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Any-Angle Routing Algorithm for Microfluidic Biochips Driven by Flow Path

Jisuanji Yanjiu yu Fazhan/Computer Research and Development 2025年第4期62卷 978-988页

作者： Youlin, Pan Shuai, Guo Xing, Huang Genggeng, Liu College of Computer and Data Science Fuzhou University Fuzhou350116 China Engineering Research Center of Big Data Intelligence Fuzhou University Ministry of Education Fuzhou350116 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350116 China School of Computer Science Northwestern Polytechnical University Xi’an710072 China

Continuous-flow microfluidic biochips (CFMBs) have become a hot research topic in recent years due to their ability to perform biochemical assays automatically and efficiently. For the first time, PathDriver+ takes the requirements of the actual fluid transportation into account in the design process of CFMBs and implements the actual fluid transport and removal, and plans separate flow paths for each transport task, which have been neglected in previous work. However, PathDriver+ does not take full advantage of the flexibility of CFMBs routing because it only considers the optimization of flow channel length for the global routing in the mesh model, except for the detailed routing. In addition, PathDriver+ only considers the X architecture, while the existing work shows that the any-angle routing can utilize the routing resources more efficiently and shorten the flow channel length. To address the above issues, we propose a flow path-driven arbitrary angle routing algorithm, which can improve the utilization of routing resources and reduce the flow channel length while considering the actual fluid transportation requirements. The proposed algorithm constructs a search graph based on constrained Delaunay triangulation to improve the search efficiency of routing solutions while ensuring the routing quality. Then, a Dijkstra-based flow path routing method is used on the constructed search graph to generate a routing result with a short channel length quickly. In addition, in the routing process, channel reuse strategy and intersection optimization strategy are proposed for the flow path reuse and intersection number optimization problems, respectively, to further improve the quality of routing results. The experimental results show that compared with the latest work PathDriver+, the length of channels, the number of ports used, and the number of channel intersections are significantly reduced by 33.21%, 11.04%, and 44.79%, respectively, and the channel reuse rate is i

关键词： High level synthesis

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Control Logic Routing for Continuous-Flow Microfluidic Biochips Based on Deep Reinforcement Learning

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Jisuanji Yanjiu yu Fazhan/Computer Research and Development 2025年第4期62卷 950-962页

作者： Cai, Huayang Huang, Xing Liu, Genggeng College of Computer and Data Science Fuzhou University Fuzhou350116 China Engineering Research Center of Big Data Intelligence Fuzhou University Ministry of Education Fuzhou350116 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350116 China School of Computer Science Northwestern Polytechnical University Xi’an710072 China

With the advancement of electronic design automation, continuous-flow microfluidic biochips have become one of the most promising platforms for biochemical experiments. This chip manipulates fluid samples in milliliters or nanoliters by utilizing internal microvalves and microchannels, and thus automatically performs basic biochemical experiments, such as mixing and detection. To achieve the correct bioassay function, the microvalves deployed inside the chip are usually managed by a multiplexer-based control logic, and valves receive control signals from a core input through the control channel for accurate switching. Since biochemical reactions typically require high sensitivity, the length of control paths connecting each valve needs to be reduced to ensure immediate signal propagation, and thus to reduce the signal propagation delay. In addition, to reduce the fabrication cost of chips, a vital issue to be addressed in the logic architecture design is how to effectively reduce the total channel length within the control logic. To address the above issues, we propose a deep reinforcement learning-based control logic routing algorithm to minimize the signal propagation delay and total control channel length, thereby automatically constructing an efficient control channel network. The algorithm employs the dueling deep Q-network architecture as the agent of the deep reinforcement learning framework to evaluate the tradeoff between signal propagation delay and total channel length. Besides, the diagonal channel routing is implemented for the first time for control logic, thus fundamentally improving the efficiency of valve switching operations and reducing the fabrication cost of the chip. The experimental results demonstrate that the proposed algorithm can effectively construct a high-performance and low-cost control logic architecture. © 2025 Science Press. All rights reserved.

关键词： Deep reinforcement learning

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AMHF-TP: Multifunctional therapeutic peptides prediction based on multi-granularity hierarchical features

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Quantitative Biology 2025年第1期 44-58页

作者： Shouheng Tuo YanLing Zhu Jiangkun Lin Jiewei Jiang School of Computer Science and Technology Xi'an University of Posts and Telecommunications Shaanxi Key Laboratory of Network Data Analysis and Intelligent Processing Xi'an Key Laboratory of Big Data and Intelligent Computing School of Electronic Engineering Xi'an University of Posts and Telecommunications

Multifunctional therapeutic peptides(MFTP) hold immense potential in diverse therapeutic contexts, yet their prediction and identification remain challenging due to the limitations of traditional methodologies, such as extensive training durations, limited sample sizes, and inadequate generalization capabilities. To address these issues, we present AMHF-TP, an advanced method for MFTP recognition that utilizes attention mechanisms and multi-granularity hierarchical features to enhance performance. The AMHF-TP is composed of four key components: a migration learning module that leverages pretrained models to extract atomic compositional features of MFTP sequences; a convolutional neural network and selfattention module that refine feature extraction from amino acid sequences and their secondary structures; a hypergraph module that constructs a hypergraph for complex similarity representation between MFTP sequences; and a hierarchical feature extraction module that integrates multimodal peptide sequence features. Compared with leading methods,the proposed AMHF-TP demonstrates superior precision, accuracy, and coverage, underscoring its effectiveness and robustness in MFTP recognition. The comparative analysis of separate hierarchical models and the combined model, as well as with five contemporary models, reveals AMHF-TP's exceptional performance and stability in recognition tasks.

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Medical Image Segmentation Based on 3d Pdc with Swin Transformer

SSRN

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SSRN 2025年

作者： Fan, Lin Ding, Xiaojia Wang, Zhongmin Wang, Hai Zhang, Rong School of Computer Science and Technology Xi’an University of Posts and Telecommunications Shaanxi Xi’an710121 China Shaanxi Key Laboratory of Network Data Analysis and Intelligent Processing Shaanxi Xi’an710121 China Xi’an Key Laboratory of Big Data and Intelligent Computing Shaanxi Xi’an710121 China The School of Information Science and Technology Northwest University Shaanxi Xi’an710121 China

3D medical image segmentation is vital for disease diagnosis and effective treatment strategies. Despite the advancements in Convolutional Neural Networks (CNN), their fixed receptive fields constrain global context modeling, leading to suboptimal performance, particularly with complex shapes and multi-scale variations. Transformer enhances the global modeling capability through self-attention mechanism. However, challenges persist in capturing fine-grained local features and extracting edge features. To overcome these issues, In this study, a dual-path encoder is proposed, which consists of a 3D PDC and a Swin Transformer and is combined with a CNN for the decoder. The 3D PDC module extracts local features by calculating the differences between neighboring pixels. To improve the ability of capturing edge structures, three 3D PDC variants (3D CPDC, 3D APDC, and 3D RPDC) are proposed to optimize the processing ability of complex edges, multi-directional edges, and multi-scale structures, respectively. After performance evaluation, the selected CARV combinations (3D CPDC, 3D APDC, 3D RPDC, and 3D ordinary convolution) achieve a compromise between high segmentation accuracy and low computational cost. The Swin Transformer encoder captures global context using a hierarchical shift-window mechanism, while the CNN decoder fuses features progressively to produce precise pixel-level segmentation. The proposed method exceeds the performance of existing state-of-the-art techniques, as shown by experiments conducted on the BTCV, FLARE21, and AMOS22 datasets. © 2025, The Authors. All rights reserved.

关键词： Image segmentation

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Community-Aware Heterogeneous Graph Contrastive Learning 19th

Community-Aware Heterogeneous Graph Contrastive Learning

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19th CCF Conference on Computer Supported Cooperative Work and Social computing, ChineseCSCW 2024

作者： Li, Xinying Wu, Ling Guo, Kun College of Computer and Data Science Fuzhou University Fuzhou350108 China Engineering Research Center of Big Data Intelligence Ministry of Education Fuzhou350108 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350108 China

ISBN: (纸本)9789819623723

Recently, heterogeneous graph contrastive learning, which can mine supervision signals from the data, has attracted widespread attention. However, most existing methods employ random data augmentation strategies to construct contrastive views, which may destroy the semantic information in heterogeneous graphs. Moreover, they often select positive and negative samples based solely on node-level proximity and overlook hard samples that are difficult to distinguish from anchors. To solve the above problems, we propose a Community-Aware Heterogeneous Graph Contrastive Learning model called CAHGCL. In particular, we design an adaptive data augmentation strategy to construct views, including feature augmentation and topology augmentation. To improve the quality of samples, we propose a dynamic sample weighting strategy based on node similarity and community information, capable of identifying both hard positive samples and hard negative samples. Finally, we introduce community-level contrast to improve community cohesion. Extensive experiments and analyses demonstrate that CAHGCL consistently outperforms state-of-the-art baselines on three datasets. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Contrastive Learning

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Community Evolution Tracking Based on High-Order Neighbor Consideration and Node Change Identification 19th

Community Evolution Tracking Based on High-Order Neighbor C...

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19th CCF Conference on Computer Supported Cooperative Work and Social computing, ChineseCSCW 2024

作者： Zhang, Yunan Wang, Chaohui Wu, Ling Guo, Kun College of Computer and Data Science Fuzhou University Fuzhou350108 China Engineering Research Center of Big Data Intelligence Ministry of Education Fuzhou350108 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350108 China

ISBN: (纸本)9789819623723

Community evolution tracking is widely used in complex network analysis, which analyzes and identifies how communities evolve over time based on dynamic community detection. However, the current incremental dynamic community detection method has the phenomenon of ’concept drift’, which leads to inaccurate tracking of community evolution. Although some studies on dynamic community detection have proposed to perform global community detection on the network by timing or when the error information accumulates to a certain extent, this method will lead to a sudden change in community division, which will interrupt the evolution sequence of some communities and bring great difficulties to the continuous tracking of community evolution. In addition, the current community evolution tracking methods match the communities of two adjacent snapshots, and it is difficult to capture the fine-grained evolution process within the community. This paper proposes a community evolution tracking algorithm based on high-order neighbor consideration and node change identification. Firstly, based on an incremental update strategy that considers high-order neighbors, we adaptively expand the scope of incremental updates to reduce the accumulation of error information. Secondly, through the node change identification strategy to mine fine-grained community evolution events. Experiments show that our method can effectively track the evolution of communities in dynamic networks. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Community evolution Complex network Dynamic network Evolution tracking

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D-FGNAE: Decentralized Federated Graph Normalized AutoEncoder 19th

D-FGNAE: Decentralized Federated Graph Normalized AutoEncode...

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19th CCF Conference on Computer Supported Cooperative Work and Social computing, ChineseCSCW 2024

作者： Liang, Yuting Cai, Weixin Guo, Kun College of Computer and Data Science Fuzhou University Fuzhou350108 China Engineering Research Center of Big Data Intelligence Ministry of Education Fuzhou350108 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350108 China

ISBN: (纸本)9789819623723

Graphs widely exist in real-world, and Graph Neural Networks (GNNs) have exhibited exceptional efficacy in graph learning in diverse fields. With the strengthening of data privacy protection worldwide in recent years, Federated graph neural networks (FedGNNs) have gained increasing attention in academia and industry owing to their ability to train the model in a collaborative manner while complying with the privacy protection regulations. However, in federated learning, the non-independent and identically distributed (non-IID) problem of local data possessed by multiple participants can significantly undermine model accuracy. We propose a new Decentralized Federated Graph Normalized AutoEncoder (D-FGNAE). First, the model is designed as a decentralized federated learning framework with dynamically assigned tripartite roles. This design eliminates the fixed server role found in traditional federated learning, enhances system fault tolerance, avoids single points of failure, and protects model privacy. Second, the splitting and correcting of calculation by layer in the model, along with the special design of the normalization layer, effectively tackle the non-IID problem in both the structural and attribute aspects. Experimental results on real-world networks demonstrate the effectiveness of D-FGNAE, which can achieve nearly the same accuracy as the centralized model. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Federated learning

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UGCM-LU: A Unified Stream and Batch Graph computing Model with Local Update for Community Detection 19th

UGCM-LU: A Unified Stream and Batch Graph Computing Model w...

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19th CCF Conference on Computer Supported Cooperative Work and Social computing, ChineseCSCW 2024

作者： Li, Hong Wu, Ling Guo, Kun College of Computer and Data Science Fuzhou University Fuzhou350108 China Engineering Research Center of Big Data Intelligence Ministry of Education Fuzhou350108 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350108 China

ISBN: (纸本)9789819623723

Unified stream and batch computing (USBC) aims to incorporate stream and batch computation into a unified framework, thereby enabling the development of a one-stop solution for stream and batch data processing and enhancing the generalization of the framework. However, research on unified graph computing models (UGCMs) faces several challenges. First, existing UGCMs need to consider all graph information in the cache during the incremental update phase, thus leading to decreased execution efficiency. Second, existing UGCMs use fixed bytes to store nodes without considering the actual space occupied by nodes resulting in wasted memory when dealing with large graphs. This paper proposes a UGCM with Local Updates for community detection (UGCM-LU). We first implement a local update strategy to consider partial information of the graph to achieve incremental updates. Secondly, we also designed a byte-compression-based module to store graph data according to the space occupied by nodes. The experimental results show the effectiveness and efficiency of the model in real-world and artificial networks. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Lutetium alloys

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SolBERT: Advancing solidity smart contract similarity analysis via self-supervised pre-training and contrastive fine-tuning

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Information and Software Technology 2025年 184卷

作者： Tian, Zhenzhou Teng, Yudong Ke, Xianqun Chen, Yanping Chen, Lingwei School of Computer Science and Technology Xi'an University of Posts and Telecommunications Shaanxi Xi'an710121 China Shaanxi Key Laboratory of Network Data Analysis and Intelligent Processing Xi'an University of Posts and Telecommunications Shaanxi Xi'an710121 China Xi'an Key Laboratory of Big Data and Intelligent Computing Xi'an University of Posts and Telecommunications Shaanxi Xi'an710121 China Department of Computer Science and Engineering Wright State University DaytonOH45435 United States

Context: Reliable and effective similarity analysis for the smart contracts facilitates the maintenance and quality assurance of the smart contract ecosystem. However, existing signature-based methods and code representation learning-based methods suffer from limitations such as heavy-weight program analysis payloads or suboptimal contract encodings. Objective: This paper aims to design a fully unsupervised language model for better capturing the syntactic and semantic richness of Solidity code, and utilizes it for advancing the effectiveness of smart contract similarity analysis. Methods: Inspired by the impressive semantic learning capability of pre-trained language models (PLMs), we propose SolBERT, a PLM specifically tailored for enhancing Solidity smart contracts similarity detection. To ensure it produces high-quality encodings, SolBERT leverages BERT-style pre-training with the masked language modeling (MLM) and token type prediction (TTP) tasks applied on code-structure-aware token sequences derived from the contracts’ abstract syntax trees (ASTs) through structure-retaining tree linearization and light-weight normalization to learn a base model. On this basis, self-supervised contrastive fine-tuning and unsupervised whitening operations are further performed to optimize contract encoding generation. Results: Experiments are conducted on three contract similarity-related tasks, including contract clone detection, bug detection, and code clustering. The results indicate that SolBERT significantly outperforms state-of-the-art approaches with average absolute gains of 21.33% and 21.50% in terms of F1, and 17.78% and 26.60% in terms of accuracy for the clone detection and bug detection tasks, respectively;and an average absolute gain of 17.97% for code clustering task. When applying both contrastive fine-tuning and whitening optimizations, SolBERT also shows superior performance than the case of lacking any of them. Conclusion: The proposed approach, SolBERT, ca

关键词： Reliability analysis

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An Encoder-Decoder Model Based On Spiking Neural Networks For Address Event Representation Object Recognition

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IEEE Transactions on Cognitive and Developmental Systems 2025年

作者： Du, Sichun Zhu, Haodi Zhang, Yang Hong, Qinghui Hunan University College of Computer Science and Electronic Engineering Changsha418002 China Shenzhen University Computer Vision Institute School of Computer Science and Software Engineering National Engineering Laboratory for Big Data System Computing Technology Guangdong Key Laboratory of Intelligent Information Processing Shenzhen518060 China

Address event representation (AER) object recognition task has attracted extensive attention in neuromorphic vision processing. The spike-based and event-driven computation inherent in the spiking neural network (SNN) provides an energy-saving solution for AER object recognition. However, SNN with spike timing dependent plasticity (STDP) learning rule has not achieved satisfying AER object recognition performance. This work proposes an SNN-based encoder-decoder model to improve the recognition performance of AER objects. An STDP-based locally connected spiking neural network (LC-SNN) is proposed as an encoder to extract rich spatiotemporal features from AER event flows more flexibly. After the encoder extracts and learns primary features, we propose a fully connected spiking neural network (FC-SNN) based on the reward-modulated spike-timing-dependent plasticity (R-STDP) learning rule as a decoder to learn higher-level features for classification. In addition, we improved the winner-take-all (WTA) mechanisms and R-STDP learning rule in the decoder based on the reward and punish decision, enabling the network to perform better. The experiments are performed on the N-MNIST, MNIST-DVS, and the DVS Gesture datasets, improving the accuracy of the best existing plasticity-based SNN by 0.19%, 0.27% and 1.35%, respectively. © 2016 IEEE.

关键词： Decoding

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