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19P Therapeutic targets in non-small cell lung cancer: Preclinical and human studies of carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) expression and its associated molecular landscape

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Annals of Oncology 2021年 32卷 S1381-S1381页

作者： J. Adam A-M. Lefebvre C. Nicolazzi C. Larois F. Attenot F. Falda-Buscaiot C. Dib N. Ternès N. Masson A-L. Bauchet B. Demers M. Chadjaa S. Sidhu C. Combeau J-C. Soria J-Y. Scoazec S. Naimi E. Angevin C. Henry Pathology Institut Gustave Roussy Villejuif France Molecular Histopathology and Bio-Imaging Translational Sciences Unit Sanofi Chilly-Mazarin France Oncology Research Sanofi R&D Sanofi Vitry-sur-Seine France Molecular Histopathology and Bio-Imaging Translational Sciences Unit Sanofi Vitry-sur-Seine France Oncology Research Department Sanofi Vitry-sur-Seine France Early Oncology Sanofi Vitry-sur-Seine France Oncology Sanofi Vitry-sur-Seine France Biostatistics and Programming Sanofi Chilly-Mazarin France IT&M Stats Sanofi Paris France Translational Medicine and Early Development/Biomarkers and Clinical Bioanalyses Sanofi Chilly-Mazarin France Early Development Oncology Sanofi Vitry-sur-Seine France Oncology Development Sanofi Vitry-sur-Seine France Pharmacology Sanofi Vitry-sur-Seine France Translational Medicine and Early Development Sanofi Vitry-sur-Seine France Drug development Department Institut Gustave Roussy Villejuif France Université Paris Saclay Institut Gustave Roussy Villejuif France Molecular and Digital Histopathology Research and Development Sanofi Vitry-sur-Seine France Early Drug Development Institut Gustave Roussy Villejuif France Oncology R&D (research) Sanofi Vitry-sur-Seine France

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EFFICACY AND SAFETY OF EXPERIMENTAL CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS VERSUS AXICABTAGENE CILOLEUCEL (YESCARTA) FOR THE TREATMENT OF RELAPSED/REFRACTORY LARGE B-CELL LYMPHOMA: MATCHING ADJUSTED INDIRECT COMPARISONS AND SYSTEMATIC REVIEW

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Hematology, Transfusion and Cell Therapy 2021年 43卷 S256-S256页

作者： B Weinstein B Muresan S Solano AV Macedo Y Lee Y Su Y Ahn C Camargo G Kim D Carpenter Department of Environmental Health Sciences School of Public Health University at Albany Rensselaer United Kingdom Health Sciences Unit University of Groningen University Medical Center Groningen Groningen The Netherlands Principles and Practice of Clinical Research (PPCR) Program ECPE Harvard T.H. Chan School of Public Health Boston United Kingdom Hematology Clinic Hospital da Polícia Militar Belo Horizonte MG Brazil Department of Pharmaceutical Sciences School of Pharmacy Texas Tech University Health Sciences Center Amarillo United Kingdom Inari Medical Biostatistics and Programming Department Irvine United Kingdom Department of Plastic Surgery Faculdade de Medicina Universidade de São Paulo (FMUSP) São Paulo SP Brazil Institute of Experimental and Clinical Pharmacology and Toxicology Faculty of Medicine University of Freiburg Freiburg Germany Institute for Health and the Environment University at Albany Rensselaer United Kingdom

Introduction Despite the high response rates seen with Chimeric Antigen Receptor (CAR) T-cell therapy for relapsed/refractory Large B-cell lymphoma (R/R LBCL), post-therapy relapse remains a key challenge. To date, no study has evaluated the comparative efficacy and safety of experimental CAR T-cell products versus currently approved CAR T-cell therapies. Objective To indirectly compare the efficacy and safety of novel, experimental CAR T-cell products against the first FDA-approved CAR T-cell construct, Axicabtagene ciloleucel (Yescarta). Methods In compliance with the PRISMA guidelines, we performed a systematic review, which identified 16 independent, early-phase clinical trials consisting of 193 LBCL patients with individual patient data (IPD). We categorized eight pooled populations based on the target antigens (CD19, CD20), co-stimulatory domains (CD28, 4-1BB), and CAR T-cells administered with or without concomitant autologous stem cell transplant (ASCT). The pooled populations were categorized as follows: (1) dual targeting strategies, such as tandem ***20, n = 28; (2) co-infusion of CD19 and CD20 CARs, n = 21; (3) third-generation CARs, n = 26; (4) CD19 CARs with modified constructs for reduced toxicity, including ***.86, n = 21; and (5) ***828Z, n = 14; (6) CD19. 4-1BB.S manufactured in China, n = 24; (7) concomitant ASCT and ***28, n = 45; and (8) CD20 CARs with a 4-1BB co-stimulatory domain, n = 14. A Matching Adjusted Indirect Comparison (MAIC) statistical technique was applied to account for heterogeneity in the study population across trials. Estimates for the experimental CAR T-cell trials were adjusted using patient-level data to match the ZUMA-1 (Yescarta, n = 108) study population based on mutually reported key baseline covariates, including age, disease stage, histology, refractoriness, number of prior lines of therapy, and extranodal disease. The study endpoints for this study included progression-free survival (PFS), cytokine r

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Correction to: Comparison of lipidome profiles of Caenorhabditis elegans-results from an inter-laboratory ring trial

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Metabolomics : Official journal of the Metabolomic Society 2021年第3期17卷 33页

作者： Britta Spanier Anne Laurençon Anna Weiser Nathalie Pujol Shizue Omi Aiko Barsch Ansgar Korf Sven W Meyer Jonathan J Ewbank Francesca Palladino Steve Garvis Hugo Aguilaniu Michael Witting Chair of Metabolic Programming Technische Universität München Gregor-Mendel-Straße 2 85354 Freising Germany. UMR5242 Ecole Normale Supérieure de Lyon Centre National de la Recherche Scientifique Université de Lyon Lyon France. Turing Center for Living Systems Aix Marseille Univ CNRS INSERM CIML Marseille France. Bruker Daltonics Fahrenheitstr. 4 28359 Bremen Germany. Laboratoire de Biologie Moléculaire de la Cellule UMR5239 CNRS/ENS Lyon/UCBL/HCL Ecole Normale Supérieure de Lyon 46 allée d'Italie 69364 Lyon cedex 07 France. Instituto Serrapilheira Rua Dias Ferreira 78 Leblon Rio de Janeiro Brazil. Research Unit Analytical BioGeoChemistry Helmholtz Zentrum München German Research Center for Environmental Health Ingolstaedter Landstrasse 1 85764 Neuherberg Germany. michael.witting@helmholtz-muenchen.de. Metabolomics and Proteomics Core Helmholtz Zentrum München German Research Center for Environmental Health Ingolstaedter Landstrasse 1 85764 Neuherberg Germany. michael.witting@helmholtz-muenchen.de. Chair of Analytical Food Chemistry Technische Universität München Alte Akademie 10 85354 Freising-Weihenstephan Germany. michael.witting@helmholtz-muenchen.de.

A correction to this paper has been published: https://***/10.1007/s11306-021-01784-5

关键词： Biochemistry general Molecular Medicine Cell Biology Developmental Biology Biomedicine

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806P Updated toxicity profile and relapse-free survival outcomes using an adapted pyrexia management algorithm in patients with resected stage III BRAF V600E/K-mutant melanoma treated with adjuvant dabrafenib plus trametinib in COMBI-APlus

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Annals of Oncology 2022年 33卷 S914-S914页

作者： M. Del Vecchio V.G. Atkinson B. Ryll A.M. Menzies F. Aubin V. Chiarion Sileni V. Ferraresi T. Lesimple G. Rinaldi P. Saiag C. Robert C. Dutriaux H.J. Gogas L. Demidov A. Gupta H. Banerjee S. Sudhir F. Miranda M.R. Lau J.J. Grob Department of Medical Oncology and Hematology Unit of Melanoma Medical Oncology Fondazione IRCCS - Istituto Nazionale dei Tumori Milan Italy Division of Cancer Services Princess Alexandra Hospital - University of Queensland Qld Australia Melanoma Department Melanoma Patient Network Europe MPNE Uppsala Sweden Department of Medical Oncology Melanoma Institute Australia The University of Sydney Royal North Shore and Mater Hospitals Sydney NSW Australia Department of Dermatology University Hospital and Inserm Besançon France Azienda Ospedaliera Di Padova Padua Italy Sarcomas and Rare Tumors Unit IRCCS Regina Elena National Cancer Institute (IRE) Rome Italy Département d'Oncologie Médicale CLCC Eugène Marquis Rennes France Department of Surgical Oncological and Oral Sciences Section of Oncology University of Palermo Palermo Italy Service de Dermatologie Générale et Oncologique Hôpital A Paré Assistance Publique-Hôpitaux de Paris Boulogne-Billancourt France Department of Medicine Gustave Roussy and Paris-Saclay University Villejiuf France Department of Dermatology University Hospital of Bordeaux / CHU De Bordeaux Hospital Saint-André Bordeaux France First Department of Internal Medicine Laiko General Hospital National and Kapodistrian University of Athens School of Medicine Athens Greece Tumor Biotherapy N.N. Blokhin Russian Cancer Research Center Moscow Russian Federation Medical Oncology The Christie NHS Foundation Trust Manchester UK Analytics Novartis Pharmaceuticals Corporation East Hanover NJ USA Biostatistics & Statistical Programming Novartis Healthcare Private Limited Hyderabad India Clinical Operations Novartis Pharmaceuticals Corporation East Hanover NJ USA Medical Affairs Department Novartis Pharma AG Basel Switzerland Dermatology and Skin Cancer Department Aix-Marseille University Marseille France

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Dynamics of cholera outbreak with bacteriophage and periodic rate of contact

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International Journal of Dynamics and Control 2016年第3期4卷 284-292页

作者： Panja, Prabir Mondal, Shyamal Kumar Chattopadhyay, Joydev Department of Applied Mathematics with Oceanology and Computer Programming Vidyasagar University MidnaporeW.B.721 102 India Agricultural and Ecological Research Unit ISI 203 B.T.Road Kolkata India

In this paper, a cholera epidemic model with periodic transmission rate has been considered and discussed. It is shown that the disease free equilibrium point is globally asymptotically stable and also seen that the cholera disease is disappeared if the basic reproduction number is less than one. When the basic reproduction number is grater than one, then the endemic equilibrium is globally asymptotically stable. Finally, numerical simulations have been given for the existence of the analytical results. © 2015, Springer-Verlag Berlin Heidelberg.

关键词： Bacteriophages

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Including gap junctions into distributed neuronal network simulations 1

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2nd International Workshop on Brain-Inspired Computing, BrainComp 2015

作者： Hahne, Jan Helias, Moritz Kunkel, Susanne Igarashi, Jun Kitayama, Itaru Wylie, Brian Bolten, Matthias Frommer, Andreas Diesmann, Markus School of Mathematics and Natural Sciences University of Wuppertal Wuppertal Germany and JARA BRAIN Institute I Jülich Research Centre Jülich Germany RIKEN Advanced Institute for Computational Science Programming Environment Research Team Kobe Japan Department of Computational Science and Technology School of Computer Science and Communication KTH Royal Institute of Technology Stockholm Sweden Simulation Laboratory Neuroscience Bernstein Facility for Simulation and Database Technology Institute for Advanced Simulation Jülich Aachen Research Alliance Jülich Research Centre Jülich Germany Okinawa Institute of Science and Technology Neural Computation Unit Okinawa Japan Laboratory for Neural Circuit Theory RIKEN Brain Science Institute Wako Japan HPC Usability Research Team RIKEN Advanced Institute for Computational Science Kobe Japan Jülich Supercomputing Centre Jülich Research Centre Jülich Germany Institut für Mathematik Universität Kassel Kassel Germany Department of Psychiatry Psychotherapy and Psychosomatics Medical Faculty RWTH Aachen University Aachen Germany Department of Physics Faculty 1 RWTH Aachen University Aachen Germany

ISBN: (数字)9783319508627

ISBN: (纸本)9783319508610

Contemporary simulation technology for neuronal networks enables the simulation of brain-scale networks using neuron models with a single or a few compartments. However, distributed simulations at full cell density are still lacking the electrical coupling between cells via so called gap junctions. This is due to the absence of efficient algorithms to simulate gap junctions on large parallel computers. The difficulty is that gap junctions require an instantaneous interaction between the coupled neurons, whereas the efficiency of simulation codes for spiking neurons relies on delayed communication. In a recent paper [15] we describe a technology to overcome this obstacle. Here, we give an overview of the challenges to include gap junctions into a distributed simulation scheme for neuronal networks and present an implementation of the new technology available in the NEural Simulation Tool (NEST 2.10.0). Subsequently we introduce the usage of gap junctions in model scripts as well as benchmarks assessing the performance and overhead of the technology on the supercomputers JUQUEEN and K computer. © Springer International Publishing AG 2016.

关键词： Supercomputers

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P442 Incidence of pneumonia and other respiratory tract infections with vedolizumab treatment for inflammatory bowel disease: clinical trial experience

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Journal of Crohn's and Colitis 2017年第suppl_1期11卷 S301-S302页

作者： Feagan, B. Bhayat, F. Khalid, J.M. Palo, W. Blake, A. Shetzline, M. Travis, S. Robarts Research Institute University of Western Ontario Robarts Clinical Trials London Canada Takeda Development Centre Europe Ltd Global Pharmacovigilance London United Kingdom Takeda Development Centre Europe Ltd Evidence and Value Generation London United Kingdom Takeda Development Center Americas Inc. Global Statistics and Statistical Programming Deerfield United States Takeda Development Center Europe Ltd Global Pharmacovigilance London United Kingdom Takeda Pharmaceuticals International Co. Clinical Science GI Cambridge United States University of Oxford Translational Gastroenterology Unit Nuffield Department of Medicine Oxford United Kingdom

Background:Vedolizumab (VDZ) is a humanised monoclonal antibody that binds to α4β7integrin and selectively blocks gut-specific lymphocyte trafficking. Although upper respiratory tract infections (URTIs) have been reported with VDZ [1] its gut selectivity may reduce the risk of respiratory tract infections (RTIs), including pneumonia, compared with therapies producing systemic immunosuppression (e.g. anti-tumour necrosis factor-alpha [TNFα] agents). We aimed to determine the incidence of RTIs associated with VDZ treatment in the clinical trial ***:Safety data from VDZ phase 3 randomised controlled trials (RCTs) in ulcerative colitis (UC; GEMINI 1) and Crohn's disease (CD; GEMINI 2) and a phase 3 open-label extension (OLE; C13008 ongoing study in both UC and CD) were used to calculate the incidence of lower RTIs (LRTIs), including pneumonia, and URTIs using the MedDRA High Level Terms “lower respiratory tract and lung infections” and “upper respiratory tract infections”. A Cox proportional hazards model was used to identify potential predictors of these AEs for the pooled GEMINI 1 and 2 ***:Of 1731 patients in the pooled RCT population and 2243 patients in the OLE, mean (SD) ages were 37.9 (12.7) years and 39.1 (13.2) years, respectively; 43% and 50%, respectively, had disease duration ≥7 years; and 57% and 59%, respectively, had prior anti-TNFα therapy. In the RCTs, the rate of LRTIs, including pneumonia, was similar in the VDZ and placebo groups (Table 1). Rates of LRTIs were higher for VDZ-treated patients with CD than with UC. Most LRTI and URTI AEs were not serious and did not result in treatment discontinuation. Predictors of increased incidence of LRTIs were identified as being a current or former smoker, female sex and prior anti-TNFα therapy (Table 2). Predictors of URTIs were: being a current smoker, concomitant narcotic use and prior anti-TNFα ***:In this post hoc analysis, VDZ treatment of IBD was not associated with

关键词： smoking integrins crohn's disease inflammatory bowel disease ulcerative colitis monoclonal antibodies lymphocytes narcotics necrosis pneumonia randomization respiratory system respiratory tract infections safety therapeutic immunosuppression natural immunosuppression neoplasms lower respiratory tract infections lung infections upper respiratory infections risk reduction withdrawing treatment pharmacovigilance prescribing behavior illness length binding (molecular function) vedolizumab

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Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

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Nature communications 2018年第1期9卷 2162页

作者： Sílvia Bonàs-Guarch Marta Guindo-Martínez Irene Miguel-Escalada Niels Grarup David Sebastian Elias Rodriguez-Fos Friman Sánchez Mercè Planas-Fèlix Paula Cortes-Sánchez Santi González Pascal Timshel Tune H Pers Claire C Morgan Ignasi Moran Goutham Atla Juan R González Montserrat Puiggros Jonathan Martí Ehm A Andersson Carlos Díaz Rosa M Badia Miriam Udler Aaron Leong Varindepal Kaur Jason Flannick Torben Jørgensen Allan Linneberg Marit E Jørgensen Daniel R Witte Cramer Christensen Ivan Brandslund Emil V Appel Robert A Scott Jian'an Luan Claudia Langenberg Nicholas J Wareham Oluf Pedersen Antonio Zorzano Jose C Florez Torben Hansen Jorge Ferrer Josep Maria Mercader David Torrents Barcelona Supercomputing Center (BSC) Joint BSC-CRG-IRB Research Program in Computational Biology 08034 Barcelona Spain. Genomic Programming of Beta-cells Laboratory Institut d'Investigacions August Pi i Sunyer (IDIBAPS) 08036 Barcelona Spain. Instituto de Salud Carlos III Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) 28029 Madrid Spain. Section of Epigenomics and Disease Department of Medicine Imperial College London London W12 0NN UK. The Novo Nordisk Foundation Center for Basic Metabolic Research Section for Metabolic Genetics Faculty of Health and Medical Sciences University of Copenhagen 2100 Copenhagen Denmark. Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute of Science and Technology Baldiri Reixac 10-12 08028 Barcelona Spain. Departament de Bioquímica i Biomedicina Molecular Facultat de Biologia Universitat de Barcelona 08028 Barcelona Spain. Computer Sciences Department Barcelona Supercomputing Center (BSC-CNS) 08034 Barcelona Spain. Department of Epidemiology Research Statens Serum Institut 2300 Copenhagen Denmark. Division of Endocrinology and Center for Basic and Translational Obesity Research Boston Children's Hospital Boston MA 02116 USA. Medical and Population Genetics Program Broad Institute of MIT and Harvard Cambridge MA 02142 USA. ISGlobal Centre for Research in Environmental Epidemiology (CREAL) 08003 Barcelona Spain. CIBER Epidemiología y Salud Pública (CIBERESP) 28029 Madrid Spain. Universitat Pompeu Fabra (UPF) 08003 Barcelona Spain. Artificial Intelligence Research Institute (IIIA) Spanish Council for Scientific Research (CSIC) 28006 Madrid Spain. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA 02142 USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA 02114 USA. Division of General Internal Medicine Massachusetts General Hospital Bost

In the originally published version of this Article, the affiliation details for Santi González, Jian'an Luan and Claudia Langenberg were inadvertently omitted. Santi González should have been affiliated with 'Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB research Program in Computational Biology, 08034 Barcelona, Spain', and Jian'an Luan and Claudia Langenberg should have been affiliated with 'MRC Epidemiology unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK'. Furthermore, the abstract contained an error in the SNP ID for the rare variant in chromosome Xq23, which was incorrectly given as rs146662057 and should have been rs146662075. These errors have now been corrected in both the PDF and HTML versions of the Article.

关键词： Diabetes Genome-wide association studies

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The Effect of Monetary Policy on Commodity Prices: Disentangling the Evidence for Individual Prices

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Economics research International 2014年第1期2014卷

作者： Carolina Arteaga Cabrales Joan Camilo Granados Castro Jair Ojeda Joya Inflation and Macroeconomic Programming Department Banco de la República Colombia Research Unit Banco de la República Carrera 7 No. 14-78 Bogotá Colombia

We study the effect of monetary policy shocks on commodity prices. While most of the literature has found that expansionary shocks have a positive effect on aggregate price indices, we study the effect on individual prices of a sample of four commodities. This set of commodity prices is essential to understand the dynamics of the balance of payments in Colombia. The analysis is based on structural VAR models; we identify monetary policy shocks following Kim (1999, 2003) upon quarterly data for commodity prices and their fundamentals for the period from 1980q1 to 2010q3. Our results show that commodity prices overshoot their long run equilibrium in response to a contractionary shock in the US monetary policy and, in contrast with literature, the response of the individual prices considered is stronger than what has been found in aggregate indices. Additionally, it is found that the monetary policy explains a substantial share of the fluctuations in prices.

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Diversity analysis on boosting nominal concepts

Diversity analysis on boosting nominal concepts

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16th Pacific-Asia Conference on Advances in Knowledge Discovery and Data Mining, PAKDD 2012

作者： Meddouri, Nida Khoufi, Héla Maddouri, Mondher Sadok Research Unit on Programming Algorithmics and Heuristics - URPAH Faculty of Science of Tunis - FST Tunis - El Manar University Tunisia College of Community Hinakiyah Taibah University - Medinah Monawara Saudi Arabia

ISBN: (纸本)9783642302169

In this paper, we investigate how the diversity of nominal classifier ensembles affects the AdaBoost performance [13]. Using 5 real data sets from the UCI Machine Learning Repository and 3 different diversity measures, we show that Statistic measure is mostly correlated with AdaBoost performance for 2-class problems. The experimental results suggest that the performance of AdaBoost depend on the nominal classifier diversity that can be used as a stopping criteria in ensemble learning. © 2012 Springer-Verlag.

关键词： Adaptive boosting

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