BrownsvilleTX78520 United States Department of Astronomy and Astrophysics University of California Santa CruzCA95064 United States Department of Astronomy The Ohio State University 140 West 18th Avenue ColumbusOH43210 United States Astrophysics Group Keele University StaffordshireST5 5BG United Kingdom European Southern Observatory Alonso de Córdova 3107 Vitacura Casilla Santiago19001 Chile Facultad de Ingeniería y Ciencias Universidad Adolfo Ibáñez Av. Diagonal las Torres 2640 Peñalolén Santiago Chile Millennium Institute for Astrophysics Chile Data Observatory Foundation Chile Kotizarovci Observatory Sarsoni 90 Viskovo51216 Croatia Department of Physics and Astronomy University of Louisville LouisvilleKY40292 United States Observatri de Ca l'Ou United States Villa'39 Observatory LandersCA92285 United States El Sauce Observatory Coquimbo Province Chile Department of Physics and Astronomy Brigham Young Un

We present the discovery and characterization of six short-period, transiting giant planets from NASA's Transiting Exoplanet Survey Satellite (TESS) - TOI-1811 (TIC 376524552), TOI-2025 (TIC 394050135), TOI-2145 (TIC 88992642), TOI-2152 (TIC 395393265), TOI-2154 (TIC 428787891), & TOI-2497 (TIC 97568467). All six planets orbit bright host stars (8.9 P = 0.99-1.45 RJ), have masses ranging from 0.92 to 5.26 MJ, and orbit F, G, and K stars (4766 ≤ Teff ≤ 7360 K). We detect a significant orbital eccentricity for the three longest-period systems in our sample: TOI-2025 b (P = 8.872 days, 0.394+0.035..0.038, TOI-2145 b (P = 10.261 days, e = 0.208+0.034-0.047, and TOI-2497 b (P = 10.656 days, e = 0.195+0.043-0.040. TOI-2145 b and TOI-2497 b both orbit subgiant host stars (3.8 +0.38-0.37 MJ (TOI-2145 b) and 4.82 ± 0.41 MJ (TOI-2497 b). These six new discoveries contribute to the larger community effort to use TESS to create a magnitude-complete, self-consistent sample of giant planets with well-determined parameters for future detailed studies. Copyright © 2022, The Authors. All rights reserved.

关键词： Satellites

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The associations of childhood adversities and mental disorders with suicidal thoughts and behaviors - Results from the World Mental Health International College Student Initiative

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Psychiatry Research 2025年 350卷 116555页

作者： Mortier, Philippe Yang, Xue Altwaijri, Yasmin A. Holdcraft, Jacob A. Lee, Sue Sampson, Nancy A Albor, Yesica Alhadi, Ahmad N. Alonso, Jordi Al-Saud, Nouf K. Andersson, Claes Atwoli, Lukoye Auerbach, Randy P. Muaka, Caroline Ayuya Báez-Mansur, Patricia M. Ballester, Laura Bantjes, Jason Baumeister, Harald Bendtsen, Marcus Benjet, Corina Berman, Anne H. Bruffaerts, Ronny Carrasco, Paula Chan, Silver C.N. Cohut, Irina Covarrubias Díaz Couder, María Anabell Crockett, Marcelo A. Cuijpers, Pim David, Oana A. Dong, Dong Ebert, David D. Gaete, Jorge Felez-Nobrega, Mireia García Forero, Carlos Gili, Margalida Gutiérrez-García, Raúl A. Haro, Josep Maria Hasking, Penelope Hunt, Xanthe Husky, Mathilde M. Jaguga, Florence Jansen, Leontien Langer, Álvaro I. Liu, Yan Mac-Ginty, Scarlett Martínez, Vania Mason, Andre Mathai, Muthoni McLafferty, Margaret Miranda-Mendizabal, Andrea Murray, Elaine K. Musyoka, Catherine M. Papasteri, Claudiu C. Piqueras, José A. Popescu, Codruta A. Rapsey, Charlene Robinson, Kealagh Rodriguez-Jimenez, Tiscar Scarf, Damian Siu, Oi-ling Stein, Dan J. Struijs, Sascha Y. Tomoiaga, Cristina T. Valdés-García, Karla Patricia Vereecke, Shelby Vigo, Daniel V. Wang, Angel Y. Wong, Samuel Y.S. Kessler, Ronald C. Health Services Research Group Hospital del Mar Research Institute Carrer del Doctor Aiguader 88 Barcelona 08003 Spain Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública Instituto de Salud Carlos III (CIBERESP ISCIII) Av. Monforte de Lemos 3-5. Pabellón 11. Planta 0 Madrid 28029 Spain The Jockey Club School of Public Health and Primary Care Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China Biostatistics Epidemiology and Scientific Computing Department King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia Department of Health Care Policy Harvard Medical School Boston MA United States Center for Global Mental Health Research Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Mexico City Mexico Department of Psychiatry College of Medicine King Saud University Riyadh Saudi Arabia SABIC Psychological Health Research & Applications Chair (SPHRAC) Department of Psychiatry College of Medicine King Saud University Riyadh Saudi Arabia Department of Medicine and Life Sciences Pompeu Fabra University (UPF) Barcelona Spain Department of Criminology Malmö University Malmö Sweden Department of Medicine Medical College East Africa the Aga Khan University Nairobi Kenya Brain and Mind Institute the Aga Khan University Nairobi Kenya Department of Mental Health and Behavioural Sciences Moi University School of Medicine Eldoret Kenya Department of Psychiatry Columbia University New York NY United States Department of Psychology & Counselling Daystar University Nairobi Kenya Coordinación de Desarrollo Académico y Servicios Educativos Universidad la Salle Ciudad Victoria Ciudad Victoria Mexico Mental Health Alcohol Substance Use and Tobacco Research Unit South African Medical Research Council Cape Town South Africa Department of Psychiatry and Mental Health University of Cape Town South Africa Department of Clinical Psychology and Psychotherapy Ulm University Ulm Germany Department of Healt

Objective: To investigate the associations of demographic variables, childhood adversities (CAs), and mental disorders (MDx) with onset, transition, and persistence of suicidal thoughts and behaviors (STB) among first-year university students. Method: Poisson regression models within a discrete-time survival framework were constructed using web-based self-report survey data from 72,288 incoming university students across 18 countries (response rate=20.9%;median age=19 years, 57.9% female, 1.4% transgender, 21.0% non-heterosexual). These models examined the associations of four demographic variables, five CAs, and eight MDx with STB outcomes. Results: Lifetime prevalence of suicidal ideation, plans, and attempts was 47.0%, 26.0%, and 9.6%, respectively;12-month estimates were 30.6%, 14.0%, and 2.3%. In unadjusted analyses, associations were strongest between lifetime onset of suicidal ideation and CAs (RR range 4.4–7.0), particularly parental psychopathology (relative risk [RR]=7.0 [95% CI 6.5–7.7]), followed by MDx (RR range 1.3–3.0). Of the demographic subgroups, transgender students had highest risk of STB (lifetime ideation onset RR=2.4 [2.3–2.6];ideation-to-attempt transition RR=1.5 [1.3–1.8]). In fully adjusted models, strongest predictors of lifetime ideation onset were emotional abuse (RR=2.1 [1.9–2.2]), major depressive disorder (RR=2.0 [1.9–2.1]), and bipolar disorder (RR=1.8 [1.6–2.0]). Ideation-to-attempt transition remained most strongly associated with panic disorder (RR=1.5 [1.3–1.7]), bipolar disorder (RR=1.4 [1.2–1.7]), and sexual abuse (RR=1.4 [1.2–1.7]). Most predictors were significantly but weakly associated with persistence of ideation and plan, while only physical abuse remained associated with repeated suicide attempts (RR=1.3 [1.0–1.8]). Conclusion: CAs and MDx are strong predictors of both onset of and transition within the STB spectrum, underscoring the importance of implementing early-life prevention interventions. © 2025 The Author(s)

关键词： Adverse childhood experiences Mental health Prevalence Risk factors Self-injurious behavior Students Suicide

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Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

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eClinicalMedicine 2023年 64卷 102193-102193页

作者： Wu, Dongze Jin, Yingzhao Xing, Yuhan Abate, Melsew Dagne Abbasian, Mohammadreza Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abd-Allah, Foad Abdelmasseh, Michael Abdollahifar, Mohammad-Amin Abdulah, Deldar Morad Abedi, Aidin Abedi, Vida Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Abuabara, Katrina Abyadeh, Morteza Addo, Isaac Yeboah Adeniji, Kayode Nelson Adepoju, Abiola Victor Adesina, Miracle Ayomikun Adnani, Qorinah Estiningtyas Sakilah Afarideh, Mohsen Aghamiri, Shahin Agodi, Antonella Agrawal, Anurag Arriagada, Constanza Elizabeth Aguilera Ahmad, Aqeel Ahmad, Danish Ahmad, Sohail Ahmadi, Ali Ahmed, Ayman Aithala, Janardhana P. Ajadi, Abdullateef Abiodun Ajami, Marjan Akbarzadeh-Khiavi, Mostafa Alahdab, Fares AlBataineh, Mohammad T. Alemi, Sharifullah Al-Gheethi, Adel Ali Saeed Ali, Liaqat Alif, Sheikh Mohammad Almazan, Joseph Uy Almustanyir, Sami Alqahtani, Jaber S. Alqasmi, Ibrahim Altaf, Ihsan Ullah Khan Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Al-Worafi, Yaser Mohammed Aly, Hany Amani, Reza Amu, Hubert Amusa, Ganiyu Adeniyi Andrei, Catalina Liliana Ansar, Adnan Ansariniya, Hossein Anyasodor, Anayochukwu Edward Arabloo, Jalal Arefnezhad, Reza Arulappan, Judie Asghari-Jafarabadi, Mohammad Ashraf, Tahira Atata, Jamila Abdulhamid Athari, Seyyed Shamsadin Atlaw, Daniel Atout, Maha Moh'd Wahbi Aujayeb, Avinash Awan, Asma Tahir Ayatollahi, Haleh Azadnajafabad, Sina Azzam, Ahmed Y. Badawi, Alaa Badiye, Ashish D. Bagherieh, Sara Baig, Atif Amin Bantie, Berihun Bantie Barchitta, Martina Bardhan, Mainak Barker-Collo, Suzanne Lyn Barone-Adesi, Francesco Batra, Kavita Bayileyegn, Nebiyou Simegnew Behnoush, Amir Hossein Belgaumi, Uzma Iqbal Bemanalizadeh, Maryam Bensenor, Isabela M. Beyene, Kebede A. Bhagavathula, Akshaya Srikanth Bhardwaj, Pankaj Bhaskar, Sonu Bhat, Ajay Nagesh Bitaraf, Saeid Bitra, Veera R. Boloor, Archith Bora, Kaustubh Botelho, João Silva Buchbinder, Rachelle Calina, Daniela Cámera, Luis Alberto Carvalho, Andre F. Chan, Jeffrey Shi Kai Chattu, Vijay Kumar Abebe, Endeshaw Chekol Department of Rheumatology and Immunology Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China China Department of Medicine & Therapeutics The Chinese University of Hong Kong Hong Kong Department of Paediatrics The Chinese University of Hong Kong Hong Kong School of Pharmacy The Chinese University of Hong Kong Hong Kong Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong Department of Nursing Woldia University Woldia Ethiopia Department of Orthopedic Surgery Harvard University Boston MA United States Postgraduate Medical Education Harvard University Boston MA United States Maternal Fetal Care Center Harvard University Boston MA United States Department of Health Policy and Oral Epidemiology Harvard University Boston MA United States Division of General Internal Medicine Harvard University Boston MA United States Department of Orthopaedic Surgery Shahid Beheshti University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Biotechnology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran Department of Immunology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran Center for Comprehensive Genetic Services Shahid Beheshti University of Medical Sciences Tehran Iran Cancer Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Functional Neuro

Background: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. Methods: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. Findings: In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and united States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. Interpretation: The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rh

关键词： Global burden of disease study Immune-mediated inflammatory disease Incidence Trend

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Insights into the broad-band emission of the TeV blazar Mrk 501 during the first X-ray polarization measurements

arXiv

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arXiv 2024年

作者： Abe, S. Abhir, J. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Aniello, T. Ansoldi, S. Engels Arcaro, C. Asano, K. Babić, A. Baquero, A. de Almeida, U. Barres Barrio, J.A. Batković, I. Antonelli, L.A. Bautista, A.A. Arbet Baxter, J. González, J. Becerra Bednarek, W. Bernardini, E. Bernardos, M. Bernete, J. Berti, A. Besenrieder, J. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Burelli, I. Busetto, G. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Ceribella, G. Chai, Y. Cifuentes, A. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. de Menezes, R. Del Popolo, A. Delfino, M. Delgado, J. Pierro Di Venere, L. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Elsaesser, D. Emery, G. Escudero, J. Mendez, C. Delgado Di Fariña, F.L. Fattorini, A. Foffano, L. Font, L. Fröse, S. Fukazawa, Y. López, R.J. García Garczarczyk, M. Gasparyan, S. Gaug, M. Paiva, J.G. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Gradetzke, T. Grau, R. Green, D. Green, J.G. Günther, P. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Hrupec, D. Hütten, M. Imazawa, R. Ishio, K. Martínez, I. Jiménez Kayanoki, T. Kerszberg, D. Kluge, G.W. Herrera, J. Kobayashi, Y. Kouch, P.M. Kubo, H. Kushida, J. Lezáun, M. Láinez Lamastra, A. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lyard, E. de Oliveira Fraga, B. Machado Majumdar, P. Makariev, M. Maneva, G. Mang, N. Manganaro, M. Mangano, S. Mannheim, K. Mariotti, M. Martínez, M. Martínez-Chicharro, M. Mas-Aguilar, A. Mazin, D. Menchiari, S. Mender, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. González, M. Molero Molina, E. Mondal, H.A. Moralejo, A. Morcuende, D. Nakamori, T. Nanci, C. Neustroev, V. Nigro, C. Nikolić, L. Nilsson, K. Nishijima, K. Ekoume, T. Njoh Noda, K. Nozaki, S. Ohtani, Y. Okumura, A. Otero-Santos, J. The University of Tokyo Chiba Kashiwa277-8582 Japan ETH Zürich ZürichCH-8093 Switzerland Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna La Laguna TenerifeE-38200 Spain Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain RomeI-00136 Italy Università di Udine INFN Trieste UdineI-33100 Italy Max-Planck-Institut für Physik MünchenD-80805 Germany Università di Padova INFN PadovaI-35131 Italy Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Bellaterra BarcelonaE-08193 Spain Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Università di Pisa INFN Pisa PisaI-56126 Italy Department for Physics and Technology University of Bergen Norway INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy INFN MAGIC Group INFN Sezione di Catania Dipartimento di Fisica e Astronomia University of Catania CataniaI-95123 Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica dell’Università e del Politecnico di Bari BariI-70125 Italy Croatian MAGIC Group University of Rijeka Faculty of Physics Rijeka51000 Croatia Technische Universität Dortmund DortmundD-44221 Germany University of Geneva Chemin d’Ecogia 16 VersoixCH-1290 Switzerland Japanese MAGIC Group: Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan ZeuthenD-15738 Germany Armenian MAGIC Group: ICRANet-Armenia Yerevan0019 Armenia Split21000 Croatia Universität Würzburg Würzbu

Aims. We present the first multi-wavelength study of Mrk 501 including very-high-energy (VHE) γ-ray observations simultaneous to X-ray polarization measurements from the Imaging X-ray Polarimetry Explorer (IXPE). Methods. We use radio-to-VHE data from a multi-wavelength campaign organized between 2022-03-01 and 2022-07-19 (MJD 59639 to MJD 59779). The observations were performed by MAGIC, Fermi-LAT, NuSTAR, Swift (XRT and UVOT), and several instruments covering the optical and radio bands to complement the IXPE pointings. We characterize the dynamics of the broad-band emission around the X-ray polarization measurements through its multi-band fractional variability and correlations, and compare changes observed in the polarization degree to changes seen in the broad-band emission using a multi-zone leptonic scenario. Results. During the IXPE pointings, the VHE state is close to the average behavior with a 0.2-1 TeV flux of 20% - 50% the emission of the Crab Nebula. Additionally, it shows low variability and a hint of correlation between VHE and X-rays. Despite the average VHE activity, an extreme X-ray behavior is measured for the first two IXPE pointings in March 2022 (MJD 59646 to 59648 and MJD 59665 to 59667) with a synchrotron peak frequency > 1 keV. For the third IXPE pointing in July 2022 (MJD 59769 to 59772), the synchrotron peak shifts towards lower energies and the optical/X-ray polarization degrees drop. All three IXPE epochs show an atypically low Compton dominance in the γ-rays. The X-ray polarization is systematically higher than at lower energies, suggesting an energy-stratification of the jet. While during the IXPE epochs the polarization angle in the X-ray, optical and radio bands align well, we find a clear discrepancy in the optical and radio polarization angles in the middle of the campaign. Such results further strengthen the hypothesis of an energy-stratified jet. We model the broad-band spectra simultaneous to the IXPE pointings assuming a compa

关键词： Gamma rays

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State of the art in selection of variables and functional forms in multivariable analysis-outstanding issues

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Diagnostic and prognostic research 2020年第1期4卷 3页

作者： Willi Sauerbrei Aris Perperoglou Matthias Schmid Michal Abrahamowicz Heiko Becher Harald Binder Daniela Dunkler Frank E Harrell Patrick Royston Georg Heinze 1Institute of Medical Biometry and Statistics Faculty of Medicine and Medical Center University of Freiburg Freiburg Germany. Data Science and Artificial Intelligence AstraZeneca Cambridge UK. 3Department of Medical Biometry Informatics and Epidemiology Faculty of Medicine University of Bonn Bonn Germany. 4McGill University Health Centre McGill University Montreal Canada. 5Institute for Medical Biometry and Epidemiology University Medical Center Hamburg-Eppendorf Hamburg Germany. 6Section for Clinical Biometrics Center for Medical Statistics Informatics and Intelligent Systems Medical University of Vienna Vienna Austria. 7Department of Biostatistics School of Medicine Vanderbilt University Nashville TN USA. 8MRC Clinical Trials Unit at UCL Institute of Clinical Trials and Methodology University College London London UK.

BACKGROUND:How to select variables and identify functional forms for continuous variables is a key concern when creating a multivariable model. Ad hoc 'traditional' approaches to variable selection have been in use for at least 50 years. Similarly, methods for determining functional forms for continuous variables were first suggested many years ago. More recently, many alternative approaches to address these two challenges have been proposed, but knowledge of their properties and meaningful comparisons between them are scarce. To define a state of the art and to provide evidence-supported guidance to researchers who have only a basic level of statistical knowledge, many outstanding issues in multivariable modelling remain. Our main aims are to identify and illustrate such gaps in the literature and present them at a moderate technical level to the wide community of practitioners, researchers and students of statistics. METHODS:We briefly discuss general issues in building descriptive regression models, strategies for variable selection, different ways of choosing functional forms for continuous variables and methods for combining the selection of variables and functions. We discuss two examples, taken from the medical literature, to illustrate problems in the practice of modelling. RESULTS:Our overview revealed that there is not yet enough evidence on which to base recommendations for the selection of variables and functional forms in multivariable analysis. Such evidence may come from comparisons between alternative methods. In particular, we highlight seven important topics that require further investigation and make suggestions for the direction of further research. CONCLUSIONS:Selection of variables and of functional forms are important topics in multivariable analysis. To define a state of the art and to provide evidence-supported guidance to researchers who have only a basic level of statistical knowledge, further comparative research is required.

关键词： Bias Categorisation Descriptive modelling Empirical evidence Fractional polynomials Methods for variable selection STRATOS initiative Shrinkage Spline procedures

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Varying the Stiffness and Diffusivity of Rod-Shaped Microgels Independently through Their Molecular Building Blocks

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Angewandte Chemie 2023年第44期135卷 e202309779-e202309779页

作者： Yonca Kittel Luis P. B. Guerzoni Carolina Itzin Dirk Rommel Matthias Mork Céline Bastard Bernhard Häßel Abdolrahman Omidinia-Anarkoli Silvia P. Centeno Tamás Haraszti Kyoohyun Kim Jochen Guck Alexander J. C. Kuehne Laura De Laporte DWI-Leibniz Institute for Interactive Materials e. V. Forckenbeckstraße 50 52074 Aachen Germany Institute of Technical and Macromolecular Chemistry RWTH Aachen University Worringerweg 1–2 52074 Aachen Germany Institute of Organic and Macromolecular Chemistry Ulm University Albert-Einstein Allee 11 89081 Ulm Germany Contribution: Conceptualization (equal) Data curation (lead) Formal analysis (lead) Investigation (lead) Project administration (lead) Visualization (lead) Writing - original draft (lead) Contribution: Conceptualization (equal) Investigation (supporting) Supervision (supporting) Writing - review & editing (supporting) Contribution: Investigation (supporting) Validation (supporting) Visualization (supporting) Writing - review & editing (equal) Contribution: Conceptualization (supporting) Investigation (supporting) Validation (supporting) Writing - review & editing (equal) Contribution: Conceptualization (supporting) Formal analysis (supporting) Investigation (supporting) Visualization (supporting) Writing - review & editing (equal) Center for Biohybrid Medical Systems (CBMS) Advanced Materials for Biomedicine (AMB) Institute of Applied Medical Engineering (AME) Forckenbeckstraße 55 52074 Aachen Germany Contribution: Conceptualization (supporting) Validation (supporting) Visualization (supporting) Writing - original draft (supporting) Writing - review & editing (equal) Contribution: Formal analysis (equal) Software (lead) Validation (supporting) Visualization (supporting) Writing - original draft (supporting) Writing - review & editing (equal) Max Planck Institute for the Science of Light and Max-Planck-Zentrum für Physik und Medizin Staudtstraße 2 91058 Erlangen Germany Contribution: Conceptualization (supporting) Investigation (supporting) Software (supporting) Validation (supporting) Visualization (supporting) Writing - original draft (supporting) Writing - review & editing (equal) Contribution: Conceptualization (supporting) Writing - review

Microgels are water-swollen, crosslinked polymers that are widely used as colloidal building blocks in scaffold materials for tissue engineering and regenerative medicine. Microgels can be controlled in their stiffness, degree of swelling, and mesh size depending on their polymer architecture, crosslink density, and fabrication method—all of which influence their function and interaction with the environment. Currently, there is a lack of understanding of how the polymer composition influences the internal structure of soft microgels and how this morphology affects specific biomedical applications. In this report, we systematically vary the architecture and molar mass of polyethylene glycol-acrylate (PEG-Ac) precursors, as well as their concentration and combination, to gain insight in the different parameters that affect the internal structure of rod-shaped microgels. We characterize the mechanical properties and diffusivity, as well as the conversion of acrylate groups during photopolymerization, in both bulk hydrogels and microgels produced from the PEG-Ac precursors. Furthermore, we investigate cell-microgel interaction, and we observe improved cell spreading on microgels with more accessible RGD peptide and with a stiffness in a range of 20 kPa to 50 kPa lead to better cell growth.

关键词： Diffusion Internal Structure Mechanical Properties Microfluidics PEG Microgels

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Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes

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Nature communications 2022年第1期13卷 5767页

作者： Jennifer L Halford Valerie N Morrill Seung Hoan Choi Sean J Jurgens Giorgio Melloni Nicholas A Marston Lu-Chen Weng Victor Nauffal Amelia W Hall Sophia Gunn Christina A Austin-Tse James P Pirruccello Shaan Khurshid Heidi L Rehm Emelia J Benjamin Eric Boerwinkle Jennifer A Brody Adolfo Correa Brandon K Fornwalt Namrata Gupta Christopher M Haggerty Stephanie Harris Susan R Heckbert Charles C Hong Charles Kooperberg Henry J Lin Ruth J F Loos Braxton D Mitchell Alanna C Morrison Wendy Post Bruce M Psaty Susan Redline Kenneth M Rice Stephen S Rich Jerome I Rotter Peter F Schnatz Elsayed Z Soliman Nona Sotoodehnia Eugene K Wong Marc S Sabatine Christian T Ruff Kathryn L Lunetta Patrick T Ellinor Steven A Lubitz Cardiovascular Disease Initiative Broad Institute of MIT and Harvard Cambridge MA USA. Department of Medicine Massachusetts General Hospital Boston MA USA. Cardiovascular Research Center Massachusetts General Hospital Boston MA USA. Department of Experimental Cardiology Amsterdam UMC Amsterdam The Netherlands. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Boston MA USA. Gene Regulation Observatory and Epigenomics Platform Broad Institute of MIT and Harvard Cambridge MA USA. Department of Biostatistics Boston University School of Public Health Boston MA USA. Laboratory for Molecular Medicine Mass General Brigham Personalized Medicine Cambridge MA USA. Harvard Medical School Boston MA USA. Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. Demoulas Center for Cardiac Arrhythmias Massachusetts General Hospital Boston MA USA. NHLBI and Boston University's Framingham Heart Study Framingham MA USA. Department of Medicine Boston Medical Center Boston University School of Medicine Boston MA USA. Department of Epidemiology Boston University School of Public Health Boston MA USA. Human Genetics Center Department of Epidemiology Human Genetics and Environmental Sciences School of Public Health The University of Texas Health Science Center at Houston Houston TX USA. Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle WA USA. Departments of Medicine Pediatrics and Population Health Science University of Mississippi Medical Center Jackson MS USA. Department of Translational Data Science and Informatics Geisinger Danville PA USA. Heart Institute Geisinger Danville PA USA. Department of Radiology Geisinger Danville PA USA. Department of Epidemiology University of Washington Seattle WA USA. University of Maryland School of Medicine Baltimore MD USA. Division of Public Health Sciences Fred Hutchinson Cancer Center Seattle WA USA. The Insti

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Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery

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Nature neuroscience 2025年第1期28卷 216页

作者： Boyan Bonev Gonçalo Castelo-Branco Fei Chen Simone Codeluppi M Ryan Corces Jean Fan Myriam Heiman Kenneth Harris Fumitaka Inoue Manolis Kellis Ariel Levine Mo Lotfollahi Chongyuan Luo Kristen R Maynard Mor Nitzan Vijay Ramani Rahul Satijia Lucas Schirmer Yin Shen Na Sun Gilad S Green Fabian Theis Xiao Wang Joshua D Welch Ozgun Gokce Genevieve Konopka Shane Liddelow Evan Macosko Omer Ali Bayraktar Naomi Habib Tomasz J Nowakowski Helmholtz Pioneer Campus Helmholtz Zentrum München Neuherberg Germany. Physiological Genomics Biomedical Center Ludwig-Maximilians-Universität München Munich Germany. Laboratory of Molecular Neurobiology Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden. The Broad Institute of MIT and Harvard Cambridge MA USA. Moleculent Stockholm Sweden. Gladstone Institute of Neurological Disease San Francisco CA USA. Gladstone Institute of Data Science and Biotechnology San Francisco CA USA. Department of Neurology University of California San Francisco San Francisco CA USA. Department of Biomedical Engineering Johns Hopkins University Baltimore MD USA. Department of Brain and Cognitive Sciences MIT Cambridge MA USA. The Picower Institute for Learning and Memory MIT Cambridge MA USA. UCL Queen Square Institute of Neurology University College London London UK. Institute for the Advanced Study of Human Biology (WPI-ASHBi) Kyoto University Kyoto Japan. Computer Science and Artificial Intelligence Lab Massachusetts Institute of Technology Cambridge MA USA. Spinal Circuits and Plasticity Unit National Institute of Neurological Disorders and Stroke Bethesda MD USA. Institute of Computational Biology Helmholtz Center Munich - German Research Center for Environmental Health Neuherberg Germany. Wellcome Sanger Institute Wellcome Genome Campus Cambridge UK. Department of Human Genetics University of California Los Angeles Los Angeles CA USA. Lieber Institute for Brain Development Baltimore MD USA. Department of Psychiatry Johns Hopkins School of Medicine Baltimore MD USA. Department of Neuroscience Johns Hopkins School of Medicine Baltimore MD USA. School of Computer Science and Engineering The Hebrew University of Jerusalem Jerusalem Israel. Racah Institute of Physics The Hebrew University of Jerusalem Jerusalem Israel. Faculty of Medicine The Hebrew University of Jerusalem Jerusalem Israel. Department of Biochemis

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MedShapeNet - A Large-Scale dataset of 3D Medical Shapes for Computer Vision

arXiv

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arXiv 2023年

作者： Li, Jianning Zhou, Zongwei Yang, Jiancheng Pepe, Antonio Gsaxner, Christina Luijten, Gijs Qu, Chongyu Zhang, Tiezheng Chen, Xiaoxi Li, Wenxuan Wodzinski, Marek Friedrich, Paul Xie, Kangxian Jin, Yuan Ambigapathy, Narmada Nasca, Enrico Solak, Naida Melito, Gian Marco Vu, Viet Duc Memon, Afaque R. Schlachta, Christopher De Ribaupierre, Sandrine Patel, Rajnikant Eagleson, Roy Chen, Xiaojun Mächler, Heinrich Kirschke, Jan Stefan de la Rosa, Ezequiel Christ, Patrick Ferdinand Li, Hongwei Bran Ellis, David G. Aizenberg, Michele R. Gatidis, Sergios Küstner, Thomas Shusharina, Nadya Heller, Nicholas Andrearczyk, Vincent Depeursinge, Adrien Hatt, Mathieu Sekuboyina, Anjany Löffler, Maximilian Liebl, Hans Dorent, Reuben Vercauteren, Tom Shapey, Jonathan Kujawa, Aaron Cornelissen, Stefan Langenhuizen, Patrick Ben-Hamadou, Achraf Rekik, Ahmed Pujades, Sergi Boyer, Edmond Bolelli, Federico Grana, Costantino Lumetti, Luca Salehi, Hamidreza Ma, Jun Zhang, Yao Gharleghi, Ramtin Beier, Susann Sowmya, Arcot Garza-Villarreal, Eduardo A. Balducci, Thania Angeles-Valdez, Diego Souza, Roberto Rittner, Leticia Frayne, Richard Ji, Yuanfeng Ferrari, Vincenzo Chatterjee, Soumick Dubost, Florian Schreiber, Stefanie Mattern, Hendrik Speck, Oliver Haehn, Daniel John, Christoph Nürnberger, Andreas Pedrosa, João Ferreira, Carlos Aresta, Guilherme Cunha, António Campilho, Aurélio Suter, Yannick Garcia, Jose Lalande, Alain Vandenbossche, Vicky Van Oevelen, Aline Duquesne, Kate Mekhzoum, Hamza Vandemeulebroucke, Jef Audenaert, Emmanuel Krebs, Claudia van Leeuwen, Timo Vereecke, Evie Heidemeyer, Hauke Röhrig, Rainer Hölzle, Frank Badeli, Vahid Krieger, Kathrin Gunzer, Matthias Chen, Jianxu van Meegdenburg, Timo Dada, Amin Balzer, Miriam Fragemann, Jana Jonske, Frederic Rempe, Moritz Malorodov, Stanislav Bahnsen, Fin H. Seibold, Constantin Jaus, Alexander Marinov, Zdravko Jaeger, Paul F. Stiefelhagen, Rainer Santos, Ana Sofia Lindo, Mariana Ferreira, André Alves, Victor Kamp, Michael Abourayya, Amr Nensa, Felix Hörst, Fabian Brehmer, Alexander Hein Girardetstraße 2 Essen45131 Germany Graz University of Technology Inffeldgasse 16c Graz8010 Austria Graz Austria The Department of Computer Science Johns Hopkins University Malone Hall 3400 N Charles St BaltimoreMD21218 United States Rte Cantonale Lausanne1015 Switzerland The Department of Measurement and Electronics AGH University of Science and Technology Krakow Poland Sierre Switzerland Department of Biomedical Engineering University of Basel Hegenheimermattweg Allschwil167C CH-4123 Switzerland The Boston College 140 Commonwealth Ave Chestnut HillMA02467 United States University Hospital B7-200 339 Windermere Road LondonN6A 5A5 Canada The Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai200240 China The Research Center for Connected Healthcare Big Data ZhejiangLab Zhejiang Hangzhou311121 China The Faculty of Statistics Technical University Dortmund August-Schmidt-Straße 1 Dortmund44227 Germany The Institute of Mechanics Graz University of Technology Kopernikusgasse 24/IV Graz8010 Austria The Institute of Biomedical Manufacturing and Life Quality Engineering State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai200240 China The Department of Cardiac Surgery Medical University Graz Auenbruggerplatz 29 Graz8036 Austria The Department of Diagnostic and Interventional Radiology University Hospital Giessen Justus-Liebig-University Giessen Klinikstraße 33 Giessen35392 Germany The Department of Mechanical Engineering Mehran University of Engineering and Technology Jamshoro Sindh76062 Pakistan The Institute of Medical Robotics Shanghai Jiao Tong University Shanghai China The Geschäftsführender Oberarzt Abteilung für Interventionelle und Diagnostische Neuroradiologie Universitätsklinikum der Technischen Universität München Ismaningerstr. 22 München81675 Germany icometrix Kolonel Be

Prior to the deep learning era, shape was commonly used to describe the objects. Nowadays, state-of-the-art (SOTA) algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from numerous shape-related publications in premier vision conferences as well as the growing popularity of ShapeNet (about 51,300 models) and Princeton ModelNet (127,915 models). For the medical domain, we present a large collection of anatomical shapes (e.g., bones, organs, vessels) and 3D models of surgical instrument, called MedShapeNet, created to facilitate the translation of data-driven vision algorithms to medical applications and to adapt SOTA vision algorithms to medical problems. As a unique feature, we directly model the majority of shapes on the imaging data of real patients. As of today, MedShapeNet includes 23 datasets with more than 100,000 shapes that are paired with annotations (ground truth). Our data is freely accessible via a web interface and a Python application programming interface (API) and can be used for discriminative, reconstructive, and variational benchmarks as well as various applications in virtual, augmented, or mixed reality, and 3D printing. Exemplary, we present use cases in the fields of classification of brain tumors, skull reconstructions, multi-class anatomy completion, education, and 3D printing. In future, we will extend the data and improve the interfaces. The project pages are: https://***/ and https://***/Jianningli/*** Codes 68T01 © 2023, CC BY.

关键词： Large dataset

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Author Correction: Evidence for multi-fragmentation and mass shedding of boulders on rubble-pile binary asteroid system (65803) Didymos

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Nature communications 2024年第1期15卷 10021页

作者： M Pajola F Tusberti A Lucchetti O Barnouin S Cambioni C M Ernst E Dotto R T Daly G Poggiali M Hirabayashi R Nakano E Mazzotta Epifani N L Chabot V Della Corte A Rivkin H Agrusa Y Zhang L Penasa R-L Ballouz S Ivanovski N Murdoch A Rossi C Robin S Ieva J B Vincent F Ferrari S D Raducan A Campo-Bagatin L Parro P Benavidez G Tancredi Ö Karatekin J M Trigo-Rodriguez J Sunshine T Farnham E Asphaug J D P Deshapriya P H A Hasselmann J Beccarelli S R Schwartz P Abell P Michel A Cheng J R Brucato A Zinzi M Amoroso S Pirrotta G Impresario I Bertini A Capannolo S Caporali M Ceresoli G Cremonese M Dall'Ora I Gai L Gomez Casajus E Gramigna R Lasagni Manghi M Lavagna M Lombardo D Modenini P Palumbo D Perna P Tortora M Zannoni G Zanotti INAF-Astronomical Observatory of Padova Padova Italy. maurizio.pajola@inaf.it. INAF-Astronomical Observatory of Padova Padova Italy. Johns Hopkins University Applied Physics Laboratory Laurel MD USA. Department of Earth Atmospheric and Planetary Sciences Massachussets Institute of Technology Cambridge MA USA. INAF-Osservatorio Astronomico di Roma Roma Italy. INAF-Osservatorio Astrofisico di Arcetri Firenze Italy. LESIA-Observatorie de Paris PSL Paris France. Georgia Institute of Technology Atlanta GA USA. Department of Aerospace Engineering Auburn University Auburn AL USA. INAF-Osservatorio Astronomico di Capodimonte Napoli Italy. Department of Astronomy University of Maryland College Park MD USA. Université Côte d'Azur Observatoire de la Côte d'Azur CNRS Laboratoire Lagrange Nice France. Climate & Space Sciences and Engineering University of Michigan Hayward MI USA. INAF-Osservatorio Astronomico di Trieste Trieste Italy. Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO) Université de Toulouse France. IFAC-CNR Sesto Fiorentino Firenze Italy. DLR Berlin Berlin Germany. Dipartimento di Scienze e Tecnologie Aerospaziali Politecnico di Milano-Bovisa Campus Milano Italy. Space Research and Planetary Sciences Physikalisches Institut University of Bern Bern Switzerland. Universidad de Alicante de Alicante Spain. University of Arizona Tucson AZ USA. Dpto. Astronomia Facultad Ciencias Igua Montevideo Uruguay. Royal Observatory of Belgium Uccle Belgium. Institute of Space Sciences (ICE CSIC) and Institut d'Estudis Espacials de Catalunya (IEEC) Barcelona Spain. Planetary Science Institute NASA Johnson Space Center Houston TX USA. Department of Systems Innovation School of Engineering The University of Tokyo Tokyo Japan. Agenzia Spaziale Italiana Roma Italy. Space Science Data Center-ASI Roma Italy. Dipartimento di Scienze & Tecnologie Università degli Studi di Napoli "Parthenope" Napoli Italy. Dipartimento di Ingegneria Indu

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