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A Novel Peptide from Walnut (Juglans Regia L.) Protein Extends Lifespan in Caenorhabditis Elegans by Molecular Docking and Experimental Validation

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SSRN 2024年

作者： Chen, Jinghui Huang, Chao Wu, Qiming Du, Jun Kan, Juntao Zhu, Ling Wu, Gangcheng Liu, Tongtong Wang, Li Zhang, Hui National Engineering Research Center for Functional Food Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province School of Food Science and Technology Jiangnan University 1800 Lihu Avenue Wuxi214122 China Nutrilite Health Institute Shanghai200031 China Binzhou Zhongyu Food Company Limited Binzhou Zhongyu Academy of Agricultural Sciences National Industry Technical Innovation Center for Wheat Processing China Bohai Advanced Technology Institute China

Walnut peptides have been demonstrated in multiple studies to exhibit a range of biological activities, such as antioxidation, improvement of oxidative stress, and anti-inflammation. Walnut peptides prepared by enzymatic hydrolysis of walnut proteins, which are obtained from peeled walnut kernels after oil extraction, were used to intervene in experiments with Caenorhabditis elegans to explore their ability to delay aging in nematodes. The results showed that walnut peptides not only increased the average lifespan of nematodes but also improved indicators related to healthy lifespan, such as increased locomotive ability, increased pharyngeal pumping rate, and maintenance of nematode body length;a reduction in the accumulation of lipofuscin and MDA;increased ability to withstand heat and oxidative damage;and increased activity of antioxidative enzymes (SOD, CAT, and GSH-px). Through virtual screening, 32 potential bioactive peptides below 3 kDa were identified. Molecular docking experiments confirmed these peptides have stable binding capacities with proteins (DAF-2, AGE-1, AKT-1, and AKT-2) in the insulin/IGF-1 signaling pathway, with peptide P9 showing the lowest binding energy. Intervention in Caenorhabditis elegans with the synthesized P9 significantly extended the average lifespan of the nematodes. Additionally, P9 could promote mRNA expression of genes in the FoxO/DAF-16 signaling pathway, including hsp-16.2, daf-16, ctl-1, gst-4, and sod-3. These findings demonstrated the significance of walnut peptides for the food and pharmaceutical sectors in the creation of novel functional foods and nutraceuticals. © 2024, The Authors. All rights reserved.

关键词： Peptides

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Synergistic Effect of Gellan Gum and Guar Gum on Improving the Foaming Properties of Soy Protein Isolate-Based Complexes: Interaction Mechanism and Interfacial Behavior

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SSRN 2024年

作者： Han, Yameng Zhu, Ling Chen, Jinghui Liu, Tongtong Wu, Gangcheng Zhang, Hui National Engineering Research Center for Functional Food Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province School of Food Science and Technology Jiangnan University Jiangsu Wuxi214122 China Jiangnan University China Binzhou Zhongyu Food Company Limited Binzhou Zhongyu Academy of Agricultural Sciences National Industry Technical Innovation Center for Wheat Processing Shandong Binzhou256603 China Bohai Advanced Technology Institute Shandong Binzhou256606 China

Interactions among multi-component play a critical role in modulating the foaming properties of aerated foods. This study evaluated the mechanisms of synergistic improvement of gellan gum (GEG) and guar gum (GUG) on the foaming properties of soy protein isolate (SPI)-based complex. The results showed that the GEG/GUG ratio was closely related to the intermolecular interactions of SPI-based ternary complex and the dynamical changing of its foaming properties. The SPI/GEG/GUG ternary complex with a GEG/GUG ratio of 2/3 exhibited the highest foamability (195%) and comparable foam stability (99.17%), which were 32.95% and 2.99% higher than that of SPI/GEG binary complex. At this ratio, GUG promoted the interactions between SPI and GEG, and would be bound to complex's surface through hydrogen bonding, resulting in the increase of particle size and surface charge, and the decrease of surface hydrophobicity. Although this reduced the diffusion of complex onto the air/water interface, its increased permeation rate and molecular rearrangement behavior were the potential mechanisms to improve the foaming properties. Additionally, the synergistic effect of GEG and GUG also enhanced the elastic strength and solid characteristics of foam systems. This study provided a theoretical guidance for the targeted modulation of foaming properties of multi-component aerated foods. © 2024, The Authors. All rights reserved.

关键词： Hydrogen bonds

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Low Methane Emissions from the Natural Gas Distribution System Indicated by Mobile Measurements in a Chinese Megacity Hangzhou

ACS ES&T Air

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ACS ES&T Air 2024年第12期1卷 1511-1518页

作者： Shuang Zhao Yuzhong Zhang Ruosi Liang Wei Chen Xinchun Xie Rui Wang Zheng Xia Jiandong Shen Yilong Wang Huilin Chen Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of Engineering Westlake University Hangzhou 310024 China Institute of Advanced Technology Westlake Institute for Advanced Study Hangzhou 310024 China College of Environmental and Resource Sciences Zhejiang University Hangzhou Zhejiang 310058 China Zhejiang Ecological and Environmental Monitoring Center Hangzhou 310012 China Zhejiang Key Laboratory of Ecological and Environmental Monitoring Forewarning and Quality Control Hangzhou 310012 China Hangzhou Ecological Environment Monitoring Center of Zhejiang Province Hangzhou 310020 China State Key Laboratory of Tibetan Plateau Earth System Resources and Environment (TPESRE) Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100101 China Joint International Research Laboratory of Atmospheric and Earth System Sciences School of Atmospheric Sciences Nanjing University Nanjing 210023 China

The consumption of natural gas (NG) in China has quadrupled over the past decade. However, there is an absence of measurement-based assessment of methane emissions from NG consumption, including those from the urban distribution network. Here, we conducted a mobile survey with concurrent measurements of ambient methane concentrations, carbon dioxide concentrations, and13CH4isotopic signatures in the center and suburban areas of Hangzhou, a megacity in East China, from November 2021 to June 2022. We detected 176 leak indications in the 1408 km road covered with 32% attributed to NG leaks based on the source isotopic signature and the methane-to-carbon dioxide ratio derived from the Keeling plot and measured concentrations. We quantified the flux using Weller’s empirical equation, which yielded an emission factor of 115 L·d–1·km–1in Hangzhou. The value ranges from 16 to 314 L·d–1·km–1by accounting for various uncertainty sources. This emission factor falls on the lower end compared to previous studies conducted in North American and European cities. Our findings confirm the effectiveness of mobile surveys in detecting methane emission sources in urban China.

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Identification and Screening of Novel Umami Peptides from Skipjack Tuna (Katsuwonus Pelamis) Hydrolysates Using Ead/Cid Based Micro-Uplc-Qtof-Ms and the Molecular Interaction with T1r1/T1r3 Taste Receptor

SSRN

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SSRN 2024年

作者： Shi, Cui Hu, Di Wei, Lai Yang, Xiaoqing Wang, Shan Chen, Jian Zhang, Yiqi Dong, Xiuping Dai, Zhiyuan Lu, Yanbin Zhejiang Key Laboratory of Food Microbiology and Nutritional Health Institute of Seafood Zhejiang Gongshang University Hangzhou310018 China SKL of Marine Food Processing & Safety Control National Engineering Research Center of Seafood School of Food Science and Technology Dalian Polytechnic University Dalian116034 China Shanghai AB Sciex Analytical Instrument Trading Co. Ltd. Shanghai200050 China

In this study, the enzymatic hydrolysate of Katsuwonus pelamis was purified by ultrafiltration and further identified through micro-ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (micro-UPLC-QTOF-MS). The potential umami peptides were identified using both conventional collision-induced dissociation (CID) and novel electron-activated dissociation (EAD) fragmentation techniques. Nine novel umami peptides with iUmami-SCM > 588 were screened. Sensory evaluation and electronic tongue analysis were performed to confirm the taste characteristics of the umami peptides, indicating that these umami peptides all exhibited varying degrees of umami taste. Molecular docking and molecular dynamics simulation were utilized to investigate the interaction with T1R1/T1R3 taste receptors. The docking results revealed that Asp234, Ser23, Glu231, and Ile237 appeared most frequently in all docking sites and formed stable complexes through hydrogen bonding and electrostatic interactions. Furthermore, molecular dynamics simulation allowed for a more comprehensive analysis of their interactions within a dynamic environment, providing a deeper understanding of the umami perception mechanism involving umami peptides and receptors. © 2024, The Authors. All rights reserved.

关键词： Peptides

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Deciphering the Probiotic Properties and Safety Assessment of a Novel Marine Multi-Stress-Tolerant Aromatic Yeast Pichia Kudriavzevii Hj2 Based on Whole Genome-Sequencing and Phenotype Analysis

SSRN

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SSRN 2023年

作者： Li, Yanmei Mo, Xueyan Xiong, Jianwen Huang, Kunmei Zheng, Minglei Ou, Qian Su, Guijiao Jiang, Chengjian State Key Laboratory for Conservation and Utilization of Subtropical Agrobioresources Guangxi Research Center for Microbial and Enzyme Engineering Technology College of Life Science and Technology Guangxi University Nanning530004 China Guangxi Key Laboratory for Green Processing of Sugar Resources College of Biological and Chemical Engineering Guangxi University of Science and Technology Liuzhou545006 China Liuzhou Key Laboratory of Plant-derived Ingredients of Liuzhou Luosifen Liuzhou Special Food Flavor and Quality Control Research Center of Engineering Technology Department of Food and Chemical Engineering Liuzhou Institute of Technology Liuzhou545616 China

With the increasing demand for diversified health, the characteristic probiotics species resources need to be expanded. Here, a novel marine multi-stress-tolerant aromatic yeast Pichia kudriavzevii HJ2 was identified from marine mangrove. Based on the characterization of probiotic properties in vivo and in vitro, the yeast could assimilate multiple carbon sources, and generate volatile flavor metabolites, achieved a 79.98% cholesterol removal rate with efficient in vivo survival and adhesion capabilities, and showed a strong antioxidant capacity. HJ2 also released hydrolase and fermented dietary fiber to yield SCFAs, contributing to disease prevention and treatment. Then, the safety was assessed according to phenotype and whole genome-sequencing analysis. No virulence genes or ARGs were annotated in the HJ2 genome. A few biogenic amines (BA)-related genes were observed, but the production of various BA and total BA were far below the food-defined thresholds. HJ2 did not produce virulence enzymes such as DNase, phospholipase, gelatinase, or coagulase, and exhibited sensitivity to amphotericin B and anidulafungin without β-hemolysis. An in vivo acute toxicity test conducted on mice demonstrated that HJ2 is safe. In conclusion, HJ2 could be considered safe and be further used as a potential probiotic candidate for further clinical trials. © 2023, The Authors. All rights reserved.

关键词： Yeast

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Methyl Salicylate Fumigation Improves the Synthesis of Lactones and C6/9 Volatile Compounds of Apricot During Low Temperature Storage

SSRN

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SSRN 2024年

作者： Sun, Yuzhu Fan, Xinguang Sun, Chanchan Li, Xiulian Zeng, Xiangquan Gong, Hansheng Liu, Meng Du, Zhilei Sun, Shuyang School of Food Engineering Yantai Key Laboratory of Nanoscience and Technology for Prepared Food Yantai Engineering Research Center of Food Green Processing and Quality Control Ludong University Shandong Yantai264025 China College of Life Sciences Yantai University Shandong Yantai264025 China School of Pharmacy Binzhou Medical University Shandong Yantai264003 China Rizhao Inspection and testing center of agricultural products quality safety Shandong Rizhao276800 China Department of Food Science College of Agriculture Purdue University West LafayetteIN47906 United States

The apricot fruit was prone to chilling injury symptoms in time of low temperature storage, resulting in a decline in aroma quality. The effect of methyl salicylate (MeSA, 0.1 mmol·L-1, 1.0 mmol·L-1 and 2.0 mmol L-1) fumigation on aroma quality of apricot was studied in ‘Jintaiyang’ and ‘Pingdingxiang’ cultivars. The results demonstrated that 1.0 mmol·L-1 of MeSA could enhance the storage quality of apricot by inhibiting firmness decline, ethylene production and respiration rate. The primary aroma volatiles identified in apricots were C6 volatile compounds, esters, and lactones. MeSA suppressed the activities of LOX and ADH, resulting in the reduced C6 alcohols. MeSA stimulated the contents of esters and lactones by enhancing the activities of HPL, AAT and ACX. Consequently, this facilitated the revival of ‘fruit aroma’ in apricot at low temperature storage. Therefore, MeSA fumigation might be used as a potentially effective method for improving the aroma quality of apricot. © 2024, The Authors. All rights reserved.

关键词： Esters

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A Model-free False Data Injection Attack Strategy in Networked control Systems

A Model-free False Data Injection Attack Strategy in Network...

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IEEE Conference on Decision and control

作者： Xiaoyu Luo Chongrong Fang Chengcheng Zhao Jianping He The Department of Automation Shanghai Jiao Tong University Key Laboratory of System Control and Information Processing Ministry of Education of China and Shanghai Engineering Research Center of Intelligent Control and Management Shanghai China The State Key Laboratory of Industrial Control Technology and Institute of Cyberspace Research Zhejiang University China

ISBN: (数字)9781665467612

ISBN: (纸本)9781665467629

The data-driven attack strategies recently have received much attention when the full knowledge of the system model is unknown or difficult to be obtained for the adversary. Note that despite the critical parameters of the system model being unavailable for the adversary, the existing data-driven attack methods still depend on the linearity of the unknown system model. In this paper, we design a completely model-free attack strategy where the adversary with limited capability aims to compromise state variables such that the output value follows the expected trajectory. Specifically, we first construct a zeroth-order feedback optimization framework and uninterruptedly use probing signals for real-time measurements. Then, we iteratively update the attack signals along the composite direction of the gradient estimates of the objective function evaluations and the projected gradients. These objective function evaluations can be obtained only by real-time measurements. Furthermore, we characterize the optimality of these solutions via the optimality gap, which is affected by the dimensions of the attack signal, the iterations of solutions, and the convergence rate of the system. Extensive simulations are conducted to show the effectiveness of the proposed attack strategy.

关键词： Networked control systems Computational modeling Current measurement Linear programming Real-time systems Data models Time measurement

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Effects of Ultrasonic Treatment on the Physicochemical, Structural, and Functional Properties of Soluble Dietary Fiber from Coffee Peels

SSRN

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SSRN 2024年

作者： Yu, Xinxin Zhu, Ke Hu, Rongsuo Hu, Faguang Dong, Wenjiang Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province National Center of Important Tropical Crops Engineering and Technology Research Hainan Wanning571533 China School of Food Science and Engineering Ningxia University Ningxia Yinchuan750021 China Institute of Tropical and Subtropical Cash Crops Yunnan Academy of Agricultural Sciences Yunnan Baoshan678000 China Hainan Sanya572000 China

Coffee peel (CP) is an important by-product of coffee processing which is rich in bioactive components. In the present work, we extracted coffee peel soluble dietary fiber (CSDF) via ultrasound-assisted alcohol precipitation to reduce resource waste as well as environmental pollution and evaluate its structure, monosaccharide composition, and functional and physicochemical characters. Based on our findings, ultrasonic treatment decreased particle size of CSDF from 131.49±7.67 μm to 75.84±1.20 μm, and markedly improved the homogeneity. Cavitation effect of ultrasonication destroyed amorphous zone of CSDF, resulting in a decrease in its thermal stability. Increasing the ultrasonic power (0–500 W) reduced rhamnose level from 8.25% to 7.61% (P © 2024, The Authors. All rights reserved.

关键词： Ultrasonic applications

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Preparation of Robust, Water-Resistant, Antimicrobial, and Antioxidant Chitosan-Based Films by Incorporation of Cinnamaldehyde–Tannin Acid-Zinc Acetate Nanoparticles

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SSRN 2023年

作者： Yin, Wenqi Yan, Ruyu Zhou, Xiaoyi Li, Xiaojing Sang, Shangyuan McClements, David Julian Chen, Long Long, Jie Jiao, Aiquan Wang, Jinpeng Jin, Zhengyu Qiu, Chao State Key Laboratory of Food Science and Technology School of Food Science and Technology Collaborative innovation center of food safety and quality control in Jiangsu Province Jiangnan University Jiangsu Wuxi214122 China College of Light Industry and Food Engineering Nanjing Forestry University Jiangsu210037 China Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province College of Food and Pharmaceutical Sciences Ningbo University Ningbo315832 China Department of Food Science University of Massachusetts AmherstMA01060 United States

Cinnamaldehyde-tannic acid-zinc acetate nanoparticles (CTZA NPs) assembled from edible medicinal plant extracts were successfully incorporated into chitosan films. FTIR spectroscopy analysis indicated that there were strong electrostatic and hydrogen bond interactions between the chitosan and CTZA NPs in the film matrix, which led to an increase in the tensile strength of the films by around 525%. Incorporation of 0.6% or 0.8% CTZA NPs led to films that could undergo appreciable stretching in water without breaking which was attributed to the high hydrophobicity of the nanoparticles. Furthermore, the incorporation of the CTZA NPs enhanced the UV adsorption, antibacterial, and antioxidant properties of the films, while reducing their water vapor permeability. Moreover, it was possible to print inks onto the films because the presence of the hydrophobic CTZA NPs facilitated the deposition of carbon powder onto their surfaces. The films produced in this study may therefore be useful for commercial applications. © 2023, The Authors. All rights reserved.

关键词： Antioxidants

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Comparison of Phenolic Profile and Antioxidant Activity of Artocarpus Heterophyllus Lam. (Jackfruit) Pulp From21 Different Cultivars

SSRN

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SSRN 2023年

作者： Cheng, Ming Li, Chuan Gu, Yu Chen, Xiaoai Wu, Gang Tan, Lehe Zhang, Yanjun Zhu, Kexue Spice and Beverage Research Institute Chinese Academy of Tropical Agricultural Sciences Hainan Wanning571533 China School of Food Science and Engineering Hainan University Hainan Haikou570228 China Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province Hainan Wanning571533 China National Center of Important Tropical Crops Engineering and Technology Research Hainan Wanning571533 China

Jackfruit (Artocarpus heterophyllus Lam.) exhibits important biological activities, and its antioxidant effect is closely related to its rich phenolic compounds. The present study compared the total phenolic content (TPC), total flavonoid content (TFC), and phenolic components in Jackfruit pulp from 21 different cultivars. A total of 66 phenolic compounds were identified using UPLC-ESI-Q-TOF-MS/MS. The quantity and content of the detected phenolic compounds varied significantly among different cultivars. Results showed that "Malaysia 1" had the highest TPC, TFC and antioxidant capacity among 21 jackfruit cultivars. Procyanidins B1 and p-coumaric acid may be the main phenolic compounds affecting the antioxidant ability of jackfruit pulp, according to a significant correlation between polyphenol content and antioxidant property. The results of the principal component analysis showed differences in the dominance of the samples for different phenolic compounds. Our findings may serve as a theoretical foundation for further jackfruit processing and functional food development. © 2023, The Authors. All rights reserved.

关键词： Principal component analysis

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