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arXiv 2025年

作者： Sun, Geng Xiao, Jian Li, Jiahui Wang, Jiacheng Kang, Jiawen Niyato, Dusit Mao, Shiwen College of Computer Science and Technology Jilin University Changchun130012 China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun130012 China affiliated with the College of Computing and Data Science Nanyang Technological University Singapore639798 Singapore School of Computer Science and Engineering Nanyang Technological University Singapore639798 Singapore School of Automation Guangdong University of Technology Guangzhou510641 China Department of Electrical and Computer Engineering Auburn University AuburnAL36849-5201 United States

Unmanned aerial vehicles (UAVs) have emerged as the potential aerial base stations (BSs) to improve terrestrial communications. However, the limited onboard energy and antenna power of a UAV restrict its communication range and transmission capability. To address these limitations, this work employs collaborative beamforming through a UAV-enabled virtual antenna array to improve transmission performance from the UAV to terrestrial mobile users, under interference from non-associated BSs and dynamic channel conditions. Specifically, we introduce a memory-based random walk model to more accurately depict the mobility patterns of terrestrial mobile users. Following this, we formulate a multi-objective optimization problem (MOP) focused on maximizing the transmission rate while minimizing the flight energy consumption of the UAV swarm. Given the NP-hard nature of the formulated MOP and the highly dynamic environment, we transform this problem into a multi-objective Markov decision process and propose an improved evolutionary multi-objective reinforcement learning algorithm. Specifically, this algorithm introduces an evolutionary learning approach to obtain the approximate Pareto set for the formulated MOP. Moreover, the algorithm incorporates a long short-term memory network and hyper-sphere-based task selection method to discern the movement patterns of terrestrial mobile users and improve the diversity of the obtained Pareto set. Simulation results demonstrate that the proposed method effectively generates a diverse range of non-dominated policies and outperforms existing methods. Additional simulations demonstrate the scalability and robustness of the proposed CB-based method under different system parameters and various unexpected circumstances. © 2025, CC0.

关键词： Unmanned aerial vehicles (UAV)

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Deep learning radiomics model related with genomics phenotypes for pathological complete response prediction in locally advanced rectal cancer under neoadjuvant chemoradiotherapy

Deep learning radiomics model related with genomics phenotyp...

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IEEE International Symposium on Information (IT) in Medicine and Education, ITME

作者： Ye Wang Zhen Pan Lanyan Lin Huajun Cai Feng Ding Chaojun Tan Dingyuan Zheng Yajun Xie Guoxian Guan Department of Colorectal Surgery The First Affiliated Hospital of Fujian Medical University Fuzhou China Department of Geriatric Medicine Fujian Key Laboratory of Geriatrics Diseases Fujian Provincial Center for Geriatrics Fuzhou University Affiliated Provincial Hospital Shengli Clinical Medical College of Fujian Medical University Fuzhou China Fujian Huaye Information Technology Co. Ltd China School of Big Data \& Key Laboratory of Data Science and Intelligent Computing Fuzhou University of International Studies and Trade Fuzhou China Department of Colorectal Surgery The First Affiliated Hospital of Fujian Medical University National Regional Medical Center Binhai Campus of the First Affiliated Hospital Fuzhou China

ISBN: (数字)9798350356670

ISBN: (纸本)9798350356687

Background: Developing a treatment strategy after neoadjuvant chemoradiotherapy (nCRT) based on accurate pathological complete response (pCR) predictions is crucial for locally advanced rectal cancer (LARC).Objective: To determine the effectiveness of a radiomics model using diffusion-weighted imaging (DWI) and T2-weighted in predicting post-nCRT pCR efficacy after ***: This study enrolled 237 LARC patients who had radical surgery under nCRT between February 2020 and August 2023. Tumor tissues from 54 patients were RNA sequenced. Radiomics features from preoperative MRI data were used to develop a model for deep learning via the LASSO algorithm. ROC curves were used to assess the model performance. Following Spearman's correlation, analyses of transcriptomic data were conducted to identify the genes correlated with the DPL ***: The DPL model, incorporating 7 features and 5 machine-learning algorithms, was used to create risk assessment models. The RF model excelled in predicting pCR, achieving an AUC of 0.91, accuracy of 0.88, and F1 score of 0.89. Furthermore, catabolic processes and pathways related to immunity were associated with selected DPL ***: The modified MRI-based radiomics model shows good predictive efficacy in predicting pCR after nCRT in LARC patients. Additionally, we investigated the genomic phenotypes associated with DPL.

关键词： Deep learning Support vector machines Pathology Analytical models Transcriptomics Predictive models data models Random forests Radiomics Cancer

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A deep learning system for predicting time to progression of diabetic retinopathy

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NATURE MEDICINE 2024年第2期30卷 358-359页

作者： [Anonymous] Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Center for Diabetes Shanghai China MOE Key Laboratory of AI School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Department of Ophthalmology Huadong Sanatorium Wuxi China Department of Ophthalmology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong China Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore Department of Computer Science and Engineering The Hong Kong University of Science and Technology Hong Kong China Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Hong Kong China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Department of Ophthalmology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Medical Records and Statistics Office Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Geriatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Tech

We developed and validated a deep learning system (termed DeepDR Plus) in a diverse, multiethnic, multi-country dataset to predict personalized risk and time to progression of diabetic retinopathy. We show that DeepDR Plus can be integrated into the clinical workflow to promote individualized intervention strategies for the management of diabetic retinopathy.

关键词： Diabetes complications Machine learning Predictive markers

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An Early Detection Model of Prostate Cancer Based on MRI

An Early Detection Model of Prostate Cancer Based on MRI

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IEEE International Conference on data science in Cyberspace (DSC)

作者： Yuankun Liu Lumin Xing Di Wang Xin Nie Xueyan Zhang Di Wu Wenjian Liu Faculty of Data Science City University of Macau China Shandong Provincial Qianfoshan Hospital The First Affiliated Hospital of Shandong First Medical University Jinan China Key Laboratory of Computing Power Network and Information Security Ministry of Education Shandong Computer Science Center Qilu University of Technology (Shandong Academy of Sciences) Jinan China Shandong Provincial Key Laboratory of Computer Networks Shandong Fundamental Research Center for Computer Science Jinan China Chongqing Jianzhu College Chongqing China School of Information Work Office Shandong Youth University of Political Science Jinan China School of Mathematics Physics and Computing University of Southern Queensland Queensland Australia

ISBN: (数字)9798350391367

ISBN: (纸本)9798350391374

Prostate cancer is a prevalent form of cancer among men, with a high rate of occurrence but relatively lower mortality compared to other types of cancer. Early detection is crucial because it allows for earlier intervention, potentially preventing progression to more severe stages, and improving patient outcomes. However, human diagnosis is time-consuming and inefficient, an autonomous early detection system is essential for saving lives. To address this challenge, we propose a novel MoE-MRIViT framework that uses advanced machine learning and computer vision techniques to analyze MRI images and identify features indicative of prostate cancer. The system processes the data using a vision transformer to extract precise prostate cancer features from MRI scans, and uses attention mechanisms to focus on significant areas. Through the MoE-MRIViT intervention in two stages, we have achieved superior results compared to the state-of-the-art (SOTA) methods. Experimental results demonstrate that our model achieves an impressive accuracy of 94.84%, outperforming the ResNet-101 and the basic ViT models, which achieve accuracies of 89.4% and 92.31%, respectively.

关键词： Computer vision Visualization Accuracy Magnetic resonance imaging Mortality Transformers Feature extraction Reliability Prostate cancer Medical diagnostic imaging

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Privacy-Preserving Federated Foundation Model for Generalist Ultrasound Artificial Intelligence

arXiv

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arXiv 2024年

作者： Jiang, Yuncheng Feng, Chun-Mei Ren, Jinke Wei, Jun Zhang, Zixun Hu, Yiwen Liu, Yunbi Sun, Rui Tang, Xuemei Du, Juan Wan, Xiang Xu, Yong Du, Bo Gao, Xin Wang, Guangyu Zhou, Shaohua Cui, Shuguang Goh, Rick Siow Mong Liu, Yong Li, Zhen Shenzhen518172 China Shenzhen518172 China Institute of High Performance Computing Agency for Science Technology and Research Singapore138632 Singapore College of Computer Science and Software Engineering Shenzhen University Shenzhen518060 China Shenzhen Research Institute of Big Data Shenzhen518172 China South China Hospital Health Science Center Shenzhen University Shenzhen518111 China School of Computer Science Nanjing University of Posts and Telecommunications Nanjing210023 China Affiliated Hospital of North Sichuan Medical College Sichuan637000 China North Sichuan Medical College Sichuan637000 China Shenzhen518055 China School of Computer Science Wuhan University Wuhan430072 China Thuwal23955-6900 Saudi Arabia Thuwal23955-6900 Saudi Arabia Beijing University of Posts and Telecommunications Beijing100876 China School of Biomedical Engineering Suzhou Institute for Advanced Research University of Science and Technology of China Suzhou215123 China Institute of Computing Technology Chinese Academy of Sciences Beijing100190 China

Ultrasound imaging is widely used in clinical diagnosis due to its non-invasive nature and real-time capabilities. However, conventional ultrasound diagnostics face several limitations, including high dependence on physician expertise and suboptimal image quality, which complicates interpretation and increases the likelihood of diagnostic errors. Artificial intelligence (AI) has emerged as a promising solution to enhance clinical diagnosis, particularly in detecting abnormalities across various biomedical imaging modalities. Nonetheless, current AI models for ultrasound imaging face critical challenges. First, these models often require large volumes of labeled medical data, raising concerns over patient privacy breaches. Second, most existing models are task-specific, which restricts their broader clinical utility. To overcome these challenges, we present UltraFedFM, an innovative privacy-preserving ultrasound foundation model. UltraFedFM is collaboratively pre-trained using federated learning across 16 distributed medical institutions in 9 countries, leveraging a dataset of over 1 million ultrasound images covering 19 organs and 10 ultrasound modalities. This extensive and diverse data, combined with a secure training framework, enables UltraFedFM to exhibit strong generalization and diagnostic capabilities. It achieves an average area under the receiver operating characteristic curve (AUROC) of 0.927 for disease diagnosis and a dice similarity coefficient (DSC) of 0.878 for lesion segmentation. Notably, UltraFedFM surpasses the diagnostic accuracy of mid-level ultrasonographers (4–8 years of experience) and matches the performance of expert-level sonographers (10+ years of experience) in the joint diagnosis of 8 common systemic diseases. These findings indicate that UltraFedFM can significantly enhance clinical diagnostics while safeguarding patient privacy, marking a significant advancement in AI-driven ultrasound imaging for future clinical applications. Copyri

关键词： Differential privacy

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Evaluating the Use of Large Language Model to Identify Top Research Priorities in Hematology

Evaluating the Use of Large Language Model to Identify Top R...

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International Conference on e-health Networking, Applications and Services (HealthCom)

作者： Huiqin Chen Fangwan Huang Xuanyun Liu Yinli Tan Dihua Zhang Dongqi Li Glen M. Borchert Ming Tan Jingshan Huang Department of Pediatrics The Third Affiliated Hospital Sun Yatsen University Guangzhou China College of Computer and Data Science Fuzhou University Fuzhou China Department of Nephrology The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Economics & School of Information and Computer Sciences University of California Irvine Irvine U.S.A. Department of Pharmacology College of Medicine University of South Alabama Mobile U.S.A. Institute of Biochemistry and Molecular Biology Institute of Biomedical Sciences China Medical University Taichung Taiwan School of Computing College of Medicine University of South Alabama Mobile U.S.A.

The field of hematology is highly progressive and dynamic requiring researchers to commit significant amounts of time and effort towards staying abreast of the most crucial research areas. As such, in this work we assess the potential of ChatGPT for identifying research priorities within five key topics in hematology: acute lymphocytic leukemia, immunotherapy, targeted therapy, hematopoietic stem cell transplantation, and acute myeloid leukemia. After ChatGPT was employed to generate specific research questions in these areas, a panel of seven experienced hematologists independently reviewed and rated resultant research questions based on four parameters: relevance, originality, clarity, and specificity on a scale of 1 to 5, with 5 denoting the highest score. Excitingly, the mean and median grades of the four parameters were all above 4, indicating that the hematologists strongly agreed that the problems generated by ChatGPT were generally highly specific, clear, relevant, and original. As such, although further work will clearly be required, we suggest our current study indicates that Large Language Models (LLMs), such as ChatGPT, may very well represent valuable new tools for more efficiently identifying and prioritizing impactful research questions in the field of hematology.

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Artificial Intelligence without Restriction Surpassing Human Intelligence with Probability One: Theoretical Insight into Secrets of the Brain with AI Twins of the Brain

arXiv

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arXiv 2024年

作者： Huang, Guang-Bin Westover, M. Brandon Tan, Eng-King Wang, Haibo Cui, Dongshun Ma, Wei-Ying Wang, Tiantong He, Qi Wei, Haikun Wang, Ning Tian, Qiyuan Lam, Kwok-Yan Yao, Xin Wong, Tien Yin School of Automation Southeast University Nanjing China Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of Education Nanjing China Beth Israel Deaconess Medical Center Harvard Medical School Boston United States Department of Neurology National Neuroscience Institute Singapore Research Centre of Big Data and Artificial Intelligence for Medicine First Affiliated Hospital of Sun Yat-Sen University Guangzhou China Duke-NUS Medical School National University of Singapore Singapore Mind PointEye Singapore Institute for AI Industry Research Tsinghua University Beijing China College of Computing and Data Science Nanyang Technological University Singapore School of Biomedical Engineering Tsinghua University Beijing China Singapore AI Safety Institute Nanyang Technological University Singapore School of Data Science Lingnan University Hong Kong School of Computer Science University of Birmingham United Kingdom Singapore Eye Research Institute Singapore National Eye Centre Singapore Tsinghua Medicine Tsinghua University Beijing China

Artificial Intelligence (AI) has apparently become one of the most important techniques discovered by humans in history while the human brain is widely recognized as one of the most complex systems in the universe. One fundamental critical question which would affect human sustainability remains open: Will artificial intelligence (AI) evolve to surpass human intelligence in the future? This paper shows that in theory new AI twins with fresh cellular level of AI techniques for neuroscience could approximate the brain and its functioning systems (e.g. perception and cognition functions) with any expected small error and AI without restrictions could surpass human intelligence with probability one in the end. This paper indirectly proves the validity of the conjecture made by Frank Rosenblatt 70 years ago about the potential capabilities of AI, especially in the realm of artificial neural networks. This paper also gives the answer to the two widely discussed fundamental questions: 1) whether AI could have potentials of discovering new principles in nature;2) whether error backpropagation (BP) algorithm commonly and efficiently used in tuning parameters in AI applications is also adopted in the brain. Intelligence is just one of fortuitous but sophisticated creations of the nature which has not been fully discovered. Like mathematics and physics, with no restrictions artificial intelligence would lead to a new subject with its self-contained systems and principles. We anticipate that this paper opens new doors for 1) AI twins and other AI techniques to be used in cellular level of efficient neuroscience dynamic analysis, functioning analysis of the brain and brain illness solutions;2) new worldwide collaborative scheme for interdisciplinary teams concurrently working on and modelling different types of neurons and synapses and different level of functioning subsystems of the brain with AI techniques;3) development of low energy of AI techniques with the aid of fundament

关键词： Neurology

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Single-cell omics: experimental workflow, data analyses and applications

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science China(Life sciences) 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University(The Second People’s Hospital of Wuhu City)Wuhu 241000China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration(Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji UniversityShanghai 200092China Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Research Institute of Intelligent Computing Zhejiang LabHangzhou 311121China Shanghai Research Institute for Intelligent Autonomous Systems Shanghai 201210China Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314103China Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology(CQB)Peking UniversityBeijing 100871China Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women’s HospitalZhejiang University School of MedicineHangzhou 310006China Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal U

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular *** exploration of how the genomes orchestrate the formation and maintenance of each cell,and control the cellular phenotypes of various organismsis,is both captivating and *** the inception of the first single-cell RNA technology,technologies related to single-cell sequencing have experienced rapid advancements in recent *** technologies have expanded horizontally to include single-cell genome,epigenome,proteome,and metabolome,while vertically,they have progressed to integrate multiple omics data and incorporate additional information such as spatial scRNA-seq and CRISPR ***-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases,including ***,we comprehensively summarize recent advances in single-cell omics technologies,with a specific focus on the methodology *** overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Combined compression and encryption of linear wireless sensor network data using autoencoders

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Scientific reports 2025年第1期15卷 17771页

作者： N Shylashree Sachin Kumar Hong Min Department of Electronics and Communication RV College of Engineering Affiliated to VTU Belagavi Bengaluru 560059 India. Big Data and Machine Learning Lab South Ural State University Chelyabinsk Russia. Akian College of Science and Engineering American University of Armenia Yerevan 0019 Armenia. School of Computing Gachon University Seongnam Republic of Korea. hmin@gachon.ac.kr.

In a linear wireless sensor network (LWSN), sensor nodes are deployed in a linear fashion to monitor and gather data along a linear path or route. Generally, the base station collects the data from the contiguously placed nodes in the same order. When the sensors are deployed closely and with a gradual variation of sensor data along the route, a high degree of correlation exists among the sensed data. The sensed data sequence can be compressed with very low loss in such a situation. In this paper, a joint compression and encryption method for LWSN data is presented. The method is based on the dimension reduction property of an autoencoder at the bottleneck section. The Encoder part of the trained Autoencoder, housed at the Base Station (BS), reduces the number of data samples at the encoded output. Hence, the data gets compressed at the output of the Encoder. The output of the Encoder is encrypted using an asymmetric encryption that provides immunity to the Chosen Plaintext Attack. Thus, both data compression and encryption are achieved together at the BS. Therefore, the procedure at the BS is denoted as joint compression and encryption. The encrypted data is sent to the Cloud Server for secured storage and further distribution to the End User, where it is decrypted and subsequently decompressed by the Decoder part of the trained Autoencoder. The decompressed data sequence is very nearly equal to the original data sequence. The proposed lossy compression has a mean square reconstruction error of less than 0.5 for compression ratios in the range of 5 to 10. The compression time taken is short even though the Autoencoder training process, which occurs once in a while, takes a relatively long time.

关键词： Autoencoder with supervised learning Chosen plaintext attack Integer matrix keys Joint compression and encryption Linear wireless sensor network Secured cloud storage

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Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study

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The Lancet Digital Health 2025年第5期7卷 100868页

作者： Meng, Ziyao Guan, Zhouyu Yu, Shujie Wu, Yilan Zhao, Yaoning Shen, Jie Lim, Cynthia Ciwei Chen, Tingli Yang, Dawei Ran, An Ran He, Feng Hamzah, Haslina Singh, Sarkaaj Abd Raof, Anis Syazwani Lee-Boey, Jian Wen Samuel Lim, Soo-Kun Sun, Xufang Ge, Shuwang Xu, Gang Su, Hua Cheng, Yang Lu, Feng Liao, Xiaofei Jin, Hai Deng, Chenxin Ruan, Lei Zhang, Cuntai Wu, Chan Dai, Rongping Jin, Yixiao Wang, Wenxiao Li, Tingyao Liu, Ruhan Li, Jiajia Shu, Jia Lu, Yuwei Wang, Xiangning Wu, Qiang Qin, Yiming Tang, Jin Sheng, Xiaohua Jiao, Qiong Yang, Xiaokang Guo, Minyi McKay, Gareth J Hogg, Ruth E Liew, Gerald Chee, Evelyn Yi Lyn Hsu, Wynne Lee, Mong Li Szeto, Simon Luk, Andrea O Y Chan, Juliana C N Cheung, Carol Y Tan, Gavin Siew Wei Tham, Yih-Chung Cheng, Ching-Yu Sabanayagam, Charumathi Lim, Lee-Ling Jia, Weiping Li, Huating Sheng, Bin Wong, Tien Yin Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Institute for Proactive Healthcare Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Centre for Diabetes Shanghai Key Laboratory of Diabetes Mellitus Shanghai China MOE Key Laboratory of AI School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Beijing Tsinghua Changgung Hospital Eye Center School of Clinical Medicine Tsinghua Medicine Tsinghua University Beijing China Medical Records and Statistics Office Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Renal Medicine Singapore General Hospital SingHealth-Duke Academic Medical Centre Singapore Singapore Department of Ophthalmology Shanghai Health and Medical Center Wuxi China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong Special Administrative Region China Singapore Eye Research Institute Singapore National Eye Centre Singapore Department of Medicine Faculty of Medicine Universiti Malaya Kuala Lumpur Malaysia Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Hubei Wuhan China Department of Nephrology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Nephrology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Ophthalmology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China National Engineering Research Centre for Big Dat

Background: Improving the accessibility of screening diabetic kidney disease (DKD) and differentiating isolated diabetic nephropathy from non-diabetic kidney disease (NDKD) are two major challenges in the field of diabetes care. We aimed to develop and validate an artificial intelligence (AI) deep learning system to detect DKD and isolated diabetic nephropathy from retinal fundus images. Methods: In this population-based study, we developed a retinal image-based AI-deep learning system, DeepDKD, pretrained using 734 084 retinal fundus images. First, for DKD detection, we used 486 312 retinal images from 121 578 participants in the Shanghai Integrated Diabetes Prevention and Care System for development and internal validation, and ten multi-ethnic datasets from China, Singapore, Malaysia, Australia, and the UK (65 406 participants) for external validation. Second, to differentiate isolated diabetic nephropathy from NDKD, we used 1068 retinal images from 267 participants for development and internal validation, and three multi-ethnic datasets from China, Malaysia, and the UK (244 participants) for external validation. Finally, we conducted two proof-of-concept studies: a prospective real-world study with 3 months' follow-up to evaluate the effectiveness of DeepDKD in screening DKD;and a longitudinal analysis of the effectiveness of DeepDKD in differentiating isolated diabetic nephropathy from NDKD on renal function changes with 4·6 years' follow-up. Findings: For detecting DKD, DeepDKD achieved an area under the receiver operating characteristic curve (AUC) of 0·842 (95% CI 0·838–0·846) on the internal validation dataset and AUCs of 0·791–0·826 across external validation datasets. For differentiating isolated diabetic nephropathy from NDKD, DeepDKD achieved an AUC of 0·906 (0·825–0·966) on the internal validation dataset and AUCs of 0·733–0·844 across external validation datasets. In the prospective study, compared with the metadata model, DeepDKD could detect DKD wit

关键词： Deep learning

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