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Dengue diversity across spatial and temporal scales: Local structure and the effect of host population size

Science 2017年第6331期355卷 1302-1306页

作者： Salje, Henrik Lessler, Justin Berry, Irina Maljkovic Melendrez, Melanie C. Endy, Timothy Kalayanarooj, Siripen A-Nuegoonpipat, Atchareeya Chanama, Sumalee Sangkijporn, Somchai Klungthong, Chonticha Thaisomboonsuk, Butsaya Nisalak, Ananda Gibbons, Robert V. Iamsirithaworn, Sopon MacAreo, Louis R. Yoon, In-Kyu Sangarsang, Areerat Jarman, Richard G. Cummings, Derek A.T. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore 21205 MD United States Mathematical Modelling of Infectious Diseases Unit Institut Pasteur Paris France CNRS URA3012 Paris 75015 France Center of Bioinformatics Biostatistics and Integrative Biology Institut Pasteur Paris 75015 France Viral Diseases Branch Walter Reed Army Institute of Research Silver Spring 20910 MD United States Department of Medicine Upstate Medical University of New York Syracuse New York 13210 NY United States Queen Sirikit National Institute of Child Health Bangkok Thailand National Institute of Health Department of Medical Sciences Nonthaburi Thailand Department of Virology Armed Forces Research Institute of Medical Sciences Bangkok Thailand Department of Disease Control Ministry of Public Health Nonthaburi Thailand International Vaccine Institute Seoul South Korea Department of Biology University of Florida Gainesville 32610 FL United States Emerging Pathogens Institute University of Florida Gainesville 32610 FL United States

A fundamental mystery for dengue and other infectious pathogens is how observed patterns of cases relate to actual chains of individual transmission events. These pathways are intimately tied to the mechanisms by which strains interact and compete across spatial scales. Phylogeographic methods have been used to characterize pathogen dispersal at global and regional scales but have yielded few insights into the local spatiotemporal structure of endemic transmission. Using geolocated genotype (800 cases) and serotype (17,291 cases) data, we show that in Bangkok, Thailand, 60% of dengue cases living <200 meters apart come from the same transmission chain, as opposed to 3% of cases separated by 1 to 5 kilometers. At distances <200 meters from a case (encompassing an average of 1300 people in Bangkok), the effective number of chains is 1.7. This number rises by a factor of 7 for each 10-fold increase in the population of the "enclosed" region. This trend is observed regardless of whether population density or area increases, though increases in density over 7000 people per square kilometer do not lead to additional chains. Within Thailand these chains quickly mix, and by the next dengue season viral lineages are no longer highly spatially structured within the country. In contrast, viral flow to neighboring countries is limited. These findings are consistent with local, density-dependent transmission and implicate densely populated communities as key sources of viral diversity, with home location the focal point of transmission. These findings have important implications for targeted vector control and active surveillance.

关键词： DENGUE prevention DENGUE AEDES aegypti ENDEMIC infections TRANSMISSION RISK factors

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Correction to: A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19: the DAWn-Antico study

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Trials 2020年第1期21卷 1033页

作者： T Vanassche M M Engelen Q Van Thillo J Wauters J Gunst C Wouters C Vandenbriele S Rex L Liesenborghs A Wilmer P Meersseman G Van den Berghe D Dauwe G Verbeke M Thomeer T Fivez D Mesotten D Ruttens L Heytens I Dapper S Tuyls B De Tavernier P Verhamme Center for Molecular and Vascular Biology KU Leuven Department of Cardiovascular Sciences KU Leuven Leuven Belgium. thomas.vanassche@uzleuven.be. Department of Cardiovascular Sciences University Hospitals Leuven Leuven Belgium. thomas.vanassche@uzleuven.be. Center for Molecular and Vascular Biology KU Leuven Department of Cardiovascular Sciences KU Leuven Leuven Belgium. Department of Cardiovascular Sciences University Hospitals Leuven Leuven Belgium. Center for Cancer Biology VIB Leuven Belgium. Department of General Internal Medicine Medical Intensive Care Unit University Hospitals Leuven Leuven Belgium. Clinical Department and Laboratory of Intensive Care Medicine Department of Cellular and Molecular Medicine KU Leuven Leuven Belgium. Pediatric Rheumatology University Hospitals Leuven Leuven Belgium. Laboratory of Adaptive Immunology & Immunobiology Department of Microbiology and Immunology KU Leuven Leuven Belgium. Department of Anesthesiology University Hospitals Leuven Leuven Belgium. REGA Institute KU Leuven Leuven Belgium. Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat) KU Leuven Leuven and Hasselt University (UHasselt) Hasselt Belgium. Department of Respiratory Medicine Ziekenhuis Oost-Limburg Genk Belgium. Department of Medicine and Life Sciences Hasselt University Diepenbeek Belgium. Department of Anaesthesiology Intensive Care Emergency Medicine and Pain Therapy Ziekenhuis Oost-Limburg Genk Belgium. Department of Anesthestiology GZA hospital group Antwerp Belgium. Emergency Medicine and Intensive Care GZA hospital group Antwerp Belgium. Respiratory Medicine GZA hospital group Antwerp Belgium.

An amendment to this paper has been published and can be accessed via the original article.

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Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk

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European journal of human genetics : EJHG 2022年第5期30卷 630-631页

作者： Eileen O Dareng Jonathan P Tyrer Daniel R Barnes Michelle R Jones Xin Yang Katja K H Aben Muriel A Adank Simona Agata Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Gerasimos Aravantinos Banu K Arun Annelie Augustinsson Judith Balmaña Elisa V Bandera Rosa B Barkardottir Daniel Barrowdale Matthias W Beckmann Alicia Beeghly-Fadiel Javier Benitez Marina Bermisheva Marcus Q Bernardini Line Bjorge Amanda Black Natalia V Bogdanova Bernardo Bonanni Ake Borg James D Brenton Agnieszka Budzilowska Ralf Butzow Saundra S Buys Hui Cai Maria A Caligo Ian Campbell Rikki Cannioto Hayley Cassingham Jenny Chang-Claude Stephen J Chanock Kexin Chen Yoke-Eng Chiew Wendy K Chung Kathleen B M Claes Sarah Colonna Linda S Cook Fergus J Couch Mary B Daly Fanny Dao Eleanor Davies Miguel de la Hoya Robin de Putter Joe Dennis Allison DePersia Peter Devilee Orland Diez Yuan Chun Ding Jennifer A Doherty Susan M Domchek Thilo Dörk Andreas du Bois Matthias Dürst Diana M Eccles Heather A Eliassen Christoph Engel Gareth D Evans Peter A Fasching James M Flanagan Renée T Fortner Eva Machackova Eitan Friedman Patricia A Ganz Judy Garber Francesca Gensini Graham G Giles Gord Glendon Andrew K Godwin Marc T Goodman Mark H Greene Jacek Gronwald Eric Hahnen Christopher A Haiman Niclas Håkansson Ute Hamann Thomas V O Hansen Holly R Harris Mikael Hartman Florian Heitz Michelle A T Hildebrandt Estrid Høgdall Claus K Høgdall John L Hopper Ruea-Yea Huang Chad Huff Peter J Hulick David G Huntsman Evgeny N Imyanitov Claudine Isaacs Anna Jakubowska Paul A James Ramunas Janavicius Allan Jensen Oskar Th Johannsson Esther M John Michael E Jones Daehee Kang Beth Y Karlan Anthony Karnezis Linda E Kelemen Elza Khusnutdinova Lambertus A Kiemeney Byoung-Gie Kim Susanne K Kjaer Ian Komenaka Jolanta Kupryjanczyk Allison W Kurian Ava Kwong Diether Lambrechts Melissa C Larson Conxi Lazaro Nhu D Le Goska Leslie Jenny Lester Fabienne Lesueur Douglas A Levine Lian Li Jingmei Li Jennifer T Loud Karen H Lu Jan Lubiński Phuong L Mai Siranoush Manoukian Jeffrey R Marks Ra University of Cambridge Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care Cambridge UK. University of Cambridge Centre for Cancer Genetic Epidemiology Department of Oncology Cambridge UK. Center for Bioinformatics and Functional Genomics Cedars-Sinai Medical Center Los Angeles CA USA. Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen The Netherlands. Netherlands Comprehensive Cancer Organisation Utrecht The Netherlands. The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital Family Cancer Clinic Amsterdam The Netherlands. Veneto Institute of Oncology IOV-IRCCS Immunology and Molecular Oncology Unit Padua Italy. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Fred A. Litwin Center for Cancer Genetics Toronto ON Canada. University of Toronto Department of Molecular Genetics Toronto ON Canada. University of California Irvine Department of Epidemiology Genetic Epidemiology Research Institute Irvine CA USA. N.N. Alexandrov Research Institute of Oncology and Medical Radiology Minsk Belarus. 'Agii Anargiri' Cancer Hospital Athens Greece. University of Texas MD Anderson Cancer Center Department of Breast Medical Oncology Houston TX USA. Lund University Department of Cancer Epidemiology Clinical Sciences Lund Sweden. Vall d'Hebron Institute of Oncology Hereditary cancer Genetics Group Barcelona Spain. University Hospital of Vall d'Hebron Department of Medical Oncology Barcelona Spain. Rutgers Cancer Institute of New Jersey Cancer Prevention and Control Program New Brunswick NJ USA. Landspitali University Hospital Department of Pathology Reykjavik Iceland. University of Iceland BMC (Biomedical Centre) Faculty of Medicine Reykjavik Iceland. University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg Department of Gynecology and Obstetrics Comprehensive Cancer Center ER-EMN Erlangen Germany. Vanderbilt University School of Medicine Division of Epide

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Genomic research data generation, analysis and sharing – challenges in the African setting

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Data Science Journal 2017年 16卷

作者： Mulder, Nicola Adebamowo, Clement A. Adebamowo, Sally N. Adebayo, Oladimeji Adeleye, Osimhiarherhuo Alibi, Mohamed Baichoo, Shakuntala Benkahla, Alia Fadlelmola, Faisal M. Ghazal, Hassan Ghedira, Kais Matimba, Alice Moussa, Ahmed Mungloo-Dilmohamud, Zahra Owolabi, Mayowa O. Radouani, Fouzia Rotimi, Charles N. Stein, Dan J. Souiai, Oussama Computational Biology Division Department of Integrative Biomedical Sciences Institute for Infectious Disease and Molecular Medicine University of Cape Town South Africa Department of Epidemiology and Public Health University of Maryland Greenebaum Comprehensive Cancer Center University of Maryland School of Medicine BaltimoreMD21201 United States Department of Medicine University College Hospital Ibadan Nigeria Federal Medical Centre Abeokuta Nigeria Université Tunis El Manar Institut Pasteur de Tunis Laboratory of BioInformatics BioMathematics and BioStatistics Tunisia University of Mauritius Mauritius Centre for Bioinformatics and Systems Biology Faculty of Science University of Khartoum Sudan Future University of Sudan Sudan Laboratory of Physiology and Genetics University Mohamed Premier Morocco Department of Clinical Pharmacology University of Zimbabwe Harare Zimbabwe SDET ENSAT Abdelmalek Essaadi University Morocco Institut Pasteur du Maroc Casablanca Morocco Morocco Center for Research on Genomics and Global Health National Human Genome Research Institute NIH BethesdaMD20892 United States Department of Psychiatry University of Cape Town MRC Unit on Risk and Resilience in Mental Disorders South Africa

Genomics is the study of the genetic material that constitutes the genomes of organisms. This genetic material can be sequenced and it provides a powerful tool for the study of human, plant and animal evolutionary history and diseases. Genomics research is becoming increasingly commonplace due to significant advances in and reducing costs of technologies such as sequencing. This has led to new challenges including increasing cost and complexity of data. There is, therefore, an increasing need for computing infrastructure and skills to manage, store, analyze and interpret the data. In addition, there is a significant cost associated with recruitment of participants and collection and processing of biological samples, particularly for large human genetics studies on specific diseases. As a result, researchers are often reluctant to share the data due to the effort and associated cost. In Africa, where researchers are most commonly at the study recruitment, determination of phenotypes and collection of biological samples end of the genomic research spectrum, rather than the generation of genomic data, data sharing without adequate safeguards for the interests of the primary data generators is a concern. There are substantial ethical considerations in the sharing of human genomics data. The broad consent for data sharing preferred by genomics researchers and funders does not necessarily align with the expectations of researchers, research participants, legal authorities and bioethicists. In Africa, this is complicated by concerns about comprehension of genomics research studies, quality of research ethics reviews and understanding of the implications of broad consent, secondary analyses of shared data, return of results and incidental findings. Additional challenges with genomics research in Africa include the inability to transfer, store, process and analyze large-scale genomics data on the continent, because this requires highly specialized skills and expensive comput

关键词： Genome

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Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

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Archives of virology 2021年第12期166卷 3567-3579页

作者： Jens H Kuhn Scott Adkins Bernard R Agwanda Rim Al Kubrusli Sergey V Alkhovsky Gaya K Amarasinghe Tatjana Avšič-Županc María A Ayllón Justin Bahl Anne Balkema-Buschmann Matthew J Ballinger Christopher F Basler Sina Bavari Martin Beer Nicolas Bejerman Andrew J Bennett Dennis A Bente Éric Bergeron Brian H Bird Carol D Blair Kim R Blasdell Dag-Ragnar Blystad Jamie Bojko Wayne B Borth Steven Bradfute Rachel Breyta Thomas Briese Paul A Brown Judith K Brown Ursula J Buchholz Michael J Buchmeier Alexander Bukreyev Felicity Burt Carmen Büttner Charles H Calisher Mengji Cao Inmaculada Casas Kartik Chandran Rémi N Charrel Qi Cheng Yuya Chiaki Marco Chiapello Il-Ryong Choi Marina Ciuffo J Christopher S Clegg Ian Crozier Elena Dal Bó Juan Carlos de la Torre Xavier de Lamballerie Rik L de Swart Humberto Debat Nolwenn M Dheilly Emiliano Di Cicco Nicholas Di Paola Francesco Di Serio Ralf G Dietzgen Michele Digiaro Olga Dolnik Michael A Drebot J Felix Drexler William G Dundon W Paul Duprex Ralf Dürrwald John M Dye Andrew J Easton Hideki Ebihara Toufic Elbeaino Koray Ergünay Hugh W Ferguson Anthony R Fooks Marco Forgia Pierre B H Formenty Jana Fránová Juliana Freitas-Astúa Jingjing Fu Stephanie Fürl Selma Gago-Zachert George Fú Gāo María Laura García Adolfo García-Sastre Aura R Garrison Thomas Gaskin Jean-Paul J Gonzalez Anthony Griffiths Tony L Goldberg Martin H Groschup Stephan Günther Roy A Hall John Hammond Tong Han Jussi Hepojoki Roger Hewson Jiang Hong Ni Hong Seiji Hongo Masayuki Horie John S Hu Tao Hu Holly R Hughes Florian Hüttner Timothy H Hyndman M Ilyas Risto Jalkanen Dàohóng Jiāng Gilda B Jonson Sandra Junglen Fujio Kadono Karia H Kaukinen Michael Kawate Boris Klempa Jonas Klingström Gary Kobinger Igor Koloniuk Hideki Kondō Eugene V Koonin Mart Krupovic Kenji Kubota Gael Kurath Lies Laenen Amy J Lambert Stanley L Langevin Benhur Lee Elliot J Lefkowitz Eric M Leroy Shaorong Li Longhui Li Jiànróng Lǐ Huazhen Liu Igor S Lukashevich Piet Maes William Marciel de Souza Marco Marklewitz Sergio H Marshall Shin-Yi L Marzano Se Integrated Research Facility at Fort Detrick National Institute of Allergy and Infectious Diseases National Institutes of Health Frederick MD USA. kuhnjens@mail.nih.gov. United States Department of Agriculture Agricultural Research Service US Horticultural Research Laboratory Fort Pierce FL USA. Zoology Department National Museums of Kenya Nairobi Kenya. Jomo Kenyatta University of Agriculture & Technology Nairobi Kenya. Division Phytomedicine Faculty of Life Sciences Humboldt-Universität zu Berlin Berlin Germany. D.I. Ivanovsky Institute of Virology of N.F. Gamaleya National Center on Epidemiology and Microbiology of Ministry of Health of Russian Federation Moscow Russia. Department of Pathology and Immunology Washington University School of Medicine St. Louis MO USA. Faculty of Medicine University of Ljubljana Ljubljana Slovenia. Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Campus de Montegancedo Pozuelo de Alarcón Madrid Spain. Departamento de Biotecnología-Biología Vegetal Escuela Técnica Superior de Ingeniería Agronómica Alimentaria y de Biosistemas Universidad Politécnica de Madrid Madrid Spain. Center for Ecology of Infectious Diseases Department of Infectious Diseases Department of Epidemiology and Biostatistics Insitute of Bioinformatics University of Georgia Athens GA USA. Institute of Novel and Emerging Infectious Diseases Friedrich-Loeffler-Institut Federal Research Institute for Animal Health Greifswald-Insel Riems Germany. Department of Biological Sciences Mississippi State University Mississippi State MS USA. Center for Microbial Pathogenesis Institute for Biomedical Sciences Georgia State University Atlanta GA USA. Edge BioInnovation Consulting and Mgt Frederick MD USA. Institute of Diagnostic Virology Friedrich-Loeffler-Institut Greifswald-Insel Riems Germany. UFyMA INTA-CONICET Cordoba Argentina. Genomics and Bioinformatics D

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Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

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Nature communications 2023年第1期14卷 716页

作者： Itziar de Rojas Sonia Moreno-Grau Niccolo Tesi Benjamin Grenier-Boley Victor Andrade Iris E Jansen Nancy L Pedersen Najada Stringa Anna Zettergren Isabel Hernández Laura Montrreal Carmen Antúnez Anna Antonell Rick M Tankard Joshua C Bis Rebecca Sims Céline Bellenguez Inés Quintela Antonio González-Perez Miguel Calero Emilio Franco-Macías Juan Macías Rafael Blesa Laura Cervera-Carles Manuel Menéndez-González Ana Frank-García Jose Luís Royo Fermin Moreno Raquel Huerto Vilas Miquel Baquero Mónica Diez-Fairen Carmen Lage Sebastián García-Madrona Pablo García-González Emilio Alarcón-Martín Sergi Valero Oscar Sotolongo-Grau Abbe Ullgren Adam C Naj Afina W Lemstra Alba Benaque Alba Pérez-Cordón Alberto Benussi Alberto Rábano Alessandro Padovani Alessio Squassina Alexandre de Mendonça Alfonso Arias Pastor Almar A L Kok Alun Meggy Ana Belén Pastor Ana Espinosa Anaïs Corma-Gómez Angel Martín Montes Ángela Sanabria Anita L DeStefano Anja Schneider Annakaisa Haapasalo Anne Kinhult Ståhlbom Anne Tybjærg-Hansen Annette M Hartmann Annika Spottke Arturo Corbatón-Anchuelo Arvid Rongve Barbara Borroni Beatrice Arosio Benedetta Nacmias Børge G Nordestgaard Brian W Kunkle Camille Charbonnier Carla Abdelnour Carlo Masullo Carmen Martínez Rodríguez Carmen Muñoz-Fernandez Carole Dufouil Caroline Graff Catarina B Ferreira Caterina Chillotti Chandra A Reynolds Chiara Fenoglio Christine Van Broeckhoven Christopher Clark Claudia Pisanu Claudia L Satizabal Clive Holmes Dolores Buiza-Rueda Dag Aarsland Dan Rujescu Daniel Alcolea Daniela Galimberti David Wallon Davide Seripa Edna Grünblatt Efthimios Dardiotis Emrah Düzel Elio Scarpini Elisa Conti Elisa Rubino Ellen Gelpi Eloy Rodriguez-Rodriguez Emmanuelle Duron Eric Boerwinkle Evelyn Ferri Fabrizio Tagliavini Fahri Küçükali Florence Pasquier Florentino Sanchez-Garcia Francesca Mangialasche Frank Jessen Gaël Nicolas Geir Selbæk Gemma Ortega Geneviève Chêne Georgios Hadjigeorgiou Giacomina Rossi Gianfranco Spalletta Giorgio Giaccone Giulia Grande Giuliano Binetti Goran Papenberg Harald Hampel Research Center and Memory clinic Fundació ACE Institut Català de Neurociències Aplicades Universitat Internacional de Catalunya Barcelona Spain. CIBERNED Network Center for Biomedical Research in Neurodegenerative Diseases National Institute of Health Carlos III Madrid Spain. Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam The Netherlands. Section Genomics of Neurodegenerative Diseases and Aging Department of Clinical Genetics Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam The Netherlands. Delft Bioinformatics Lab Delft Univeristy of Technology Delft The Netherlands. Univ. Lille Inserm Institut Pasteur de Lille CHU Lille U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases Lille France. Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy University of Cologne Medical Faculty Cologne Germany. Department of Neurodegenerative diseases and Geriatric Psychiatry University Clinic Bonn Bonn Germany. Department of Complex Trait Genetics Center for Neurogenomics and Cognitive Research Amsterdam Neuroscience VU University Amsterdam The Netherlands. Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden. Amsterdam UMC-Vrije Universiteit Amsterdam Department of Epidemiology and Data Science Amsterdam Public Health Research Institute Amsterdam The Netherlands. Neuropsychiatric Epidemiology Unit Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy Centre for Ageing and Health (AgeCap) University of Gothenburg Gothenburg Sweden. Unidad de Demencias Hospital Clínico Universitario Virgen de la Arrixaca Murcia Spain. Alzheimer's disease and other cognitive disorders unit. Service of Neurology Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer University of Barcelona Barcelona Spain

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Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer

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Nature communications 2021年第1期12卷 7354页

作者： Wei Zhou Ben Brumpton Omer Kabil Julius Gudmundsson Gudmar Thorleifsson Josh Weinstock Matthew Zawistowski Jonas B Nielsen Layal Chaker Marco Medici Alexander Teumer Silvia Naitza Serena Sanna Ulla T Schultheiss Anne Cappola Juha Karjalainen Mitja Kurki Morgan Oneka Peter Taylor Lars G Fritsche Sarah E Graham Brooke N Wolford William Overton Humaira Rasheed Eirin B Haug Maiken E Gabrielsen Anne Heidi Skogholt Ida Surakka George Davey Smith Anita Pandit Tanmoy Roychowdhury Whitney E Hornsby Jon G Jonasson Leigha Senter Sandya Liyanarachchi Matthew D Ringel Li Xu Lambertus A Kiemeney Huiling He Romana T Netea-Maier Jose I Mayordomo Theo S Plantinga Jon Hrafnkelsson Hannes Hjartarson Erich M Sturgis Aarno Palotie Mark Daly Cintia E Citterio Peter Arvan Chad M Brummett Michael Boehnke Albert de la Chapelle Kari Stefansson Kristian Hveem Cristen J Willer Bjørn Olav Åsvold Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor Michigan USA. wzhou@***. Analytic and Translational Genetics Unit Massachusetts General Hospital Boston Massachusetts USA. wzhou@***. Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA. wzhou@***. Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge Massachusetts USA. wzhou@***. K.G. Jebsen Center for Genetic Epidemiology Department of Public Health and Nursing NTNU Norwegian University of Science and Technology Trondheim Norway. Medical Research Council (MRC) Integrative Epidemiology Unit University of Bristol Bristol UK. Department of Thoracic Medicine St. Olavs Hospital Trondheim University Hospital Trondheim Norway. Department of Biological Chemistry University of Michigan Medical School Ann Arbor Michigan USA. Division of Metabolism Endocrinology and Diabetes University of Michigan Medical School Ann Arbor Michigan USA. deCODE genetics/AMGEN 101 Reykjavik Iceland. Center for Statistical Genetics and Department of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan USA. Department of Internal Medicine Division of Cardiology University of Michigan Medical School Ann Arbor Michigan USA. Department of Epidemiology Research Statens Serum Institute Copenhagen Denmark. Erasmus MC Academic Center for Thyroid Diseases Rotterdam The Netherlands. Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands. Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands. Division of Endocrinology Department of Internal Medicine Radboud University Medical Centre Radboud Institute for Molecular Life Sciences 6500HB Nijmegen The Netherlands. Institute for Community Medicine University Medicine Greifswald Greifswald Germany. DZHK (German Center for Cardiovascular Research) Partner Site Greifswald Greifswald Germany. Istit

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A second update on mapping the human genetic architecture of COVID-19

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Nature 2023年第7977期621卷 E7-E26页

作者： Masahiro Kanai Christine Stevens Benjamin M. Neale Mark Daly Andrea Ganna Amy Trankiem Mary K. Balaconis Samuli Ripatti Lindo Nkambul Mark J. Daly Sam Bryant Matthew Solomonson Shea J. Andrews Mattia Cordioli Juha Karjalainen Juha Mehtonen Matti Pirinen Andrea Corbetta Bradley Jermy Kati Donner Katja Kivinen Aarno Palotie Mari Kaunisto Kumar Veerapen Konrad J. Karczewski Alicia R. Martin Elizabeth G. Atkinson Kristin Tsuo Nikolas Baya Rahul Gupta Raymond K. Walters Duncan S. Palmer Gopal Sarma Nathan Cheng Wenhan Lu Claire Churchhouse Jacqueline I. Goldstein Daniel King Wei Zhou Cotton Seed Hilary Finucane F. Kyle Satterstrom Gita A. Pathak Akiko Iwasaki Karolina Chwialkowska Karolina Chwiałkowska Brooke N. Wolford Hajar Fauzan Ahmad Shea Andrews Kathrin Aprile von Hohenstaufen Puoti Palwende R. Boua Guillaume Butler-Laporte Celia M. T. Greenwood Bartha M. Knoppers Mark Lathrop Carmen L. Cadilla Francesca Colombo Nicole Dueker Chloe Kirk Atanu Kumar Dutta Yasser M. El-Sherbiny Jehan J. El-Jawhari Doaa Shahin Ahmed Elzeiny Tamer A. Mansour Madonna M. Eltoukhy Attia A. S. Mohamed Sahar Esmaeeli Annika Faucon Israel Fernández Cadenas Israel Fernandez-Cadenas Laia Llucià-Carol Natalia Cullell Elena Muiño Jara Cárcel-Márquez Margherita Francescatto Laurent Francioli Lindokuhle Nkambule Jatin Arora Soumya Raychaudhuri Caroline Cusick Lude Franke Macarena Fuentes Macarena Fuentes-Guajardo David Gómez Cabrero Emi N. Harry Philip Jansen József L. Szentpéteri Réka Várnai Elżbieta Kaja Athanasios Kousathanas Dorote Pasko Mark J. Caulfield Alex Stuckey Christopher A. Odhams Susan Walker Daniel Rhodes Richard H. Scott Loukas Moutsianas Afshan Siddiq Peter Goddard Sally Donovan Tala Zainy Fiona Maleady-Crowe Linda Todd Shahla Salehi Greg Elgar Georgia Chan Prabhu Arumugam Christine Patch Augusto Rendon Tom A. Fowler Jose E. Krieger Sanjay K. Patel Audrey Lemaçon Sophie Limou Pietro Lió Eirini Marouli Charles Hinds Minttu M. Marttila Carolina Medina-Gómez Isabelle Migeotte Soumyajit Mondal Andrés Moreno-Estrada Leire Moya Tomok Broad Institute of MIT and Harvard Cambridge MA USA Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA USA Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Program in Bioinformatics and Integrative Genomics Harvard Medical School Boston MA USA Institute for Molecular Medicine Finland (FIMM) University of Helsinki Helsinki Finland Institute for Molecular Medicine Finland University of Helsinki Helsinki Finland Institute for Molecular Medicine Finland (FIMM) HiLIFE University of Helsinki Helsinki Finland Public Health Faculty of Medicine University of Helsinki Helsinki Finland Analytic & Translational Genetics Unit Massachusetts General Hospital Boston MA USA Stanley Center for Psychiatric Research & Program in Medical and Population Genetics Cambridge UK Institute for Molecular Medicine Finland (FIMM) Univerisity of Helsinki Helsinki Finland University of California San Francisco San Francisco CA USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Program in Biological and Biomedical Sciences Harvard Medical School Boston MA USA Department of Psychiatry School of Medicine Yale University New Haven CT USA Veteran Affairs Connecticut Healthcare System West Haven CT USA Yale University New Haven CT USA Centre for Bioinformatics and Data Analysis Medical University of Bialystok Bialystok Poland Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang Pahang Malaysia Icahn School of Medicine at Mount Sinai New York NY USA Genolier Innovation Network and Hub Swiss Medical Network Genolier Healthcare Campus Genolier Switzerland Immediate Independent Multidisciplinary Med & Biotech Research Association Milan Italy Clinical Research Unit of Nanor

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Author Correction: N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes

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Nature microbiology 2018年第8期3卷 962页

作者： Francis Impens Nathalie Rolhion Lilliana Radoshevich Christophe Bécavin Mélodie Duval Jeffrey Mellin Francisco García Del Portillo M Graciela Pucciarelli Allison H Williams Pascale Cossart Département de Biologie Cellulaire et Infection Institut Pasteur Unité des Interactions Bactéries-Cellules F-75015 Paris France. Inserm U604 F-75015 Paris France. INRA Unité sous-contrat 2020 F-75015 Paris France. Medical Biotechnology Center VIB Ghent University 9000 Ghent Belgium. Institut Pasteur Bioinformatics and Biostatistics Hub C3BI USR 3756 IP CNRS Paris France. Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB-CSIC) Madrid Spain. Departamento de Biología Molecular Universidad Autónoma de Madrid Centro de Biología Molecular 'Severo Ochoa' (CBMSO-CSIC) Madrid Spain. Département de Microbiologie Institut Pasteur Unité des Biologie et génétique de la paroi bactérienne F-75015 Paris France. INSERM Groupe Avenir F-75015 Paris France. Département de Biologie Cellulaire et Infection Institut Pasteur Unité des Interactions Bactéries-Cellules F-75015 Paris France. pascale.cossart@pasteur.fr. Inserm U604 F-75015 Paris France. pascale.cossart@pasteur.fr. INRA Unité sous-contrat 2020 F-75015 Paris France. pascale.cossart@pasteur.fr.

This Article contains a URL for a publically available whole-genome browser ( http://*** ). However, due to technical constraint, this website has been replaced with an alternative ( https://*** ).

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51, pg 659, 2019)

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NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

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