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An Injectable Hydroxyapatite Microsphere Filler Loaded with Ghk-Cu Tripeptide for Anti-Inflammatory and Antioxidant

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SSRN 2025年

作者： Hu, Die Zhang, Xuexun Gong, Shiwen Ma, Wentao Cheng, Bo Yang, Jing Yan, Lesan Li, Binbin Qiu, Tong Wang, Xinyu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan430070 China Sanya Science and Education Innovation Park Wuhan University of Technology Sanya572000 China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu hydrogen Valley Foshan528200 China Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology Wuhan430070 China School of Foreign Languages Wuhan University of Technology Wuhan430070 China Department of Stomatology Zhongnan Hospital of Wuhan University Wuhan430060 China

With the wide application of soft tissue fillers, implant material-induced inflammatory reactions have become a key factor affecting the therapeutic efficacy. This study developed an injectable filler with enhanced anti-inflammatory and antioxidant effects by adsorbing glycyl-L-histidyl-L-lysine copper complex (GHK-Cu) onto hydroxyapatite microspheres (HAPs), marking the first combination of HAPs and GHK-Cu to address inflammation caused by soft tissue fillers. GHK-Cu was successfully loaded onto HAPs by electrostatic adsorption. HAPs were then mixed with carboxymethyl cellulose (CMC), glycerol (GLY), and water to form GHK-Cu@CMHA gel. The study focus on the effective combination of HAPs as a carrier for sustained GHK-Cu delivery and the anti-inflammatory properties of GHK-Cu. GHK-Cu@CMHA exhibits sustained release properties for 7 days, which ensures prolonged therapeutic effects, minimizes peptide waste and reduces injection frequency, with good flowability and injectability. In the model of LPS-induced inflammation model in vivo and in vitro, GHK-Cu@CMHA gel reduced levels of inflammatory factors and Reactive oxygen species (ROS) levels decreased, while superoxide dismutase (SOD) activity was enhanced. In this process, H&E staining and Masson staining revealed significant collagen deposition. These findings further confirm that GHK-Cu@CMHA is a novel injectable soft tissue filler with good anti-inflammatory and antioxidant properties, which holds well potential for inflammation inhibition. © 2025, The Authors. All rights reserved.

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Perfecting and extending the near-infrared imaging window

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Light(Science & Applications) 2021年第10期10卷 1949-1966页

作者： Zhe Feng Tao Tang Tianxiang Wu Xiaoming Yu Yuhuang Zhang Meng Wang Junyan Zheng Yanyun Ying Siyi Chen Jing Zhou Xiaoxiao Fan Dan Zhang Shengliang Li Mingxi Zhang Jun Qian State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang University310058 HangzhouChina Intelligent Optics&Photonics Research Center Jiaxing Institute of Zhejiang University314000 JiaxingZhejiang ProvinceChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology430070 WuhanChina Key Laboratory of Reproductive Genetics(Ministry of Education) Department of Reproductive EndocrinologyWomen’s HospitalZhejiang University School of Medicine310006 HangzhouChina College of Pharmaceutical Sciences Soochow University215123 SuzhouChina

In vivo fluorescence imaging in the second near-infrared window(NIR-II)has been considered as a promising technique for visualizing ***,the definition of the NIR-II region and the mechanism accounting for the excellent performance still need to be ***,we simulate the photon propagation in the NIR region(to 2340 nm),confirm the positive contribution of moderate light absorption by water in intravital imaging and perfect the NIR-II window as 900–1880 nm,where 1400–1500 and 1700–1880 nm are defined as NIR-IIx and NIR-IIc regions,***,2080–2340 nm is newly proposed as the third near-infrared(NIR-III)window,which is believed to provide the best imaging *** wide-field fluorescence microscopy in the brain is performed around the NIRIIx region,with excellent optical sectioning strength and the largest imaging depth of intravital NIR-II fluorescence microscopy to *** also propose 1400 nm long-pass detection in off-peak NIR-II imaging whose performance exceeds that of NIR-IIb imaging,using bright fluorophores with short emission wavelength.

关键词： perfect Perfect fir

MXene-based photocatalysts

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Journal of materials Science & technology 2020年第21期56卷 18-44页

作者： Panyong Kuang Jingxiang Low Bei Cheng Jiaguo Yu Jiajie Fan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Hefei National Laboratory for Physical Sciences at the Microscale Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)School of Chemistry and Materials Scienceand National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei230026China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China

Transition metal carbide or nitride(MXene)is regarded as next-generation two-dimensional(2D)materials for various applications,such as photocatalysis,electrocatalysis,supercapacitor,lithium-ion battery and biomedicine,because of its unique physicochemical *** photocatalysis,MXene could allow fast photogenerated charge carrier separation and provide abundant surface functional groups for light harvesting materials,rendering feasible the high photoconversion ***,enormous theoretical and experimental studies have been recently made and shown the potential of MXene in various photocatalytic ***,we provide a brief overview of the MXene-based materials,along with their functions in photocatalytic ***,we summarize the recent advances and progresses of MXene-based photocatalysts,ranging from solar fuel production to pollutant ***,we present concluding remarks and the outlooks for achieving highly efficient MXene-based photocatalysts.

关键词： MXene Two-dimensional material Photocatalysis Ti3C2 Solar fuel production

Proportion Dependent Osteogenic Activity of Electrospun Nano-Hydroxyapatite/Polylactic Acid Fiber Membrane in Vitro and in Vivo

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SSRN 2022年

作者： Liang, Bangbang Feng, Tianyi Yuan, Xiaoting Zhao, Kang Li, Chengyu Han, Yingchao State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology Wuhan430070 China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen Valley Foshan528200 China

Herein, nano-hydroxyapatite(nHAP) of 0-20wt% was incorporated in polylactic acid(PLA) to construct nHAP/PLA electrospun fiber membrane, and the effects of nHAP on the physicochemical properties and osteogenic activities were investigated, aiming to optimize the proportion of nHAP/PLA for a better bone repair effect. Results showed that nHAP was approximately evenly incorporated in PLA fiber and increased the fiber surface hydrophilicity. The composite membrane displayed a nHAP content-dependent mechanical property with the maximum enhancements of 29.1%, 113.2% and 45.8% in tensile strength, breaking elongation and Young’s modulus, respectively. Biological experiments demonstrated the nHAP content-dependent osteogenic activity of nHAP/PLA fiber membrane. The nHAP of 6-10wt% in membrane presented a significant promotion effect on the proliferation and differentiation of BMSCs. In vivo experiments of stacked implantation of membrane displayed the multilayer growth in pure PLA group due to the hydrophobicity of PLA resulting interlayer space and single-layer growth in nHAP/PLA group because of the hydrophilicity improved adhesion of layers. However, the 6-10wt%nHAP/PLA could promote cell recruitment and infiltration, and increase the osteogenesis with enhancements of 41% in BV/TV and 37% in BMD, respectively. Our study provides helpful supports for the preparation of composite electrospun membrane with improved osteogenic activity by optimizing the organic-inorganic proportion. © 2022, The Authors. All rights reserved.

关键词： Nanocomposites

External field-assisted catalysis

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eScience 2025年

作者： Linbo Jiang Lintao Jiang Xu Luo Ruidong Li Qingqu Zhou Weihao Zeng Jun Yu Lei Chen Shichun Mu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070 China

In recent years, substantial effort has been dedicated to improving the intrinsic catalytic activity of catalysts through structural modification, component regulation, and chemical state optimization. However, complexity in the design and construction of catalysts, and the possibility of encountering performance ceilings, may constrain their widespread use. Currently, the introduction of in situ external fields, such as force, electric, magnetic, acoustic, light, and thermal fields, is an attractive approach to enhance the catalytic efficiency of catalysts. Such in situ physical fields feature continuity, reversibility, and controllability, and can exert external force or energy on catalysts, thereby affecting their microscopic structures and electron arrangements, accelerating their mass transfer and reaction kinetics. Mutual coupling and conversion among different external fields are also worth exploring. Various in situ external field effects work in multifaceted ways to promote catalysis in energy-environment systems by optimizing mass/energy transfer processes, modifying structures, and accelerating catalytic reaction kinetics, thereby significantly improving the catalytic properties of materials. This review summarizes and analyzes the latest developments in external field-assisted methods for boosting catalyst performance. The external field effect, related catalysis mechanism, and external field-enhanced catalysis are highlighted, and we discuss future challenges, countermeasures, and opportunities for external field-assisted catalysis and beyond.

关键词： Catalysis External field Field-assisted effects Reaction mechanism

Soluble Ultra-High Molecular Weight Poly(4,4′-Diphenylether-5,5′-Bibenzimidazole) Based Membranes with Remarkable Mechanical Strength and Specific Proton Conductivity for High Temperature Proton Exchange Membrane Fuel Cells

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SSRN 2023年

作者： Liu, Guoliang Wang, Ailian Ji, Wenxi Zhang, Longgui Wu, Jianing Zhang, Taoyi Tang, Haolin Zhang, Haining State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Nr. 122 Luoshi Rd. Wuhan430070 China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan528200 China Research Institute of Chemical Industry Co. Ltd Beijing100013 China Hubei Key Laboratory of Fuel Cell Technology Wuhan University of Technology Wuhan430070 China

Reducing the thickness of membrane electrolyte is one important direction to improve Ohmic polarization and the according performance of high-temperature proton exchange membrane fuel cells for its widespread applications. Herein, we report that robust thin membranes can be formed using a soluble ether-contained poly(4,4′-diphenylether-5,5′-bibenzimidazole) with an ultra-high molecular weight of 170 kDa. Due to the enhanced chain entanglement of high molecular weight polymers, the formed thin membrane exhibits promising mechanical strength, thermal and oxidation stability. The optimized membrane with thickness of 61 µm and phosphoric acid uptake of 606 wt.% has the high specific proton conductivity of 25.9 S cm-2 at 160 oC under anhydrous conditions and mechanical strength of 11.2 MPa. The accordingly fabricated membrane electrode assembly delivers a peak power density of 0.544 W cm-2 with the open circuit voltage of 0.915 V at 160 oC using air as oxidant, outperforming the value of 0.522 W cm-2 for the commercial membrane electrode assembly with thickness of 250 µm and phosphoric acid uptake of 1018 wt.%. © 2023, The Authors. All rights reserved.

关键词： Proton conductivity

PVDF/carbon directional microchannels-enhanced ion diode-like hydrogel-based pressure sensors

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Chemical Engineering Journal 2025年 516卷

作者： Wen, Xuezhong Zhang, Hongjian Eom, Taeuk Jeong, Chang Kyu Zhang, Yong State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and Engineering Wuhan University of Technology Wuhan430070 China Center for Smart Materials and Device Integration Wuhan University of Technology Wuhan430070 China Division of Advanced Materials Engineering Jeonbuk National University Jeonbuk Jeonju54896 Cuba Department of JBNU-KIST Industry-Academia Convergence Research Jeonbuk National University Jeonbuk Jeonju54896 Cuba Department of Energy Storage/Conversion Engineering of Graduate School & Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonbuk Jeonju54896 Cuba

Hydrogels are promising candidates for flexible electronics but are often constrained by narrow pressure-sensing ranges and unstable ion migration. To overcome these limitations, we developed an ionic hydrogel sensor incorporating diode-inspired bipolar architectures (PSSNa/PDACl) and poly(vinylidene fluoride)/carbon directional microchannels (PCDMC). The optimized 5-PCNPC hydrogel exhibits a broad pressure-sensing range (2.3–100 kPa) with a sensitivity of 0.360 mV·kPa−1 (a 34.8 % enhancement) and a rectification ratio of 12.9, enabled by PCDMC-guided anisotropic ion transport and rapid stress dissipation (337 ms recovery). With excellent durability over 500 cycles and a power density of 1.17 mW·m−2, the hydrogel sensor demonstrates its potential in practical applications, including a 5 × 5 touchpad for spatial pressure mapping and real-time monitoring of respiration, swallowing, grasping and locomotion. This study underscores the potential of hydrogel-based sensors with wide-range operability for next-generation wearables and interactive systems. © 2025 Elsevier B.V.

关键词： Carbon carbon composites

Enhancing Lithium Metal Battery Performance Through Reaction Center Shifting in Partially Fluorinated Electrolytes with Localized High Anion Concentration

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SSRN 2023年

作者： Yang, Tong Zhang, Wenna Shen, Chunli Ren, Long Liao, Xiaobin Guo, Yaqing Zhao, Yan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Science and Technology Wuhan430070 China The Institute of Technological Sciences Wuhan University Wuhan Hubei430072 China College of Materials Science and Engineering Sichuan University Chengdu610065 China Wuhan University China College of Chemistry and Materials Engineering Wenzhou University Wenzhou325035 China State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan430074 China

The design of a compatible electrolyte is crucial for achieving long-lifespan in lithium-metal batteries (LMBs). In this study, we report on a partially fluorinated electrolyte characterized by a weak solvation interaction of Li+ and a localized high anion concentration in the first solvation shell. This unique solvation structure shifts the reaction centers from solvent molecules to anions, enabling the predominant participation of anions in the formation of a LiF-rich solid-electrolyte interphase (SEI). Electrochemical experiments demonstrate efficient Li+ transfer kinetics, reduced Li nucleation overpotential polarization (28 mV), and extended cycling life in Li||Li cells using the partially fluorinated electrolyte. When tested in Li||NCM811 cells, the designed electrolyte delivers a capacity retention of 89.30% and exhibits a high average Coulombic efficiency of 99.80% over 100 cycles with a charge-potential cut-off of 4.6 V vs. Li/Li+ under the current density of 0.4 C. Furthermore, even at a current density of 1C, the cells maintain 81.90% capacity retention and a high average Coulombic efficiency of 99.40% after 180 cycles. This work underscores the significance of weak-solvation interaction in partially fluorinated electrolytes and highlights the crucial role of solvent structure in enabling the long-term stability and high-energy density of LMBs. © 2023, The Authors. All rights reserved.

关键词： Density functional theory

Low Anisotropy and Excellent Energy Absorption of Additively Manufactured Porous Ti-6al-4v Alloy Consisting of Disordered Trapezo-Rhombic Dodecahedron Cell Structures

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SSRN 2024年

作者： Zhao, Rusheng Guo, Shiyue Zhang, Fan Zhang, Wen Yang, Dongsheng Yue, Xuezheng Guo, Xiangyu Tang, Huiling Liu, Yang Hubei Longzhong Laboratory Xiangyang441000 China Graduate School of Systems Design Tokyo Metropolitan University Tokyo1910065 Japan The State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan430070 China School of Mechanical Engineering Hunan University of Science and Technology Xiangtan411201 China School of Materials Science and Engineering University of Shanghai for Science and Technology Shanghai200082 China Wuhan University of Technology China

Additive manufacturing (AM) can fabricate porous metals with exceptional characteristics for lightweight structural applications and energy absorption. The mechanical properties of porous metals are determined by porosity, cell shape, cell size, and loading direction. In this study, porous Ti-6Al-4V samples with ordered and disordered cellular structures were manufactured using the laser powder bed fusion (L-PBF) process, and the anisotropic compression behavior under different regularities was systematically investigated. The results show that samples with ordered cellular structures exhibited higher compressive strength under z-axis compression but were prone to shear band formation under x- and y-axis compression, leading to a significant reduction in strength. As regularity decreased, shear bands gradually disappeared, and the samples exhibited more uniform plastic deformation. Notably, when the regularity coefficient R = 0.8, the samples showed the best overall mechanical performance in all directions, including the highest plastic collapse strength and energy absorption capacity. With decreasing regularity, the anisotropy of the porous structures also decreased. Additionally, when R = 0.4, the anisotropy of mechanical performance parameters was minimized;however, when R = 0.8, the overall performance of the mechanical parameters was optimal. These results indicate that effectively adjusting the regularity of the pore structure is key to achieving isotropy and optimizing overall mechanical performance. Compared to simply choosing ordered cells, adjusting the regularity of the cell structure can achieve excellent mechanical properties and reduce anisotropy, which is of significant value for lightweight structures and energy absorption applications. © 2024, The Authors. All rights reserved.

关键词： Anisotropy