Optimal Bioprinting Parameters and Experimental Investigation of Acellular Dermal Matrix Scaffold

作     者：Qingxi Hu Yiming Wang Dongchao Yang Haiguang Zhang Zhicheng Song Yan Gu 

作者机构：Rapid Manufacturing Engineering CenterSchool of Mechatronic Engineering and AutomationShanghai UniversityShanghaiChina Shanghai Key Laboratory of Intelligent Manufacturing and RoboticsShanghai UniversityShanghaiChina National Demonstration Center for Experimental Engineering Training EducationShanghai UniversityShanghaiChina Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai200011China 

出 版 物：《Journal of Renewable Materials》 (可再生材料杂志（英文）)

年 卷 期：2021年第9卷第1期

页      面：1-16页

核心收录：

学科分类：082903[工学-林产化学加工工程] 08[工学] 0829[工学-林业工程] 082201[工学-制浆造纸工程] 0822[工学-轻工技术与工程] 

基　　金：This research was funded by National Natural Science Foundation of China Grant Nos.51775324 and 81970455 

主　　题：Bioprinting acellular dermal matrix scaffolds printability tissue engineering 

摘      要：Acellular dermal matrix(ADM)as a biomaterial is currently believed to be promising tissue repair *** the development of tissue engineering,ADM is increasingly used as biological *** explored the feasibility and performance of ADM biological scaffolds that fabricated by 3D *** paper presented our study on the printability of 3D printed ADM scaffolds,with a focus on identifying the influence of printing parameters/conditions on *** characterize the printability,we examined the fiber morphology,pore size,strand diameter,and mechanical property of the printed *** results revealed that the printability could be affected by a number of factors and among them,the most considerable one was related to the nozzle diameter and the composition of *** then evaluated the biocompatibility in terms of cytotoxicity,cell proliferation and *** vitro evaluation of the ADM scaffolds was carried out and the experimental results indicated that cells were viable and proliferative during the period of *** vivo results also indicated that the defect area was well repaired without any noticeable infection,hematoma and other *** conclusion,ADM could be reconstructed with 3D printing technology and ADM biological scaffold has potential applications for tissue engineering.