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23rd International Conference on Medical Image computing and computer-Assisted Intervention, MICCAI 2020

作者： Zhang, Hao Xia, Likun Song, Ran Yang, Jianlong Hao, Huaying Liu, Jiang Zhao, Yitian College of Information Engineering Capital Normal University Beijing China Cixi Institute of Biomedical Engineering Ningbo Institute of Industrial Technology Chinese Academy of Sciences Ningbo China School of Control Science and Engineering Shandong University Jinan China Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen China International Science and Technology Cooperation Base of Electronic System Reliability and Mathematical Interdisciplinary Capital Normal University Beijing China Laboratory of Neural Computing and Intelligent Perception Capital Normal University Beijing China Beijing Advanced Innovation Center for Imaging Theory and Technology Capital Normal University Beijing China

ISBN: (纸本)9783030597245

Automated extraction of cerebrovascular is of great importance in understanding the mechanism, diagnosis, and treatment of many cerebrovascular pathologies. However, segmentation of cerebrovascular networks from magnetic resonance angiography (MRA) imagery continues to be challenging because of relatively poor contrast and inhomogeneous backgrounds, and the anatomical variations, complex geometry and topology of the networks themselves. In this paper, we present a novel cerebrovascular segmentation framework that consists of image enhancement and segmentation phases. We aim to remove redundant features, while retaining edge information in shallow features when combining these with deep features. We first employ a Retinex model, which is able to model noise explicitly to aid removal of imaging noise, as well as reducing redundancy within an image and emphasizing the vessel regions, thereby simplifying the subsequent segmentation problem. Subsequently, a reverse edge attention module is employed to discover edge information by paying particular attention to the regions that are not salient in high-level semantic features. The experimental results show that the proposed framework enables the reverse edge attention network to deliver a reliable cerebrovascular segmentation. © 2020, Springer Nature Switzerland AG.

关键词： Image enhancement

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FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare

arXiv

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arXiv 2023年

作者： Lekadir, Karim Feragen, Aasa Fofanah, Abdul Joseph Frangi, Alejandro F. Buyx, Alena Emelie, Anais Lara, Andrea Porras, Antonio R. Chan, An-Wen Navarro, Arcadi Glocker, Ben Botwe, Benard O. Khanal, Bishesh Beger, Brigit Wu, Carol C. Cintas, Celia Langlotz, Curtis P. Rueckert, Daniel Mzurikwao, Deogratias Fotiadis, Dimitrios I. Zhussupov, Doszhan Ferrante, Enzo Meijering, Erik Weicken, Eva González, Fabio A. Asselbergs, Folkert W. Prior, Fred Krestin, Gabriel P. Collins, Gary S. Tegenaw, Geletaw S. Kaissis, Georgios Misuraca, Gianluca Tsakou, Gianna Dwivedi, Girish Kondylakis, Haridimos Jayakody, Harsha Woodruf, Henry C. Mayer, Horst Joachim Aerts, Hugo JWL Walsh, Ian Chouvarda, Ioanna Buvat, Irène Tributsch, Isabell Rekik, Islem Duncan, James Kalpathy-Cramer, Jayashree Zahir, Jihad Park, Jinah Mongan, John Gichoya, Judy W. Schnabel, Julia A. Kushibar, Kaisar Riklund, Katrine Mori, Kensaku Marias, Kostas Amugongo, Lameck M. Fromont, Lauren A. Maier-Hein, Lena Alberich, Leonor Cerdá Rittner, Leticia Phiri, Lighton Marrakchi-Kacem, Linda Donoso-Bach, Lluís Martí-Bonmatí, Luis Cardoso, M. Jorge Bobowicz, Maciej Shabani, Mahsa Tsiknakis, Manolis Zuluaga, Maria A. Bielikova, Maria Fritzsche, Marie-Christine Camacho, Marina Linguraru, Marius George Wenzel, Markus De Bruijne, Marleen Tolsgaard, Martin G. Ghassemi, Marzyeh Ashrafuzzaman, Md Goisauf, Melanie Yaqub, Mohammad Abadía, Mónica Cano Mahmoud, Mukhtar M.E. Elattar, Mustafa Rieke, Nicola Papanikolaou, Nikolaos Lazrak, Noussair Díaz, Oliver Salvado, Olivier Pujol, Oriol Sall, Ousmane Guevara, Pamela Gordebeke, Peter Lambin, Philippe Brown, Pieta Abolmaesumi, Purang Dou, Qi Lu, Qinghua Osuala, Richard Nakasi, Rose Zhou, S. Kevin Napel, Sandy Colantonio, Sara Albarqouni, Shadi Joshi, Smriti Carter, Stacy Klein, Stefan Petersen, Steffen E. Aussó, Susanna Awate, Suyash Raviv, Tammy Riklin Cook, Tessa Mutsvangwa, Tinashe E.M. Rogers, Wendy A. Niessen, Wiro J. Puig-Bosch, Xènia Zeng, Yi Mohammed, Yunusa G. Aquino, Yves Saint James Salahuddin, Zohaib Starmans, Martijn P.A. Department de Matemàtiques i Informàtica Universitat de Barcelona Barcelona Spain Barcelona Spain DTU Compute Technical University of Denmark Kgs Lyngby Denmark Department of Mathematics and Computer Science Faculty of Science and Technology Milton Margai Technical University Freetown Sierra Leone Center for Computational Imaging & Simulation Technologies in Biomedicine Schools of Computing and Medicine University of Leeds Leeds United Kingdom Cardiovascular Science and Electronic Engineering Departments KU Leuven Leuven Belgium Institute of History and Ethics in Medicine Technical University of Munich Munich Germany Faculty of Engineering of Systems Informatics and Sciences of Computing Galileo University Guatemala City Guatemala Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus AuroraCO United States Department of Medicine Women’s College Research Institute University of Toronto Toronto Canada Universitat Pompeu Fabra BarcelonaBeta Brain Research Center Barcelona Spain Department of Computing Imperial College London London United Kingdom School of Biomedical & Allied Health Sciences University of Ghana Accra Ghana Department of Midwifery & Radiography School of Health & Psychological Sciences City University of London United Kingdom Kathmandu Nepal European Heart Network Brussels Belgium Department of Thoracic Imaging University of Texas MD Anderson Cancer Center Houston United States IBM Research Africa Nairobi Kenya Departments of Radiology Medicine and Biomedical Data Science Stanford University School of Medicine Stanford United States Institute for AI and Informatics in Medicine Klinikum rechts der Isar Technical University Munich Munich Germany Department of Computing Imperial College London London United Kingdom Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania United Republic of Ioannina Greece Almaty AI Lab Almaty Kazakhstan

Background: Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. In recent years, concerns have been raised about the clinical, technical, ethical and legal risks associated with healthcare AI. To increase adoption in the real world, it is essential that AI technologies are trusted and accepted by patients, clinicians, health organisations and authorities. This paper describes the FUTURE-AI framework as the first international consensus guideline for trustworthy AI in healthcare. Methods: The FUTURE-AI consortium was founded in 2021 and now comprises 117 interdisciplinary experts from 50 countries representing all continents, including AI scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two-year period, the consortium established guiding principles and best practices for trustworthy and deployable AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. Findings: The FUTURE-AI framework was established based on six guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 30 best practices were defined, addressing technical, clinical, socio-ethical and legal dimensions of trustworthy AI. The recommendations cover the entire lifecycle of healthcare AI, from design, development and validation to regulation, deployment, and monitoring. Interpretation: FUTURE-AI is a structured, risk-informed framework which provides guidance for constructing healthcare AI tools that will be trusted, deployed and adopted in real-world clinical practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of healthcare AI. Copyright © 2023, The Authors. All rights

关键词： Clinical research

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AngularGrad: A New Optimization Technique for Angular Convergence of Convolutional Neural Networks

arXiv

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arXiv 2021年

作者： Roy, Swalpa Kumar Paoletti, Mercedes E. Haut, Juan M. Dubey, Shiv Ram Kar, Purbayan Plaza, Antonio Chaudhuri, Bidyut B. The Computer Science and Engineering Alipurduar Government Engineering and Management College 736206 India The Hyperspectral Computing Laboratory Department of Technology of Computers and Communications University of Extremadura Cáceres10003 Spain The Computer Vision and Biometrics Lab Indian Institute of Information Technology Prayagraj Uttar Pradesh Allahabad211015 India The Media Analysis Group Sony Research India Private Limited Karnataka Bangalore560103 India The Computer Vision and Pattern Recognition Unit Indian Statistical Institute Kolkata700108 India

Convolutional neural networks (CNNs) are trained using stochastic gradient descent (SGD)-based optimizers. Recently, the adaptive moment estimation (Adam) optimizer has become very popular due to its adaptive momentum, which tackles the dying gradient problem of SGD. Nevertheless, existing optimizers are still unable to exploit the optimization curvature information efficiently. This paper proposes a new AngularGrad optimizer that considers the behavior of the direction/angle of consecutive gradients. This is the first attempt in the literature to exploit the gradient angular information apart from its magnitude. The proposed AngularGrad generates a score to control the step size based on the gradient angular information of previous iterations. Thus, the optimization steps become smoother as a more accurate step size of immediate past gradients is captured through the angular information. Two variants of AngularGrad are developed based on the use of Tangent or Cosine functions for computing the gradient angular information. Theoretically, AngularGrad exhibits the same regret bound as Adam for convergence purposes. Nevertheless, extensive experiments conducted on benchmark data sets against state-of-the-art methods reveal a superior performance of AngularGrad. Source code: https://***/mhaut/AngularGrad. Copyright © 2021, The Authors. All rights reserved.

关键词： Optimization

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LMS-Net: A learned Mumford-Shah network for binary few-shot medical image segmentation

引用

Medical Image Analysis 2025年

作者： Shengdong Zhang Fan Jia Xiang Li Hao Zhang Jun Shi Liyan Ma Shihui Ying Department of Mathematics School of Science Shanghai University Shanghai 200444 China Department of Mathematics and Scientific Computing and Imaging (SCI) Institute University of Utah Salt Lake City 84102 UT USA School of Computer Science and Technology East China Normal University Shanghai 200444 China School of Communication and Information Engineering Shanghai University Shanghai 200444 China School of Computer Engineering and Science Shanghai University Shanghai 200444 China School of Mechatronic Engineering and Automation Shanghai Key Laboratory of Intelligent Manufacturing and Robotics Shanghai University Shanghai 200444 China Shanghai Institute of Applied Mathematics and Mechanics Shanghai 200072 China School of Mechanics and Engineering Science Shanghai University Shanghai 200072 China

Few-shot semantic segmentation (FSS) methods have shown great promise in handling data-scarce scenarios, particularly in medical image segmentation tasks. However, most existing FSS architectures lack sufficient interpretability and fail to fully incorporate the underlying physical structures of semantic regions. To address these issues, in this paper, we propose a novel deep unfolding network, called the Learned Mumford-Shah Network (LMS-Net), for the FSS task. Specifically, motivated by the effectiveness of pixel-to-prototype comparison in prototypical FSS methods and the capability of deep priors to model complex spatial structures, we leverage our learned Mumford-Shah model (LMS model) as a mathematical foundation to integrate these insights into a unified framework. By reformulating the LMS model into prototype update and mask update tasks, we propose an alternating optimization algorithm to solve it efficiently. Further, the iterative steps of this algorithm are unfolded into corresponding network modules, resulting in LMS-Net with clear interpretability. Comprehensive experiments on three publicly available medical segmentation datasets verify the effectiveness of our method, demonstrating superior accuracy and robustness in handling complex structures and adapting to challenging segmentation scenarios. These results highlight the potential of LMS-Net to advance FSS in medical imaging applications. Our code will be available at: https://***/SDZhang01/LMSNet .

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A latent encoder coupled generative adversarial network (LE-GAN) for efficient hyperspectral image super-resolution

arXiv

引用

arXiv 2021年

作者： Shi, Yue Han, Liangxiu Han, Lianghao Chang, Sheng Hu, Tongle Dancey, Darren Department of Computing and Mathematics Faculty of Science and Engineering Manchester Metropolitan University ManchesterM1 5GD United Kingdom Department of Computer Science Brunel University UB8 3PH United Kingdom State Key Laboratory of Remote Sensing Science Aerospace Information Research Institute Chinese Academy of Sciences Beijing100101 China College of Plant Protection Hebei Agriculture University Baoding070001 China

Realistic hyperspectral image (HSI) super-resolution (SR) techniques aim to generate a high-resolution (HR) HSI with higher spectral and spatial fidelity from its low-resolution (LR) counterpart. The generative adversarial network (GAN) has proven to be an effective deep learning framework for image super-resolution. However, the optimisation process of existing GAN-based models frequently suffers from the problem of mode collapse, leading to the limited capacity of spectral-spatial invariant reconstruction. This may cause the spectral-spatial distortion on the generated HSI, especially with a large upscaling factor. To alleviate the problem of mode collapse, this work has proposed a novel GAN model coupled with a latent encoder (LE-GAN), which can map the generated spectral-spatial features from the image space to the latent space and produce a coupling component to regularise the generated samples. Essentially, we treat an HSI as a high-dimensional manifold embedded in a latent space. Thus, the optimisation of GAN models is converted to the problem of learning the distributions of high-resolution HSI samples in the latent space, making the distributions of the generated super-resolution HSIs closer to those of their original high-resolution counterparts. We have conducted experimental evaluations on the model performance of super-resolution and its capability in alleviating mode collapse. The proposed approach has been tested and validated based on two real HSI datasets with different sensors (i.e. AVIRIS and UHD-185) for various upscaling factors (i.e. ×2, ×4, ×8) and added noise levels (i.e. ∞ db, 40 db, 80 db), and compared with the state-of-the-art super-resolution models (i.e. HyCoNet, LTTR, BAGAN, SR- GAN, WGAN). Experimental results show that the proposed model outperforms the competitors on the superresolution quality, robustness, and alleviation of mode collapse. The proposed approach is able to capture spectral and spatial details and generate more faith

关键词： Generative adversarial networks

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Assessing the memory ability of recurrent neural networks

arXiv

引用

arXiv 2020年

作者： Zhang, Cheng Li, Qiuchi Hua, Lingyu Song, Dawei Tianjin Key Laboratory of Cognitive Computing and Application Tianjin University Tianjin China Department of Information Engineering University of Padua Padua Italy School of Computer Science Beijing Institute of Technology Beijing China School of Computer Science Beijing Institute of Technology Beijing China

It is known that Recurrent Neural Networks (RNNs) can remember, in their hidden layers, part of the semantic information expressed by a sequence (e.g., a sentence) that is being processed. Different types of recurrent units have been designed to enable RNNs to remember information over longer time spans. However, the memory abilities of different recurrent units are still theoretically and empirically unclear, thus limiting the development of more effective and explainable RNNs. To tackle the problem, in this paper, we identify and analyze the internal and external factors that affect the memory ability of RNNs, and propose a Semantic Euclidean Space to represent the semantics expressed by a sequence. Based on the Semantic Euclidean Space, a series of evaluation indicators are defined to measure the memory abilities of different recurrent units and analyze their limitations. These evaluation indicators also provide a useful guidance to select suitable sequence lengths for different RNNs during training. Copyright © 2020, The Authors. All rights reserved.

关键词： Semantics

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Better, Not Just More: Data-Centric Machine Learning for Earth Observation

arXiv

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arXiv 2023年

作者： Roscher, Ribana Rußwurm, Marc Gevaert, Caroline Kampffmeyer, Michael dos Santos, Jefersson A. Vakalopoulou, Maria Hänsch, Ronny Hansen, Stine Nogueira, Keiller Prexl, Jonathan Tuia, Devis Data Science for Crop Systems Group Forschungszentrum Jülich GmbH Wilhelm-Johnen-Straße Jülich52428 Germany Remote Sensing Group University of Bonn Niebuhrstr. 1a Bonn53113 Germany Laboratory of Geo-information Science and Remote Sensing Wageningen University Droevendaalsesteeg 3 Wageningen Gelderland6708 PB Netherlands Department of Earth Observation Science Faculty ITC University of Twente Drienerlolaan 5 Enschede Overijssel7522 NB Netherlands Department of Physics and Technology UiT The Arctic University of Norway Klokkargårdsbakken 35 Tromsø9019 Norway Department of Computer Science University of Sheffield Sheffield City Centre 211 Portobello SheffieldS1 4DP United Kingdom Münchner Str. 20 Oberpfaffenhofen-Wessling82234 Germany Computing Science and Mathematics University of Stirling StirlingFK9 4LA United Kingdom Department of Aerospace Engineering University of the Bundeswehr Munich Werner-Heisenberg-Weg 39 Neubiberg Bavaria85579 Germany Ronquos 86 Sion1951 Switzerland

Recent developments and research in modern machine learning have led to substantial improvements in the geospatial field. Although numerous deep learning architectures and models have been proposed, the majority of them have been solely developed on benchmark datasets that lack strong real-world relevance. Furthermore, the performance of many methods has already saturated on these datasets. We argue that a shift from a model-centric view to a complementary data-centric perspective is necessary for further improvements in accuracy, generalization ability, and real impact on end-user applications. Furthermore, considering the entire machine learning cycle—from problem definition to model deployment with feedback—is crucial for enhancing machine learning models that can be reliable in unforeseen situations. This work presents a definition as well as a precise categorization and overview of automated data-centric learning approaches for geospatial data. It highlights the complementary role of data-centric learning with respect to model-centric in the larger machine learning deployment cycle. We review papers across the entire geospatial field and categorize them into different groups. A set of representative experiments shows concrete implementation examples. These examples provide concrete steps to act on geospatial data with data-centric machine learning approaches. © 2023, CC BY.

关键词： Adversarial machine learning

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Multiview feature selection combining latent space and similarity structure learning

引用

Pattern Recognition 2026年 169卷

作者： Zhuowen Li Hongmei Chen Tengyu Yin Zhong Yuan Chuan Luo Shi-Jinn Horng Tianrui Li School of Computing and Artificial Intelligence Southwest Jiaotong University Chengdu 611756 China National Engineering Laboratory of Integrated Transportation Big Data Application Technology Southwest Jiaotong University Chengdu 611756 China Engineering Research Center of Sustainable Urban Intelligent Transportation Ministry of Education Chengdu 611756 PR China Manufacturing Industry Chains Collaboration and Information Support Technology Key Laboratory of Sichuan Province Southwest Jiaotong University Chengdu 611756 PR China College of Computer Science Sichuan University Chengdu 610065 China Department of Computer Science and Information Engineering Asia University Taichung 41354 Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung 404327 Taiwan

Unsupervised multiview feature selection dependent on similar or clustering structures has dramatically progressed, but both ignore the mutually reinforcing relationship between structure learning. Firstly, the two methods of appeal ignore the possibility of shared joint learning, although they can learn coherent information. Secondly, they are inadequate for data structure learning and lack awareness of co-learning global and local structures. This paper proposes an unsupervised feature selection method (SCSF_FS) that integrates similarity and clustering structures learning to capture intrinsic information in data. Specifically, we use latent space learning to partition multiple data matrices into view-specific base matrices and clustering metrics. Structural learning is used to transform specific clustering metrics into coherent clustering structures. In addition, adaptive weights are used on each view’s similarity matrix to learn a consistent similarity structure, while laplacian graph learning is introduced to unify the similarity and clustering structures. Consequently, a unified framework is designed to unify multiview consistency learning, global structure, and local structure preservation. Moreover, an optimization iteration algorithm is designed to solve it. Comparison with eight algorithms shows the effectiveness of the proposed method.

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Enhancing Collaborative Inference on Heterogeneous Edge Devices via Adaptive Ensemble Knowledge Distillation

引用

IEEE Journal on Selected Areas in Communications 2025年

作者： Wu, Shangrui Li, Yupeng Wang, Wenhua Guo, Jianxiong Fan, Wentao Liu, Qin Jia, Weijia Yu, Shui Cao, Jiannong Wang, Tian Beijing Normal-Hong Kong Baptist University Guangdong Provincial/Zhuhai Key Laboratory of IRADS Department of Computer Science Zhuhai China Hong Kong Baptist University Hong Kong Hong Kong Hong Kong Baptist University Department of Interactive Media Hong Kong Hong Kong Beijing Normal University Institute of Artificial Intelligence and Future Networks Zhuhai China Xi'an University of Posts and Telecommunications Shaanxi Key Laboratory of Information Communication Network and Security Shaanxi Xi'an China Hunan University College of Computer Science and Electronic Engineering Changsha China University of Technology Sydney School of Computer Science Sydney Australia The Hong Kong Polytechnic University Department of Computing Hong Kong Hong Kong

The integration of edge computing with deep neural networks (DNNs) is crucial for intelligent industrial cyber-physical systems. Typically, deploying DNNs on heterogeneous edge devices relies on methods like model compression and partitioning. However, these approaches often result in homogeneous models across devices. This homogeneity limits the collective capability of edge computing systems, particularly in terms of generalization to diverse data distributions and adaptation to dynamic industrial environments. In this work, we propose to treat each DNN on an edge device as an independent model, aggregating their capabilities via ensemble learning to enhance generalization and dynamic adaptability. To realize this, we introduce the Adaptive Ensemble Knowledge Distillation Framework (AEKDF), combining cloud-based model training with edge computing based collaborative inference. In the cloud, AEKDF develops an enhanced Born Again Network that generates diverse, lightweight models tailored to specific edge devices through knowledge distillation. This process ensures model diversity which is critical to effective ensemble learning. On the edge, AEKDF employs an adaptive ensemble technique that aggregates prediction logits across devices, enabling rapid adaptation to changing environments and maintaining inference efficiency. Our extensive evaluations conducted on a realistic prototype demonstrate the substantial boost in predictive performance achieved by our AEKDF, showcasing a 4% to 10% accuracy improvement on the CIFAR-100 compared to conventional single-model approaches, while maintaining low latency. © 1983-2012 IEEE.

关键词： Deep neural networks

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Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study

引用

The Lancet Digital Health 2025年第5期7卷 100868页

作者： Meng, Ziyao Guan, Zhouyu Yu, Shujie Wu, Yilan Zhao, Yaoning Shen, Jie Lim, Cynthia Ciwei Chen, Tingli Yang, Dawei Ran, An Ran He, Feng Hamzah, Haslina Singh, Sarkaaj Abd Raof, Anis Syazwani Lee-Boey, Jian Wen Samuel Lim, Soo-Kun Sun, Xufang Ge, Shuwang Xu, Gang Su, Hua Cheng, Yang Lu, Feng Liao, Xiaofei Jin, Hai Deng, Chenxin Ruan, Lei Zhang, Cuntai Wu, Chan Dai, Rongping Jin, Yixiao Wang, Wenxiao Li, Tingyao Liu, Ruhan Li, Jiajia Shu, Jia Lu, Yuwei Wang, Xiangning Wu, Qiang Qin, Yiming Tang, Jin Sheng, Xiaohua Jiao, Qiong Yang, Xiaokang Guo, Minyi McKay, Gareth J Hogg, Ruth E Liew, Gerald Chee, Evelyn Yi Lyn Hsu, Wynne Lee, Mong Li Szeto, Simon Luk, Andrea O Y Chan, Juliana C N Cheung, Carol Y Tan, Gavin Siew Wei Tham, Yih-Chung Cheng, Ching-Yu Sabanayagam, Charumathi Lim, Lee-Ling Jia, Weiping Li, Huating Sheng, Bin Wong, Tien Yin Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Institute for Proactive Healthcare Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Centre for Diabetes Shanghai Key Laboratory of Diabetes Mellitus Shanghai China MOE Key Laboratory of AI School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Beijing Tsinghua Changgung Hospital Eye Center School of Clinical Medicine Tsinghua Medicine Tsinghua University Beijing China Medical Records and Statistics Office Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Renal Medicine Singapore General Hospital SingHealth-Duke Academic Medical Centre Singapore Singapore Department of Ophthalmology Shanghai Health and Medical Center Wuxi China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong Special Administrative Region China Singapore Eye Research Institute Singapore National Eye Centre Singapore Department of Medicine Faculty of Medicine Universiti Malaya Kuala Lumpur Malaysia Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Hubei Wuhan China Department of Nephrology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Nephrology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Ophthalmology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China National Engineering Research Centre for Big Dat

Background: Improving the accessibility of screening diabetic kidney disease (DKD) and differentiating isolated diabetic nephropathy from non-diabetic kidney disease (NDKD) are two major challenges in the field of diabetes care. We aimed to develop and validate an artificial intelligence (AI) deep learning system to detect DKD and isolated diabetic nephropathy from retinal fundus images. Methods: In this population-based study, we developed a retinal image-based AI-deep learning system, DeepDKD, pretrained using 734 084 retinal fundus images. First, for DKD detection, we used 486 312 retinal images from 121 578 participants in the Shanghai Integrated Diabetes Prevention and Care System for development and internal validation, and ten multi-ethnic datasets from China, Singapore, Malaysia, Australia, and the UK (65 406 participants) for external validation. Second, to differentiate isolated diabetic nephropathy from NDKD, we used 1068 retinal images from 267 participants for development and internal validation, and three multi-ethnic datasets from China, Malaysia, and the UK (244 participants) for external validation. Finally, we conducted two proof-of-concept studies: a prospective real-world study with 3 months' follow-up to evaluate the effectiveness of DeepDKD in screening DKD;and a longitudinal analysis of the effectiveness of DeepDKD in differentiating isolated diabetic nephropathy from NDKD on renal function changes with 4·6 years' follow-up. Findings: For detecting DKD, DeepDKD achieved an area under the receiver operating characteristic curve (AUC) of 0·842 (95% CI 0·838–0·846) on the internal validation dataset and AUCs of 0·791–0·826 across external validation datasets. For differentiating isolated diabetic nephropathy from NDKD, DeepDKD achieved an AUC of 0·906 (0·825–0·966) on the internal validation dataset and AUCs of 0·733–0·844 across external validation datasets. In the prospective study, compared with the metadata model, DeepDKD could detect DKD wit

关键词： Deep learning

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