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Predictable and precise template-free CRISPR editing of pathogenic variants (vol 563, pg 646, 2018)

NATURE 2019年第7746期567卷 E1-E2页

作者： Shen, Max W. Arbab, Mandana Hsu, Jonathan Y. Worstell, Daniel Culbertson, Sannie J. Krabbe, Olga Cassa, Christopher A. Liu, David R. Gifford, David K. Sherwood, Richard I. Computational and Systems Biology Program Massachusetts Institute of Technology Cambridge USA Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge USA Merkin Institute of Transformative Technologies in Healthcare Broad Institute of Harvard and MIT Cambridge USA Department of Chemistry and Chemical Biology Harvard University Cambridge USA Howard Hughes Medical Institute Harvard University Cambridge USA Department of Biological Engineering Massachusetts Institute of Technology Cambridge USA Molecular Pathology Unit Center for Cancer Research and Center for Computational and Integrative Biology Massachusetts General Hospital Charlestown USA Division of Genetics Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Boston USA Hubrecht Institute for Developmental Biology and Stem Cell Research Royal Netherlands Academy of Arts and Sciences (KNAW) Utrecht The Netherlands Broad Institute of MIT and Harvard Cambridge USA Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge USA

In this Article, a data processing error affected Fig. 3e and Extended Data Table 2; these errors have been corrected online.

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First polarisation measurement of coherently photoproduced J/ψ in ultra-peripheral Pb–Pb collisions at s_NN=5.02 TeV

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Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics 2025年 865卷

作者： Acharya, S. Adamová, D. Adler, A. Aglieri Rinella, G. Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. Ahn, S.U. Ahuja, I. Akindinov, A. Al-Turany, M. Aleksandrov, D. Alessandro, B. Alfanda, H.M. Alfaro Molina, R. Ali, B. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alocco, G. Alt, T. Altsybeev, I. Alvarado, J.R. Anaam, M.N. Andrei, C. Andronic, A. Anguelov, V. Antinori, F. Antonioli, P. Apadula, N. Aphecetche, L. Appelshäuser, H. Arata, C. Arcelli, S. Aresti, M. Arnaldi, R. Arneiro, J.G.M.C.A. Arsene, I.C. Arslandok, M. Augustinus, A. Averbeck, R. Azmi, M.D. Badalà, A. Bae, J. Baek, Y.W. Bai, X. Bailhache, R. Bailung, Y. Balbino, A. Baldisseri, A. Balis, B. Banerjee, D. Banoo, Z. Barbera, R. Barile, F. Barioglio, L. Barlou, M. Barnaföldi, G.G. Barnby, L.S. Barret, V. Barreto, L. Bartels, C. Barth, K. Bartsch, E. Bastid, N. Basu, S. Batigne, G. Battistini, D. Batyunya, B. Bauri, D. Bazo Alba, J.L. Bearden, I.G. Beattie, C. Becht, P. Behera, D. Belikov, I. Bell Hechavarria, A.D.C. Bellini, F. Bellwied, R. Belokurova, S. Belyaev, V. Bencedi, G. Beole, S. Bercuci, A. Berdnikov, Y. Berdnikova, A. Bergmann, L. Besoiu, M.G. Betev, L. Bhaduri, P.P. Bhasin, A. Bhat, M.A. Bhattacharjee, B. Bianchi, L. Bianchi, N. Bielčík, J. Bielčíková, J. Biernat, J. Bigot, A.P. Bilandzic, A. Biro, G. Biswas, S. Bize, N. Blair, J.T. Blau, D. Blidaru, M.B. Bluhme, N. Blume, C. Boca, G. Bock, F. Bodova, T. Bogdanov, A. Boi, S. Bok, J. Boldizsár, L. Bombara, M. Bond, P.M. Bonomi, G. Borel, H. Borissov, A. Borquez Carcamo, A.G. Bossi, H. Botta, E. Bouziani, Y.E.M. Bratrud, L. Braun-Munzinger, P. Bregant, M. Broz, M. Bruno, G.E. Buckland, M.D. Budnikov, D. Buesching, H. Bufalino, S. Buhler, P. Buthelezi, Z. Bylinkin, A. Bysiak, S.A. Cai, M. Caines, H. Caliva, A. Calvo Villar, E. Camacho, J.M.M. Camerini, P. Canedo, F.D.M. Cantway, S.L. Carabas, M. Carballo, A.A. Carnesecchi, F. Caron, R. Carvalho, L.A.D. Castillo Castellanos, J. Catalano, F. Ceballos Sanchez, C. Chakaberia, I. Chakraborty, P. Chandra, S. Chapeland, S. Chartier, M. Chattopa A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation Yerevan Armenia AGH University of Krakow Cracow Poland Bogolyubov Institute for Theoretical Physics National Academy of Sciences of Ukraine Kiev Ukraine Bose Institute Department of Physics Centre for Astroparticle Physics and Space Science (CAPSS) Kolkata India California Polytechnic State University San Luis Obispo CA United States Central China Normal University Wuhan China Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN) Havana Cuba Centro de Investigación y de Estudios Avanzados (CINVESTAV) Mexico City and Mérida Mexico Chicago State University Chicago IL United States China Institute of Atomic Energy Beijing China Chungbuk National University Cheongju South Korea Comenius University Bratislava Faculty of Mathematics Physics and Informatics Bratislava Slovakia COMSATS University Islamabad Islamabad Pakistan Creighton University Omaha NE United States Department of Physics Aligarh Muslim University Aligarh India Department of Physics Pusan National University Pusan South Korea Department of Physics Sejong University Seoul South Korea Department of Physics University of California Berkeley CA United States Department of Physics University of Oslo Oslo Norway Department of Physics and Technology University of Bergen Bergen Norway Dipartimento di Fisica Università di Pavia Pavia Italy Dipartimento di Fisica dell'Università Sezione INFN Cagliari Italy Dipartimento di Fisica dell'Università Sezione INFN Trieste Italy Dipartimento di Fisica dell'Università Sezione INFN Turin Italy Dipartimento di Fisica e Astronomia dell'Università Sezione INFN Bologna Italy Dipartimento di Fisica e Astronomia dell'Università Sezione INFN Catania Italy Dipartimento di Fisica e Astronomia dell'Università Sezione INFN Padova Italy Dipartimento di Fisica ‘E.R. Caianiello’ dell'Università Gruppo Collegato INFN Salerno Italy Dipartimento DISAT del Politecnico

The first measurement of the polarisation of coherently photoproduced J/ψ mesons in ultra-peripheral Pb–Pb collisions, using data at sNN=5.02 TeV, is presented. The J/ψ meson is measured via its dimuon decay channe...

The first measurement of the polarisation of coherently photoproduced J/ψ mesons in ultra-peripheral Pb–Pb collisions, using data at s_NN=5.02 TeV, is presented. The J/ψ meson is measured via its dimuon decay channel in the forward rapidity interval −4.0−1 ± 5% (syst) is analysed. Hadronic activity is highly suppressed since the interaction is mediated by a photon. The polar and azimuthal angle distributions of the decay muons are measured, and the polarisation parameters λ_θ, λ_φ, λ_θφ are extracted. The analysis is carried out in the helicity frame. The results are found to be consistent with a transversely polarised J/ψ. These values are compared with previous measurements by the H1 and ZEUS experiments. The polarisation parameters of coherent J/ψ photoproduction in Pb–Pb collisions are found to be consistent with the s-channel helicity conservation hypothesis. © 2025 CERN for the benefit of the ALICE Collaboration

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The eROSITA Final Equatorial-Depth Survey (eFEDS): Catalog of galaxy clusters and groups

arXiv

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arXiv 2021年

作者： Liu, Ang Bulbul, E. Ghirardini, V. Liu, T. Klein, M. Clerc, N. Özsoy, Y. Ramos-Ceja, M.E. Pacaud, F. Comparat, J. Okabe, N. Bahar, Y.E. Biffi, V. Brunner, H. Brüggen, M. Buchner, J. Ider Chitham, J. Chiu, I. Dolag, K. Gatuzz, E. Gonzalez, J. Hoang, D.N. Lamer, G. Merloni, A. Nandra, K. Oguri, M. Ota, N. Predehl, P. Reiprich, T.H. Salvato, M. Schrabback, T. Sanders, J.S. Seppi, R. Thibaud, Q. Max Planck Institute for Extraterrestrial Physics Giessenbachstrasse 1 Garching85748 Germany Universitaets-Sternwarte Muenchen Fakultaet fuer Physik LMU Munich Scheinerstr. 1 Munich81679 Germany IRAP Université de Toulouse CNRS UPS CNES Toulouse France Universität Bonn Auf dem Hügel 71 Bonn53121 Germany Physics Program Graduate School of Advanced Science and Engineering Hiroshima University 1-3-1 Kagamiyama Hiroshima Higashi-Hiroshima739-8526 Japan Hiroshima Astrophysical Science Center Hiroshima University 1-3-1 Kagamiyama Hiroshima Higashi-Hiroshima739-8526 Japan Core Research for Energetic Universe Hiroshima University 1-3-1 Kagamiyama Hiroshima Higashi-Hiroshima739-8526 Japan INAF - Osservatorio Astronomico di Trieste via Tiepolo 11 TriesteI-34143 Italy IFPU - Institute for Fundamental Physics of the Universe Via Beirut 2 TriesteI-34014 Italy University of Hamburg Hamburger Sternwarte Gojenbergsweg 112 Hamburg21029 Germany Tsung-Dao Lee Institute Key Laboratory for Particle Physics Astrophysics and Cosmology Ministry of Education Shanghai Jiao Tong University Shanghai200240 China Department of Astronomy School of Physics and Astronomy Shanghai Key Laboratory for Particle Physics and Cosmology Shanghai Jiao Tong University Shanghai200240 China 11F of AS/NTU Astronomy-Mathematics Building No.1 Sec. 4 Roosevelt Rd Taipei10617 Taiwan An der Sternwarte 16 Potsdam14482 Germany Research Center for the Early Universe The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Department of Physics The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan The University of Tokyo 5-1-5 Kashiwanoha Chiba Kashiwa277-8582 Japan Department of Physics Nara Women's University Kitauoyanishimachi Nara630-8506 Japan

Aims. The eROSITA Final Equatorial-Depth Survey has been carried out during the performance verification phase of the Spectrum-Roentgen-Gamma/eROSITA telescope and was completed in November 2019. This survey is designed to provide the first eROSITA-selected sample of clusters and groups and to test the predictions for the all-sky survey in the context of cosmological studies with clusters of galaxies. Methods. In the area of ∼140 square degrees covered by eFEDS, 542 candidate clusters and groups of galaxies were detected as extended X-ray sources with the eSASS source detection algorithm. We performed imaging and spectral analysis of the 542 cluster candidates with eROSITA X-ray data and studied the properties of the sample. Results. We provide the catalog of candidate galaxy clusters and groups detected by eROSITA in the eFEDS field down to a flux of ∼ 10−14 erg s−1 cm−2 in the soft band (0.5-2 keV) within 10. The clusters are distributed in the redshift range z =[0.01, 1.3] with a median redshift zmedian = 0.35. With eROSITA X-ray data, we measured the temperature of the intracluster medium within two radii, 300 kpc and 500 kpc, and constrained the temperature with > 2σ confidence level for ∼ 1/5 (102 out of 542) of the sample. The average temperature of these clusters is ∼2 keV. Radial profiles of flux, luminosity, electron density, and gas mass were measured from the precise modeling of the imaging data. The selection function, the purity, and the completeness of the catalog are examined and discussed in detail. The contamination fraction is ∼ 1/5 in this sample and is dominated by misidentified point sources. The X-ray luminosity function of the clusters agrees well with the results obtained from other recent X-ray surveys. We also find 19 supercluster candidates in this field, most of which are located at redshifts between 0.1 and 0.5, including one cluster at z ∼ 0.36 that was presented previously. Conclusions. The eFEDS cluster and group catalog at the final

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Correction: New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms and therapeutic opportunities

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Experimental hematology & oncology 2022年第1期11卷 106页

作者： Mengyuan Dai Miao Liu Hua Yang Can Küçük Hua You Laboratory for Excellence in Systems Biomedicine of Pediatric Oncology Department of Hematology and Oncology Pediatric Research Institute Chongqing Key Laboratory of Pediatrics Ministry of Education Key Laboratory of Child Development and Disorders International Science and Technology Cooperation Base of Child Development and Critical Disorders National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical University 136 Zhongshan Second Road Yuzhong District Chongqing 401122 China. Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston USA. Department of Basic Medicine and Biomedical Engineering School of Medical Foshan University Foshan China. İzmir International Biomedicine and Genome Institute Dokuz Eylül University İzmir Türkiye. Basic and Translational Research Program İzmir Biomedicine and Genome Center İzmir Türkiye. Department of Medical Biology Faculty of Medicine Dokuz Eylül University İzmir Türkiye. Laboratory for Excellence in Systems Biomedicine of Pediatric Oncology Department of Hematology and Oncology Pediatric Research Institute Chongqing Key Laboratory of Pediatrics Ministry of Education Key Laboratory of Child Development and Disorders International Science and Technology Cooperation Base of Child Development and Critical Disorders National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical University 136 Zhongshan Second Road Yuzhong District Chongqing 401122 China. youhua307@***.

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Identified charged-hadron production in p+Al, He3+Au, and Cu+Au collisions at sNN=200GeV and in U+U collisions at sNN=193GeV

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Physical Review C 2024年第5期109卷 054910-054910页

作者： N. J. Abdulameer U. Acharya A. Adare C. Aidala N. N. Ajitanand Y. Akiba R. Akimoto J. Alexander M. Alfred V. Andrieux K. Aoki N. Apadula H. Asano E. T. Atomssa T. C. Awes B. Azmoun V. Babintsev M. Bai X. Bai N. S. Bandara B. Bannier K. N. Barish S. Bathe V. Baublis C. Baumann S. Baumgart A. Bazilevsky M. Beaumier S. Beckman R. Belmont A. Berdnikov Y. Berdnikov L. Bichon D. Black B. Blankenship D. S. Blau J. S. Bok V. Borisov K. Boyle M. L. Brooks J. Bryslawskyj H. Buesching V. Bumazhnov S. Butsyk S. Campbell V. Canoa Roman R. Cervantes C.-H. Chen D. Chen M. Chiu C. Y. Chi I. J. Choi J. B. Choi S. Choi P. Christiansen T. Chujo V. Cianciolo Z. Citron B. A. Cole M. Connors R. Corliss Y. Corrales Morales N. Cronin N. Crossette M. Csanád T. Csörgő L. D'Orazio T. W. Danley A. Datta M. S. Daugherity G. David C. T. Dean K. DeBlasio K. Dehmelt A. Denisov A. Deshpande E. J. Desmond L. Ding A. Dion P. B. Diss D. Dixit V. Doomra J. H. Do O. Drapier A. Drees K. A. Drees J. M. Durham A. Durum H. En'yo T. Engelmore A. Enokizono R. Esha K. O. Eyser B. Fadem W. Fan N. Feege D. E. Fields M. Finger, Jr. M. Finger D. Firak D. Fitzgerald F. Fleuret S. L. Fokin J. E. Frantz A. Franz A. D. Frawley Y. Fukao Y. Fukuda T. Fusayasu K. Gainey P. Gallus C. Gal P. Garg A. Garishvili I. Garishvili H. Ge M. Giles F. Giordano A. Glenn X. Gong M. Gonin Y. Goto R. Granier de Cassagnac N. Grau S. V. Greene M. Grosse Perdekamp Y. Gu T. Gunji T. Guo H. Guragain T. Hachiya J. S. Haggerty K. I. Hahn H. Hamagaki H. F. Hamilton J. Hanks S. Y. Han M. Harvey S. Hasegawa T. O. S. Haseler K. Hashimoto R. Hayano T. K. Hemmick T. Hester X. He J. C. Hill K. Hill A. Hodges R. S. Hollis K. Homma B. Hong T. Hoshino N. Hotvedt J. Huang T. Ichihara Y. Ikeda K. Imai Y. Imazu M. Inaba A. Iordanova D. Isenhower A. Isinhue D. Ivanishchev B. V. Jacak S. J. Jeon M. Jezghani X. Jiang Z. Ji B. M. Johnson K. S. Joo D. Jouan D. S. Jumper J. Kamin S. Kanda B. H. Kang J. H. Kang J. S. Kang D. Kapukchyan J. Kapustinsky S. Karthas D. Kawall A. V. Kazantsev J. A. Key V. Khachatrya Debrecen University H-4010 Debrecen Egyetem tér 1 Hungary Georgia State University Atlanta Georgia 30303 USA University of Colorado Boulder Colorado 80309 USA Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Department of Physics University of Michigan Ann Arbor Michigan 48109 USA Chemistry Department State University of New York at Stony Brook Stony Brook New York 11794 USA RIKEN Nishina Center for Accelerator-Based Science Wako Saitama 351-0198 Japan RIKEN BNL Research Center Brookhaven National Laboratory Upton New York 11973 USA Center for Nuclear Study Graduate School of Science University of Tokyo 7-3-1 Hongo Bunkyo Tokyo 113-0033 Japan Department of Physics and Astronomy Howard University Washington DC 20059 USA KEK High Energy Accelerator Research Organization Tsukuba Ibaraki 305-0801 Japan Iowa State University Ames Iowa 50011 USA Department of Physics and Astronomy State University of New York at Stony Brook Stony Brook New York 11794 USA Kyoto University Kyoto 606-8502 Japan Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA Physics Department Brookhaven National Laboratory Upton New York 11973 USA IHEP Protvino State Research Center of Russian Federation Institute for High Energy Physics Protvino 142281 Russia Collider-Accelerator Department Brookhaven National Laboratory Upton New York 11973 USA Science and Technology on Nuclear Data Laboratory China Institute of Atomic Energy Beijing 102413 People's Republic of China Department of Physics University of Massachusetts Amherst Massachusetts 01003 USA University of California-Riverside Riverside California 92521 USA Baruch College City University of New York New York New York 10010 USA Petersburg Nuclear Physics Institute Gatchina Leningrad Region 188300 Russia Physics and Astronomy Department University of North Carolina at Greensboro Greensboro North Carolina 27412 USA Vanderbilt University Nashville Tennessee 37235 USA Saint Petersburg Stat

The PHENIX experiment has performed a systematic study of identified charged-hadron (π±, K±, p, p¯) production at midrapidity in p+Al, He3+Au, and Cu+Au collisions at sNN=200GeV and U+U collisions at sNN=193GeV. Identified charged-hadron invariant transverse-momentum (pT) and transverse-mass (mT) spectra are presented and interpreted in terms of radially expanding thermalized systems. The particle ratios of K/π and p/π have been measured in different centrality ranges of large (Cu+Au and U+U) and small (p+Al and He3+Au) collision systems. The values of K/π ratios measured in all considered collision systems were found to be consistent with those measured in p+p collisions. However, the values of p/π ratios measured in large collision systems reach the values of ≈0.6, which is a factor of ≈2 larger than in p+p collisions. These results can be qualitatively understood in terms of the baryon enhancement expected from hadronization by recombination. Identified charged-hadron nuclear-modification factors (RAB) are also presented. Enhancement of proton RAB values over meson RAB values was observed in central He3+Au, Cu+Au, and U+U collisions. The proton RAB values measured in the p+Al collision system were found to be consistent with RAB values of ϕ, π±, K±, and π0 mesons, which may indicate that the size of the system produced in p+Al collisions is too small for recombination to cause a noticeable increase in proton production.

关键词： Hadron production Relativistic heavy-ion collisions Hadrons Kaons Pions Protons

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The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia program

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Schizophrenia 2025年第1期11卷 1-14页

作者： Harms, Michael P. Cho, Kang-Ik K. Anticevic, Alan Bolo, Nicolas R. Bouix, Sylvain Campbell, Dylan Cannon, Tyrone D. Cecchi, Guillermo Goncalves, Mathias Haidar, Anastasia Hughes, Dylan E. Izyurov, Igor John, Omar Kapur, Tina Kim, Nicholas Kotler, Elana Kubicki, Marek Kuperman, Joshua M. Laulette, Kristen Lindberg, Ulrich Markiewicz, Christopher Ning, Lipeng Poldrack, Russell A. Rathi, Yogesh Romo, Paul A. Tamayo, Zailyn Wannan, Cassandra Wickham, Alana Yassin, Walid Zhou, Juan Helen Addington, Jean Alameda, Luis Arango, Celso Breitborde, Nicholas J. K. Broome, Matthew R. Cadenhead, Kristin S. Calkins, Monica E. Chen, Eric Yu Hai Choi, Jimmy Conus, Philippe Corcoran, Cheryl M. Cornblatt, Barbara A. Diaz-Caneja, Covadonga M. Ellman, Lauren M. Fusar-Poli, Paolo Gaspar, Pablo A. Gerber, Carla Glenthøj, Louise Birkedal Horton, Leslie E. Hui, Christy Lai Ming Kambeitz, Joseph Kambeitz-Ilankovic, Lana Keshavan, Matcheri S. Kim, Sung-Wan Koutsouleris, Nikolaos Kwon, Jun Soo Langbein, Kerstin Mamah, Daniel Mathalon, Daniel H. Mittal, Vijay A. Nordentoft, Merete Pearlson, Godfrey D. Perez, Jesus Perkins, Diana O. Powers, Albert R. Rogers, Jack Sabb, Fred W. Schiffman, Jason Shah, Jai L. Silverstein, Steven M. Smesny, Stefan Stone, William S. Strauss, Gregory P. Thompson, Judy L. Upthegrove, Rachel Verma, Swapna K. Wang, Jijun Wolf, Daniel H. Kahn, Rene S. Kane, John M. McGorry, Patrick D. Nelson, Barnaby Woods, Scott W. Shenton, Martha E. Wood, Stephen J. Bearden, Carrie E. Pasternak, Ofer Department of Psychiatry Washington University School of Medicine St. Louis MO United States Department of Psychiatry Brigham and Women’s Hospital Harvard Medical School Boston MA United States Department of Psychiatry Yale University School of Medicine New Haven CT United States Department of Psychiatry Beth Israel Deaconess Medical Center Harvard Medical School Boston MA United States Department of Software Engineering and Information Technology École de technologie supérieure Montréal QC Canada Department of Psychology Yale University New Haven CT United States T.J. Watson Research Laboratory IBM Research Yorktown Heights NY United States Department of Psychology Stanford University Stanford CA United States Department of Psychology University of California Los Angeles CA United States Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany Massachusetts General Hospital Harvard Medical School Boston MA United States Department of Radiology Brigham and Women’s Hospital Harvard Medical School Boston MA United States Department of Radiology University of California San Diego CA United States Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital - Rigshospitalet Glostrup Denmark Seaman Family MR Research Centre Calgary AB Canada Orygen Parkville VIC Australia Centre for Sleep and Cognition and Centre for Translational MR Research Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Department of Psychiatry Hotchkiss Brain Institute University of Calgary Calgary AB Canada General Psychiatry Service Treatment and Early Intervention in Psychosis Program Lausanne University Hospital and University of Lausanne Lausanne Switzerland Department of Child and Adolescent Psychiatry Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón Instituto de Salud Carlos III School of Medicine Universidad Complutense Madrid Spain

Neuroimaging with MRI has been a frequent component of studies of individuals at clinical high risk (CHR) for developing psychosis, with goals of understanding potential brain regions and systems impacted in the CHR state and identifying prognostic or predictive biomarkers that can enhance our ability to forecast clinical outcomes. To date, most studies involving MRI in CHR are likely not sufficiently powered to generate robust and generalizable neuroimaging results. Here, we describe the prospective, advanced, and modern neuroimaging protocol that was implemented in a complex multi-site, multi-vendor environment, as part of the large-scale Accelerating Medicines Partnership® Schizophrenia program (AMP® SCZ), including the rationale for various choices. This protocol includes T1- and T2-weighted structural scans, resting-state fMRI, and diffusion-weighted imaging collected at two time points, approximately 2 months apart. We also present preliminary variance component analyses of several measures, such as signal- and contrast-to-noise ratio (SNR/CNR) and spatial smoothness, to provide quantitative data on the relative percentages of participant, site, and platform (i.e., scanner model) variance. Site-related variance is generally small (typically <10%). For the SNR/CNR measures from the structural and fMRI scans, participant variance is the largest component (as desired;40–76%). However, for SNR/CNR in the diffusion scans, there is substantial platform-related variance (>55%) due to differences in the diffusion imaging hardware capabilities of the different scanners. Also, spatial smoothness generally has a large platform-related variance due to inherent, difficult to control, differences between vendors in their acquisitions and reconstructions. These results illustrate some of the factors that will need to be considered in analyses of the AMP SCZ neuroimaging data, which will be the largest CHR cohort to date. Watch Dr. Harms discuss this article at https://vimeo.

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Charm- and bottom-quark production in Au+Au collisions at sNN=200 GeV

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Physical Review C 2024年第4期109卷 044907-044907页

作者： N. J. Abdulameer U. Acharya A. Adare C. Aidala N. N. Ajitanand Y. Akiba M. Alfred N. Apadula H. Asano B. Azmoun V. Babintsev M. Bai N. S. Bandara B. Bannier K. N. Barish S. Bathe A. Bazilevsky M. Beaumier S. Beckman R. Belmont A. Berdnikov Y. Berdnikov L. Bichon B. Blankenship D. S. Blau J. S. Bok V. Borisov K. Boyle M. L. Brooks J. Bryslawskyj V. Bumazhnov S. Campbell V. Canoa Roman C.-H. Chen M. Chiu C. Y. Chi I. J. Choi J. B. Choi T. Chujo Z. Citron M. Connors R. Corliss Y. Corrales Morales M. Csanád T. Csörgő T. W. Danley A. Datta M. S. Daugherity G. David C. T. Dean K. DeBlasio K. Dehmelt A. Denisov A. Deshpande E. J. Desmond A. Dion P. B. Diss J. H. Do V. Doomra A. Drees K. A. Drees J. M. Durham A. Durum A. Enokizono R. Esha B. Fadem W. Fan N. Feege D. E. Fields M. Finger, Jr. M. Finger D. Firak D. Fitzgerald S. L. Fokin J. E. Frantz A. Franz A. D. Frawley P. Gallus C. Gal P. Garg H. Ge M. Giles F. Giordano A. Glenn Y. Goto N. Grau S. V. Greene M. Grosse Perdekamp T. Gunji T. Hachiya J. S. Haggerty K. I. Hahn H. Hamagaki H. F. Hamilton J. Hanks S. Y. Han M. Harvey S. Hasegawa T. O. S. Haseler K. Hashimoto T. K. Hemmick X. He J. C. Hill A. Hodges R. S. Hollis K. Homma B. Hong T. Hoshino N. Hotvedt J. Huang K. Imai M. Inaba A. Iordanova D. Isenhower D. Ivanishchev B. V. Jacak M. Jezghani X. Jiang Z. Ji B. M. Johnson D. Jouan D. S. Jumper S. Kanda J. H. Kang D. Kawall A. V. Kazantsev J. A. Key V. Khachatryan A. Khanzadeev A. Khatiwada B. Kimelman C. Kim D. J. Kim E.-J. Kim G. W. Kim M. Kim T. Kim D. Kincses A. Kingan E. Kistenev R. Kitamura J. Klatsky D. Kleinjan P. Kline T. Koblesky B. Komkov D. Kotov L. Kovacs B. Kurgyis K. Kurita M. Kurosawa Y. Kwon J. G. Lajoie D. Larionova A. Lebedev S. Lee S. H. Lee M. J. Leitch N. A. Lewis S. H. Lim M. X. Liu X. Li D. A. Loomis D. Lynch S. Lökös T. Majoros Y. I. Makdisi M. Makek A. Manion V. I. Manko E. Mannel M. McCumber P. L. McGaughey D. McGlinchey C. McKinney A. Meles M. Mendoza A. C. Mignerey A. Milov D. K. Mishra J. T. Mitchell M. Mitrankova Iu. Mitrankov S. Miyas Debrecen University H-4010 Debrecen Egyetem tér 1 Hungary Georgia State University Atlanta Georgia 30303 USA University of Colorado Boulder Colorado 80309 USA Department of Physics University of Michigan Ann Arbor Michigan 48109-1040 USA Chemistry Department Stony Brook University SUNY Stony Brook New York 11794-3400 USA RIKEN Nishina Center for Accelerator-Based Science Wako Saitama 351-0198 Japan RIKEN BNL Research Center Brookhaven National Laboratory Upton New York 11973-5000 USA Department of Physics and Astronomy Howard University Washington DC 20059 USA Iowa State University Ames Iowa 50011 USA Department of Physics and Astronomy Stony Brook University SUNY Stony Brook New York 11794-3800 USA Kyoto University Kyoto 606-8502 Japan Physics Department Brookhaven National Laboratory Upton New York 11973-5000 USA IHEP Protvino State Research Center of Russian Federation Institute for High Energy Physics Protvino 142281 Russia Collider-Accelerator Department Brookhaven National Laboratory Upton New York 11973-5000 USA Department of Physics University of Massachusetts Amherst Massachusetts 01003-9337 USA University of California-Riverside Riverside California 92521 USA Baruch College City University of New York New York New York 10010 USA Physics and Astronomy Department University of North Carolina at Greensboro Greensboro North Carolina 27412 USA Saint Petersburg State Polytechnic University St. Petersburg 195251 Russia Vanderbilt University Nashville Tennessee 37235 USA National Research Center “Kurchatov Institute” Moscow 123098 Russia National Research Nuclear University MEPhI Moscow Engineering Physics Institute Moscow 115409 Russia New Mexico State University Las Cruces New Mexico 88003 USA Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Columbia University New York New York 10027 and Nevis Laboratories Irvington New York 10533 USA University of Illinois at Urbana-Champaign Urbana Illinois 61801 USA Je

The invariant yield of electrons from open-heavy-flavor decays for 1<pT<8 GeV/c at midrapidity |y|<0.35 in Au+Au collisions at sNN = 200 GeV has been measured by the PHENIX experiment at the BNL Relativistic ... 详细信息

The invariant yield of electrons from open-heavy-flavor decays for 1

关键词： Hadronic decays Jets & heavy flavor physics Particle & resonance production Bottom quark Charm quark Hadron colliders

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Correction to: Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2

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BMC infectious diseases 2021年第1期21卷 628页

作者： Bianca A Trombetta Savannah E Kandigian Robert R Kitchen Korneel Grauwet Pia Kivisäkk Webb Glenn A Miller Charles G Jennings Sejal Jain Samara Miller Yikai Kuo Thadryan Sweeney Tal Gilboa Maia Norman Daimon P Simmons Christopher E Ramirez Melissa Bedard Catherine Fink Jina Ko Esmarline J De León Peralta Gerald Watts Emma Gomez-Rivas Vannessa Davis Rocky M Barilla Jianing Wang Pierre Cunin Samuel Bates Chevaun Morrison-Smith Benjamin Nicholson Edmond Wong Leena El-Mufti Michael Kann Anna Bolling Brooke Fortin Hayden Ventresca Wen Zhou Santiago Pardo Megan Kwock Aditi Hazra Leo Cheng Q Rushdy Ahmad James A Toombs Rebecca Larson Haley Pleskow Nell Meosky Luo Christina Samaha Unnati M Pandya Pushpamali De Silva Sally Zhou Zakary Ganhadeiro Sara Yohannes Rakiesha Gay Jacqueline Slavik Shibani S Mukerji Petr Jarolim David R Walt Becky C Carlyle Lauren L Ritterhouse Sara Suliman Department of Neurology Massachusetts General Hospital Harvard Medical School Charlestown Boston MA USA. Department of Medicine Harvard Medical School Boston MA USA. Mass General Brigham Innovation Boston MA USA. Cardiology Division Massachusetts General Hospital Charlestown MA USA. Department of Neurosurgery Brigham and Women's Hospital Harvard Medical School Boston MA USA. Department of Medical Oncology and Center for Cancer-Genome Discovery Dana-Farber Cancer Institute Boston MA USA. Department of Pathology Harvard Medical School Boston MA USA. Center for Regenerative Medicine Massachusetts General Hospital Boston MA USA. Harvard Stem Cell Institute Cambridge MA USA. Department of Psychiatry Massachusetts General Hospital Boston MA USA. Wyss Institute for Biologically Inspired Engineering Harvard University Boston MA USA. Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA USA. Sackler School of Biomedical Sciences Tufts University School of Medicine Boston MA USA. Division of Rheumatology Inflammation and Immunity Brigham and Women's Hospital Boston MA USA. Medical Diagnostic Technology Evaluation LLC Carlisle MA USA. Center for Systems Biology Massachusetts General Hospital Boston MA USA. Department of Pathology Massachusetts General Hospital Boston MA USA. Wellman Center for Photomedicine Massachusetts General Research Institute Boston MA USA. Department of Dermatology Massachusetts General Hospital Boston MA USA. Evergrande Center for Immunologic Diseases Brigham and Women's Hospital Boston MA USA. Cardiovascular Division Department of Medicine Brigham and Women's Hospital Boston MA USA. Functional Genomics Laboratory Channing Division of Network Medicine Brigham and Women's Hospital Boston MA USA. Center for Cancer Research Massachusetts General Hospital Harvard Medical School Charlestown MA USA. Division of Nephrology and Endocrine Unit Department of Medicine Massachusetts

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Multimuons in cosmic-ray events as seen in ALICE at the LHC

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Journal of Cosmology and Astroparticle Physics 2025年第4期2025卷 009-009页

作者： Acharya, S. Agarwal, A. Aglieri Rinella, G. Aglietta, L. Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. Ahn, S.U. Ahuja, I. Akindinov, A. Akishina, V. Al-Turany, M. Aleksandrov, D. Alessandro, B. Alfanda, H.M. Alfaro Molina, R. Ali, B. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alocco, G. Alt, T. Altamura, A.R. Altsybeev, I. Alvarado, J.R. Alvarez, C.O.R. Anaam, M.N. Andrei, C. Andreou, N. Andronic, A. Andronov, E. Anguelov, V. Antinori, F. Antonioli, P. Apadula, N. Aphecetche, L. Appelshäuser, H. Arata, C. Arcelli, S. Arnaldi, R. Arneiro, J.G.M.C.A. Arsene, I.C. Arslandok, M. Augustinus, A. Averbeck, R. Averyanov, D. Azmi, M.D. Baba, H. Badalà, A. Bae, J. Bae, Y. Baek, Y.W. Bai, X. Bailhache, R. Bailung, Y. Bala, R. Balbino, A. Baldisseri, A. Balis, B. Banoo, Z. Barbasova, V. Barile, F. Barioglio, L. Barlou, M. Barman, B. Barnaföldi, G.G. Barnby, L.S. Barreau, E. Barret, V. Barreto, L. Bartels, C. Barth, K. Bartsch, E. Bastid, N. Basu, S. Batigne, G. Battistini, D. Batyunya, B. Bauri, D. Bazo Alba, J.L. Bearden, I.G. Beattie, C. Becht, P. Behera, D. Belikov, I. Bell Hechavarria, A.D.C. Bellini, F. Bellwied, R. Belokurova, S. Beltran, L.G.E. Beltran, Y.A.V. Bencedi, G. Bensaoula, A. Beole, S. Berdnikov, Y. Berdnikova, A. Bergmann, L. Besoiu, M.G. Betev, L. Bhaduri, P.P. Bhasin, A. Bhattacharjee, B. Bianchi, L. Bielčík, J. Bielčíková, J. Bigot, A.P. Bilandzic, A. Biro, G. Biswas, S. Bize, N. Blair, J.T. Blau, D. Blidaru, M.B. Bluhme, N. Blume, C. Bock, F. Bodova, T. Bok, J. Boldizsár, L. Bombara, M. Bond, P.M. Bonomi, G. Borel, H. Borissov, A. Borquez Carcamo, A.G. Botta, E. Bouziani, Y.E.M. Bratrud, L. Braun-Munzinger, P. Bregant, M. Broz, M. Bruno, G.E. Buchakchiev, V.D. Buckland, M.D. Budnikov, D. Buesching, H. Bufalino, S. Buhler, P. Burmasov, N. Buthelezi, Z. Bylinkin, A. Bysiak, S.A. Cabanillas Noris, J.C. Cabrera, M.F.T. Caines, H. Caliva, A. Calvo Villar, E. Camacho, J.M.M. Camerini, P. Canedo, F.D.M. Cantway, S.L. Carabas, M. Carballo, A.A. Carnesecchi, F. Caron, R. Carvalho, L.A.D. Castillo Castel A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation Yerevan Armenia AGH University of Krakow Cracow Poland Bogolyubov Institute for Theoretical Physics National Academy of Sciences of Ukraine Kiev Ukraine Bose Institute Department of Physics Centre for Astroparticle Physics and Space Science (CAPSS) Kolkata India California Polytechnic State University San Luis Obispo CA United States Central China Normal University Wuhan China Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN) Havana Cuba Centro de Investigación y de Estudios Avanzados (CINVESTAV) Mérida Mexico City Mexico Chicago State University Chicago IL United States China Institute of Atomic Energy Beijing China China University of Geosciences Wuhan China Chungbuk National University Cheongju South Korea Comenius University Bratislava Faculty of Mathematics Physics and Informatics Bratislava Slovakia Creighton University Omaha NE United States Department of Physics Aligarh Muslim University Aligarh India Department of Physics Pusan National University Pusan South Korea Department of Physics Sejong University Seoul South Korea Department of Physics University of California Berkeley CA United States Department of Physics University of Oslo Oslo Norway Department of Physics and Technology University of Bergen Bergen Norway Dipartimento di Fisica Università di Pavia Pavia Italy Dipartimento di Fisica dell’Università Sezione INFN Cagliari Italy Dipartimento di Fisica dell’Università Sezione INFN Trieste Italy Dipartimento di Fisica dell’Università Sezione INFN Turin Italy Dipartimento di Fisica e Astronomia dell’Università Sezione INFN Bologna Italy Dipartimento di Fisica e Astronomia dell’Università Sezione INFN Catania Italy Dipartimento di Fisica e Astronomia dell’Università Sezione INFN Padova Italy Dipartimento di Fisica ‘E.R. Caianiello’ dell’Università Gruppo Collegato INFN Salerno Italy Dipartimento DISAT del Politecnico Sezione

ALICE is a large experiment at the CERN Large Hadron Collider. Located 52 meters underground, its detectors are suitable to measure muons produced by cosmic-ray interactions in the atmosphere. In this paper, the studies of the cosmic muons registered by ALICE during Run 2 (2015–2018) are described. The analysis is limited to multimuon events defined as events with more than four detected muons (N_µ > 4) and in the zenith angle range 0^◦ < θ < 50^◦. The results are compared with Monte Carlo simulations using three of the main hadronic interaction models describing the air shower development in the atmosphere: QGSJET-II-04, EPOS-LHC, and SIBYLL 2.3d. The interval of the primary cosmic-ray energy involved in the measured muon multiplicity distribution is about 4×10¹⁵ < E_prim < 6×10¹⁶ eV. In this interval none of the three models is able to describe precisely the trend of the composition of cosmic rays as the energy increases. However, QGSJET-II-04 is found to be the only model capable of reproducing reasonably well the muon multiplicity distribution, assuming a heavy composition of the primary cosmic rays over the whole energy range, while SIBYLL 2.3d and EPOS-LHC underpredict the number of muons in a large interval of multiplicity by more than 20% and 30%, respectively. The rate of high muon multiplicity events (N_µ > 100) obtained with QGSJET-II-04 and SIBYLL 2.3d is compatible with the data, while EPOS-LHC produces a significantly lower rate (55% of the measured rate). For both QGSJET-II-04 and SIBYLL 2.3d, the rate is close to the data when the composition is assumed to be dominated by heavy elements, an outcome compatible with the average energy E_prim ∼ 10¹⁷ eV of these events. This result places significant constraints on more exotic production mechanisms. © 2025 The Author(s).

关键词： cosmic ray experiments cosmic rays detectors

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TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A (vol 603, pg 131, 2022)

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NATURE 2024年第8020期631卷 E7-E7页

作者： Brown, Anna-Leigh Wilkins, Oscar G. Keuss, Matthew J. Hill, Sarah E. Zanovello, Matteo Lee, Weaverly Colleen Bampton, Alexander Lee, Flora C. Y. Masino, Laura Qi, Yue A. Bryce-Smith, Sam Gatt, Ariana Hallegger, Martina Fagegaltier, Delphine Phatnani, Hemali Phatnani, Hemali Newcombe, Jia Gustavsson, Emil K. Seddighi, Sahba Reyes, Joel F. Coon, Steven L. Ramos, Daniel Schiavo, Giampietro Fisher, Elizabeth M. C. Raj, Towfique Secrier, Maria Lashley, Tammaryn Ule, Jernej Buratti, Emanuele Humphrey, Jack Ward, Michael E. Fratta, Pietro UCL Queen Square Motor Neuron Disease Centre Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology UCL London UK The Francis Crick Institute London UK UK Dementia Research Institute University College London London UK Department of Molecular Biology and Nanobiotechnology National Institute of Chemistry Ljubljana Slovenia National Institute of Neurological Disorders and Stroke NIH Bethesda MD USA Medical Scientist Training Program Johns Hopkins University School of Medicine Baltimore MD USA Center for Alzheimer’s and Related Dementias National Institutes of Health Bethesda MD USA Queen Square Brain Bank UCL Queen Square Institute of Neurology University College London London UK Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology University College London London UK Great Ormond Street Institute of Child Health Genetics and Genomic Medicine University College London London UK Center for Genomics of Neurodegenerative Disease New York Genome Center (NYGC) New York NY USA NeuroResource Department of Neuroinflammation UCL Queen Square Institute of Neurology London UK Molecular Genomics Core Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH Bethesda MD USA Nash Family Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY USA Ronald M. Loeb Center for Alzheimer’s Disease Icahn School of Medicine at Mount Sinai New York NY USA Department of Pathology Fishberg Department of Neuroscience Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai New York NY USA Estelle and Daniel Maggin Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics Evolution and Environment UCL Genetics Institute University College London London UK Mole

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