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Animal Research and One Health 2023年第2期1卷

作者： Philip Lymbery Compassion in World Farming International Godalming UK Contribution: Conceptualization (lead) Data curation (lead) Formal analysis (lead) Funding acquisition (lead) Investigation (lead) Methodology (lead) Project administration (lead) Resources (lead) Software (lead) Supervision (lead) Validation (lead) Visualization (lead) Writing - original draft (lead) Writing - review & editing (lead)

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Cover Image, Volume 139, Issue 44

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Journal of Applied Polymer Science 2022年第44期139卷

作者： Keziban Huner Ferdane Karaman Contribution: Conceptualization (equal) Data curation (equal) Formal analysis (lead) Investigation (equal) Methodology (supporting) Project administration (equal) Resources (supporting) Software (equal) Supervision (equal) Validation (equal) Visualization (lead) Writing - original draft (lead) Writing - review & editing (lead) Contribution: Conceptualization (equal) Data curation (equal) Formal analysis (supporting) Investigation (equal) Methodology (lead) Project administration (equal) Resources (lead) Software (equal) Supervision (equal) Validation (equal) Visualization (supporting) Writing - original draft (supporting) Writing - review & editing (supporting)

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Evolution of a Strategy for Concise Enantioselective Total Synthesis of the Salinosporamide Family of Natural Products

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Angewandte Chemie 2022年第41期134卷

作者： Soojun Park Jiwoo Lee Prof. Dr. Jae Hyun Kim Yeji Jeong Dr. Seokwoo Lee Su Won Lee Prof. Dr. Sanghee Kim College of Pharmacy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea Contribution: Conceptualization (lead) Formal analysis (lead) Investigation (lead) Software (lead) Visualization (lead) Writing - original draft (lead) Contribution: Data curation (supporting) Formal analysis (supporting) Validation (supporting) Writing - original draft (supporting) College of Pharmacy Chung-Ang University 84 Heukseok-ro Seoul 06974 Republic of Korea Contribution: Conceptualization (equal) Formal analysis (equal) Project administration (supporting) Contribution: Data curation (supporting) Writing - original draft (supporting) Contribution: Visualization (supporting) Contribution: Data curation (supporting) Contribution: Conceptualization (lead) Project administration (lead) Supervision (lead) Writing - review & editing (lead)

Our first strategy for rapidly accessing pyrrolidinone cores of salinosporamides involved combined use of memory of chirality and dynamic kinetic resolution principles in aldol reactions of the serine-derived 5-oxazolidinone substrate, which was ultimately unsuccessful with respect to enantioselectivity. This failure led us to the revised strategy. The influence of the stereocenter in 5-oxazolidinone enabled selective installation of the C-2 stereocenter. The intramolecular aldol reaction of the C-2 stereodefined aldol substrate was successful. An unexpected hydrolytic dynamic kinetic resolution was observed in hydrolyses of the bicyclic aldol products. This unprecedented substrate-driven hydrolytic dynamic kinetic resolution was utilized in preparing the pyrrolidinone core with excellent efficiency. Through this strategy, the concise total syntheses of salinosporamides A and B as well as cinnabaramides A, E, and F were achieved with high selectivity.

关键词： Heterocycles Kinetic Resolution Natural Products Salinosporamides Total Synthesis

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Cover Image, Volume 140, Issue 7

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Journal of Applied Polymer Science 2023年第7期140卷

作者： Monika Flejszar Paweł Chmielarz Marcin Oszajca Contribution: Data curation (equal) Formal analysis (lead) Investigation (lead) Methodology (equal) Resources (lead) Validation (equal) Visualization (lead) Writing - original draft (equal) Writing - review & editing (equal) Contribution: Conceptualization (lead) Data curation (equal) Funding acquisition (lead) Methodology (equal) Project administration (lead) Supervision (lead) Validation (equal) Writing - original draft (equal) Writing - review & editing (equal) Contribution: Investigation (supporting)

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Liquid Precursor-Guided Phase Engineering of Single-Crystal VO2Beams

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Angewandte Chemie 2023年第16期135卷

作者： Run Shi Yonghuang Wu Zeqin Xin Jing Guo Zonglin Li Bochen Zhao Ruixuan Peng Chenyu Li Enze Wang Bolun Wang Xiaolong Zhang Prof. Chun Cheng Prof. Kai Liu State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084 China Contribution: Data curation (lead) Formal analysis (lead) Funding acquisition (equal) Investigation (lead) Methodology (lead) Project administration (lead) Resources (lead) Visualization (lead) Writing - original draft (lead) Writing - review & editing (equal) Contribution: Investigation (equal) Visualization (equal) Contribution: Data curation (supporting) Project administration (equal) Contribution: Formal analysis (supporting) Resources (equal) Contribution: Software (supporting) Contribution: Methodology (supporting) Contribution: Visualization (supporting) Contribution: Project administration (supporting) Contribution: Conceptualization (supporting) Contribution: Supervision (supporting) Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen 518055 China Contribution: Funding acquisition (equal) Supervision (equal) Writing - review & editing (lead) Contribution: Funding acquisition (lead) Supervision (lead) Validation (lead) Writing - review & editing (lead)

The study of VO 2 flourishes due to its rich competing phases induced by slight stoichiometry variations. However, the vague mechanism of stoichiometry manipulation makes the precise phase engineering of VO 2 still challenging. Here, stoichiometry manipulation of single-crystal VO 2 beams in liquid-assisted growth is systematically studied. Contrary to previous experience, oxygen-rich VO 2 phases are abnormally synthesized under a reduced oxygen concentration, revealing the important function of liquid V 2 O 5 precursor: It submerges VO 2 crystals and stabilizes their stoichiometric phase (M1) by isolating them from the reactive atmosphere, while the uncovered crystals are oxidized by the growth atmosphere. By varying the thickness of liquid V 2 O 5 precursor and thus the exposure time of VO 2 to the atmosphere, various VO 2 phases (M1, T, and M2) can be selectively stabilized. Furthermore, this liquid precursor-guided growth can be used to spatially manages multiphase structures in single VO 2 beams, enriching their deformation modes for actuation applications.

关键词： Actuators Phase Engineering Stoichiometry Manipulation Strongly Correlated Materials Vanadium Dioxide

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Synchronous Elimination of Excess Photoinstable PbI2and Interfacial Band Mismatch for Efficient and Stable Perovskite Solar Cells

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Angewandte Chemie 2023年第1期136卷

作者： Jiacheng He Wangping Sheng Jia Yang Yang Zhong Qianqian Cai Yikun Liu Zhao Guo Prof. Licheng Tan Prof. Yiwang Chen College of Chemistry and Chemical Engineering/Institute of Polymers and Energy Chemistry (IPEC) Nanchang University 999 Xuefu Avenue Nanchang 330031 China Contribution: Conceptualization (lead) Data curation (lead) Formal analysis (lead) Investigation (lead) Methodology (lead) Supervision (lead) Validation (lead) Visualization (lead) Writing - original draft (lead) Writing - review & editing (lead) Contribution: Conceptualization (equal) Data curation (equal) Formal analysis (equal) Investigation (equal) Writing - original draft (equal) Writing - review & editing (equal) National Engineering Research Center for Carbohydrate Synthesis/Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University 99 Ziyang Avenue Nanchang 330022 China Contribution: Formal analysis (supporting) Investigation (supporting) Software (supporting) Supervision (supporting) Visualization (supporting) Writing - original draft (supporting) Writing - review & editing (supporting) Contribution: Investigation (supporting) Methodology (supporting) Project administration (supporting) Resources (supporting) Software (supporting) Contribution: Data curation (supporting) Formal analysis (supporting) Project administration (supporting) Validation (supporting) Writing - original draft (supporting) Contribution: Conceptualization (supporting) Formal analysis (supporting) Investigation (supporting) Validation (supporting) Contribution: Investigation (supporting) Methodology (supporting) Peking University Yangtze Delta Insititute of Optoelectronics 60 Chongzhou Avenue Nantong 226010 China Contribution: Conceptualization (supporting) Data curation (supporting) Formal analysis (supporting) Funding acquisition (lead) Investigation (supporting) Project administration (lead) Resources (lead) Supervision (lead) Writing - original draft (lead) Writing - review & editing (lead) Contribution: Conceptualization (lead) Data curation (supporting

Eliminating the undesired photoinstability of excess lead iodide (PbI 2 ) in the perovskite film and reducing the energy mismatch between the perovskite layer and heterogeneous interfaces are urgent issues to be addressed in the preparation of perovskite solar cells (PVSCs) by two-step sequential deposition method. Here, the 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF 4 ) is employed to convert superfluous PbI 2 to more robust 1D EMIMPbI 3 which can withstand lattice strain, while forming an interfacial dipole layer at the SnO 2 /perovskite interface to reconfigure the interfacial energy band structure and accelerate the charge extraction. Consequently, the unencapsulated PVSCs device attains a champion efficiency of 24.28 % with one of the highest open-circuit voltage (1.19 V). Moreover, the unencapsulated devices showcase significantly improved thermal stability, enhanced environmental stability and remarkable operational stability accompanied by 85 % of primitive efficiency retained over 1500 h at maximum power point tracking under continuous illumination.

关键词： Defect Passivation Energy Level Reconfiguration Excess PbI2 Interfacial Dipole Layer Perovskite Solar Cells

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Glucose-Responsive Charge-Switchable Lipid Nanoparticles for Insulin Delivery

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Angewandte Chemie 2023年第20期135卷

作者： Yun Liu Yanfang Wang Yuejun Yao Juan Zhang Wei Liu Kangfan Ji Xinwei Wei Yuanwu Wang Prof. Xiangsheng Liu Prof. Shiming Zhang Prof. Jinqiang Wang Prof. Zhen Gu Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical Sciences Zhejiang University 310058 Hangzhou China Jinhua Institute of Zhejiang University 321299 Jinhua China Contribution: Data curation (lead) Formal analysis (lead) Investigation (lead) Methodology (lead) Software (lead) Validation (lead) Visualization (lead) Writing - original draft (lead) Writing - review & editing (lead) Contribution: Data curation (supporting) Investigation (supporting) Visualization (supporting) Contribution: Data curation (supporting) Formal analysis (supporting) Investigation (supporting) Contribution: Formal analysis (supporting) Investigation (supporting) Methodology (supporting) Contribution: Formal analysis (supporting) Investigation (supporting) Contribution: Writing - review & editing (supporting) Contribution: Investigation (supporting) Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences 310022 Hangzhou China Department of Electrical and Electronic Engineering The University of Hong Kong 999077 Hong Kong SAR China Second Affiliated Hospital Zhejiang University School of Medicine 310009 Hangzhou China Contribution: Conceptualization (lead) Data curation (equal) Formal analysis (equal) Funding acquisition (lead) Investigation (lead) Methodology (equal) Project administration (lead) Resources (lead) Software (lead) Supervision (lead) Validation (supporting) Visualization (supporting) Writing - review & editing (lead) Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University 310009 Hangzhou China Zhejiang Laboratory of Systems & Precision Medicine Zhejiang University Medical Center 310009 Hangzhou China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University 310009 Hangzhou China Contribution: Funding acquisition (lead) Project administration (lead) Resources (lead) Softwar

Lipid nanoparticle-based drug delivery systems have a profound clinical impact on nucleic acid-based therapy and vaccination. Recombinant human insulin, a negatively-charged biomolecule like mRNA, may also be delivered by rationally-designed positively-charged lipid nanoparticles with glucose-sensing elements and be released in a glucose-responsive manner. Herein, we have designed phenylboronic acid-based quaternary amine-type cationic lipids that can self-assemble into spherical lipid nanoparticles in an aqueous solution. Upon mixing insulin and the lipid nanoparticles, a heterostructured insulin complex is formed immediately arising from the electrostatic attraction. In a hyperglycemia-relevant glucose solution, lipid nanoparticles become less positively charged over time, leading to reduced attraction and subsequent insulin release. Compared with native insulin, this lipid nanoparticle-based glucose-responsive insulin shows prolonged blood glucose regulation ability and blood glucose-triggered insulin release in a type 1 diabetic mouse model.

关键词： Diabetes Drug Delivery Glucose-Responsive Insulin Delivery Lipid Nanoparticles

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Targeted Degradation of PD-L1 and Activation of the STING Pathway by Carbon-Dot-Based PROTACs for Cancer Immunotherapy

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Angewandte Chemie 2023年第11期135卷

作者： Dr. Wen Su Dr. Mixiao Tan Zhihang Wang Jie Zhang Wenping Huang Haohao Song Xinye Wang Prof. Haitao Ran Prof. Yanfeng Gao Prof. Guangjun Nie Prof. Hai Wang CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China Contribution: Data curation (lead) Formal analysis (lead) Investigation (lead) Validation (lead) Visualization (lead) Chongqing Key Laboratory of Ultrasound Molecular Imaging The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China Contribution: Data curation (equal) Formal analysis (equal) Investigation (equal) Software (equal) Validation (equal) Visualization (equal) Contribution: Data curation (supporting) Methodology (supporting) Visualization (supporting) Contribution: Data curation (supporting) Methodology (supporting) Validation (supporting) Contribution: Methodology (supporting) Software (supporting) Contribution: Software (equal) Contribution: Data curation (supporting) Contribution: Supervision (supporting) School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat-sen University Shenzhen 518107 China Contribution: Methodology (supporting) Writing - review & editing (supporting) Contribution: Funding acquisition (equal) Resources (equal) Supervision (equal) Writing - review & editing (equal) Contribution: Conceptualization (lead) Funding acquisition (lead) Project administration (lead) Resources (lead) Supervision (lead) Writing - original draft (lead) Writing - review & editing (lead)

Proteolysis targeting chimeras (PROTACs) technology is an emerging approach to degrade disease-associated proteins. Here, we report carbon-dot (CD)-based PROTACs (CDTACs) that degrade membrane proteins via the ubiquitin-proteasome system. CDTACs can bind to programmed cell death ligand 1 (PD-L1), recruit cereblon (CRBN) to induce PD-L1 ubiquitination, and degrade them with proteasomes. Fasting-mimicking diet (FMD) is also used to enhance the cellular uptake and proteasome activity. More than 99 % or 90 % of PD-L1 in CT26 or B16-F10 tumor cells can be degraded by CDTACs, respectively. Furthermore, CDTACs can activate the stimulator of interferon genes (STING) pathway to trigger immune responses. Thus, CDTACs with FMD treatment effectively inhibit the growth of CT26 and B16-F10 tumors. Compared with small-molecule-based PROTACs, CDTACs offer several advantages, such as efficient membrane protein degradation, targeted tumor accumulation, immune system activation, and in vivo detection.

关键词： Cancer Therapy Carbon Dots Nanomedicine PROTACs

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A Multifunctional Polymer as an Interfacial Layer for Efficient and Stable Perovskite Solar Cells

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Angewandte Chemie 2022年第2期135卷

作者： Bingqian Zhang Chen Chen Xianzhao Wang Xiaofan Du Dachang Liu Xiuhong Sun Zhipeng Li Lianzheng Hao Caiyun Gao Yimeng Li Zhipeng Shao Xiao Wang Prof. Guanglei Cui Prof. Shuping Pang Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China College of Materials Science and Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China Shandong Energy Institute Qingdao 266101 P. R. China Contribution: Conceptualization (equal) Data curation (lead) Formal analysis (lead) Investigation (lead) Methodology (lead) Project administration (equal) Validation (lead) Visualization (equal) Writing - original draft (lead) Writing - review & editing (equal) Contribution: Data curation (supporting) Formal analysis (supporting) Investigation (supporting) Methodology (supporting) Visualization (supporting) Contribution: Data curation (supporting) Formal analysis (supporting) Investigation (supporting) Resources (equal) Validation (supporting) Contribution: Methodology (supporting) Software (lead) Contribution: Formal analysis (supporting) Methodology (supporting) Resources (supporting) Validation (supporting) Visualization (supporting) Writing - review & editing (supporting) Contribution: Formal analysis (supporting) Investigation (supporting) Validation (supporting) Writing - review & editing (supporting) Contribution: Methodology (supporting) Validation (supporting) Visualization (supporting) Contribution: Investigation (supporting) Methodology (supporting) Validation (supporting) Contribution: Formal analysis (supporting) Resources (supporting) Validation (supporting) Contribution: Investigation (supporting) Validation (supporting) Contribution: Investigation (supporting) Methodology (supporting) Contribution: Conceptualization (equal) Formal analysis (supporting) Funding acquisition (equal) Investigation (supporting) Methodology (supporting) Project administration (equal) Supervision (equal) Validation (equal) Visualization (equal) Writing - review & editing (equal) Contribution: Methodology (supporting) Supervision (supporting) Contribution: Conceptualization (equal) Dat

Metal-cation defects and halogen-anion defects in perovskite films are critical to the efficiency and stability of perovskite solar cells (PSCs). In this work, a random polymer, poly(methyl methacrylate- co -acrylamide) (PMMA-AM), was synthesized to serve as an interfacial passivation layer for synergistically passivating the under-coordinated Pb 2+ and anchor the I - of the [PbI 6 ] 4− octahedron. Additionally, the interfacial PMMA-AM passivation layer cannot be destroyed during the hole transport layer deposition because of its low solubility in chlorobenzene. This passivation leads to an enhancement in the open-circuit voltage from 1.12 to 1.22 V and improved stability in solar cell devices, with the device maintaining 95 % of the initial power conversion efficiency (PCE) over 1000 h of maximum power point tracking. Additionally, a large-area solar cell module was fabricated using this approach, achieving a PCE of 20.64 %.

关键词： Passivation Perovskite Polymer Solar Cells Stability

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Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation (vol 11, e12221, 2022)

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JOURNAL OF EXTRACELLULAR VESICLES 2022年第6期11卷 e12221页

作者： You, Bo Pan, Si Gu, M. Zhang, K. Xia, T. Zhang, S. Chen, W. Xie, H. Fan, Y. Yao, H. Cheng, T. Zhang, P. Liu, D. You, Y. Department of Otolaryngology Head and Neck Surgery Affiliated Hospital of Nantong University Nantong Jiangsu Province China Institute of Otolaryngology Head and Neck Surgery Affiliated Hospital of Nantong University Nantong Jiangsu Province China Contribution: Data curation (equal) Formal analysis (equal) Investigation (equal) Methodology (equal) Resources (equal) Software (equal) Supervision (equal) Validation (equal) Visualization (equal) Contribution: Investigation (equal) Validation (equal) Contribution: Investigation (equal) Software (equal) Contribution: Investigation (equal) Visualization (equal) Laboratory of Neuroregeneration of Jiangsu Ministry of Education Nantong University Nantong Jiangsu Province China Dr. Yiwen You Department of Otolaryngology Head and Neck Surgery Affiliated Hospital of Nantong University Xisi Road 20 Nantong 226001 Jiangsu Province China. Contribution: Conceptualization (supporting) Investigation (equal) Methodology (equal) Dong Liu Laboratory of Neuroregeneration of Jiangsu Ministry of Education Nantong University Nantong Jiangsu Province China Contribution: Conceptualization (lead) Investigation (equal) Methodology (equal) Project administration (lead)

Tumour-associated angiogenesis plays a critical role in metastasis, the main cause of malignancy-related death. Extracellular vesicles (EVs) can regulate angiogenesis to participate in tumour metastasis. Our previous study showed that EVs rich in HAX1 are associated with in metastasis of nasopharyngeal carcinoma (NPC). However, the mechanism by which HAX1 of EVs promotes metastasis and angiogenesis is unclear. In this study, we demonstrated that EVs rich in HAX1 promote angiogenesis phenotype by activating the FAK pathway in endothelial cells (ECs) by increasing expression level of ITGB6. The expression level of HAX1 is markedly correlated with microvessel density (MVDs) in NPC and head and neck cancers based on an analysis of IHC. In addition to a series of in vitro cellular analyses, in vivo models revealed that HAX1 was correlated with migration and blood vessel formation of ECs, and metastasis of NPC. Using ribosome profiling, we found that HAX1 regulates the FAK pathway to influence microvessel formation and promote NPC metastasis by enhancing the translation efficiency of ITGB6. Our findings demonstrate that HAX1 can be used as an important biomarker for NPC metastasis, providing a novel basis for antiangiogenesis therapy in clinical settings.

关键词： angiogenesis extracellular vesicles FAK pathway HAX1 ITGB6 nasopharyngeal carcinoma translation

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