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Typical Values in Digital Mammography Within the Framework of Diagnostic Reference Levels 9th

Typical Values in Digital Mammography Within the Framework o...

9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Real, J.V. Malthez, A.L.M.C. Graduate Program in Biomedical Engineering Federal University of Technology - Paraná Curitiba Brazil Clinical Hospital Complex of the Federal University of Paraná/Diagnostic Imaging Unit Curitiba Brazil

ISBN: (纸本)9783031494093

In the context of diagnostic reference levels (DRLs), typical values of mean glandular dose were established from a survey of mammographic examinations performed in a university hospital in Curitiba, Paraná, Brazil. This study represents an initial approach to the implementation of DRLs at the specific medical institution, as a means to improve the activities related to the radiological protection of patients managed by the Diagnostic Imaging Unit. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Medical imaging

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An Electrochemical HbA1c Immunosensor With a Simple Electrode of Gold Nanoparticle Monolayer

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IEEE Sensors Journal 2023年第15期23卷 16579-16584页

作者： Tseng, Chun-Chiang Lin, Ying-Ting Wang, Gou-Jen National Chung-Hsing University Department of Mechanical Engineering Taichung40227 Taiwan National Chung-Hsing University Program in Tissue Engineering and Regenerative Medicine Taichung40227 Taiwan National Chung-Hsing University Department of Mechanical Engineering The Graduate Institute of Biomedical Engineering Taichung40227 Taiwan

This study developed a novel electrochemical glycosylated hemoglobin (HbA1c) immunosensor. Polyethylene terephthalate (PET) was used as a substrate. After gold (Au) film sputtering on the PET surface, 1,6-hexanedithol with thiol groups on both terminals was used as an intermediary to attach a monolayer of uniformly distributed Au nanoparticles (AuNPs) to the Au thin film to form a nanostructured electrode. HbA1c antibodies were successfully immobilized on the AuNP monolayer via the self-assembled monolayer (SAM) approach. To mimic a real clinical detection environment, a calibration curve for HbA1c detection was performed in a mixture solution containing heparin sodium, red blood cell (RBC) lysis buffer, artificial human serum, and hemoglobin. The experimental results revealed that the proposed HbA1c immunosensor detected HbA1c in a linear range from 2500 to 10 000 ng/mL with a limit of detection of 2253 ng/mL. The developed HbA1c-sensing chip offers the advantages of simple operation, low cost, short detection time, and provides high feasibility for clinical application. © 2001-2012 IEEE.

关键词： Gold nanoparticles

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Multiplexed Nanoscopy via Buffer Exchange

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ACS Nano 2024年第34期18卷 23445-23456页

作者： Chang, Ting-Jui Ben Yang, T. Tony Department of Electrical Engineering National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei10617 Taiwan Department of Physics National Taiwan University Taipei10617 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei10617 Taiwan

Understanding cellular functions, particularly in their intricate complexity, can greatly benefit from the spatial mapping of diverse molecules through multitarget single-molecule localization microscopy (SMLM). Existing methodologies, primarily restricting the encoding dimensions to color and lifetime or requiring cyclic staining, often involve broad chromatic detection, specialized optical configurations, or sophisticated labeling techniques. Here, we propose a simple approach called buffer-exchange stochastic optical reconstruction microscopy (beSTORM), which introduces an additional dimension to differentiate between single molecules irrespective of their spectral properties. This method leverages the distinguishable photoblinking responses to distinct buffer conditions, offering a straightforward yet effective means of fluorophore discrimination. Through buffer exchanges, beSTORM achieves multitarget SMLM imaging with minimal crosstalk. Direct integration with expansion microscopy (ExM) demonstrates its capability to resolve up to six proteins at the molecular level within a single emission color without chromatic aberration. Overall, beSTORM presents a highly compatible imaging platform, promising significant advancements in highly multiplexed nanoscopy for exploring multiple targets in biological systems with nanoscale precision. © 2024 The Authors. Published by American Chemical Society.

关键词： Stochastic systems

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Integrated Numerical Model for Hemodynamic Simulation of Human Atria Under Atrial Fibrillation by Coupling 3D Electrophysiological Activity 9th

Integrated Numerical Model for Hemodynamic Simulation of Hum...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Lameu, João Siles, Jimena G. Sandoval, Italo McInnis, Melissa Salinet, João HEartLab - Biomedical Engineering Federal University of ABC São Bernardo do Campo Brazil Graduate Program in Biotechnoscience Federal University of ABC São Paulo Brazil

ISBN: (纸本)9783031494000

Atrial Fibrillation (AF) is the most common cardiac arrhythmia, increasing the chance of ischemic events five-fold. AF is characterized by fast and abnormal electrical activity, leading to disturbance in atrial contraction, resulting in pro-thrombotic zones due to blood stagnation. Literature shows that hemodynamic modeling using Computational Fluid Dynamics (CFD) has been used to evaluate the hemodynamic outcomes of atria chambers under AF;however, with simplifications related to the electromechanical effects of AF. This study aims to present an integrated analysis by coupling electrophysiological information to a hemodynamic model. A patient undergoing an electrophysiology study was enrolled. Firstly, the patient underwent Magnetic Resonance Imaging (MRI) scan, followed by an electrophysiology study. From MRI images, atrial shell was segmented through a semiautomatic image processing pipeline. Then, multi-electrode catheters were used to acquire electrophysiology signals, allowing determination of local activation times in the 3D atria shell. The 3D mapping provided AF activation patterns used as boundary conditions in the hemodynamic model. The mechanical effects from AF activity were coupled into the blood flow using a momentum method, allowing the local oscillatory wall motion to be mimicked due to the AF activity and its propagation effects through the blood flow. Statistical analysis of fundamental hemodynamic field properties (pressure and wall shear stress, WSS) exhibited a higher dispersion when considering the momentum method. The hemodynamic field presented larger pro-thrombotic zones (WSS ≤ 0.1 Pa) when considering the wall effects of AF activity © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Computational fluid dynamics

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Interfering with sleep apnea

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Bioelectronic Medicine 2024年第1期10卷 1-3页

作者： Pedersen, Nigel Paul Astorga, Raul Castillo Department of Neurology School of Medicine and Center for Neuroscience University of California Davis 1515 Newton Court DavisCA95618 United States Graduate Program in Biomedical Engineering University of California DavisCA95618 United States

The effects of electromagnetic interference have been hiding in plain sight for millennia and are now being applied to the non-invasive stimulation of deep tissues. In the article by Missey et al., the effect of non-invasive stimulation of the hypoglossal nerve by an interference envelope of interfering carrier waves is examined in mice and participants with sleep apnea. This stimulation is capable of activating the nerve and reducing apnea-hypopnea events. Temporally interfering electric fields have potential applications far beyond hypoglossal stimulation and may represent a revolutionary new approach to treating illness and understanding the functional organization of the nervous system. © 2024, The Author(s).

关键词： Electric fields

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3D Image Generation from X-ray Projections Using Generative Adversarial Networks 23

3D Image Generation from X-ray Projections Using Generative ...

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23rd IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2023

作者： AlShurbaji, Mohammad Dhou, Salam Biomedical Engineering Graduate Program American University of Sharjah Sharjah United Arab Emirates Department of Computer Science and Engineering American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9798350393118

The human brain can effortlessly imagine a 3D image from only 2D images with a little expertise and imagination, but for machines, this is not a trivial task. Because of this, reconstructing 3D images from 2D ones is a hot topic and has many applications. In this paper, we propose a Generative Adversarial Network (GAN)-based approach that generates CT-like images using pairs of orthogonal X-ray projections taken from different angles. In this work, a variety of orthogonal pairs from different angles, ranging from 0 &90 to 60 &150, were considered as input to the 3D image generation model. The effectiveness of the proposed method was assessed by measuring the Structural Similarity Index (SSIM) and Peak Signal-to-Noise Ratio (PSNR), which resulted in values of 0.641 and 29.21, respectively. Furthermore, the model's ability to capture the respiratory motion in the input projections and reflect it in the generated images was also assessed. This work demonstrated the feasibility of generating CT-like images from X-ray projections captured from different orthogonal angles taking into consideration the respiratory motion exhibited in these projections. © 2023 IEEE.

关键词： Generative adversarial networks

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NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, Photothermal, and Chemodynamic Therapy

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ACS Applied Materials and Interfaces 2024年第20期16卷 25622-25636页

作者： Thirumurugan, Senthilkumar Muthiah, Kayalvizhi Samuvel Lin, Yu-Chien Dhawan, Udesh Liu, Wai-Ching Wang, An-Ni Liu, Xinke Hsiao, Michael Tseng, Ching-Li Chung, Ren-Jei No. 1 Section 3 Zhongxiao East Road Taipei10608 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Faculty of Science and Technology Technological and Higher Education Institute of Hong Kong Hong Kong New Territories999077 Hong Kong Scrona AG Grubenstrasse 9 Zürich8045 Switzerland College of Materials Science and Engineering Chinese Engineering and Research Institute of Microelectronics Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore Genomics Research Center Academia Sinica Taipei115 Taiwan Department and Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei10608 Taiwan

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to develop novel therapies to effectively treat this disease. In this study, iron selenide nanorods (FeSe2 NRs) were designed for use in magnetic hyperthermic, photothermal, and chemodynamic therapy (MHT/PTT/CDT) for breast cancer. To illustrate their efficacy, FeSe2 NRs were modified with the chemotherapeutic agent methotrexate (MTX). MTX-modified FeSe2 (FeSe2-MTX) exhibited excellent controlled drug release properties. Fe2+ released from FeSe2 NRs induced the release of •OH from H2O2 via a Fenton/Fenton-like reaction, enhancing the efficacy of CDT. Under alternating magnetic field (AMF) stimulation and 808 nm laser irradiation, FeSe2-MTX exerted potent hyperthermic and photothermal effects by suppressing tumor growth in a breast cancer nude mouse model. In addition, FeSe2 NRs can be used for magnetic resonance imaging in vivo by incorporating their superparamagnetic characteristics into a single nanomaterial. Overall, we presented a novel technique for the precise delivery of functional nanosystems to tumors that can enhance the efficacy of breast cancer treatment. © 2024 The Authors. Published by American Chemical Society

关键词： Magnetic resonance imaging

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Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

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Effects of Tecartherapy on Body Tissue: A Systematic Review

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Journal of biomedical Science and engineering 2023年第10期16卷 133-148页

作者： Adriana Mitie Ida Eduardo Borba Neves Adriana Maria Wan Stadnik Graduate Program in Biomedical Engineering Universidade Tecnológica Federal do Paraná Curitiba Brazil

Electrophysical devices based on diathermy are one of the modalities used by many professionals to treat pain. The objective of this study was to identify the effects of Tecartherapy on healthy and unhealthy tissues. A systematic review of Tecartherapy technology was carried out. Articles published up to the year 2023 were investigated. The search argument used was “Capacitive-resistive electrical transfer” OR “Tecar” OR “Therapy Tecar” OR “CRET” in the BVS, Cochrane, PEDro, PubMed, IEEE Explore databases, Scielo and Web of Science. As for the main results of using Tecartherapy, there is an increase in temperature. In healthy tissues there is an increase in local blood flow, a decrease in muscle fatigue and an increase in muscle flexibility. In addition to the effects observed on healthy tissues, pain reduction and improved joint function were also observed. It was concluded that this technology has similar effects to other diathermy, but Tecartherapy proved to be safer and more comfortable. .

关键词： CRET Electrical Transfer Diathermy Capacitive-Resistive

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Dental Imaging Using a Higher Signal-to-Noise Ratio Optical Coherence Tomography System

Dental Imaging Using a Higher Signal-to-Noise Ratio Optical ...

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2023 IEEE International Conference on Electrical, Computer and Energy Technologies, ICECET 2023

作者： Azeez, Akeem. A. Mezgebo, Biniyam Franca, Rodrigo Sherif, Sherif S. University of Manitoba Biomedical Engineering Graduate Program Winnipeg Canada University of Manitoba Dept. of Electrical and Computer Engineering Winnipeg Canada University of Manitoba Dept. of Restorative Dentistry Winnipeg Canada

ISBN: (纸本)9798350327816

This paper presents an optical coherence tomography (OCT) system in conjunction with a novel image reconstruction technique employed for in vitro imaging of human teeth. The primary goal is to enhance the signal-to-noise ratio (SNR) in the obtained images. The study entails a comparative analysis between the conventional Fast Fourier Transform (FFT) OCT image reconstruction method and a newly introduced scaled nonuniform discrete Fourier transform (NDFT) approach. The findings reveal that the NDFT method consistently delivers superior results in terms of peak signal-to-noise ratio (PSNR) and overall image quality, even when dealing with redundant and nonuniform frequency domain samples. In light of these results, this paper concludes that integrating NDFT into OCT procedures has the potential to significantly enhance the quality of image reconstructions, thereby fostering its broader application in the field of dental imaging. © 2023 IEEE.

关键词： dental imaging frame theory image reconstruction Optical Coherence Tomography (OCT) signal processing

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