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Convergent evidence linking neonatal vitamin D status and risk of neurodevelopmental disorders: a Danish case-cohort study

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The Lancet Psychiatry 2025年第6期12卷 410-420页

作者： Horsdal, Henriette Thisted Albiñana, Clara Zhu, Zhihong Boelt, Sanne Grundvad Borbye-Lorenzen, Nis Cohen, Arieh S Skogstrand, Kristin Melgaard, Lars MacSween, Nadia Jensen Thorbek, Marta Jadwiga Plana-Ripoll, Oleguer Petersen, Liselotte Vogdrup Bulik, Cynthia M B⊘rglum, Anders D Mors, Ole Nordentoft, Merete Werge, Thomas Moen, Gunn-Helen Wray, Naomi R Vilhjálmsson, Bjarni J Agerbo, Esben Pedersen, Carsten B⊘cker Mortensen, Preben Bo McGrath, John J National Centre for Register-Based Research Aarhus University Aarhus Denmark Centre for Integrated Register-based Research at Aarhus University Aarhus University Aarhus Denmark Big Data Centre for Environment and Health Aarhus University Aarhus Denmark Department of Biomedicine Aarhus University Aarhus Denmark Department of Clinical Medicine Aarhus University Aarhus Denmark Bioinformatics Research Centre Aarhus University Aarhus Denmark Department of Psychiatry University of Oxford Oxford United Kingdom Institute for Molecular Bioscience University of Queensland Brisbane QLD Australia University of Queensland Frazer Institute University of Queensland Brisbane QLD Australia Queensland Brain Institute University of Queensland Brisbane QLD Australia Novo Nordisk Foundation Center for Genomic Mechanisms of Disease Broad Institute Cambridge MA United States Danish Center for Neonatal Screening Department of Congenital Disorders Statens Serum Institut Copenhagen Denmark Department of Clinical Genetics Pathology and Molecular Diagnostics Office for Medical Services Lund Region Skåne Sweden Department of Clinical Epidemiology Aarhus University and Aarhus University Hospital Aarhus Denmark Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill NC United States Department of Nutrition University of North Carolina at Chapel Hill Chapel Hill NC United States Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden The Lundbeck Foundation Initiative for Integrative Psychiatric Research Aarhus Denmark Department of Biomedicine Center for Genomics and Personalized Medicine Aarhus Denmark Psychosis Research Unit Department of Psychiatry Aarhus University Hospital Aarhus Denmark Copenhagen Research Centre for Mental Health Mental Health Services in the Capital Region of Denmark University of Copenhagen Copenhagen Denmark Department of Clinical Medicine Faculty of Health Sciences University of Cop

Background: There is growing evidence linking neonatal vitamin D deficiency to an increased risk of schizophrenia, ADHD, and autism spectrum disorder (ASD). The aim of this study was to examine the association between...

Background: There is growing evidence linking neonatal vitamin D deficiency to an increased risk of schizophrenia, ADHD, and autism spectrum disorder (ASD). The aim of this study was to examine the association between two vitamin D biomarkers (25 hydroxyvitamin D [25(OH)D] and vitamin D-binding protein [DBP], and their related genetic correlates) and the risk of six mental disorders. Methods: We used a population-based, case-cohort sample of all individuals born in Denmark between 1981 and 2005. Using Danish health registers with follow-up to Dec 31, 2012, we identified individuals diagnosed with major depressive disorder, bipolar disorder, schizophrenia, ADHD, ASD, and anorexia nervosa based on ICD-10 criteria. Additionally, a random subcohort from the general population was selected. Based on neonatal dried blood spots, we measured concentrations of 25(OH)D and DBP. Our primary analyses were based on hazard ratios (HR) with 95% CI and absolute risks for the six mental disorders according to measured concentrations of 25(OH)D and DBP. As secondary analyses, we examined the association between genetic predictors of 25(OH)D and DBP, and the six mental disorders, and Mendelian randomisation analyses based on published summary statistics for 25(OH)D, DBP, and the six mental disorders. People with lived experience contributed to the development of the guiding hypothesis. Findings: We used the total population from the iPSYCH2012 design (n=88 764), which included individuals who developed the six mental disorders, major depressive disorder (n=24 240), bipolar disorder (n=1928), schizophrenia (n=3540), ADHD (n=18 726), ASD (n=16 146), anorexia nervosa (n=3643), and the randomly sampled subcohort (n=30 000). Among those who met a range of inclusion criteria (eg, measured 25[OH]D, DBP or genotype, and predominantly European ancestry), we measured 25(OH)D or DBP in 71 793 individuals (38 118 [53·1%] male and 33 675 [46·9%] female);65 952 had 25(OH)D and 66 797 the DBP measur

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P-319 Opposite functional alterations between aged endometria and that of women with uterine disorders offer plausible explanations to the increased incidence of uterine disorders with age

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Human Reproduction 2022年第SUPPLEMENT_1期37卷

作者： Devesa Peiro, A Sebastian-Leon, P Garcia-Garcia, F Pellicer, A Saez-Rodriguez, J Diaz-Gimeno, P IVIRMA IVI Foundation Biomedical Research Institute La Fe / University of Valencia Genomic & Systems Reproductive Medicine / Pediatrics Obstetrics & Gynaecology Valencia Spain IVIRMA IVI Foundation Biomedical Research Institute La Fe Genomic & Systems Reproductive Medicine Valencia Spain Centro de Investigación Príncipe Felipe Unit of Bioinformatics and Biostatistics Valencia Spain IVIRMA IVI Rome / IVIRMA IVI Foundation Biomedical Research Institute La Fe / University of Valencia Reproductive Medicine / Pediatrics Obstetrics & Gynaecology Rome Italy Heidelberg University and Heidelberg University Hospital- Faculty of Medicine- Bioquant Institute for Computational Biomedicine Heidelberg Germany

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#759 Comprehensive cancer genomic profiling in matched primary tumor and brain metastasis samples of ovarian cancer patients: a single-institution case series

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International Journal of Gynecological Cancer 2023年 33卷 A25-A26页

作者： Carolina Maria Sassu Camilla Nero Maria De Bonis Claudia Marchetti Angelo Minucci Giorgia Russo Pier Paolo Mattogno Alessia Piermattei Luciano Giacò Alessandro Olivi Diana Giannarelli Anna Fagotti Giovanni Scambia Dipartimento Scienze della Salute della Donna del Bambino e di Sanita` Pubblica Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Dipartimento Scienze della Vita e Sanita` Pubblica Universita` Cattolica del Sacro Cuore Rome Italy Molecular and Genomic Diagnostics Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Department of Neurosurgery Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy UOC Anatomia Patologica Generale Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Bioinformatics Facility Core Research Gemelli Science and Technology Park (GSTeP) Fondazione Policlinico Universitario Agostina Gemelli IRCCS Rome Italy Facility of Epidemiology and Biostatistics Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy

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64P Integrative immune transcriptomic classification could improve patient selection for precision immunotherapy in advanced gastroesophageal adenocarcinoma

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Annals of Oncology 2022年 33卷 S1402-S1403页

作者： M. Cabeza Segura V. Gambardella F. Gimeno-Valiente J.A. Carbonell-Asins L. Alarcon-Molero A. Gonzalez-Vilanova S. Zuniga-Trejos P. Rentero-Garrido R. Villagrasa M. Gil Raga P. Richart M. Huerta S. Rosello Keranen D. Roda Perez N. Tarazona Llavero C. Martínez-Ciarpaglini J. Castillo A. Cervantes T.C. Fleitas Medical Oncology Department INCLIVA Instituto de Investigación Sanitaria Valencia Spain Medical Oncology Department INCLIVA Instituto Investigación Sanitaria Hospital Clinico Universitario de Valencia CIBERONC Valencia Spain Cancer Evolution and Genome Instability Laboratory UCL Cancer Institute London UK Bioinformatics and Biostatistics Unit INCLIVA Instituto de Investigación Sanitaria Valencia Spain Pathology Department INCLIVA Instituto de Investigación Sanitaria Valencia Spain Precision Medicine Unit INCLIVA Instituto de Investigación Sanitaria Valencia Spain Endoscopy Unit Hospital Clinico Universitario de Valencia Valencia Spain Medical Oncology Department CHGUV - Consorcio Hospital General Universitario de Valencia Valencia Spain Medical Oncology Department Hospital Universitari i Politècnic La Fe Valencia Spain Pathology Department INCLIVA Instituto Investigación Sanitaria Biochemistry and Molecular Biology Department Universidad de Valencia Valencia Spain

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2022-RA-685-ESGO What is beyond brca mutational status in high grade serous ovarian cancer? The role of hormone receptors expression

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International Journal of Gynecological Cancer 2022年 32卷 A254-A254页

作者： Emanuele Perrone Riccardo Tudisco Pia Clara Pafundi Davide Guido Alessandra Ciucci Enrica Martinelli Gian Franco Zannoni Alessia Piermattei Claudia Marchetti Camilla Nero Daniela Gallo Giovanni Scambia Anna Fagotti Gynecologic Oncology Unit Dipartimento per le Scienze della Salute della Donna del Bambino e di Sa Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Dipartimento per le Scienze della Salute della Donna del Bambino e di Sa Universita’ Cattolica del Sacro Cuore Fondazione Policlinico Universitario A. Gemelli IRCCS. Rome Italy. Rome Italy Facility of Epidemiology and Biostatistics Gemelli Generator Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Bioinformatics Facility Core Research Gemelli Science and Technology Park (GSTeP) Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italy. Rome Italy Unit of Translational Medicine for Woman and Child Health Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Rome Italy Gynecopathology and Breast Pathology Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy

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Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer (vol 40, pg 114, 2022)

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CANCER CELL 2022年第4期40卷 438-438页

作者： Fendler, Annika Shepherd, Scott T. C. Au, Lewis Wilkinson, Katalin A. Wu, Mary Schmitt, Andreas M. Tippu, Zayd Farag, Sheima Rogiers, Aljosja Harvey, Ruth Carlyle, Eleanor Edmonds, Kim Del Rosario, Lyra Lingard, Karla Mangwende, Mary Holt, Lucy Ahmod, Hamid Korteweg, Justine Foley, Tara Barber, Taja Emslie-Henry, Andrea Caulfield-, Niamh Byrne, Lynch Fiona Shum, Benjamin Gerard, Camille L. Deng, Daqi Kjaer, Svend Song, Ok-Ryul Queval, Christophe Kavanagh, Caitlin Wall, Emma C. Carr, Edward J. Namjou, Sina Caidan, Simon Gavrielides, Mike MacRae, James I. Kelly, Gavin Peat, Kema Kelly, Denise Murra, Aida Kelly, Kayleigh O'Flaherty, Molly Shea, Robyn L. Gardner, Gail Murray, Darren Popat, Sanjay Yousaf, Nadia Jhanji, Shaman Van As, Nicholas Young, Kate Furness, Andrew J. S. Pickering, Lisa Beale, Rupert Swanton, Charles Gandhi, Sonia Gamblin, Steve Bauer, David L. V. Kassiotis, George Howell, Michael Nicholson, Emma Walker, Susanna Wilkinson, Robert J. Larkin, James Turajlic, Samra Cancer Dynamics Laboratory The Francis Crick Institute London NW1 1AT UK Skin and Renal Units The Royal Marsden NHS Foundation Trust London SW3 6JJ UK Tuberculosis Laboratory The Francis Crick Institute London NW1 1AT UK Wellcome Center for Infectious Disease Research in Africa University of Cape Town Observatory 7925 Republic of South Africa High Throughput Screening Laboratory The Francis Crick Institute London NW1 1AT UK Worldwide Influenza Centre The Francis Crick Institute London NW1 1AT UK Structural Biology STP The Francis Crick Institute London NW1 1AT UK University College London Hospitals NHS Foundation Trust Biomedical Research Centre London WC1E 6BT UK Cell Biology of Infection Laboratory The Francis Crick Institute London NW1 1AT UK Safety Health & Sustainability The Francis Crick Institute London NW1 1AT UK Scientific Computing Scientific Technology Platform The Francis Crick Institute London NW1 1AT UK Metabolomics Scientific Technology Platform The Francis Crick Institute London NW1 1AT UK Department of Bioinformatics and Biostatistics The Francis Crick Institute London UK Department of Pathology The Royal Marsden NHS Foundation Trust London NW1 1AT UK Translational Cancer Biochemistry Laboratory The Institute of Cancer Research London SW7 3RP UK Lung Unit The Royal Marsden NHS Foundation Trust London SW3 6JJ UK Acute Oncology Service The Royal Marsden NHS Foundation Trust London SW3 6JJ UK Anaesthetics Perioperative Medicine and Pain Department The Royal Marsden NHS Foundation Trust London SW3 6JJ UK Clincal Oncology Unit The Royal Marsden NHS Foundation Trust London NW1 1AT UK Division of Medicine University College London London NW1 2PG UK Cancer Evolution and Genome Instability Laboratory The Francis Crick Institute London NW1 1AT UK University College London Cancer Institute London WC1E 6DD UK Neurodegeneration Biology Laboratory The Francis Crick Institute London NW1 1AT UK UCL Queen Square Institute of N

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Measurement Invariance and Psychometric Evaluation of the Tendency to Avoid Physical Activity and Sport Scale (TAPAS) Among Mainland Chinese University Students

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Psychology research and behavior management 2023年 16卷 3821-3836页

作者： Mohsen Saffari I-Hua Chen Po-Ching Huang Kerry S O'Brien Yi-Ping Hsieh Ji-Kang Chen Yun-Hsuan Chang Xingyong Jiang Nadia Bevan Yen-Ling Chang Jung-Sheng Chen Ching-Chung Tsai Mark D Griffiths Chung-Ying Lin Health Research Center Life Style Institute Baqiyatallah University of Medical Sciences Tehran Iran. Health Education Department Faculty of Health Baqiyatallah University of Medical Sciences Tehran Iran. Chinese Academy of Education Big Data Qufu Normal University Qufu People's Republic of China. Institute of Allied Health Sciences College of Medicine National Cheng Kung University Tainan Taiwan. School of Social Sciences Monash University Melbourne Australia. Department of Social Work College of Nursing and Professional Disciplines University of North Dakota Grand Forks ND USA. Department of Social Work Chinese University of Hong Kong Shatin New Territories Hong Kong. Institute of Gerontology College of Medicine National Cheng Kung University Tainan Taiwan. Institute of Behavioral Medicine College of Medicine National Cheng Kung University Tainan Taiwan. Department of Psychology National Cheng Kung University Tainan Taiwan. Institute of Genomics and Bioinformatics College of Life Sciences National Chung Hsing University Taichung Taiwan. Yangan Primary School of Qionglai City Qionglai People's Republic of China. Department of Family Medicine Cardinal Tien Hospital New Taipei Taiwan. Department of Medical Research E-Da Hospital I-Shou University Kaohsiung Taiwan. Department of Pediatrics E-Da Hospital I-Shou University Kaohsiung Taiwan. School of Medicine I-Shou University Kaohsiung Taiwan. International Gaming Research Unit Psychology Department Nottingham Trent University Nottingham UK. Department of Occupational Therapy College of Medicine National Cheng Kung University Tainan Taiwan. Department of Public Health College of Medicine National Cheng Kung University Tainan Taiwan. Biostatistics Consulting Center National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan.

Introduction:Preventative factors in young people's physical inactivity require further understanding, including related psychosocial factors (eg, body image and weight stigma). The Tendency to Avoid Physical Acti... 详细信息

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Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy (vol 112, pg 179, 2020)

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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 2020年第6期112卷 654-654页

作者： Kerns, Sarah L. Fachal, Laura Dorling, Leila Barnett, Gillian C. Baran, Andrea Peterson, Derick R. Hollenberg, Michelle Hao, Ke Di Narzo, Antonio Ahsen, Mehmet Eren Pandey, Gaurav Bentzen, Soren M. Janelsins, Michelle Ellicot, Rebecca M. Pharoah, Paul D. Burnet, Neil G. Dearnaley, David P. Gulliford, Sarah L. Hall, Emma Sydes, Matthew R. Aguado-Barrera, Miguel E. Gomez-Caamano, Antonio Carballo, Ana M. Peleteiro, Paula Lobato-Busto, Ramon Stock, Richard Stone, Nelson N. Ostrer, Harry Usmani, Nawaid Singhal, Sandeep Tsuji, Hiroshi Imai, Takashi Saito, Shiro Eeles, Rosalind DeRuyck, Kim Parliament, Matthew Dunning, Alison M. Vega, Ana Rosenstein, Barry S. West, Catharine M. L. Departments of Radiation Oncology and Surgery University of Rochester Medical Center Rochester NY. Department of Oncology. Department of Public Health and Primary Care. Centre for Cancer Genetic Epidemiology Strangeways Research Laboratory University of Cambridge Cambridge UK Department of Oncology Cambridge University Hospitals NHS Foundation Trust Cambridge UK. Department of Biostatistics and Computational Biology University of Rochester Medical Center Rochester NY. Department of Computational Biology University of Rochester Rochester NY. Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai New York NY. Division of Biostatistics and Bioinformatics Department of Epidemiology and Public Health University of Maryland Greenebaum Cancer Center School of Medicine University of Maryland Baltimore. Division of Cancer Sciences the University of Manchester Manchester Academic Health Science Centre Christie Hospital Manchester UK. Academic Urooncology Unit The Institute of Cancer Research and Royal Marsden NHS Foundation Trust London UK. Clinical Trials and Statistics Unit The Institute of Cancer Research London UK. MRC Clinical Trials Unit at UCL Institute of Clinical Trials and Methodology University College London London UK. Fundación Pública Galega de Medicina Xenómica-Servizo Galego de Saude (SERGAS & Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) Santiago de Compostela Spain. Department of Radiation Oncology. Department of Medical Physics. Complexo Hospitalario Universitario de Santiago SERGAS Santiago de Compostela Spain Department of Radiation Oncology. Department of Urology. Icahn School of Medicine at Mount Sinai New York NY Departments of Pathology and Genetics Albert Einstein College of Medicine Bronx NY. Division of Radiation Oncology Department of Oncology Cross Cancer Institute University of Alberta Edmonton Canada. National Institute of Radi

A total of 10%-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk predic...

A total of 10%-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies.;We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3871) in men of European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequency, decreased urinary stream, hematuria, rectal bleeding) were graded prospectively. We used grouped relative risk models to test associations with approximately 6 million genotyped or imputed variants (time to first grade 2 or higher toxicity event). Variants with two-sided Pmeta less than 5 × 10-8 were considered statistically significant. Bayesian false discovery probability provided an additional measure of confidence. Statistically significant variants were evaluated in three Japanese cohorts (n = 962). All statistical tests were two-sided.;Meta-analysis of the European ancestry cohorts identified three genomic signals: single nucleotide polymorphism rs17055178 with rectal bleeding (Pmeta = 6.2 × 10-10), rs10969913 with decreased urinary stream (Pmeta = 2.9 × 10-10), and rs11122573 with hematuria (Pmeta = 1.8 × 10-8). Fine-scale mapping of these three regions was used to identify another independent signal (rs147121532) associated with hematuria (Pconditional = 4.7 × 10-6). Credible causal variants at these four signals lie in gene-regulatory regions, some modulating expression of nearby genes. Previously identified variants showed consistent associations (rs17599026 with increased urinary frequency, rs7720298 with decreased urinary stream, rs1801516 with overall toxicity) in new cohorts. rs10969913 and rs17599026 had similar effects in the photon-treated Japanese cohorts.;This study increases the understanding of the architecture of common genetic variants affecting radiotoxicity, p

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Correction to: Does antrum size matter in sleeve gastrectomy? A prospective randomized study

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Surgical endoscopy 2021年第7期35卷 3533页

作者： Francesco Pizza Dario D'Antonio Francesco Saverio Lucido Claudio Gambardella Juan Antonio Carbonell Asíns Chiara Dell'Isola Salvatore Tolone Department of Surgery Hospital "A. Rizzoli" Aslnapoli2nord Naples Italy. Francesco_pizza@libero.it. Department of Surgery Hospital "A. Rizzoli" Aslnapoli2nord Naples Italy. Division of General Mininvasive and Bariatric Surgery University of Campania "Luigi Vanvitelli" Naples Italy. Bioinformatics and Biostatistics Unit Biomedical Research Institute (INCLIVA) Valencia Spain. Department of Infectious Diseases AORN "Dei Colli" Naples Italy.

This article was updated to correct Juan Antonio Carbonell Asíns’ name in the author listing: Juan Antonio (given name) Carbonell Asíns (family name).

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Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

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Nature immunology 2024年第11期25卷 2166页

作者： Martina Musella Andrea Guarracino Nicoletta Manduca Claudia Galassi Eliana Ruggiero Alessia Potenza Ester Maccafeo Gwenola Manic Luca Mattiello Sara Soliman Abdel Rehim Michele Signore Marco Pietrosanto Manuela Helmer-Citterich Matteo Pallocca Maurizio Fanciulli Tiziana Bruno Francesca De Nicola Giacomo Corleone Anna Di Benedetto Cristiana Ercolani Edoardo Pescarmona Laura Pizzuti Francesco Guidi Francesca Sperati Sara Vitale Daniele Macchia Massimo Spada Giovanna Schiavoni Fabrizio Mattei Adele De Ninno Luca Businaro Valeria Lucarini Laura Bracci Eleonora Aricò Giovanna Ziccheddu Francesco Facchiano Stefania Rossi Massimo Sanchez Alessandra Boe Mauro Biffoni Ruggero De Maria Ilio Vitale Antonella Sistigu Dipartimento di Medicina e Chirurgia Traslazionale Università Cattolica del Sacro Cuore Rome Italy. Department of Biology University of Rome 'Tor Vergata' Rome Italy. Genomics Research Centre Human Technopole Milan Italy. Department of Radiation Oncology Weill Cornell Medical College New York NY USA. Experimental Hematology Unit IRCCS San Raffaele Scientific Institute Milan Italy. Italian Institute for Genomic Medicine (IIGM) Candiolo Italy. Candiolo Cancer Institute FPO - IRCCS Candiolo Italy. RPPA Unit Proteomics Area Core Facilities Istituto Superiore di Sanità Rome Italy. UOSD Clinical Trial Center Biostatistics and Bioinformatics IRCCS Regina Elena National Cancer Institute Rome Italy. SAFU Unit IRCCS Regina Elena National Cancer Institute Rome Italy. Pathology Unit IRCCS Regina Elena National Cancer Institute Rome Italy. Division of Medical Oncology 2 IRCCS Regina Elena National Cancer Institute Rome Italy. Fondazione Policlinico Universitario 'A. Gemelli' - IRCCS Rome Italy. UOSD Clinical Trial Center Biostatistics and Bioinformatics IRCCS San Gallicano Dermatological Institute Rome Italy. Center of Animal Research and Welfare Istituto Superiore di Sanità Rome Italy. Department of Oncology and Molecular Medicine Istituto Superiore di Sanità Rome Italy. Institute for Photonics and Nanotechnologies Italian National Research Council Rome Italy. Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy Ospedale Pediatrico Bambino Gesù IRCCS Rome Italy. FaBioCell Core Facilities Istituto Superiore di Sanità Rome Italy. Oncogenomics and Epigenetics IRCCS Regina Elena National Cancer Institute Rome Italy. Cytometry Unit Core Facilities Istituto Superiore di Sanità Rome Italy. Dipartimento di Medicina e Chirurgia Traslazionale Università Cattolica del Sacro Cuore Rome Italy. ruggero.demaria@unicatt.it. Fondazione Policlinico Universitario 'A. Gemelli' - IRCCS Rome Italy. ruggero.demaria@unicatt.it. Italian Institute for Geno

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