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Correction: Extremely boosted neural network for more accurate multi-stage Cyber attack prediction in cloud computing environment

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Journal of Cloud Computing 2023年第1期12卷 1-1页

作者： Dalal, Surjeet Manoharan, Poongodi Kumar, Lilhore Umesh Seth, bijeta alsekait, Deema Mohammed Simaiya, Sarita Hamdi, Mounir Raahemifar, Kaamran Department of Computer Science and Engineering Amity University Haryana Gurugram India Division of Information and Computing Technology College of Science and Engineering Hamad Bin Khalifa University Qatar Foundation Doha Qatar School of Computing University of Louisiana Lafayette USA Department of Computer Science and Engineering Chandigarh University Mohali India Department of Computer Science and Engineering B. M. Institute of Engineering & Technology Sonipat India Department of Computer Science and Information Technology Applied College Princess Nourah Bint Abdulrahman University Riyadh Saudi Arabia College of Information Sciences and Technology Data Science and Artificial Intelligence Program State College USA School of Optometry and Vision Science Faculty of Science University of Waterloo Waterloo Canada Faculty of Engineering University of Waterloo Waterloo Canada

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Towards an international polar data coordination network

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data science Journal 2014年 13卷 PDA94-PDA102页

作者： Pulsifer, P.L. Yarmey, L. Godøy, Ø. Friddell, J. Parsons, M. Vincent, W.F. De bruin, T. Manley, W. Gaylord, A. Hayes, A. Nickels, S. Tweedie, C. Larsen, J.R. Huck, J. National Snow and Ice Data Center University of Colorado BoulderCO80309-0449 United States Norwegian Meteorological Institute Henrik Mohns plass 1 Oslo0313 Norway Canadian Cryospheric Information Network University of Waterloo 200 University Ave. W. WaterlooONN2L 3G1 Canada Research Data Alliance Rensselaer Polytechnic Institute TroyNY12180 United States CEN: Centre d'Etudes Nordiques Laval University Quebec CityG1V 0A6 Canada NIOZ Royal Netherlands Institute for Sea Research Texel Netherlands Institute of Alpine and Arctic Research University of Colorado BoulderCO80309-0450 United States Nuna Technologies PO Box 1483 HomerAK99603 United States Geomatics and Cartographic Research Centre Carleton University 1125 Colonel By Dr. OttawaONK1S 5B6 Canada Inuit Quajisarvingat 75 Albert St. OttawaONK1P 5E7 Canada Biology and the Environmental Science and Engineering Program University of Texas at El Paso El PasoTX79968 United States University of Alberta Libraries University of Alberta EdmontonABT6G 2J8 Canada

data management is integral to sound polar science. Through analysis of documents reporting on meetings of the Arctic data management community, a set of priorities and strategies are identified. These include the need to improve data sharing, make use of existing resources, and better engage stakeholders. Network theory is applied to a preliminary inventory of polar and global data management actors to improve understanding of the emerging community of practice. Under the name the Arctic data Coordination Network, we propose a model network that can support the community in achieving their goals through improving connectivity between existing actors.

关键词： Interoperability

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Galactic transient sources with the Cherenkov Telescope Array Observatory

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Monthly Notices of the Royal Astronomical Society 2025年第1期540卷 205–238页

作者： Abe, K Abe, S Abhir, J Abhishek, A Acero, F Acharyya, A Adam, R Aguasca-Cabot, A Agudo, I Aguirre-Santaella, A Alfaro, J Alfaro, R Alvarez-Crespo, N Alves batista, R Amans, J-P Amato, E Ambrosi, G Ambrosino, F Angüner, E O Antonelli, L A Aramo, C Arcaro, C Arnesen, T T H Asano, K Ascasibar, Y Aschersleben, J Ashkar, H Augusto Stuani, L baack, D backes, M balazs, C balbo, M baquero Larriva, A barbosa Martins, V barres de Almeida, U barrio, J A barrios-Jiménez, L batković, I batzofin, R baxter, J becerra González, J becker Tjus, J belmont, R benbow, W bernete, J bernlöhr, K berti, A bertucci, b beshley, V bhattacharjee, P bhattacharyya, S bigongiari, C bissaldi, E blanch, O blazek, J bocchino, F boisson, C bolmont, J bonnoli, G bonollo, A bordas, P bosnjak, Z bottacini, E böttcher, M bradascio, F bronzini, E brown, A M brunelli, G bulgarelli, A burelli, I burger-Scheidlin, C burmistrov, L burton, M buscemi, M Cailleux, J Campoy-Ordaz, A Cantlay, b K Capasso, G Caproni, A Capuzzo-Dolcetta, R Caraveo, P Caroff, S Carosi, A Carosi, R Carquin, E Carrasco, M-S Cascone, E Cassol, F Castaldini, L Castrejon, N Castro-Tirado, A J Cerasole, D Ceribella, G Cerruti, M Chadwick, P M Chaty, S Chen, A W Chernyakova, M Chiavassa, A Chudoba, J Chytka, L Cicciari, G M Cifuentes, A Coimbra Araujo, C H Colapietro, M Conforti, V Contreras, J L Cortina, J Costa, A Costantini, H Cotter, G Cristofari, P Cuevas, O Curtis-Ginsberg, Z D’Aì, A D’Amico, G D’Ammando, F Dai, S Dazzi, F de bony de Lavergne, M De Caprio, V De Cesare, G De Frondat Laadim, F de Gouveia Dal Pino, E M De Lotto, b De Lucia, M de Martino, D de Menezes, R de Naurois, M de Ona Wilhelmi, E de Souza, V del Peral, L del Valle, M V Delgado, C Dell’aiera, M Della Valle, M della Volpe, D Depaoli, D Devin, J Di Girolamo, T Di Piano, A Di Pierro, F Di Tria, R Di Venere, L Diebold, S Dignam, C Dima, R Dinesh, A Djuvsland, J Dominik, R M Dominis Prester, D Donini, A Dorner, D Dörner, J Doro, M Dubos, C Ducci, L Dwarkadas, V V Ebr, J Eckner, C Egberts, K Einecke, S Elsässer, D Emery Department of Physics Tokai University 4-1-1 Kita-Kaname Hiratsuka Kanagawa 259-1292 Japan Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Kashiwa Chiba 277-8582 Japan ETH Zürich Institute for Particle Physics and Astrophysics Otto-Stern-Weg 5 CH-8093 Zürich Switzerland INFN and Università degli Studi di Siena Dipartimento di Scienze Fisiche della Terra e dell’Ambiente (DSFTA) Sezione di Fisica Via Roma 56 I-53100 Siena Italy Université Paris-Saclay Université Paris Cité CEA CNRS AIM F-91191 Gif-sur-Yvette Cedex France FSLAC IRL 2009 CNRS/IAC E-38205 La Laguna Tenerife Spain University of Alabama Tuscaloosa Department of Physics and Astronomy Gallalee Hall Box 870324 Tuscaloosa AL 35487-0324 USA Université Côte d’Azur Observatoire de la Côte d’Azur CNRS Laboratoire Lagrange UF 06304 Nice France Laboratoire Leprince-Ringuet CNRS/IN2P3 École Polytechnique Institut Polytechnique de Paris F-91120 Palaiseau France Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 E-08028 Barcelona Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n E-18008 Granada Spain Institute for Computational Cosmology and Department of Physics Durham University South Road Durham DH1 3LE UK Pontificia Universidad Católica de Chile Av. Libertador Bernardo O’Higgins 340 8331150 Santiago Chile Universidad Nacional Autónoma de México Delegación Coyoacán 04510 Ciudad de México Mexico IPARCOS-UCM Instituto de Física de Partículas y del Cosmos and EMFTEL Department Universidad Complutense de Madrid E-28040 Madrid Spain Instituto de Física Teórica UAM/CSIC and Departamento de Física Teórica Universidad Autónoma de Madrid c/ Nicolás Cabrera 13-15 Campus de Cantoblanco UAM E-28049 Madrid Spain LUTH GEPI and LERMA Observatoire de Paris Université PSL Université Paris Cité CNRS 5 place Jules Janssen F-92190 Meudon France INAF – Osservatorio

A wide variety of Galactic sources show transient emission at soft and hard X-ray energies: low- and high-mass X-ray binaries containing compact objects, isolated neutron stars exhibiting extreme variability as magnetars as well as pulsar-wind nebulae. Although most of them can show emission up to MeV and/or GeV energies, many have not yet been detected in the TeV domain by Imaging Atmospheric Cherenkov Telescopes. In this paper, we explore the feasibility of detecting new Galactic transients with the Cherenkov Telescope Array Observatory (CTAO) and the prospects for studying them with Target of Opportunity observations. We show that CTAO will likely detect new sources in the TeV regime, such as the massive microquasars in the Cygnus region, low-mass X-ray binaries with low-viewing angle, flaring emission from the Crab pulsar-wind nebula or other novae explosions, among others. Since some of these sources could also exhibit emission at larger time-scales, we additionally test their detectability at longer exposures. We finally discuss the multiwavelength synergies with other instruments and large astronomical facilities.

关键词： binaries: general stars: magnetars novae cataclysmic variables pulsars: general gamma-rays: general

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COMPUTER-SYSTEM ARCHITECTURE CONCEPTS FOR FUTURE COMbAT SYSTEMS

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NAVAL ENGINEERS JOURNAL 1990年第3期102卷 43-62页

作者： ZITZMAN, LH FALATKO, SM PAPACH, JL Dr. Lewis H. Zitzman:is the group supervisor of the Advanced Systems Design Group Fleet Systems Department The Johns Hopkins University Applied Physics Laboratory (JHU/APL). He has been employed at JHU/APL since 1972 performing applied research in computer science and in investigating and applying advanced computer technologies to Navy shipboard systems. He is currently chairman of Aegis Computer Architecture Data Bus and Fiber Optics Working Group from which many concepts for this paper were generated. Dr. Zitzman received his B.S. degree in physics from Brigham Young University in 1963 and his M.S. and Ph.D. degrees in physics from the University of Illinois in 1967 and 1972 respectively. Stephen M. Falatko:was a senior engineering analyst in the Combat Systems Engineering Department Comptek Research Incorporated for the majority of this effort. He is currently employed at ManTech Services Corporation. During his eight-year career first at The Johns Hopkins University Applied Physics Laboratory and currently with ManTech Mr. Falatko's work has centered around the development of requirements and specifications for future Navy systems and the application of advanced technology to Navy command and control systems. He is a member of both the Computer Architecture Fiber Optics and Data Bus Working Group and the Aegis Fiber Optics Working Group. Mr. Falatko received his B.S. degree in aerospace engineering with high distinction from the University of Virginia in 1982 and his M.S. degree in applied physics from The Johns Hopkins University in 1985. Mr. Falatko is a member of Tau Beta Pi Sigma Gamma Tau the American Society of Naval Engineers and the U.S. Naval Institute. Janet L. Papach:is a section leader and senior engineering analyst in the Combat Systems Engineering Department Comptek Research Incorporated. She has ten years' experience as an analyst supporting NavSea Spa War and the U.S. Department of State. She currently participates in working group efforts under Aegis Combat System Doctrin

This paper sets forth computer systems architecture concepts for the combat system of the 2010–2030 timeframe that satisfy the needs of the next generation of surface combatants. It builds upon the current Aegis computer systems architecture, expanding that architecture while preserving, and adhering to, the Aegis fundamental principle of thorough systems engineering, dedicated to maintaining a well integrated, highly reliable, and easily operable combat system. The implementation of these proposed computer systems concepts in a coherent architecture would support the future battle force capable combat system and allow the expansion necessary to accommodate evolutionary changes in both the threat environment and the technology then available to effectively counter that threat. Changes to the current Aegis computer architecture must be carefully and effectively managed such that the fleet will retain its combat readiness capability at all times. This paper describes a possible transition approach for evolving the current Aegis computer architecture to a general architecture for the future. The proposed computer systems architecture concepts encompass the use of combinations of physically distributed, microprocessor-based computers, collocated with the equipment they support or embedded within the equipment itself. They draw heavily on widely used and available industry standards, including instruction set architectures (ISAs), backplane busses, microprocessors, computer programming languages and development environments, and local area networks (LANs). In this proposal, LANs, based on fiber optics, will provide the interconnection to support system expandability, redundancy, and higher data throughput rates. A system of cross connected LANs will support a high level of combat system integration, spanning the major warfare areas, and will facilitate the coordination and development of a coherent multi-warfare tactical picture supporting the future combatant command st

关键词： Computer Architecture

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STUDENT PRIZE PAPER: The Illnesses No Longer Understand: Changing Concepts of Health and Curing in a Rural Mexican Community

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Medical Anthropology Quarterly 1977年第2期8卷 5-11页

作者： Kathleen Musante DeWalt Kathleen DeWalt is a fourth year graduate student in the Dept of Biocultural Anthropology Connecticut-Storrs and in the Social Sciences and Health Services Training Program in the Dept of Community Medicine and Health Care at the U Conn Health Center Farmington. She received her B.A. in 1971 and her M.A. in 1976 both in Anthropology from Connecticut. The work on which this paper is based was carried out in a village in the municipio of Temascalcingo between January and December 1973 about 11 months in all. She had first worked in the Temascalcingo area in summer 1970 supported by a National Science Foundation undergraduate research grant. In 1971 she began her graduate study in the Dept of Anthropology at Connecticut but decided to discontinue her studies at that time in order to be with her husband while he carried out his Ph.D. dissertation research on agricultural modernization in Mexico. During this period however Ms. DeWalt was able to carry out a preliminary study of her own which focused on medical behavior and diet. When she returned from the field she resumed her studies by entering the Social Sciences and Health Services Doctoral Training Program located in the Dept of Community Medicine at the U of Connecticut Health Center. Ms. DeWalt has just completed her Ph.D. qualifying examinations at Connecticut and plans to begin work on her dissertation shortly. Her dissertation will focus on the effects of economic diversification on diet and nutrition in the Temascalcingo area. While the research carried out thus far will serve as background and provide baseline data she expects to spend an additional 4–6 months in the field in 1977.

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Interactive tools for signal processing education. The signal processing instructional facility (SPIF lab) at Washington State University

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Computer Applications in Engineering Education 1993年第6期1卷 517-517页

作者： bamberger, R.H. Signal Processing Instructional Facility School of Electrical Engineering and Computer Science Washington State University Pullman WA 99164-2752 Dr. Roberto H. Bamberger:was born on January 30 1965 in Buenos Aires Argentina. He received his B.E.E and PhD from the Georgia Institute of Technology in 1986 and 1990 respectively. Currently Dr. Bamberger is an assistant professor in the School of Electrical Engineering and Computer Science at Washington State University. Dr. Bamberger's research program is focused on the design implementation and application of multidimensional multirate filter banks subband image and video compression analysis of nonstationary data and application of digital signal processing techniques in the design of analog and mixed-mode integrated circuits. Dr. Bamberger is the founder and director of the Signal Processing Instructional Facility (SPIF Lab) at Washington State University. The SPIF Lab features interactive multimedia-based tools for teaching concepts related to linear systems theory. Dr. Bamberger is active in developing multimedia-based instructional laboratories for a variety of other topics as well. In addition to his teaching and research programs Dr. Bamberger is an associate editor for theIEEE Transactions on Signal Processingand a member of the editorial board forComputer Applications in Engineering Education. Dr. Bamberger is also advisor to the WSU Student Branch of the IEEE and assistant director of the WSU Cougar Marching Band. Dr. Bamberger is a member of Phi Eta Sigma Eta Kappa Nu Tau Beta Pi and Kappa Kappa Psi.

The Signal Processing Instructional Facility (SPIF Lab) is an experiment in using in interactive multimedia for teaching concepts related to linear systems theory and signal processing. The goals of the SPIF lab are to augment, enhance, and interconnect sophomore, junior, and senior level courses with the common thread of linear systems and transforms by unifying the experimentation medium. In this fashion, physical phenomenon is returned to the forefront of engineering education. The laboratory features powerful Mathematica Notebooks (a form of hypertext) and interactive applications that use dedicated DSP microprocessors.

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lenstronomy II: A gravitational lensing software ecosystem

arXiv

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arXiv 2021年

作者： birrer, Simon Shajib, Anowar J. Gilman, Daniel Galan, Aymeric Aalbers, Jelle Millon, Martin Morgan, Robert Pagano, Giulia Park, Ji Won Teodori, Luca Tessore, Nicolas Ueland, Madison van de Vyvere, Lyne Wagner-Carena, Sebastian Wempe, Ewoud Yang, Lilan Ding, Xuheng Schmidt, Thomas Sluse, Dominique Zhang, Ming Amara, Adam Kavli Institute for Particle Astrophysics and Cosmology Department of Physics Stanford University StanfordCA94305 United States SLAC National Accelerator Laboratory Menlo ParkCA94025 United States Department of Astronomy & Astrophysics University of Chicago ChicagoIL60637 United States Department of Physics and Astronomy University of California Los AngelesCA90095 United States Department of Astronomy and Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada Switzerland Physics Department University of Wisconsin-Madison 1150 University Avenue MadisonWI53706 United States Legacy Survey of Space and Time Corporation Data Science Fellowship Program United States Weizmann Institute 234 Herzl Street Rehovot7610001 Israel Department of Physics and Astronomy University College London Gower Street LondonWC1E 6BT United Kingdom STAR Institute Université de Liège Quartier Agora - Allée du six Août 19c LiègeB-4000 Belgium Kapteyn Astronomical Institute University of Groningen PO Box 800 Groningen9700 AV Netherlands School of Physics and Technology Wuhan University Wuhan430072 China UTIAS University of Tokyo Kashiwa Chiba277-8583 Japan Xinjiang Astronomical Observatory Chinese Academy of Sciences 150 Science 1-Street Urumqi831001 China Institute of Cosmology and Gravitation University of Portsmouth PortsmouthPO1 3FX United Kingdom

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CAD CAM GOES TO SEA - THE SAAR-5 DESIGN AND CONSTRUCTION

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NAVAL ENGINEERS JOURNAL 1992年第3期104卷 148-155页

作者： LINDGREN, JR SOLITARIO, WA MOORE, AP STREIFF, MA John R. Lindgren Jr:. is vice president for engineering at Ingalls Shipbuilding Inc. a Division of Litton Industries in Pascagoula Miss. He joined Ingalls in 1958 and has held various positions in the Engineering Division and participated in the design of numerous merchant ships drill rigs submarines and surface combatants and auxiliary support ships. Mr. Lindgren is a 1958 graduate of the University of Southwest Louisiana. His degree is in mechanical engineering and he is also a licensed professional engineer. William A. Solitario:is the director of advanced technology at Ingalls Shipbuilding Inc. in Pascagoula Miss. He received his B.S. degree in chemical engineering from the City University of New York and has 28 years experience in marine engineering and design. His current responsibilities include the direction of Ingalls' IRAD programs and several Navy-funded R&D programs to improve ship's performance and reduce ship's operating costs. He is a member of the Society of Naval Architects and Marine Engineers and past chairman of the Gulf Section East Area. Arnold P. Moore:is the director design engineering at Ingalls Shipbuilding where he is responsible for all new construction design and engineering activities. Prior to promotion to his current position Mr. Moore served as chief naval architect at Ingalls. He has 24 years experience in ship design construction and repair. Mr. Moore holds the professional degree of ocean engineer as well as a master's degree in naval architecture and marine engineering from MIT. He also earned a bachelor's degree in naval science from the U.S. Naval Academy and is a registered professional engineer. Mr. Moore served as an engineering duty officer in the U.S. Navy and is currently a captain in the Naval Reserve. He is a past chairman of the Gulf Section of the Society of Naval Architects and Marine Engineers and a member of the American Society of Naval Engineers and Sigma Xi. Michel A. Streiff:is the manager of CAD/CAM applications at Ingalls Shipbuilding Inc. His

The SA'AR-5 Corvette program is the first major warship construction to be entirely accomplished using a 3-dimensional, interference checked computer based design. This paper discusses the organization and approach used to create the design models which form the basis for interference checking as well as the source of extracted production data. The design or product model is the nucleus of the computer data base that defines the configuration of the entire ship. The data base includes geometry, weight, and material, as well as production control data. The ability of the computer to link such diverse information is the key to maintaining configuration control during the course of the design and construction. The ease with which formatted manufacturing data (both N.C. fabrication and installation) can be extracted enables the preparation of detailed packages containing the desired geometry as well as the associated material and sequencing data, thus assuring the producibility of the design. The SA'AR-5 design is CAD/CAM's state of the art in U.S. shipbuilding.

关键词： Warships

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OPTIMADE, an API for exchanging materials data

arXiv

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arXiv 2021年

作者： Andersen, Casper W. Armiento, Rickard blokhin, Evgeny Conduit, Gareth J. Dwaraknath, Shyam Evans, Matthew L. Fekete, Ádám Gopakumar, Abhijith Gražulis, Saulius Merkys, Andrius Mohamed, Fawzi Oses, Corey Pizzi, Giovanni Rignanese, Gian-Marco Scheidgen, Markus Talirz, Leopold Toher, Cormac Winston, Donald Aversa, Rossella Choudhary, Kamal Colinet, Pauline Curtarolo, Stefano Di Stefano, Davide Draxl, Claudia Er, Suleyman Esters, Marco Fornari, Marco Giantomassi, Matteo Govoni, Marco Hautier, Geoffroy Hegde, Vinay Horton, Matthew K. Huck, Patrick Huhs, Georg Hummelshøj, Jens Kariryaa, Ankit Kozinsky, boris Kumbhar, Snehal Liu, Mohan Marzari, Nicola Morris, Andrew J. Mostofi, Arash A. Persson, Kristin A. Petretto, Guido Purcell, Thomas Ricci, Francesco Rose, Frisco Scheffler, Matthias Speckhard, Daniel Uhrin, Martin Vaitkus, Antanas Villars, Pierre Waroquiers, David Wolverton, Chris Wu, Michael Yang, Xiaoyu École Polytechnique Fédérale de Lausanne Lausanne1015 Switzerland Materials Design and Informatics Unit Department of Physics Chemistry and Biology Linköping University Sweden Tilde Materials Informatics Straßmannstraße 25 Berlin10249 Germany Materials Platform for Data Science Sepapaja 6 Tallinn15551 Estonia Theory of Condensed Matter Group Cavendish Laboratory 19 J.J. Thomson Avenue CambridgeCB3 0HE United Kingdom Lawrence Berkeley Labs BerkeleyCA United States Chemin des Étoiles 8 Louvain-la-Neuve1348 Belgium Department of Physics King's College London London United Kingdom Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States Institute of Biotechnology Life Science Center Vilnius University Saulétekio av. 7 VilniusLT-10257 Lithuania Institute of Computer Science Faculty of Mathematics and Informatics Vilnius University Naugarduko g. 24 VilniusLT-03225 Lithuania Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6 Berlin14195 Germany Center for Autonomous Materials Design Duke University DurhamNC27708 United States Department of Mechanical Engineering and Materials Science Duke University DurhamNC27708 United States Humboldt-Universität zu Berlin Institut für Physik and IRIS Adlershof Berlin12489 Germany École Polytechnique Fédérale de Lausanne Sion1951 Switzerland Trieste34136 Italy Hermann-von-Helmholtz-Platz 1 Eggenstein-Leopoldshafen76344 Germany Materials Measurement Laboratory National Institute of Standards and Technology GaithersburgMD20899 United States Ansys 300 Rustat House 62 Clifton Rd CambridgeCB1 7EG United Kingdom De Zaale 20 Eindhoven5612 AJ Netherlands Department of Physics and Science of Advanced Materials Program Central Michigan University Mount PleasantMI48859 United States Argonne National Laboratory LemontIL60439 United States Thayer School of Engineering Dartmouth College HanoverNH03755 United States Los AltosCA940

The Open databases Integration for Materials Design (OPTIMADE) consortium has designed a universal application programming interface (API) to make materials databases accessible and interoperable. We outline the first stable release of the specification, v1.0, which is already supported by many leading databases and several software packages. We illustrate the advantages of the OPTIMADE API through worked examples on each of the public materials databases that support the full API specification. © 2021, CC bY.

关键词： Specifications

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Deep-learning-based cardiovascular risk stratification using coronary artery calcium scores predicted from retinal photographs

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The Lancet Digital Health 2021年第5期3卷 e306-e316页

作者： Rim, Tyler Hyungtaek Lee, Chan Joo Tham, Yih-Chung Cheung, Ning Yu, Marco Lee, Geunyoung Kim, Youngnam Ting, Daniel S W Chong, Crystal Chun Yuen Choi, Yoon Seong Yoo, Tae Keun Ryu, Ik Hee baik, Su Jung Kim, Young Ah Kim, Sung Kyu Lee, Sang-Hak Lee, byoung Kwon Kang, Seok-Min Wong, Edmund Yick Mun Kim, Hyeon Chang Kim, Sung Soo Park, Sungha Cheng, Ching-Yu Wong, Tien Yin Singapore Eye Research Institute Singapore National Eye Centre Singapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical School Singapore Radiological Sciences Academic Clinical Programme Duke-NUS Medical School Singapore Department of Ophthalmology Institute of Vision Research Severance Hospital Yonsei University College of Medicine Seoul South Korea Department of Radiology Research Institute of Radiological Science Severance Hospital Yonsei University College of Medicine Seoul South Korea Division of Cardiology Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul South Korea Healthcare Research Team Health Promotion Center Gangnam Severance Hospital Yonsei University College of Medicine Seoul South Korea Division of Cardiology Gangnam Severance Hospital Yonsei University College of Medicine Seoul South Korea Division of Healthcare Big Data Yonsei University College of Medicine Seoul South Korea Department of Preventive Medicine Yonsei University College of Medicine Seoul South Korea Integrated Research Center for Cerebrovascular and Cardiovascular Diseases Yonsei University College of Medicine Seoul South Korea Medi Whale Seoul South Korea B&VIIt Eye Center Seoul South Korea Philip Medical Center Bundang Seongnam South Korea

background: Coronary artery calcium (CAC) score is a clinically validated marker of cardiovascular disease risk. We developed and validated a novel cardiovascular risk stratification system based on deep-learning-predicted CAC from retinal photographs. Methods: We used 216 152 retinal photographs from five datasets from South Korea, Singapore, and the UK to train and validate the algorithms. First, using one dataset from a South Korean health-screening centre, we trained a deep-learning algorithm to predict the probability of the presence of CAC (ie, deep-learning retinal CAC score, RetiCAC). We stratified RetiCAC scores into tertiles and used Cox proportional hazards models to evaluate the ability of RetiCAC to predict cardiovascular events based on external test sets from South Korea, Singapore, and the UK biobank. We evaluated the incremental values of RetiCAC when added to the Pooled Cohort Equation (PCE) for participants in the UK biobank. Findings: RetiCAC outperformed all single clinical parameter models in predicting the presence of CAC (area under the receiver operating characteristic curve of 0·742, 95% CI 0·732–0·753). Among the 527 participants in the South Korean clinical cohort, 33 (6·3%) had cardiovascular events during the 5-year follow-up. When compared with the current CAC risk stratification (0, >0–100, and >100), the three-strata RetiCAC showed comparable prognostic performance with a concordance index of 0·71. In the Singapore population-based cohort (n=8551), 310 (3·6%) participants had fatal cardiovascular events over 10 years, and the three-strata RetiCAC was significantly associated with increased risk of fatal cardiovascular events (hazard ratio [HR] trend 1·33, 95% CI 1·04–1·71). In the UK biobank (n=47 679), 337 (0·7%) participants had fatal cardiovascular events over 10 years. When added to the PCE, the three-strata RetiCAC improved cardiovascular risk stratification in the intermediate-risk group (HR trend 1·28, 95% CI 1·07–1·54) and bo

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