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18th International Joint Conference on biomedical engineering Systems and Technologies, BIOSTEC 2025

作者： Carvalho, M.A.G. Frayne, R. School of Technology University of Campinas Brazil Radiology and Clinical Neurosciences Hotchkiss Brain Institute Univ. of Calgary Canada Seaman Family MR Research Centre Foothills Medical Centre Calgary Canada Biomedical Engineering Graduate Program University of Calgary Canada Calgary Image Processing and Analysis Centre Foothills Medical Centre Calgary Canada

Graphs have been used successfully to represent and analyze brain networks for many decades. Such structural and functional studies are important for revealing interactions between distinct areas of the brain that, for ex ample, are associated with the performance of a specific task or the onset of a cognitive disorder like dementia. In this pilot study, resting-state functional magnetic resonance imaging data were acquired in a sex-balanced sample of 10 young (20.1±2.1 years) and 10 old (65.6±0.4 years), presumed healthy, adults. We examined the effects of age on whole-brain resting-state functional connectivity (RSFC) networks. We examined two main graph modeling approaches to analyze RSFC networks. These approaches employ different strategies or graph models for thresholding over the complete network or examining changes in graph density. We com puted and compared one graph metric, the modularity, that was derived from the RSFC network graph models. Considering the need for a model that must preserve the network’s connectivity, strategies that use spanning trees as seeds to gradually increase the graph’s density seem more appropriate to represent brain networks. © 2025 by SCITEPRESS– Science and Technology Publications, Lda.

关键词： Magnetic resonance imaging

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An Open-Source GPU-Based Acoustic Simulator for Fast and Accurate Modeling of Acoustic Scattering

An Open-Source GPU-Based Acoustic Simulator for Fast and Acc...

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IEEE International Symposium on Applications of Ferroelectrics (ISAF)

作者： Zixuan Tian Yun Jing Aiguo Han Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana USA Graduate Program in Acoustics Pennsylvania State University USA Department of Biomedical Engineering and Mechanics Virginia Polytechnic Institute and State University Blacksburg USA

ISBN: (数字)9798350371901

ISBN: (纸本)9798350371918

Fast, accurate, and realistic simulations of ultrasonic scattering in biological tissues play an important role in biomedical ultrasound research. This study introduces UltraWave, a new open-source ultrasound simulation tool we developed for accurately modeling acoustic and elastic wave propagation in two- and three-dimensional heterogeneous media. UltraWave allows the utilization of multiple graphics processing units (GPUs) to deliver faster and more accurate full-wave simulations. The perfectly matched layer was integrated into the simulator. UltraWave was validated against well-established scattering theories in a variety of basic scattering scenarios, and achieved similar or higher accuracy than the widely used k-Wave toolbox. Additionally, UltraWave outperformed k-Wave in terms of computational efficiency with both central processing units (CPUs) and GPUs, particularly when using GPU acceleration for elastic wave simulations. These results demonstrated the potential of UltraWave as a promising tool for biomedical ultrasound simulations.

关键词： Solid modeling Accuracy Ultrasonic imaging Biological system modeling Computational modeling Graphics processing units Media Acoustics Computational efficiency Perfectly matched layers

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Z-Laminating Assembly of Graphene Nanoflakes for Super-Strong Membranes and Functional Coatings

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ACS Applied Nano Materials 2024年第13期7卷 14957-14963页

作者： Santos, Ian Daniell Tjarks, Patrick Muthu, Jeyavelan Lin, You-Chen Yen, Zhi-Long Chand, Pradyumna Kumar Raman, Radha Nguyen, Dinh Tuan Rouhani, Mehdi Jeng, Yeau-Ren Hsieh, Ya-Ping Hofmann, Mario Department of Physics National Taiwan University Taipei 106 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei 106 Taiwan J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences Prague 18200 Czech Republic Institute of Atomic and Molecular Sciences Academia Sinica Taipei 106 Taiwan Department of Chemistry National Taiwan University Taipei 106 Taiwan Department of Physics National Central University Taoyuan 320 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Central University Taipei 106 Taiwan Department of Biomedical Engineering National Cheng Kung University 1 University Road Tainan 70101 Taiwan Department of Materials Science and Engineering National Cheng Kung University Tainan 70101 Taiwan Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng-Kung University (NCKU) Tainan 70101 Taiwan

We demonstrate the strengthening of graphene, an atomically thin carbon allotrope, by out-of-plane folding. Through lateral confinement of graphene at the water-air interface, nanoscale buckling was induced in suspended flakes, leading to an unexpected folding transition beyond a critical surface pressure. The emergence of folding was confirmed by in situ Brewster angle reflectivity and ex situ microscopy, showing a unique “z-laminated” nanostructure. Molecular dynamics simulations indicate that z-lamination yields an enhanced adhesion between neighboring flakes compared to lateral sliding, which was confirmed by a surface pressure hysteresis during the folding process. Mechanical testing reveals superior Young’s modulus and yield strength when compared to conventional graphene assemblies and even compared to composites. We demonstrate the potential of the z-lamination approach for applications in graphene-based structural materials, tribological layers, and functional electrochemical coatings. Finally, the complete recyclability of z-laminated graphene opens up new routes toward sustainable nanostructured materials. © 2024 The Authors. Published by American Chemical Society

关键词： 2D materials composites laminated graphene membranes recyclable

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Set-based state estimation of a Li-ion cell using DC programming and constrained zonotopes

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IFAC-PapersOnLine 2023年第2期56卷 7147-7153页

作者： Angelo Tottoli Alesi A. de Paula Guilherme V. Raffo Bruno O.S. Teixeira Davide M. Raimondo Department of Electrical Computer and Biomedical Engineering University of Pavia Italy Graduate Program in Electrical Engineering Universidade Federal de Minas Gerais Belo Horizonte MG Brazil Department of Electronic Engineering Universidade Federal de Minas Gerais Belo Horizonte MG Brazil

Advanced battery management systems (ABMSs) rely on mathematical models to ensure high battery safety and performance. One of the key tasks of a BMS is state estimation. In the following, we consider a single lithium-ion cell described with a dual polarization equivalent circuit model. To consider a realistic scenario, where the parameters have been identified from experimentally collected data, both parametric and measurement uncertainties are taken into account in the model. In particular, unknown but bounded uncertainties are assumed. In this setup, we address state estimation through a set-based approach using Constrained Zonotopes (CZ). Due to the model nonlinearities, a method able to propagate CZ through nonlinear mappings is demanded. Within this context, mean value and first-order Taylor CZ-based extensions were proposed which, however, might lead to conservative overestimation due to the sensitivity to the wrapping and dependency effects inherited from interval arithmetic. In the following, we suggest the use of DC programming as an alternative. The effectiveness of the proposed scheme is demonstrated in simulation for the considered Li-ion model.

关键词： Lithium-ion cells Nonlinear state estimation Uncertainty Set-based approach

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Constructing Coronary Artery Vessel Segmentation Based on Deep Learning Models and Image Processing 24

Constructing Coronary Artery Vessel Segmentation Based on De...

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8th International Conference on Medical and Health Informatics, ICMHI 2024

作者： Peng, Kang-Syuan Chang, Hsiao-Huang Hsu, Ying-Kai Chien, Ting-Ying Department of Computer Science and Engineering Yuan Ze University Taoyuan City Taiwan Cardiovascular Surgery Department Taipei Veterans General Hospital Taipei City TaiwanTaipei Medical University Taipei City Taiwan Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan City Taiwan TaiwanInnovation Center for Big Data and Digital Convergence Yuan Ze University Taoyuan City Taiwan

ISBN: (纸本)9798400716874

Narrowing of the coronary arteries is an important indicator of the severity of coronary artery disease (CAD) in patients. Previous research using deep learning to identify narrowed vessels has primarily been based on object detection, but this approach has several problems, such as the inability to detect multivessel narrowing, calculate the actual rate of narrowing, and determine the exact location of occurrence. Therefore, we believe that the determination of narrowing should return to the original method, namely, calculating the maximum and minimum diameters around the vessel. However, to automate this task, a preprocessing step for separating each vessel is needed, especially for the complex structure of the left coronary artery. We designed a deep learning model capable of analyzing an entire coronary angiography (CAG) image for the separation and tracking of vessels. This not only serves as a preprocessing step for calculating narrowing but also allows for the analysis of different vessel flow directions, providing doctors with comprehensive assessment indicators. © 2024 Copyright ACM.

关键词： Image segmentation

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Enhancing wound healing and adhesion through dopamine-assisted gelatin-silica hybrid dressings

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International Journal of Biological Macromolecules 2024年第Part2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, widely employed in hydrogel dressings, faces limitations when used in high fluid environments, hindering effective material adhesion to wound sites and subsequently reducing treatment efficacy. The rapid degradation of conventional hydrogels often results in breakdown before complete wound healing. Thus, there is a pressing need for the development of durable adhesive wound dressings. In this study, 3-glycidoxypropyltrimethoxysilane (GPTMS) was utilized as a coupling agent to create gelatin-silica hybrid (G-H) dressings through the sol-gel method. The coupling reaction established covalent bonds between gelatin and silica networks, enhancing structural stability. Dopamine (DP) was introduced to this hybrid (G-H-D) dressing to further boost adhesiveness. The efficacy of the dressings for wound management was assessed through in-vitro and in-vivo tests, along with ex-vivo bioadhesion testing on pig skin. Tensile bioadhesion tests demonstrated that the G-H-D material exhibited approximately 2.5 times greater adhesion to soft tissue in wet conditions compared to pure gelatin. Moreover, in-vitro and in-vivo wound healing experiments revealed a significant increase in wound healing rates. Consequently, this material shows promise as a viable option for use as a moist wound dressing. © 2023

关键词： Adhesion

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Modifying BiVO4 as a photocatalyst for water oxidation using constant-duration alkaline-etched post treatments

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New Journal of Chemistry 2023年第2期48卷 569-577页

作者： Hsu, Chuan-Chih Chuang, Kai-Jie Huang, Hsiao-Wen Pan, Bo-Jin Chen, Hung-Ming Husain, Sadang Yougbaré, Sibidou Hsiao, Yu-Cheng Wu, Yung-Fu Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. Ltd. Rm. 7 10F. No. 189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro Ouagadougou03 Burkina Faso International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

BiVO4 with suitable band edges and a small band gap is considered an efficient photocatalyst for the oxygen evolution reaction (OER), but short charge-transfer lengths limit its photocatalytic ability. Increasing active sites can essentially enhance oxidation reactions and photocatalytic ability. The alkaline etching technique can refine the surface properties of BiVO4 by introducing oxygen vacancies and possibly establishing a heterojunction, but suitable alkaline etching methods are rarely discussed. In this study, three alkaline etching methods, including hydrothermal, soaking, and electrodeposition processes, are first applied for a constant duration to tailor the surface properties of BiVO4 as a photocatalyst for the OER. Alkaline-etched BiVO4 prepared using hydrothermal and soaking processes shows better photocatalytic abilities due to the generation of additional oxygen vacancies, while poor photocatalytic ability is found for that fabricated using electrodeposition due to the formation of less photocatalytic VO2. The highest photocurrent density of 2.38 mA cm−2 is obtained at 1.23 V versus a reversible hydrogen electrode in an electrolyte without a hole scavenger for the BiVO4 etched in the hydrothermal process, while the untreated BiVO4 presents a photocurrent density of 0.58 mA cm−2. A photocurrent retention of 92.3% is achieved after 5000 seconds of continuous illumination. The study supplies blueprints for establishing effective alkaline etching methods for enhancing the photocatalytic ability of BiVO4, with the exception of time costs. © 2024 The Royal Society of Chemistry.

关键词： Charge transfer

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Assessment of force control improvement induced by sinusoidal vibrotactile stimulation in dominant and non-dominant hands

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Research on biomedical engineering 2021年第1期37卷 95-103页

作者： Germer, Carina Marconi Moreira, Luciana Sobral Elias, Leonardo Abdala Department of Electronics and Biomedical Engineering School of Electrical and Computer Engineering University of Campinas CampinasSP Brazil Neural Engineering Research Laboratory Center for Biomedical Engineering University of Campinas CampinasSP Brazil Cellular and Structural Biology Graduate Program Institute of Biology University of Campinas CampinasSP Brazil Faculty of Biological Sciences Center for Life Sciences Pontifical Catholic University of Campinas CampinasSP Brazil

Purpose: Vibrotactile stimulation has been shown to improve sensorimotor integration in the central nervous system, thereby enhancing motor performance in several conditions. Here we aim to address two questions: (1) Would lateral asymmetries yielding handedness influence the force control improvement induced by sinusoidal vibrotactile stimulation? (2) Does the force control improvement depend on finding an optimum stimulus intensity? Methods: Eleven participants performed a visually guided force-matching task, while different intensities of sinusoidal vibrations were applied to the index finger skin. Tasks consisted of abductions of the index fingers of dominant and non-dominant hands at 5% of their maximal voluntary contractions. The force coefficient of variation (CoV) in the condition without vibration was used as the reference (control) for later comparison with five vibration intensities. Also, force CoV in the control condition was compared with those obtained from the optimal vibration selected either from both hands or from a single hand (the one that started the experiment). Results: Despite the known sensory asymmetries in cortical and spinal circuits, handedness did not significantly influence the improvement of force control induced by sinusoidal vibrotactile stimulation during low-intensity contractions. Moreover, there was a significant reduction in force variability irrespective of the criteria used to select the vibration intensity. Conclusion: These findings add to the current knowledge on the effects of sinusoidal vibrotactile stimulation on force control and have potential implications for the development of wearable motor enhancer devices. © 2020, Sociedade Brasileira de Engenharia Biomedica.

关键词： Force control

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Schwann cells acquire a repair phenotype after assembling into spheroids and show enhanced in vivo therapeutic potential for promoting peripheral nerve repair

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Bioengineering and Translational Medicine 2024年第2期9卷 e10635页

作者： Chen, Shih-Heng Wang, Hsin-Wen Yang, Pei-Ching Chen, Shih-Shien Ho, Chia-Hsin Yang, Pei-Ching Kao, Ying-Chi Liu, Shao-Wen Chiu, Han Lin, Yu-Jie Chuang, Er-Yuan Huang, Jen-Huang Kao, Huang-Kai Huang, Chieh-Cheng Department of Plastic and Reconstructive Surgery Linkou Chang Gung Memorial Hospital Taoyuan Taiwan School of Medicine College of Medicine Chang Gung University Taoyuan Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering International Ph.D. Program in Biomedical Engineering Taipei Medical University Taipei Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University–Wan Fang Hospital Taipei Taiwan Department of Chemical Engineering National Tsing Hua University Hsinchu Taiwan

The prognosis for postinjury peripheral nerve regeneration remains suboptimal. Although transplantation of exogenous Schwann cells (SCs) has been considered a promising treatment to promote nerve repair, this strategy has been hampered in practice by the limited availability of SC sources and an insufficient postengraftment cell retention rate. In this study, to address these challenges, SCs were aggregated into spheroids before being delivered to an injured rat sciatic nerve. We found that the three-dimensional aggregation of SCs induced their acquisition of a repair phenotype, as indicated by enhanced levels of c-Jun expression/activation and decreased expression of myelin sheath protein. Furthermore, our in vitro results demonstrated the superior potential of the SC spheroid-derived secretome in promoting neurite outgrowth of dorsal root ganglion neurons, enhancing the proliferation and migration of endogenous SCs, and recruiting macrophages. Moreover, transplantation of SC spheroids into rats after sciatic nerve transection effectively increased the postinjury nerve structure restoration and motor functional recovery rates, demonstrating the therapeutic potential of SC spheroids. In summary, transplantation of preassembled SC spheroids may hold great potential for enhancing the cell delivery efficiency and the resultant therapeutic outcome, thereby improving SC-based transplantation approaches for promoting peripheral nerve regeneration. © 2023 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

关键词： Regenerative Medicine

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Facile synthesis of copper cobalt sulfide and nickel hydroxide tube-like composites as battery-type active material of energy storage devices

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Journal of Energy Storage 2023年 65卷

作者： Kuo, Tsung-Rong Fitriannisa, Istikhori Chung, Ren-Jei Lin, Kuan-Hsien Yougbaré, Sibidou Lin, Lu-Yin Wu, Yung-Fu International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan BP 218 11 Nanoro Burkina Faso Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Bimetallic sulfide has attracted much attentions as efficient electroactive materials of battery supercapacitor hybrid (BSH), because of numerous redox states, high conductivity and good energy efficiency. Developing composites having excellent chemical and electrochemical properties is necessary to enhance the energy storage features of bimetallic sulfides. In this study, CuCo2S4 and Ni(OH)2 composites (CuCo2S4@Ni(OH)2) are designed on Ni foam via the facial hydrothermal process and chemical bath deposition as the electroactive material of BSH at first time. Effects of Ni(OH)2 amounts on CuCo2S4 on electrochemical and physical properties of CuCo2S4@Ni(OH)2 are investigated. The physical mixed CuCo2S4 and Ni(OH)2 composite is also fabricated to verify synergistic effects of CuCo2S4@Ni(OH)2. A higher specific capacitance (CF) of 1583.9 F/g along with the capacity of 220.0 mAh/g are got for optimal CuCo2S4@Ni(OH)2 electrode, respectively comparing to 831.7 and 1063.3 F/g of CuCoS4 and Ni(OH)2 electrodes. A BSH is fabricated by the CuCo2S4@Ni(OH)2 electrode and the activated carbon electrode. The potential window of 1.6 V and maximum energy density of 32.1 Wh/kg at 1.1 kW/kg are achieved. The CF retention of 78% and Coulombic efficiency higher than 97% in 8000 charge/discharge cycles are also obtained for this BSH. © 2023

关键词： Sulfur compounds

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