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A 3d-printed microfluidic gradient concentration chip for rapid antibiotic-susceptibility testing

Bio-design and Manufacturing 2022年第1期5卷 210-219页

作者： Huilin Zhang Yuan Yao Yue Hui Lu Zhang Nanjia Zhou Feng Ju College of Environmental&Resource Sciences Zhejiang UniversityHangzhou 310058China Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province Hangzhou 310024China

The rise of antibiotic resistance as one of the most serious global public health threats has necessitated the timely clinical diagnosis and precise treatment of deadly bacterial *** identify which types and doses of antibiotics remain effective for fighting against multi-drug-resistant pathogens,the development of rapid and accurate antibiotic-susceptibility testing(AST)is of primary *** methods for AST in well-plate formats with disk diffusion or broth dilution are both labor-intensive and operationally *** microfluidic chip provides a versatile tool for evaluating bacterial AST and resistant *** this paper,we develop an operationally simple,3d-printed microfluidic chip for AST which automatically deploys antibiotic concentration gradients and fluorescence intensity-based reporting to ideally reduce the report time for AST to within 5 *** harnessing a commercially available,digital light processing(dLP)3d printing method that offers a rapid,high-precision microfluidic chip-manufacturing capability,we design and realize the accurate generation of on-chip antibiotic concentration gradients based on flow resistance and diffusion *** further demonstrate the employment of the microfluidic chip for the AST of *** to representative clinical antibiotics of three classes:ampicillin,chloramphenicol,and *** determined minimum inhibitory concentration values are comparable to those reported by conventional well-plate *** proposed method demonstrates a promising approach for realizing robust,convenient,and automatable AST of clinical bacterial pathogens.

关键词： microfluidics Gradient concentration chip digital light processing Antibiotic-susceptibility test Bacteria

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Whole-infrared-band camouflage with dual-band radiative heat dissipation

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Light(Science & Applications) 2023年第11期12卷 2391-2401页

作者： Bing Qin Yining Zhu Yiwei Zhou Min Qiu Qiang Li State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake University18 Shilongshan RoadHangzhou 310024 ZhejiangChina Institute of Advanced Technology Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024 ZhejiangChina

Advanced multispectral detection technologies have emerged as a significant threat to objects,necessitating the use of multiband ***,achieving effective camouflage and thermal management across the entire infrared spectrum,especially the short-wave infrared(SWIR)band,remains *** paper proposes a multilayer wavelength-selective emitter that achieves effective camouflage across the entire infrared spectrum,including the near-infrared(NIR),SWIR,mid-wave infrared(MWIR),and long-wave infrared(LWIR)bands,as well as the visible(VIS)***,the emitter enables radiative heat dissipation in two non-atmospheric windows(2.5-3μm and 5-8μm).The emitter’s properties are characterized by low emittance of 0.270/0.042/0.218 in the SWIR/MWIR/LWIR bands,and low reflectance of 0.129/0.281 in the VIS/NIR ***,the high emittance of 0.742/0.473 in the two non-atmospheric windows ensures efficient radiative heat dissipation,which results in a temperature decrement of 14.4℃ compared to the Cr reference at 2000Wm^(−2) input power *** work highlights the role of solar radiance in camouflage,and provides a comprehensive guideline for developing multiband camouflage compatible with radiative heat dissipation,from the visible to LWIR.

关键词： dissipation visible radiative

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An in-situ generated Bi-based sodiophilic substrate with high structural stability for high-performance sodium metal batteries

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Journal of Energy Chemistry 2022年第8期31卷 595-603,I0016页

作者： Lulu Li Ming Zhu Guanyao Wang Fangfang Yu Liaoyong Wen Hua-Kun Liu Shi-Xue dou Chao Wu School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200444China Institute for Superconducting&Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongNSW2522Australia Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024ZhejiangChina

Sodium(Na)metal anode exhibits a potential candidate in next-generation rechargeable batteries owing to its advantages of high earth abundance and low ***,the practical development of sodium metal batteries is inherently plagued by challenges such as the side reactions and the growth of Na *** we report a highly stable Bi-based“sodiophilic”substrate to stabilize Na anode,which is created by in-situ electrochemical reactions of 3d hierarchical porous Bi_(2)MoO_(6)(BMO)*** is initially transformed into the Bi“nanoseeds”embedded in the Na-Mo-O ***,the Bi nanoseeds working as preferential nucleation sites through the formation of BiNa alloy enable the non-dendritic Na *** asymmetric cells based on such BMO-based substrate can deliver a long-term cycling for 600 cycles at a large capacity of 4 m Ah cm^(-2) and for 800 cycles at a high current density of 10 m A cm^(-2).Even at a high depth of discharge(66.67%),the Na-predeposited BMO(Na@BMO)electrodes can cycle for more than 1600 *** limited Na@BMO anodes coupled with the Na_(3)V_(2)(PO_(4))_(3) cathodes(N/P ratio of 3)in full cells also show excellent electrochemical performance with a capacity retention of about 97.4%after 1100 cycles at 2 C.

关键词： Sodium metal anode Bi_(2)MoO_(6)microspheres Sodiophilic substrate Conversion and alloying reaction Uniform sodium deposition

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micro-scale opto-thermo-mechanical actuation in the dry adhesive regime

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Light(Science & Applications) 2021年第10期10卷 1905-1914页

作者： Weiwei Tang Wei Lyu Jinsheng Lu Fengjiang Liu Jiyong Wang Wei Yan Min Qiu Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake University18 Shilongshan RoadHangzhou 310024 Zhejiang ProvinceChina Institute of Advanced Technology Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024 Zhejiang ProvinceChina State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China

Realizing optical manipulation of microscopic objects is crucial in the research fields of life science,condensed matter physics,and physical *** non-liquid environments,this task is commonly regarded as difficult due to strong adhesive surface force(~µN)attached to solid interfaces that makes tiny optical driven force(~pN)***,by recognizing the microscopic interaction mechanism between friction force—the parallel component of surface force on a contact surface—and thermoelastic waves induced by pulsed optical absorption,we establish a general principle enabling the actuation of micro-objects on dry frictional surfaces based on the opto-thermo-mechanical ***,we predict that nanosecond pulsed optical absorption with mW-scale peak power is sufficient to tameµN-scale friction ***,we demonstrate the two-dimensional spiral motion of gold plates on micro-fibers driven by nanosecond laser pulses,and reveal the rules of motion *** results pave the way for the future development of micro-scale actuators in non-liquid environments.

关键词： friction regime absorption

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High-temperature infrared camouflage with efficient thermal management

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Light(Science & Applications) 2020年第1期9卷 1430-1437页

作者： Huanzheng Zhu Qiang Li Chunqi Zheng Yu Hong Ziquan Xu HanWang Weidong Shen Sandeep Kaur Pintu Ghosh Min Qiu State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake University18 Shilongshan RoadHangzhou 310024China Institute of Advanced Technology Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024China

High-temperature infrared(IR)camouflage is crucial to the effective concealment of high-temperature objects but remains a challenging issue,as the thermal radiation of an object is proportional to the fourth power of temperature(T4).Here,we experimentally demonstrate high-temperature IR camouflage with efficient thermal *** combining a silica aerogel for thermal insulation and a Ge/ZnS multilayer wavelength-selective emitter for simultaneous radiative cooling(high emittance in the 5-8μm non-atmospheric window)and IR camouflage(low emittance in the 8-14μm atmospheric window),the surface temperature of an object is reduced from 873 to 410 *** IR camouflage is demonstrated by indoor/outdoor(with/without earthshine)radiation temperatures of 310/248 K for an object at 873/623 K and a 78% reduction in with-earthshine lock-on *** scheme may introduce opportunities for high-temperature thermal management and infrared signal processing.

关键词： thermal earth insulation

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Flexible Integrated Photonics For On-Chip Quasi-distributed Sensing

Flexible Integrated Photonics For On-Chip Quasi-Distributed ...

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2024 Asia Communications and Photonics Conference, ACP 2024 and International Conference on Information Photonics and Optical Communications, IPOC 2024

作者： Li, Zongxi Wu, Yingchun Sun, Chunlei Chen, Zequn Tang, Renjie Luo, Ye Lin, Hongtao Li, Lan Zhejiang Key Laboratory of 3D Micro/Nano Fabrication and Characterization School of Engineering Westlake University Hangzhou China College of Information Science and Electronic Engineering Zhejiang University Hangzhou China

ISBN: (纸本)9798350379266

We introduced a flexible integrated photonic sensing strategy, covering a universal fabrication technique that allows for a wide selection of optical materials to be integrated onto flexible platforms, along with the innovative design of microcavities with an ultrawide free spectral range (FSR) and superior mechanical flexibility. Utilizing this flexible platform, we have successfully demonstrated on-chip high-spatial-resolution quasi-distributed sensing via cascading numerous one-dimensional photonic crystal micro-cavities with distinguished multiplexing capability to form large-scale sensing arrays. © 2024 IEEE.

关键词： microcavities

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视频压缩感知技术十年之旅——从理论到实际应用（英文）

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Engineering 2025年第3期 172-185页

作者：张志宏郑巳明仇旻司徒国海 david J.Brady 戴琼海索津莉袁鑫 Department of Automation Tsinghua University Research Center for Industries of the Future (RCIF) & School of Engineering Westlake University Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of Engineering Westlake University Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Wyant College of Optical Sciences University of Arizona Shanghai Artificial Intelligence Laboratory

It has been over a decade since the first coded aperture video compressive sensing(CS) system was *** underlying principle of this technology is to employ a high-frequency modulator in the optical path to modulate a recorded high-speed scene within one integration *** superimposed image captured in this manner is modulated and compressed,since multiple modulation patterns are *** this,reconstruction algorithms are utilized to recover the desired high-speed *** leading advantage of video CS is that a single captured measurement can be used to reconstruct a multi-frame video,thereby enabling a low-speed camera to capture high-speed *** by this,a number of variants of video CS systems have been built,mainly using different modulation ***,in order to obtain high-quality reconstruction videos,many algorithms have been developed,from optimization-based iterative algorithms to deep-learning-based ***,emerging deep learning methods have been dominant due to their high-speed inference and high-quality reconstruction,highlighting the possibility of deploying video CS in practical *** this end,this paper reviews the progress that has been achieved in video CS during the past *** further analyze the efforts that need to be made-in terms of both hardware and algorithms-to enable real *** gaps are put forward and future directions are summarized to help researchers and engineers working on this topic.

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Highly insulating phase of Bi_(2)O_(2)Se thin films with high electronic performance

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nano Research 2023年第2期16卷 3224-3230页

作者： Tao Wang Zhuokai Xu Ziye Zhu Mengqi Wu Zhefeng Lou Jialu Wang Wanghua Hu Xiaohui Yang Tulai Sun Xiaorui Zheng Wenbin Li Xiao Lin Department of Physics Fudan UniversityShanghai 200433China Key Laboratory for Quantum Materials of Zhejiang Province Department of PhysicsSchool of ScienceWestlake UniversityHangzhou 310024China Key Laboratory of 3D Micro/nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Center for Electron Microscopy State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology and College of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China

Bi_(2)O_(2)Se is highly competitive as a candidate of next-generation high-performance *** dubbed as semiconductor,Bi_(2)O_(2)Se films exhibited high conductance,i.e.,metallic behavior,due to spontaneously ionized ***/insulating films are of practical importance in broad applications based on low-power,high-performance electronics,the existence of which lacks firm ***,we synthesized highly insulating films in a controlled way,which exhibit semiconducting behavior with channel resistance up to 1 TΩ.The electron chemical potential lies within the band gap,in some cases,even below the charge neutrality level,signifying the trace of hole-type *** performance of insulating devices remains high,comparable to high-quality devices ***,the threshold voltage(Vth)is positive,contrary to common negative values *** indicate that our synthesis conditions suppress electron donors(Se vacancies(VSe))and promote the formation of compensating acceptors(Bi vacancies(VBi)),leading to insulating *** work offers insights into electron dynamics of Bi_(2)O_(2)Se,moves one step further towards p-type transistors and provides a valuable playground for engineering ferroelectricity in high-performance semiconductors.

关键词： Bi_(2)O_(2)Se field effect transistor high performance layered semiconductor highly insulating phase in-gap state

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Smart bioelectronics and biomedical devices

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Bio-design and Manufacturing 2022年第1期5卷 1-5页

作者： Nanjia Zhou Liang Ma Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhou 310024China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310058China School of Mechanical Engineering Zhejiang UniversityHangzhou 310058China

The development of smart bioelectronics and biomedical devices has significantly advanced the field of biomedical engineering,enabling a myriad of applications from basic biomedical research to clinical medicine and *** at the intersection of materials science,mechanical,electrical,and bioengineering,this fascinating field has attracted considerable attention from researchers all over the world,providing new healthcare solutions which were impossible *** brain–machine interface to biomedical nano/micro-robots,different materials and manufacturing methodologies have been developed to advance the functionalities of the bioelectronic systems to meet the ever-increasing demand of biological and bioinspired applications(Fig.1).

关键词： Smart interface electrical

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Visible Chalcogenide Metadevices

Visible Chalcogenide Metadevices

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2024 Photonics and Electromagnetics Research Symposium, PIERS 2024

作者： dai, Hao Shi, Yilin Song, Jieren Li, Lan Lin, Hongtao Zhejiang University State Key Laboratory of Modern Optical Instrumentation Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province College of Information Science and Electronic Engineering Hangzhou China Westlake University Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of Engineering Hangzhou China

ISBN: (纸本)9798350375909

With the evolution of the consumer electronics field, applications such as smart wearable devices, autonomous driving, AR/VR, and smartphones are setting forth more requirements for optical components, emphasizing the necessity for enhanced multifunctionality, miniaturization, and cost-efficiency. Metasurfaces composed of subwavelength nanostructures have introduced a revolutionary approach to address these requirements, undergoing significant theoretical and applied research over the past decade. However, metasurface technology still encounters challenges in optical wavelength extension, reconfigurability, and optical nonlinearities. In comparison to widely utilized metasurface materials such as HfO2 for ultraviolet, Si3N4, TiO2, GaN for visible, and aSi for near-infrared to mid-infrared, chalcogenide materials exhibit high refractive and transparency at broad optical frequencies. Additionally, chalcogenide materials hold the potential for phase change and nonlinear characteristics, rendering them ideal materials for multifunctional metasurface devices. In this study, we present the inaugural demonstration of chalcogenide metasurface in visible. We designed and fabricated foundational optical devices like metalens and vortex beam, and conducted comprehensive tests to characterize the optical performance of these devices, laying the groundwork for the expansion of chalcogenide visible metasurfaces. © 2024 IEEE.

关键词： Titanium dioxide

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