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GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

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Nature genetics 2023年第9期55卷 1471-1482页

作者： Remi Stevelink Dorothee Kasteleijn-Nolst Trenite Bobby P. C. Koeleman Dick Lindhout Anja C. M. Sonsma Ciarán Campbell Gianpiero L. Cavalleri Norman Delanty Hany El-Naggar Austin Lacey Peter Widdess-Walsh Colin P. Doherty Siwei Chen Claire Churchhouse Mark J. Daly Yen-Chen A. Feng Daniel P. Howrigan Mitja I. Kurki Benjamin M. Neale Aarno Palotie Wei Zhou Namrata Gupta Henrike O. Heyne Bassel Abou-Khalil Kevin F. Haas R. S. Taneja Oluyomi M. Adesoji Michael Nothnagel Peter Nürnberg Thomas Sander Zaid Afawi Ilan Blatt Amos D. Korczyn Elisabetta Amadori Ganna Balagura Antonella Riva Marcello Scala Paolo Scudieri Pasquale Striano Federico Zara Michele Iacomino Francesca Madia Alison Anderson Patrick Kwan Terence J. O’Brien Slavé Petrovski K. Meng Tan Marian Todaro Joseph Anderson Danielle M. Andrade Quratulain Zulfiqar Ali Grazia Annesi Pauls Auce Andreja Avbersek Simona Balestrini Vera Braatz Claudia B. Catarino Krishna Chinthapalli Jennifer Jamnadas-Khoda Dalia Kasperavičiūte Costin Leu Josemir W. Sander Sanjay M. Sisodiya Sara Zagaglia Melanie Bahlo Karen L. Oliver Mark D. Baker Beata Fonferko-Shadrach William O. Pickrell Carmen Barba Claudia Bianchini Viola Doccini Renzo Guerrini Davide Mei Martino Montomoli Elena Parrini Annalisa Vetro Karen Barboza Fabrice Bartolomei Thomas Bast Bernhard J. Steinhoff Larry Baum Stacey S. Cherny Pak Sham Tobias Baumgartner Christian E. Elger Kerstin Hallmann Wolfram S. Kunz Rainer Surges Randi von Wrede Gábor Zsurka Betül Baykan Nerses Bebek Yeşim Kesim Albert J. Becker Susanne Schoch Felicitas Becker Caitlin A. Bennett Samuel F. Berkovic Stephanie L. Leech Brigid M. Regan Ingrid E. Scheffer Bianca Berghuis Ahmad Beydoun Wassim Nasreddine Francesca Bisulli Lidia Di Vito Lorenzo Ferri Tania Giangregorio Laura Licchetta Raffaella Minardi Barbara Mostacci Carlotta Stipa Paolo Tinuper Lorenzo Muccioli Federica Pondrelli Dheeraj R. Bobbili Emadeldin Hassanin Roland Krause Zied Landoulsi Patrick May Ingo Borggraefe Christian Bosselmann Christian Hengsbach Josua Kegele Stephen Lauxmann Department of Genetics University Medical Center Utrecht Utrecht The Netherlands Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede The Netherlands School of Pharmacy and Biomolecular Sciences The Royal College of Surgeons in Ireland Dublin Ireland The FutureNeuro Research Centre Dublin Ireland Department of Neurology Beaumont Hospital Dublin Ireland Department of Neurology St. James’s Hospital Dublin Ireland Analytic and Translational Genetics Unit Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston MA USA Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of Harvard and M.I.T Cambridge MA USA Institute for Molecular Medicine Finland (FIMM) University of Helsinki Helsinki Finland Psychiatric & Neurodevelopmental Genetics Unit Department of Psychiatry Massachusetts General Hospital and Harvard Medical School Boston MA USA Division of Biostatistics Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan Hasso Plattner Institute Digital Health Center University of Potsdam Potsdam Germany Hasso Plattner Institute Mount Sinai School of Medicine New York City NY USA Department of Neurology Vanderbilt University Medical Center Nashville TN USA Cologne Center for Genomics (CCG) University of Cologne Faculty of Medicine and University Hospital Cologne Cologne Germany University Hospital Cologne Cologne Germany Department of Neurology Charité Universitaetsmedizin Berlin Campus Virchow-Clinic Berlin Germany Tel-Aviv University Sackler Faculty of Medicine Ramat Aviv Israel Department of Neurology Sheba Medical Center Ramat Gan Israel Department of Neurosciences Rehabilitation Ophthalmology Genetics Maternal and Child Health University of Genova Genova Italy IRCCS Istituto Giannina Gaslini Genova Italy Department of Medicine University of Melbour

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including 29,944 cases, stratified into three broad categories and seven subtypes of epilepsy, and 52,538 controls. We identify 26 genome-wide significant loci, 19 of which are specific to genetic generalized epilepsy (GGE). We implicate 29 likely causal genes underlying these 26 loci. SNP-based heritability analyses show that common variants explain between 39.6% and 90% of genetic risk for GGE and its subtypes. Subtype analysis revealed markedly different genetic architectures between focal and generalized epilepsies. Gene-set analyses of GGE signals implicate synaptic processes in both excitatory and inhibitory neurons in the brain. Prioritized candidate genes overlap with monogenic epilepsy genes and with targets of current antiseizure medications. Finally, we leverage our results to identify alternate drugs with predicted efficacy if repurposed for epilepsy treatment.

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Author Correction: MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists

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Nature communications 2020年第1期11卷 5308页

作者： Cong Lv Fengyin Li Xiang Li Yuhua Tian Yue Zhang Xiaole Sheng Yongli Song Qingyong Meng Shukai Yuan Liming Luan Thomas Andl Xu Feng Baowei Jiao Mingang Xu Maksim V Plikus Xing Dai Christopher Lengner Wei Cui Fazheng Ren Jianwei Shuai Sarah E Millar Zhengquan Yu State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Biological Sciences China Agricultural University Beijing 100193 China. Department of Biochemistry and Molecular Biology Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease Hebei University of Chinese Medicine Shijiazhuang Hebei 050200 China. Department of Biochemistry and Molecular Biology Basic Medical College Tianjin Medical University Tianjin 300070 China. Vanderbilt University Medical Center Nashville TN 37232 USA. State Key Laboratory of Genetic Resources and Evolution of Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China. Department of Dermatology Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA. Department of Developmental and Cell Biology Sue and Bill Gross Stem Cell Research Center for Complex Biological Systems University of California Irvine CA 92697 USA. Departments of Biological Chemistry and Dermatology School of Medicine University of California Irvine CA 92697 USA. Department of Biomedical Sciences School of Veterinary Medicine University of Pennsylvania Philadelphia PA 19104 USA. Institute for Regenerative Medicine University of Pennsylvania Philadelphia PA 19104 USA. Department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA. Institute of Reproductive and Developmental Biology Department of Surgery and Cancer Imperial College London London W12 0NN UK. Department of Physics and State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network Xiamen University Xiamen 361005 China. State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Biological Sciences China Agricultural University Beijing 100193 China. zyu@cau.edu.cn.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Erratum to: Search for heavy Higgs bosons decaying to a top quark pair in proton-proton collisions at s = 13 TeV

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Journal of High Energy Physics 2022年第3期2022卷 1-21页

作者： Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. Bergauer, T. Brandstetter, J. Dragicevic, M. Erö, J. Escalante Del Valle, A. Flechl, M. Frühwirth, R. Jeitler, M. Krammer, N. Krätschmer, I. Liko, D. Madlener, T. Mikulec, I. Rad, N. Schieck, J. Schöfbeck, R. Spanring, M. Spitzbart, D. Waltenberger, W. Wulz, C.-E. Zarucki, M. Drugakov, V. Mossolov, V. Suarez Gonzalez, J. Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. Lauwers, J. Lelek, A. Pieters, M. Rejeb Sfar, H. Van Haevermaet, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. Chhibra, S. S. D’Hondt, J. De Clercq, J. Lontkovskyi, D. Lowette, S. Marchesini, I. Moortgat, S. Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. Beghin, D. Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. Favart, L. Grebenyuk, A. Kalsi, A. K. Luetic, J. Popov, A. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. Vannerom, D. Cornelis, T. Dobur, D. Khvastunov, I. Niedziela, M. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bondu, O. Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. Giammanco, A. Lemaitre, V. Magitteri, A. Prisciandaro, J. Saggio, A. Vidal Marono, M. Vischia, P. Zobec, J. Alves, F. L. Alves, G. A. Correia Silva, G. Hensel, C. Moraes, A. Rebello Teles, P. Belchior Batista Das Chagas, E. Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Huertas Guativa, L. M. Malbouisson, H. Martins, J. Matos Figueiredo, D. Medina Jaime, M. Melo De Almeida, M. Mora Herrera, C. Mundim, L. Nogima, H. Prado Da Silva, W. L. Sanchez Rosas, L. J. Santoro, A. Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Lemos, D. S. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Wien Austria Vienna University of Technology Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Ghent University Ghent Belgium IRFU CEA Université Paris-Saclay Gif-sur-Yvette France Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual de Campinas Campinas Brazil Federal University of Rio Grande do Sul Porto Alegre Brazil UFMS Nova Andradina Brazil Universidade Federal de Pelotas Pelotas Brazil Universidade Estadual Paulista São Paulo Brazil Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China University of Chinese Academy of Sciences Beijing China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia Institute for Theoretical and Experimental Physics named by A.I. Alikhanov of NRC ‘Kurchatov Institute’ Moscow Russia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Joint Institute for Nuclear Research Dubna Russia Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Cairo University Cairo Egypt Academy of Scientific Research and Technolog

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Erratum to: Search for dark matter produced in association with a leptonically decaying Z boson in proton–proton collisions at s = 13 Te

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The European Physical Journal C 2021年第4期81卷 1-16页

作者： A. M. Sirunyan A. Tumasyan W. Adam T. Bergauer M. Dragicevic J. Erö A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko T. Madlener I. Mikulec F. M. Pitters N. Rad J. Schieck R. Schöfbeck M. Spanring S. Templ W. Waltenberger C.-E. Wulz M. Zarucki V. Chekhovsky A. Litomin V. Makarenko J. Suarez Gonzalez M. R. Darwish E. A. De Wolf D. Di Croce X. Janssen T. Kello A. Lelek M. Pieters H. Rejeb Sfar H. Van Haevermaet P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols S. S. Chhibra J. D’Hondt J. De Clercq D. Lontkovskyi S. Lowette I. Marchesini S. Moortgat A. Morton Q. Python S. Tavernier W. Van Doninck P. Van Mulders D. Beghin B. Bilin B. Clerbaux G. De Lentdecker B. Dorney L. Favart A. Grebenyuk A. K. Kalsi I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas C. Vander Velde P. Vanlaer D. Vannerom L. Wezenbeek T. Cornelis D. Dobur M. Gruchala I. Khvastunov M. Niedziela C. Roskas K. Skovpen M. Tytgat W. Verbeke B. Vermassen M. Vit G. Bruno F. Bury C. Caputo P. David C. Delaere M. Delcourt I. S. Donertas A. Giammanco V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn P. Vischia S. Wuyckens J. Zobec G. A. Alves C. Hensel A. Moraes W. L. Aldá Júnior E. Belchior Batista Das Chagas H. BRANDAO MALBOUISSON W. Carvalho J. Chinellato E. Coelho E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza J. Martins D. Matos Figueiredo M. Medina Jaime C. Mora Herrera L. Mundim H. Nogima P. Rebello Teles L. J. Sanchez Rosas A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev I. Atanasov R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov M. Bonchev A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov W. Fang Q. Guo H. Wang L. Yuan M. Ahmad Z. Hu Y. Wang E. Chapon G. M. Chen H. S. Chen M. Chen A. Kapoor D. Leggat H. Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Vienna University of Technology Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Department of Basic and Applied Sciences Faculty of Engineering Arab Academy for Science Technology and Maritime Transport Alexandria Egypt Université Libre de Bruxelles Bruxelles Belgium Vrije Universiteit Brussel Brussel Belgium Ghent University Ghent Belgium IRFU CEA Université Paris-Saclay Gif-sur-Yvette France Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual de Campinas Campinas Brazil Federal University of Rio Grande do Sul Porto Alegre Brazil UFMS Nova Andradina Brazil Universidade Federal de Pelotas Pelotas Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China University of Chinese Academy of Sciences Beijing China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) - Fudan University Shanghai China Zhejiang University Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia Institute for Theoretical and Experimental Physics named by A.I. Alikhanov of NRC ‘K

A Correction to this paper has been published: https://***/10.1140/epjc/s10052-020-08739-5

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International Society for Therapeutic Ultrasound Conference 2016

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Journal of Therapeutic Ultrasound 2017年第1期5卷 1-114页

作者： Brian Fowlkes Pejman Ghanouni Narendra Sanghvi Constantin Coussios Paul C. Lyon Michael Gray Christophoros Mannaris Marie de Saint Victor Eleanor Stride Robin Cleveland Robert Carlisle Feng Wu Mark Middleton Fergus Gleeson Jean-Franҫois Aubry Kim Butts Pauly Chrit Moonen Jacob Vortman Shirley Sharabi Dianne Daniels David Last David Guez Yoav Levy Alexander Volovick Javier Grinfeld Itay Rachmilevich Talia Amar Zion Zibly Yael Mardor Sagi Harnof Michael Plaksin Yoni Weissler Shy Shoham Eitan Kimmel Omer Naor Nairouz Farah Dong-Guk Paeng Zhiyuan Xu John Snell Anders H. Quigg Matthew Eames Changzhu Jin Ashli C. Everstine Jason P. Sheehan Beatriz S. Lopes Neal Kassell Thomas Looi Vera Khokhlova Charles Mougenot Kullervo Hynynen James Drake Michael Slayton Richard C. Amodei Keegan Compton Ashley McNelly Daniel Latt John Kearney David Melodelima Aurelien Dupre Yao Chen David Perol Jeremy Vincenot Jean-Yves Chapelon Michel Rivoire Wei Guo Guoxin Ren Guofeng Shen Michael Neidrauer Leonid Zubkov Michael S. Weingarten David J. Margolis Peter A. Lewin Nathan McDannold Jonathan Sutton Natalia Vykhodtseva Margaret Livingstone Thiele Kobus Yong-Zhi Zhang Michael Schwartz Yuexi Huang Nir Lipsman Jennifer Jain Martin Chapman Tejas Sankar Andres Lozano Robert Yeung Christakis Damianou Nikolaos Papadopoulos Omer Brokman Eyal Zadicario Ori Brenner David Castel Shih-Ying Wu Julien Grondin Wenlan Zheng Marc Heidmann Maria Eleni Karakatsani Carlos J. Sierra Sánchez Vincent Ferrera Elisa E. Konofagou Marinos Yiannakou HongSeok Cho Hwayoun Lee Mun Han Jong-Ryul Choi Taekwan Lee Sanghyun Ahn Yongmin Chang Juyoung Park Nicholas Ellens Ari Partanen Keyvan Farahani Raag Airan Alexandre Carpentier Michael Canney Alexandre Vignot Cyril Lafon Jean-yves Delattre Ahmed Idbaih Henrik Odéen Bradley Bolster Eun Kee Jeong Dennis L. Parker Pooja Gaur Xue Feng Samuel Fielden Craig Meyer Beat Werner William Grissom Michael Marx Hans Weber Valentina Taviani Brian Hargreaves Jun Tanaka Kentaro Kikuchi Ayumu Ishijima Takashi Azuma Kosuke Minamihata Satoshi Basic Radiological Sciences Division Department of Radiology University of Michigan Ann Arbor USA Stanford School of Medicine Stanford USA SonaCare Medical Indianapolis USA Institute of Biomedical Engineering University of Oxford Oxford UK HIFU Unit Churchill Hospital Oxford UK Department of Oncology University of Oxford Oxford UK Department of Radiology Churchill Hospital Oxford UK Institut Langevin Paris France Center for Imaging Sciences Imaging Division University Medical Center Utrecht The Netherlands InSighTec Haifa Israel Sheba Medical Center Ramat-Gan Israel Tel-Aviv University Tel-Aviv Israel Faculty of Biomedical Engineering & Russell Berrie Nanotechnology Institute Technion – Israel Institute of Technology Haifa Israel ELSC Center for Brain Sciences Hebrew University Jerusalem Israel Biomedical Engineering Technion- Israel Institute of Technology Haifa Israel Faculty of Life Sciences Bar Ilan University Ramat Gan Israel Focused Ultrasound Foundation Charlottesville USA Ocean System Engineering Jeju National University Jeju Republic of Korea Neurosurgery University of Virginia Charlottesville USA Biology University of Virginia Charlottesville USA Pathology University of Virginia Charlottesville USA Hospital for Sick Children Toronto Canada University of Toronto Toronto Canada University of Washington Seattle USA Philips Healthcare Markham Canada Sunnybrook Research Institute Toronto Canada Guided Therapy Systems LLC Mesa USA School of Medicine University of Arizona Tucson USA The CORE Institute Phoenix USA LabTAU - U1032 INSERM Lyon France Centre Leon Berard Lyon France Department of Oral Maxillofacial and Head Neck Oncology Shanghai 9th People’s Hospital Shanghai China The School of Biomedical Engineering Science and Health Systems Drexel University Philadelphia USA Department of Surgery College of Medicine Drexel University Philadelphia USA Biostatistics and Epidemiology University of Pennsylvania Philadelphi

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Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015

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Journal of translational medicine 2016年第1期14卷 65页

作者： Vashisht G. Y. Nanda Weiyi Peng Patrick Hwu Michael A. Davies Gennaro Ciliberto Luigi Fattore Debora Malpicci Luigi Aurisicchio Paolo Antonio Ascierto Carlo M. Croce Rita Mancini Stefani Spranger Thomas F. Gajewski Yangyang Wang Soldano Ferrone Claire Vanpouille-Box Erik Wennerberg Karsten A. Pilones Silvia C. Formenti Sandra Demaria Haidong Tang Yang Wang Yang-Xin Fu Reinhard Dummer Igor Puzanov Ahmad Tarhini Joe-Marc Chauvin Ornella Pagliano Julien Fourcade Zhaojun Sun Hong Wang Cindy Sanders John M. Kirkwood Tseng-hui Timothy Chen Mark Maurer Alan J. Korman Hassane M. Zarour David F. Stroncek Veronica Huber Licia Rivoltini Magdalena Thurin Tilman Rau Alessandro Lugli Franck Pagès Jorge Camarero Arantxa Sancho Claudio Jommi Yago Pico de Coaña Maria Wolodarski Yuya Yoshimoto Giusy Gentilcore Isabel Poschke Giuseppe V. Masucci Johan Hansson Rolf Kiessling Giosuè Scognamiglio Francesco Sabbatino Federica Zito Marino Anna Maria Anniciello Monica Cantile Margherita Cerrone Stefania Scala Crescenzo D’alterio Angela Ianaro Giuseppe Cirin Giuseppina Liguori Gerardo Bott Paul B. Chapman Caroline Robert James Larkin John B. Haanen Antoni Ribas David Hogg Omid Hamid Alessandro Testori Paul Lorigan Jeffrey A. Sosman Keith T. Flaherty Huibin Yue Shelley Coleman Ivor Caro Axel Hauschild Grant A. McArthur Mario Sznol Margaret K. Callahan Harriet Kluger Michael A. Postow RuthAnn Gordan Neil H. Segal Naiyer A. Rizvi Alexander Lesokhin Michael B. Atkins Matthew M. Burke Amanda Ralabate Angel Rivera Stephanie A. Kronenberg Blessing Agunwamba Mary Ruisi Christine Horak Joel Jiang Jedd Wolchok Paolo A. Ascierto Gabriella Liszkay Michele Maio Mario Mandalà Lev Demidov Daniil Stoyakovskiy Luc Thomas Luis de la Cruz-Merino Victoria Atkinson Caroline Dutriaux Claus Garbe Matthew Wongchenko Ilsung Chang Daniel O. Koralek Isabelle Rooney Yibing Yan Brigitte Dréno Ryan Sullivan Manish Patel Stephen Hodi Rodabe Amaria Peter Boasberg Jeffrey Wallin Xian He Edward Cha Nicole Richie Marcus Ballinger David C. Smith Todd M. Bauer Jeffrey S. Was Department of Melanoma Medical Oncology University of Texas MD Anderson Cancer Center Houston USA The University of Texas MD Anderson Cancer Center Houston USA Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale” Naples Italy IRCCS Istituto Nazionale Tumori de “Fondazione G. Pascale” Naples Italy Dipartimento di Medicina Sperimentale e Clinica Università degli Studi di Catanzaro “Magna Graecia” Catanzaro Italy Takis s.r.l. Rome Italy Unit of Medical Oncology and Innovative Therapy Istituto Nazionale per lo Studio e la Cura Tumori Fondazione “G. Pascale” Napoli Italy Unit of Melanoma Cancer Immunotherapy and Innovative Therapy Istituto Nazionale Tumori Fondazione Pascale Naples Italy IRCCS Istituto Nazionale Tumori “Fondazione G. Pascale” Naples Italy Department of Molecular Virology Immunology and Medical Genetics The Ohio State University Comprehensive Cancer Center Columbus USA Dipartimento di Chirurgia “P. Valdoni” Sapienza Università di Roma Rome Italy Dipartimento di Medicina Clinica e Molecolare Sapienza Università di Roma Rome Italy Department of Pathology University of Chicago Chicago USA Department of Medicine University of Chicago Chicago USA Department of Pathology and Department of Medicine-Section of Hematology/Oncology University of Chicago Chicago USA The University of Chicago Medicine Chicago USA Department of Surgery Massachusetts General Hospital Harvard Medical School Boston USA Department of Pathology NYU School of Medicine New York USA Department of Radiation Oncology NYU School of Medicine New York USA Department of Radiation Oncology Weill Cornell Medical College New York USA Department of Pathology University of Texas Southwestern Dallas USA Department of Dermatology University of Zurich Hospital Zurich Switzerland Dermatologische Klinik University of Zurich Zurich Switzerland University Hospital of Zurich Zurich Switzerland Universitaets Spital Zurich Switzerland Vanderbilt-Ingram Cancer Center

MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance Stefani Spranger, Thomas F. Gajewski K4 Intracellular tumor antigens as a source of targets of antibody-based immunotherapy of melanoma Yangyang Wang, Soldano Ferrone Combination therapies K5 Harnessing radiotherapy to improve responses to immunotherapy in cancer Claire Vanpouille-Box, Erik Wennerberg, Karsten A. Pilones, Silvia C. Formenti, Sandra Demaria K6 Creating a T cell-inflamed tumor microenvironment overcomes resistance to checkpoint blockade Haidong Tang, Yang Wang, Yang-Xin Fu K7 Biomarkers for treatment decisions? Reinhard Dummer K8 Combining oncolytic therapies in the era of checkpoint inhibitors Igor Puzanov K9 Immune checkpoint blockade for melanoma: should we combine or sequence ipilimumab and PD-1 antibody therapy? Michael A. Postow News in immunotherapy K10 An update on adjuvant and neoadjuvant therapy for melanom Ahmad Tarhini K11 Targeting multiple inhibitory receptors in melanoma Joe-Marc Chauvin, Ornella Pagliano, Julien Fourcade, Zhaojun Sun, Hong Wang, Cindy Sanders, John M. Kirkwood, Tseng-hui Timothy Chen, Mark Maurer, Alan J. Korman, Hassane M. Zarour K12 Improving adoptive immune therapy using genetically engineered T cells David F. Stroncek Tumor microenvironment and biomarkers K13 Myeloid cells and tumor exosomes: a crosstalk for assessing immunosuppression? Veronica Huber, Licia Rivoltini K14 Update on the SITC biomarker taskforce: progress and challenges Magdalena Thurin World-wide immunosc

关键词： Melanoma Overall Survival Melanoma Cell Melanoma Patient Melanoma Cell Line

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Vanets: Case study of a peer-to-peer video conferencing system

Vanets: Case study of a peer-to-peer video conferencing syst...

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2009 6th IEEE Consumer Communications and networking Conference, CCNC 2009

作者： Hossain, Tareq Cui, Yi Xue, Yuan Vanderbilt Advanced NETwork Systems Laboratory Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN 37212

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Minimizing rate distortion in peer-to-peer video streaming

Minimizing rate distortion in peer-to-peer video streaming

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2009 6th IEEE Consumer Communications and networking Conference, CCNC 2009

作者： Hossain, Tareq Cui, Yi Xue, Yuan Vanderbilt Advanced NETwork Systems Laboratory Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN 37212 United States

ISBN: (纸本)9781424423095

This paper addresses the problem of optimal rate allocation for video stream in peer-to-peer networks. We present a distributed rate allocation algorithm with the goal of minimizing the total video distortion among peers receiving the same video. The scheme assumes that video streams can be transcoded/re-quantized at intermediate peers. We deploy a double pricing solution that simultaneously incorporates the network and the relay constraints in the peer-to-peer network and compare it with a single pricing solution where the relay constraint is applied only after all the communicating peers converge to optimality. We combine our solution with two video adaptation techniques: transcoding using x264 and scalable coding using H.264 SVC (scalable video coding) extension. Our experiment shows that the double pricing solution consistently achieves a smaller aggregate distortion for all peers over the single pricing solution. ©2009 IEEE.

关键词： Peer to peer networks

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On the optimality of layered video streaming rate in a P2P mesh network

On the optimality of layered video streaming rate in a P2P m...

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2009 18th International Conference on Computer Communications and networks, ICCCN 2009

ISBN: (纸本)9781424445813

Layered streaming is an effective solution to address receiver heterogeneity in a Peer-to-peer (P2P) network. This paper addresses the problem of rate allocation for layered video stream in p2p mesh networks. We present a distributed rate allocation algorithm that achieves close to optimal layer allocation among peers receiving the same video. We use load balancing technique that evenly distributes layer requests to a parent peer. Weight based layer allocation technique ensures that a child peer with higher children receives higher priority in servicing layer allocation request from its parents. Results show that for up to seven layers streamed by a server, the algorithm maintains a layerdelivery ratio of 88% or more among all peers in a network. ©2009 IEEE.

关键词： Video streaming

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Minimizing Rate Distortion in Peer-to-Peer Video Streaming

Minimizing Rate Distortion in Peer-to-Peer Video Streaming

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Consumer Communications and networking Conference, CCNC IEEE

作者： Tareq Hossain Yi Cui Yuan Xue Vanderbilt Advanced Network Systems Laboratory Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN USA

This paper addresses the problem of optimal rate allocation for video stream in peer-to-peer networks. We present a distributed rate allocation algorithm with the goal of minimizing the total video distortion among peers receiving the same video. The scheme assumes that video streams can be transcoded/re- quantized at intermediate peers. We deploy a double pricing solution that simultaneously incorporates the network and the relay constraints in the peer-to-peer network and compare it with a single pricing solution where the relay constraint is applied only after all the communicating peers converge to optimality. We combine our solution with two video adaptation techniques: transcoding using times 264 and scalable coding using H.264 SVC (scalable video coding) extension. Our experiment shows that the double pricing solution consistently achieves a smaller aggregate distortion for all peers over the single pricing solution.

关键词： Rate-distortion Peer to peer computing Streaming media Relays Pricing Transcoding Aggregates Static VAr compensators Resource management Bandwidth

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