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Hydrogen's role in expanding renewable energy and reducing carbon emissions in texas

INTERNATIONAL JOURNAL OF HYDROGEN ENERGY 2025年 113卷 77-89页

作者： Li, Honglin Zhang, Jie Univ Texas Dallas Dept Mech Engn Richardson TX 75080 USA Univ Texas Dallas Ctr Wind Energy Richardson TX 75080 USA Univ Texas Dallas Dept Elect & Comp Engn Richardson TX 75080 USA

texas, with its substantial wind and solar capacities, plays a pivotal role in the U.S. strategy to achieve net-zero emissions by 2050. Despite its leadership in wind energy generation and a growing solar sector, the integration of large-scale renewable energy in texas faces significant challenges, primarily due to the intermittent nature of renewables and uncertainties surrounding future capacity expansion and demand growth. This study explores the potential of hydrogen as a solution to these challenges through a stochastic optimization model that accounts for the unpredictability of renewable energy installation timelines and fluctuations in electricity demand. The model designs a hydrogen network to mitigate geographical mismatches between energy supply and demand, providing a critical balancing mechanism. Our findings indicate that hydrogen can significantly enhance renewable energy penetration while reducing carbon emissions. Strategic placement of electrolyzers and hydrogen tanks, combined with inter-regional hydrogen transport, could satisfy up to 92.4% of hydrogen demand in certain regions. Additionally, annual hydrogen production across Electric Reliability Council of texas (ERCOT) is projected to reach 131 tons, which corresponds to a carbon emissions reduction of 1,300 tons. Sensitivity analyses further reveal that higher electricity prices for combined cycle gas-turbine plants negatively impact the system's overall energy efficiency, leading to an increase in carbon emissions. For instance, when electricity prices rise to $250 MWh-1, annual system-wide carbon emissions increase by 310 kilotons compared to the benchmark scenario. This study highlights the critical role hydrogen can play in supporting texas's renewable energy ambitions and underscores the necessity for policy backing, investment, and advancements in both hydrogen and carbon capture technologies to fully realize its potential.

关键词： Renewable energy Hydrogen Carbon emission reduction Stochastic optimization

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Rational Catalan numbers for complex reflection groups ☆

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JOURNAL OF ALGEBRA 2025年 672卷 10-30页

作者： Miller, Weston Univ Texas Dallas Dallas TX 75080 USA

Assuming standard conjectures, we show that the canonical symmetrizing trace on the Hecke algebra of irreducible spetsial complex reflection groups produces rational Catalan numbers when evaluated at powers of a Coxeter element. This extends a technique used by Galashin, Lam, Trinh, and Williams to uniformly prove the enumeration of their noncrossing Catalan objects for finite Coxeter groups. (c) 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http:// ***/licenses/by/4.0/).

关键词： Reflection groups Hecke algebras Catalan numbers

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Creating a collaborative culture of learning within a network of community mental health early psychosis programs in texas

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SCHIZOPHRENIA RESEARCH 2025年 276卷 1-7页

作者： Lopez, Molly A. Reznik, Samantha J. V. Klodnick, Vanessa Cohen, Deborah Myers, Neely Rousseau, Justin F. Aksan, Nazan de Oliveira, Eliel Strakowski, Stephen M. Univ Texas Austin Steve Hicks Sch Social Work 1823 Red River St Austin TX 78739 USA Univ Texas Austin Med Sch Austin TX USA Southern Methodist Univ Dept Anthropol Dallas TX USA Univ Texas Southwestern Med Ctr Dallas TX USA Indiana Univ Sch Med Dept Psychiat Bloomington IN USA

Learning Health Systems (LHSs) promise meaningful health care improvement through the ongoing use of data, including the lived experience of diverse constituents, such as people participating in and providing services. Most LHSs operate within a specific healthcare system, typically hospital-based, under a common electronic health record (EHR) and management structure. The Early Psychosis Intervention Network in texas (EPINET-TX) is a novel case study of a developing LHS across 16 independent community mental health clinics operating statefunded coordinated specialty care (CSC) programs for early psychosis. EPINET-TX is a partnership among a multidisciplinary research hub and state and local entities. Grounded in participatory research frameworks, multiple strategies were utilized to align partners around learning goals, build data use competencies, enhance researchers' understanding of program context, and cultivate a continuous performance improvement mindset. Key strategies for developing a LHS culture included a) intentionally building collaborative relationships, b) establishing shared values and governance, c) collaborating in research and change-focused workgroups, and d) sharing learning and growth experiences. For CSC programs operating within the public mental health system, the LHS framework provides a promising model to foster quality improvement, innovation, and action-oriented participatory research.

关键词： Learning health system Early psychosis Coordinated specialty care Participatory research Quality improvement

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NEUROBIOLOGY OF AGING 2025年 147卷 150-162页

作者： Kidwai, Ambereen Hou, Mingzhu de Chastelaine, Marianne Rugg, Michael D. Univ Texas Dallas Ctr Vital Longev Dallas TX 75235 USA Univ Texas Dallas Sch Behav & Brain Sci Dallas TX 75235 USA

The present study examines whether structural and functional variability in medial temporal lobe (MTL) neocortical regions correlate with individual differences in episodic memory and longitudinal memory change in cognitively healthy older adults. To address this question, older adults were administered a battery of neuropsychological tests on three occasions: the second occasion one month after the first test session, and a third session three years later. Structural and functional MRI data were acquired between the first two sessions and included an in-scanner associative recognition procedure enabling estimation of MTL encoding and recollection fMRI BOLD effects. Encoding effects in parahippocampal cortex correlated with associative recognition performance and baseline cognitive ability. Recollection effects in entorhinal cortex correlated with associative recognition performance and predicted memory change over the three-year follow-up interval, an association that remained after controlling for chronological age and entorhinal cortical volume. These findings suggest that entorhinal recollection effects may be indicative of the future functional integrity of the region and, hence, its capacity to support future memory performance.

关键词： Aging Encoding Entorhinal cortex Episodic memory Recollection

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The effect of Crohn's disease on outcomes after total hip arthroplasty

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ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY 2025年第1期145卷 1-5页

作者： Hinkle, Andrew J. Jones, Hunter B. Aggarwal, Vikram A. Sambandam, Senthil N. Univ Texas Southwestern Dept Orthoped Dallas TX USA Univ Texas Southwestern Dallas TX 75390 USA Univ Texas Southwestern Staff Orthoped Surg Dallas VAMC Dallas TX USA

Introduction Crohn's disease has been increasing in incidence globally and has several musculoskeletal manifestations including large joint arthritis. This study compares post-operative lengths of stay, healthcare costs, and complication rates between patients with and without Crohn's Disease (CD) following Total Hip Arthroplasty (THA). Methods Data were collected from the National Inpatient Sample Database Healthcare Cost and Utilization Project between the years 2016-2019. Patients with Crohn's Disease (CD) and without Crohn's Disease (NCD) undergoing THA were identified using International Classification of Diseases, 10th revision codes (ICD-10-CM/PCS). Length of stay, total cost, and medical and surgical complications were examined during this time period. SPSS (v 27.0 8, IBM Corp. Armonk, NY) was utilized to compare demographic and analytical statistics between CD and NCD patients undergoing THA. Results 1,171 (0.32%) CD and 366,219 (99.68%) NCD patients undergoing THA were included. Compared to NCD patients, CD patients were more likely to be Caucasian (p < 0.05), younger (p < 0.001), non-obese (p = 0.022), non-emergently admitted (p = 0.04), and have longer lengths of stay (p < 0.001). Furthermore, CD patients had higher risks of acute renal failure (OR = 1.43, p = 0.025), acute blood loss anemia (OR = 1.431, p < 0.001), blood transfusion (OR = 1.73, p < 0.001), pneumonia (OR = 2.607, p = 0.005), deep vein thrombosis (OR = 2.81, p = 0.035), periprosthetic infection (OR = 1.57, p = 0.05), and length of stay greater than 2 days (OR = 1.293, p < 0.001). However, CD patients had lower risk of periprosthetic mechanical complication (OR = 0.218, p = 0.011). Conclusion This study demonstrates that CD patients undergoing THA are younger, have longer lengths of stay, and have greater rates of both local and systemic complications than NCD patients undergoing THA. As such, this study will aid in surgical candidate selection and proper operative planning for CD patients

关键词： Crohn's disease Total hip arthroplasty Outcomes Complications Costs

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Imaging of cellular dynamics from a whole organism to subcellular scale with self-driving, multiscale microscopy

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NATURE METHODS 2025年第3期22卷 1-10页

作者： Daetwyler, Stephan Mazloom-Farsibaf, Hanieh Zhou, Felix Y. Segal, Dagan Sapoznik, Etai Chen, Bingying Westcott, Jill M. Brekken, Rolf A. Danuser, Gaudenz Fiolka, Reto Univ Texas Southwestern Med Ctr Dallas Lyda Hill Dept Bioinformat Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Dept Cell Biol Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Dept Surg Dallas TX USA Univ Texas Southwestern Med Ctr Dallas Hamon Ctr Therapeut Oncol Res Dallas TX USA Univ Texas Southwestern Med Ctr Dallas Canc Biol Grad Program Dallas TX USA Univ Texas Southwestern Med Ctr Dallas Dept Pharmacol Dallas TX USA

Most biological processes, from development to pathogenesis, span multiple time and length scales. While light-sheet fluorescence microscopy has become a fast and efficient method for imaging organisms, cells and subcellular dynamics, simultaneous observations across all these scales have remained challenging. Moreover, continuous high-resolution imaging inside living organisms has mostly been limited to a few hours, as regions of interest quickly move out of view due to sample movement and growth. Here, we present a self-driving, multiresolution light-sheet microscope platform controlled by custom Python-based software, to simultaneously observe and quantify subcellular dynamics in the context of entire organisms in vitro and in vivo over hours of imaging. We apply the platform to the study of developmental processes, cancer invasion and metastasis, and we provide quantitative multiscale analysis of immune-cancer cell interactions in zebrafish xenografts.

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STING- induced noncanonical autophagy regulates endolysosomal homeostasis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2025年第8期122卷 e2415422122页

作者： Huang, Tuozhi Sun, Chenglong Du, Fenghe Chen, Zhijian J. Univ Texas Southwestern Med Ctr Dallas Dept Mol Biol Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Ctr Inflammat Res Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas HHMI Dallas TX 75390 USA

The cGAS-STING pathway mediates innate immune responses to cytosolic DNA. In addition to its well- established role in inducing inflammatory cytokines, activation of the cGAS-STING pathway also induces noncanonical autophagy, a process involving the conjugation of the ATG8 family of ubiquitin-like proteins to membranes of the endolysosomal system. The mechanisms and functions of STING- induced autophagy remain poorly understood. In this study, we demonstrated that STING activation induced formation of pH- elevated Golgi- derived vesicles that led to ATG16L1 and V- ATPase- dependent noncanonical autophagy. We showed that STING- induced non- canonical autophagy resulted in activation of the MiT/TFE family of transcription factors (TFEB, TFE3, and MITF), which regulate lysosome biogenesis. We found that lipidation of the ATG8 proteins, particularly GABARAPs, inhibited phosphorylation of MiT/TFE transcription factors by mTORC1. The lipidated GABARAPs bound to the Folliculin- interacting proteins (FNIPs), thereby sequestering the FNIP- folliculin protein complexes from activating mTORC1, resulting in dephosphorylation and nuclear translocation of MiT/TFE transcription factors. Furthermore, we found that STING- induced autophagy activated Leucine-rich repeat kinase 2 (LRRK2), a protein implicated in Parkinson's disease, through GABARAPs lipidation. We further showed that STING- induced autophagy induced ALIX- mediated ESCRT machinery recruitment to mitigate endolysosomal perturbation. These results reveal the multifaceted functions of STING- induced noncanonical autophagy in regulating endolysosomal homeostasis.

关键词： cGAS STING autophagy TFEB ESCRT

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Concerning Safety and Efficacy of Concurrent and Consolidative Durvalumab With Thoracic Radiation Therapy in PDL1-Unselected Stage III Non-Small Cell Lung Cancer: Brief Report

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INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2025年第1期121卷 68-74页

作者： Zhang, Yuanyuan Iyengar, Puneeth Montalvo, Steven Westover, Kenneth D. Rashdan, Sawsan Donthireddy, Kavitha Kim, James Dowell, Jonathan E. Drapkin, Benjamin Bhalla, Sheena Chukwuma, Christian Nadeem, Urooba Ahn, Chul Timmerman, Robert D. Gerber, David E. Univ Texas Southwestern Med Ctr Dallas Harold C Simmons Comprehens Canc Ctr Dept Radiat Oncol Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Harold C Simmons Comprehens Canc Ctr Divis Hematol Oncol Internal Med Dallas TX USA Univ Texas Southwestern Med Ctr Dallas Dept Pathol Dallas TX USA Univ Texas Southwestern Med Ctr Dallas Peter Odonnell Jr Sch Publ Hlth Dallas TX USA

PurposeConsolidative durvalumab, an anti-programmed death ligand 1 (PDL1) immune checkpoint inhibitor, administered after concurrent chemoradiation improves outcomes of patients with locally advanced non-small cell lung cancer (NSCLC) without substantially increasing toxicities. We studied a chemotherapy-free regimen of thoracic radiation therapy (RT) with concurrent and consolidative durvalumab. Methods and MaterialsThis single-arm phase 2 trial enrolled patients with stage III NSCLC (regardless of tumor PDL1 expression), Eastern Cooperative Oncology Group (ECOG) performance status 0-1, adequate pulmonary function, and RT fields meeting standard organ constraints. Participants received 2 cycles of durvalumab (1500 mg every 4 weeks) concurrently with thoracic RT (60 Gy in 30 fractions), followed by up to 13 cycles of consolidative durvalumab. ResultsAfter 10 patients were enrolled, the trial was closed because of poor clinical outcomes. With a median follow-up of 12 months, 5 patients had disease progression and 8 patients died. Six patients experienced 15 treatment-related, grade ≥3 events, including 1 grade 4 acute kidney injury during consolidation and 2 fatal pulmonary events. One fatal pulmonary event occurred during the concurrent phase in an active smoker; the other occurred after the first cycle of consolidative durvalumab. The primary endpoint of progression-free survival at 12 months was 20% (50% for PDL1≥1% vs 0% for PDL1 unavailable or <1%). Median overall survival was not reached, 10.5 months, and 7 months, for PDL1 ≥1%, <1%, and unavailable, respectively. ConclusionsIn PDL1 unselected stage III NSCLC, thoracic RT plus concurrent and consolidative durvalumab is associated with high-grade toxicity and early disease progression.

关键词： zhang@utsouthwestern.edu

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Investigating Cancer Inequalities in Urbanizing texas with Plausible Reasoning

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ANNALS OF THE AMERICAN ASSOCIATION OF GEOGRAPHERS 2025年第2期115卷 419-440页

作者： Donegan, Connor Univ Texas Southwestern Med Ctr Odonnell Sch Publ Hlth Dallas TX 75390 USA

This article contributes to geographical methodology by presenting an epistemology of plausible reasoning (PR) as a complement to realist and reflexive frameworks for science. I introduce PR's theory of evidence, after Harold Jeffreys and George P & oacute;lya, and then extrapolate principles for nonexperimental study designs. This article leverages these principles to structure an investigation into the causes of a racial disparity in the colorectal cancer (CRC) burden in the Houston and dallas-Fort Worth metropolitan areas. Centered on a series of empirical questions pertaining to racial ghettoization, contemporary urbanization, and cancer inequalities, the study uncovers important geographic and social changes in the CRC burden in the study areas between 1999 and 2019. These include the emergence of a substantial class-related inequality in CRC incidence, the rise of aggregate racial disparities in CRC incidence outside of historically ghettoized areas, and an overall intensification of spatial CRC inequality. Drawing on fundamental cause theory and critical urban studies, I propose that these changes are a product of the uneven spread of new preventive technologies (screening colonoscopy) amid extensive and polarizing urbanization processes that are reshaping these regions. The study highlights the value of incorporating concern for dynamic macrostructures and political economy into analyses of spatial health data, and illustrates how PR can contribute to such work.

关键词： cancer disparities epistemology health geography realism

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Time to maximum pupil constriction is variable in neurocritical care patients

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JOURNAL OF CLINICAL MONITORING AND COMPUTING 2025年第1期39卷 53-58页

作者： Kamal, Abdulkadir Nairon, Emerson B. Bashmakov, Anna Aoun, Salah G. Olson, DaiWai M. Univ Texas Southwestern Med Ctr Dallas Dept Nursing Dallas TX USA Univ Texas Southwestern Med Ctr 75390 Dept Neurol 5323 Harry Hines Blvd Dallas TX 75390 USA Univ Texas SouthWestern Med Ctr 75390 Dept Neurosurg Dallas TX USA

Quantitative pupillometry (QP) use has grown exponentially. Each QP scan captures images of the pupil before, during, and after light exposure to provide component measures of the pupillary light reflex (PLR). This study explores if the time to maximum constriction (tMC) is uniform among neuroscience intensive care unit (NSICU) patients. The study enrolled 50 NSICU patients with normal PLR values in a cross-sectional study and adhered to the standard of care for pupil assessments to collect data on tMC within (comparing left eye and right eye) and between patients. The mean tMC of 0.97 (0.17) s was normally distributed across all patients and ranged from 0.46 s to 1.35 s. The mean tMC was similar for the left pupil (0.98 [0.16]s) and right pupil (0.96 [0.18]s;P =.546). The within-subject mean difference (left versus right eye) tMC was 0.13 (0.12)s and ranged from 0.0 to 0.56 s. The between-subject mean tMC was 0.97 (0.17) s and ranged from 0.46 s to 1.35 s. The tMC does not occur at a fixed point in time. Clinical applications that seek to characterize pupil health should account for varied tMC and explore relationships to discrete outcomes to determine the clinical usefulness of tMC.

关键词： Pupillometry Pupils Pupillary light reflect Critical care Assessment Cranial nerves Neurocritical care Neurology

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